The effect of baicalein on hippocampal neuronal damage and metalloproteinase activity following transient global cerebral ischaemia

Phytotherapy Research

Volumn 26, Issue 11, 2012, Pages 1614-1619

  Lee, Jung Hyun ^a   Lee, Seong Ryong ^a  

^a Keimyung University   (South Korea)

Author keywords

baicalein; global ischaemia; hippocampus; matrix metalloproteinase; Scutellaria baicalensis

Indexed keywords

BAICALEIN; CARBOXYMETHYLCELLULOSE; GELATINASE A; GELATINASE B; LAMININ;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; ENZYME ACTIVITY; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA2 REGION; HIPPOCAMPUS; HISTOPATHOLOGY; MALE; MOUSE; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; TRANSIENT ISCHEMIC ATTACK; ZYMOGRAPHY;

ANIMALS; CEREBROVASCULAR CIRCULATION; FLAVANONES; HIPPOCAMPUS; ISCHEMIC ATTACK, TRANSIENT; MALE; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; NEURONS; NEUROPROTECTIVE AGENTS;

