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Volumn 88, Issue 4, 2010, Pages 649-654

Neuregulin-1 regulates the expression of Akt, Bcl-2, and bad signaling after focal cerebral ischemia in rats

Author keywords

Akt; Bad; Bcl 2; Ischemia; Neuregulin

Indexed keywords

APOPTOSIS; BCL-2MRNA; CASPASE-3; CEREBRAL ISCHEMIA; CHAIN REACTION; DOWNSTREAM TARGET; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIDERMAL GROWTH FACTORS; INTRALUMINAL; LY294002; MIDDLE CEREBRAL ARTERY; MOLECULAR SIGNALING; NEUREGULIN; NEURONAL SURVIVAL; REPERFUSION; REVERSE TRANSCRIPTION; SPECIFIC INHIBITORS; WESTERN BLOTS;

EID: 77954945334     PISSN: 08298211     EISSN: 12086002     Source Type: Journal    
DOI: 10.1139/O09-189     Document Type: Article
Times cited : (37)

References (33)
  • 1
    • 2142771705 scopus 로고    scopus 로고
    • Altered Bad localization and interaction between Bad and BclxL in the hippocampus after transient global ischemia
    • doi:10.1016/j.brainres.2004.03.003. PMID:15120593
    • Abe, T., Takagi, N., Nakano, M., Furuya, M., and Takeo, S. 2004. Altered Bad localization and interaction between Bad and BclxL in the hippocampus after transient global ischemia. Brain Res. 1009(1-2): 159-168. doi:10.1016/j.brainres.2004.03.003. PMID:15120593.
    • (2004) Brain Res , vol.1009 , Issue.1-2 , pp. 159-168
    • Abe, T.1    Takagi, N.2    Nakano, M.3    Furuya, M.4    Takeo, S.5
  • 2
    • 0027202458 scopus 로고
    • Bcl-2 gene is highly expressed during neurogenesis in the central nervous system
    • doi:10.1006/bbrc.1993.1304. PMID:8466531
    • Abe-Dohmae, S., Harada, N., Yamada, K., and Tanaka, R. 1993. Bcl-2 gene is highly expressed during neurogenesis in the central nervous system. Biochem. Biophys. Res. Commun. 191(3): 915-921. doi:10.1006/bbrc.1993.1304. PMID:8466531.
    • (1993) Biochem. Biophys. Res. Commun , vol.191 , Issue.3 , pp. 915-921
    • Abe-Dohmae, S.1    Harada, N.2    Yamada, K.3    Tanaka, R.4
  • 3
    • 0032861770 scopus 로고    scopus 로고
    • Bcl-2 prolongs neuronal survival during hypoxia-induced apoptosis
    • doi:10.1016/S0169-328X(99), 00189-8. PMID:10529480
    • Banasiak, K.J., Cronin, T., and Haddad, G.G. 1999. bcl-2 prolongs neuronal survival during hypoxia-induced apoptosis. Brain Res. Mol. Brain Res. 72(2): 214-225. doi:10.1016/S0169-328X(99) 00189-8. PMID:10529480.
    • (1999) Brain Res. Mol. Brain Res , vol.72 , Issue.2 , pp. 214-225
    • Banasiak, K.J.1    Cronin, T.2    Haddad, G.G.3
  • 4
    • 0035368610 scopus 로고    scopus 로고
    • Neuregulin and ErbB receptor signaling pathways in the nervous system
    • doi:10.1016/S0959-4388(00)00210-5. PMID:11399426
    • Buonanno, A., and Fischbach, G.D. 2001. Neuregulin and ErbB receptor signaling pathways in the nervous system. Curr. Opin. Neurobiol. 11(3): 287-296. doi:10.1016/S0959-4388(00)00210-5. PMID:11399426.
    • (2001) Curr. Opin. Neurobiol , vol.11 , Issue.3 , pp. 287-296
    • Buonanno, A.1    Fischbach, G.D.2
  • 5
    • 0031032232 scopus 로고    scopus 로고
    • Apoptosis repressor genes Bcl-2 and Bcl-x-long are expressed in the rat brain following global ischemia
    • doi:10.1097/00004647-199701000-00002. PMID:8978381
    • Chen, J., Graham, S.H., Nakayama, M., Zhu, R.L., Jin, K., Stetler, R.A., and Simon, R.P. 1997. Apoptosis repressor genes Bcl-2 and Bcl-x-long are expressed in the rat brain following global ischemia. J. Cereb. Blood Flow Metab. 17(1): 2-10. doi:10.1097/00004647-199701000-00002. PMID:8978381.
    • (1997) J. Cereb. Blood Flow Metab , vol.17 , Issue.1 , pp. 2-10
    • Chen, J.1    Graham, S.H.2    Nakayama, M.3    Zhu, R.L.4    Jin, K.5    Stetler, R.A.6    Simon, R.P.7
  • 6
    • 42749089288 scopus 로고    scopus 로고
    • Neuroprotective effects of neuregulin-1 on B35 neuronal cells following ischemia
    • doi:10.1016/j.brainres.2008.02.059. PMID: 18410912
    • Croslan, D.R., Schoell, M.C., Ford, G.D., Pulliam, J.V., Gates, A., Clement, C.M., et al. 2008. Neuroprotective effects of neuregulin-1 on B35 neuronal cells following ischemia. Brain Res. 1210: 39-47. doi:10.1016/j.brainres.2008.02.059. PMID: 18410912.
    • (2008) Brain Res , vol.1210 , pp. 39-47
    • Croslan, D.R.1    Schoell, M.C.2    Ford, G.D.3    Pulliam, J.V.4    Gates, A.5    Clement, C.M.6
  • 7
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • doi:10.1016/S0092-8674(00)80405-5. PMID: 9346240
    • Datta, S.R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., and Greenberg, M.E. 1997. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell, 91(2): 231-241. doi:10.1016/S0092-8674(00)80405-5. PMID: 9346240.
    • (1997) Cell , vol.91 , Issue.2 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6    Greenberg, M.E.7
  • 8
    • 22344456913 scopus 로고    scopus 로고
    • Neuregulins rescue PC12-ErbB-4 cells from cell death induced by beta-amyloid peptide: Involvement of PI3K and PKC
    • doi:10.1385/JMN:26:1:057. PMID:15968086
    • Di Segni, A., Shaharabani, E., Stein, R., and Pinkas-Kramarski, R. 2005. Neuregulins rescue PC12-ErbB-4 cells from cell death induced by beta-amyloid peptide: involvement of PI3K and PKC. J. Mol. Neurosci. 26(1): 57-69. doi:10.1385/JMN:26:1:057. PMID:15968086.
    • (2005) J. Mol. Neurosci , vol.26 , Issue.1 , pp. 57-69
    • Di Segni, A.1    Shaharabani, E.2    Stein, R.3    Pinkas-Kramarski, R.4
  • 9
    • 0034537223 scopus 로고    scopus 로고
    • Closed head injury induces up-regulation of ErbB-4 receptor at the site of injury
    • doi:10.1006/mcne.2000.0894. PMID:11083921
    • Erlich, S., Shohami, E., and Pinkas-Kramarski, R. 2000. Closed head injury induces up-regulation of ErbB-4 receptor at the site of injury. Mol. Cell. Neurosci. 16(5): 597-608. doi:10.1006/mcne.2000.0894. PMID:11083921.
    • (2000) Mol. Cell Neurosci , vol.16 , Issue.5 , pp. 597-608
    • Erlich, S.1    Shohami, E.2    Pinkas-Kramarski, R.3
  • 10
    • 0035900613 scopus 로고    scopus 로고
    • ErbB-4 activation inhibits apoptosis in PC12 cells
    • doi:10.1016/S0306-4522(01)00350-5. PMID:11731109
    • Erlich, S., Goldshmit, Y., Lupowitz, Z., and Pinkas-Kramarski, R. 2001. ErbB-4 activation inhibits apoptosis in PC12 cells. Neuroscience, 107(2): 353-362. doi:10.1016/S0306-4522(01)00350-5. PMID:11731109.
    • (2001) Neuroscience , vol.107 , Issue.2 , pp. 353-362
    • Erlich, S.1    Goldshmit, Y.2    Lupowitz, Z.3    Pinkas-Kramarski, R.4
  • 11
    • 0037429649 scopus 로고    scopus 로고
    • Neuregulins: Functions, forms, and signaling strategies
    • doi:10.1016/S0014-4827(02)00102-7. PMID:12648463
    • Falls, D.L. 2003. Neuregulins: functions, forms, and signaling strategies. Exp. Cell Res. 284(1): 14-30. doi:10.1016/S0014-4827(02)00102-7. PMID:12648463.
    • (2003) Exp. Cell Res , vol.284 , Issue.1 , pp. 14-30
    • Falls, D.L.1
  • 12
    • 33646892425 scopus 로고    scopus 로고
    • Neuroprotective effects of neuregulin-1 in rat models of focal cerebral ischemia
    • doi:10.1016/j.brainres.2006. 03.007. PMID:16616052
    • Guo, W.P., Wang, J., Li, R.X., and Peng, Y.W. 2006. Neuroprotective effects of neuregulin-1 in rat models of focal cerebral ischemia. Brain Res. 1087(1): 180-185. doi:10.1016/j.brainres.2006. 03.007. PMID:16616052.
    • (2006) Brain Res , vol.1087 , Issue.1 , pp. 180-185
    • Guo, W.P.1    Wang, J.2    Li, R.X.3    Peng, Y.W.4
  • 13
    • 0032857768 scopus 로고    scopus 로고
    • Targeted disruption of the bcl-2 gene in mice exacerbates focal ischemic brain injury
    • doi:10.1023/A:1020709814456. PMID:10488913
    • Hata, R., Gillardon, F., Michaelidis, T.M., and Hossmann, K.A. 1999. Targeted disruption of the bcl-2 gene in mice exacerbates focal ischemic brain injury. Metab. Brain Dis. 14(2): 117-124. doi:10.1023/A:1020709814456. PMID:10488913.
    • (1999) Metab. Brain Dis , vol.14 , Issue.2 , pp. 117-124
    • Hata, R.1    Gillardon, F.2    Michaelidis, T.M.3    Hossmann, K.A.4
  • 14
    • 33748933367 scopus 로고    scopus 로고
    • Involvement of Akt in preconditioning-induced tolerance to ischemia in PC12 cells
    • doi:10.1038/sj. jcbfm.9600286. PMID:16511503
    • Hillion, J.A., Li, Y., Maric, D., Takanohashi, A., Klimanis, D., Barker, J.L., and Hallenbeck, J.M. 2006. Involvement of Akt in preconditioning-induced tolerance to ischemia in PC12 cells. J. Cereb. Blood Flow Metab. 26(10): 1323-1331. doi:10.1038/sj. jcbfm.9600286. PMID:16511503.
    • (2006) J. Cereb. Blood Flow Metab , vol.26 , Issue.10 , pp. 1323-1331
    • Hillion, J.A.1    Li, Y.2    Maric, D.3    Takanohashi, A.4    Klimanis, D.5    Barker, J.L.6    Hallenbeck, J.M.7
  • 15
    • 33847209168 scopus 로고    scopus 로고
    • Bad as a converging signaling molecule between survival PI3-K/Akt and death JNK in neurons after transient focal cerebral ischemia in rats
    • doi:10.1038/ sj.jcbfm.9600367. PMID:16820799
    • Kamada, H., Nito, C., Endo, H., and Chan, P.H. 2007. Bad as a converging signaling molecule between survival PI3-K/Akt and death JNK in neurons after transient focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 27(3): 521-533. doi:10.1038/ sj.jcbfm.9600367. PMID:16820799.
    • (2007) J. Cereb. Blood Flow Metab , vol.27 , Issue.3 , pp. 521-533
    • Kamada, H.1    Nito, C.2    Endo, H.3    Chan, P.H.4
  • 16
    • 36348993794 scopus 로고    scopus 로고
    • Neuroprotection by neuregulin-1 in a rat model of permanent focal cerebral ischemia
    • doi:10.1016/j.brainres.2007.09.037. PMID:17961519
    • Li, Y., Xu, Z.F., Ford, G.D., Croslan, D.R., Cairobe, T., Li, Z.Z., and Ford, B.D. 2007. Neuroprotection by neuregulin-1 in a rat model of permanent focal cerebral ischemia. Brain Res. 1184: 277-283. doi:10.1016/j.brainres.2007.09.037. PMID:17961519.
    • (2007) Brain Res , vol.1184 , pp. 277-283
    • Li, Y.1    Xu, Z.F.2    Ford, G.D.3    Croslan, D.R.4    Cairobe, T.5    Li, Z.Z.6    Ford, B.D.7
  • 17
    • 0027944004 scopus 로고
    • Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia
    • doi:10.1016/0896-6273(94)90266-6. PMID:7946326
    • Martinou, J.C., Dubois-Dauphin, M., Staple, J.K., Rodriguez, I., Frankowski, H., Missotten, M., et al. 1994. Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron, 13(4): 1017-1030. doi:10.1016/0896-6273(94)90266-6. PMID:7946326.
    • (1994) Neuron , vol.13 , Issue.4 , pp. 1017-1030
    • Martinou, J.C.1    Dubois-Dauphin, M.2    Staple, J.K.3    Rodriguez, I.4    Frankowski, H.5    Missotten, M.6
  • 18
    • 0035194849 scopus 로고    scopus 로고
    • Evidence of phosphorylation of Akt and neuronal survival after transient focal cerebral ischemia in mice
    • doi:10.1097/00004647-200112000-00009. PMID:11740206
    • Noshita, N., Lewén, A., Sugawara, T., and Chan, P.H. 2001. Evidence of phosphorylation of Akt and neuronal survival after transient focal cerebral ischemia in mice. J. Cereb. Blood Flow Metab. 21(12): 1442-1450. doi:10.1097/00004647-200112000-00009. PMID:11740206.
    • (2001) J. Cereb. Blood Flow Metab , vol.21 , Issue.12 , pp. 1442-1450
    • Noshita, N.1    Lewén, A.2    Sugawara, T.3    Chan, P.H.4
  • 19
    • 0036237137 scopus 로고    scopus 로고
    • Akt phosphorylation and neuronal survival after traumatic brain injury in mice
    • doi:10.1006/nbdi. 2002.0482. PMID:11950275
    • Noshita, N., Lewen, A., Sugawara, T., and Chan, P.H. 2002. Akt phosphorylation and neuronal survival after traumatic brain injury in mice. Neurobiol. Dis. 9(3): 294-304. doi:10.1006/nbdi. 2002.0482. PMID:11950275.
    • (2002) Neurobiol. Dis. , vol.9 , Issue.3 , pp. 294-304
    • Noshita, N.1    Lewen, A.2    Sugawara, T.3    Chan, P.H.4
  • 20
    • 0037121574 scopus 로고    scopus 로고
    • Neuregulin expression after focal stroke in the rat
    • doi:10.1016/S0304-3940(02)01126-6. PMID:12453622
    • Parker, M.W., Chen, Y., Hallenbeck, J.M., and Ford, B.D. 2002. Neuregulin expression after focal stroke in the rat. Neurosci. Lett. 334(3): 169-172. doi:10.1016/S0304-3940(02)01126-6. PMID:12453622.
    • (2002) Neurosci. Lett. , vol.334 , Issue.3 , pp. 169-172
    • Parker, M.W.1    Chen, Y.2    Hallenbeck, J.M.3    Ford, B.D.4
  • 21
    • 46449095702 scopus 로고    scopus 로고
    • Exploiting endogenous anti-apoptotic proteins for novel therapeutic strategies in cerebral ischemia
    • doi:10.1016/j.pneurobio.2008.04.003. PMID:18511172
    • Rami, A., Bechmann, I., and Stehle, J.H. 2008. Exploiting endogenous anti-apoptotic proteins for novel therapeutic strategies in cerebral ischemia. Prog. Neurobiol. 85(3): 273-296. doi:10.1016/j.pneurobio.2008.04.003. PMID:18511172.
    • (2008) Prog. Neurobiol , vol.85 , Issue.3 , pp. 273-296
    • Rami, A.1    Bechmann, I.2    Stehle, J.H.3
  • 22
    • 0027963452 scopus 로고
    • Increase in bcl-2 oncoprotein and the tolerance to ischemia-induced neuronal death in the gerbil hippocampus
    • doi:10.1016/0168-0102(94)90026-4. PMID:7527133
    • Shimazaki, K., Ishida, A., and Kawai, N. 1994. Increase in bcl-2 oncoprotein and the tolerance to ischemia-induced neuronal death in the gerbil hippocampus. Neurosci. Res. 20(1): 95-99. doi:10.1016/0168-0102(94)90026-4. PMID:7527133.
    • (1994) Neurosci. Res. , vol.20 , Issue.1 , pp. 95-99
    • Shimazaki, K.1    Ishida, A.2    Kawai, N.3
  • 23
    • 0035094458 scopus 로고    scopus 로고
    • Bcl-2 Antisense treatment prevents induction of tolerance to focal ischemia in the rat brain
    • doi:10.1097/00004647-200103000-00007. PMID:11295878
    • Shimizu, S., Nagayama, T., Jin, K.L., Zhu, L., Loeffert, J.E., Watkins, S.C., et al. 2001. bcl-2 Antisense treatment prevents induction of tolerance to focal ischemia in the rat brain. J. Cereb. Blood Flow Metab. 21(3): 233-243. doi:10.1097/00004647-200103000-00007. PMID:11295878.
    • (2001) J. Cereb. Blood Flow Metab , vol.21 , Issue.3 , pp. 233-243
    • Shimizu, S.1    Nagayama, T.2    Jin, K.L.3    Zhu, L.4    Loeffert, J.E.5    Watkins, S.C.6
  • 24
    • 0033968157 scopus 로고    scopus 로고
    • ErbB-4 activation promotes neurite outgrowth in PC12 cells
    • doi:10.1046/j.1471-4159. 2000.0740979.x. PMID:10693928
    • Vaskovsky, A., Lupowitz, Z., Erlich, S., and Pinkas-Kramarski, R. 2000. ErbB-4 activation promotes neurite outgrowth in PC12 cells. J. Neurochem. 74(3): 979-987. doi:10.1046/j.1471-4159. 2000.0740979.x. PMID:10693928.
    • (2000) J. Neurochem , vol.74 , Issue.3 , pp. 979-987
    • Vaskovsky, A.1    Lupowitz, Z.2    Erlich, S.3    Pinkas-Kramarski, R.4
  • 25
    • 49849103054 scopus 로고    scopus 로고
    • Ischemic postconditioning inhibits apoptosis after focal cerebral ischemia/reperfusion injury in the rat
    • doi:10.1161/STROKEAHA.107.507939. PMID:18583563
    • Xing, B., Chen, H., Zhang, M., Zhao, D., Jiang, R., Liu, X., and Zhang, S. 2008. Ischemic postconditioning inhibits apoptosis after focal cerebral ischemia/reperfusion injury in the rat. Stroke, 39(8): 2362-2369. doi:10.1161/STROKEAHA.107.507939. PMID:18583563.
    • (2008) Stroke , vol.39 , Issue.8 , pp. 2362-2369
    • Xing, B.1    Chen, H.2    Zhang, M.3    Zhao, D.4    Jiang, R.5    Liu, X.6    Zhang, S.7
  • 26
    • 6044220229 scopus 로고    scopus 로고
    • Neuregulin-1 is neuroprotective and attenuates inflammatory responses induced by ischemic stroke
    • doi:10.1016/j.bbrc.2004.07.149. PMID:15325249
    • Xu, Z., Jiang, J., Ford, G., and Ford, B.D. 2004. Neuregulin-1 is neuroprotective and attenuates inflammatory responses induced by ischemic stroke. Biochem. Biophys. Res. Commun. 322(2): 440-446. doi:10.1016/j.bbrc.2004.07.149. PMID:15325249.
    • (2004) Biochem. Biophys. Res. Commun , vol.322 , Issue.2 , pp. 440-446
    • Xu, Z.1    Jiang, J.2    Ford, G.3    Ford, B.D.4
  • 27
    • 22044440607 scopus 로고    scopus 로고
    • Neuroprotection by neuregulin-1 following focal stroke is associated with the attenuation of ischemia-induced pro-inflammatory and stress gene expression
    • doi:10.1016/j.nbd.2005.01.027. PMID: 16023588
    • Xu, Z., Ford, G.D., Croslan, D.R., Jiang, J., Gates, A., Allen, R., and Ford, B.D. 2005. Neuroprotection by neuregulin-1 following focal stroke is associated with the attenuation of ischemia-induced pro-inflammatory and stress gene expression. Neurobiol. Dis. 19(3): 461-470. doi:10.1016/j.nbd.2005.01.027. PMID: 16023588.
    • (2005) Neurobiol. Dis , vol.19 , Issue.3 , pp. 461-470
    • Xu, Z.1    Ford, G.D.2    Croslan, D.R.3    Jiang, J.4    Gates, A.5    Allen, R.6    Ford, B.D.7
  • 28
    • 48949104380 scopus 로고    scopus 로고
    • Neuroprotective effect of humanin on cerebral ischedmia/reperfusion injust is mediated by a PI3K/Akt pathway
    • doi:10.1016/j.brainres. 2008.06.018. PMID:18590709
    • Xu, X.S., Chua, C.C., Gao, K., Chua, K.W., Wang, H., Hamdy, R.C., Chua, B.H. 2008. Neuroprotective effect of humanin on cerebral ischedmia/reperfusion injust is mediated by a PI3K/Akt pathway. Brain Res. 1227(28): 12-18. doi:10.1016/j.brainres. 2008.06.018. PMID:18590709.
    • (2008) Brain Res , vol.1227 , Issue.28 , pp. 12-18
    • Xu, X.S.1    Chua, C.C.2    Gao, K.3    Chua, K.W.4    Wang, H.5    Hamdy, R.C.6    Chua, B.H.7
  • 29
    • 0028809209 scopus 로고
    • Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death
    • doi:10.1016/0092-8674(95)90411-5. PMID:7834748
    • Yang, E., Zha, J., Jockel, J., Boise, L.H., Thompson, C.B., and Korsmeyer, S.J. 1995. Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell, 80(2): 285-291. doi:10.1016/0092-8674(95)90411-5. PMID:7834748.
    • (1995) Cell , vol.80 , Issue.2 , pp. 285-291
    • Yang, E.1    Zha, J.2    Jockel, J.3    Boise, L.H.4    Thompson, C.B.5    Korsmeyer, S.J.6
  • 30
    • 0030584088 scopus 로고    scopus 로고
    • Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
    • doi:10.1016/S0092-8674(00)81382-3. PMID: 8929531
    • Zha, J., Harada, H., Yang, E., Jockel, J., and Korsmeyer, S.J. 1996. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell, 87(4): 619-628. doi:10.1016/S0092-8674(00)81382-3. PMID: 8929531.
    • (1996) Cell , vol.87 , Issue.4 , pp. 619-628
    • Zha, J.1    Harada, H.2    Yang, E.3    Jockel, J.4    Korsmeyer, S.J.5
  • 31
    • 2642560525 scopus 로고    scopus 로고
    • Bcl-2 transfection via herpes simplex virus blocks apoptosis-inducing factor translocation after focal ischemia in the rat
    • doi:10.1097/01.WCB.0000127161.89708.A5. PMID:15181376
    • Zhao, H., Yenari, M.A., Cheng, D., Barreto-Chang, O.L., Sapolsky, R.M., and Steinberg, G.K. 2004. Bcl-2 transfection via herpes simplex virus blocks apoptosis-inducing factor translocation after focal ischemia in the rat. J. Cereb. Blood Flow Metab. 24(6): 681-692. doi:10.1097/01.WCB.0000127161.89708.A5. PMID:15181376.
    • (2004) J. Cereb. Blood Flow Metab , vol.24 , Issue.6 , pp. 681-692
    • Zhao, H.1    Yenari, M.A.2    Cheng, D.3    Barreto-Chang, O.L.4    Sapolsky, R.M.5    Steinberg, G.K.6
  • 32
    • 27144446140 scopus 로고    scopus 로고
    • Akt contributes to neuroprotection by hypothermia against cerebral ischemia in rats
    • doi:10.1523/JNEUROSCI. 3163-05.2005. PMID:16237183
    • Zhao, H., Shimohata, T., Wang, J.Q., Sun, G.H., Schaal, D.W., Sapolsky, R.M., and Steinberg, G.K. 2005. Akt contributes to neuroprotection by hypothermia against cerebral ischemia in rats. J. Neurosci. 25(42): 9794-9806. doi:10.1523/JNEUROSCI. 3163-05.2005. PMID:16237183.
    • (2005) J. Neurosci , vol.25 , Issue.42 , pp. 9794-9806
    • Zhao, H.1    Shimohata, T.2    Wang, J.Q.3    Sun, G.H.4    Schaal, D.W.5    Sapolsky, R.M.6    Steinberg, G.K.7
  • 33
    • 33847014888 scopus 로고    scopus 로고
    • Phosphoinositide-3-kinase/akt survival signal pathways are implicated in neuronal survival after stroke
    • doi:10.1385/MN:34:3:249. PMID:17308356
    • Zhao, H., Sapolsky, R.M., and Steinberg, G.K. 2006. Phosphoinositide-3-kinase/akt survival signal pathways are implicated in neuronal survival after stroke. Mol. Neurobiol. 34(3): 249-270. doi:10.1385/MN:34:3:249. PMID:17308356.
    • (2006) Mol. Neurobiol , vol.34 , Issue.3 , pp. 249-270
    • Zhao, H.1    Sapolsky, R.M.2    Steinberg, G.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.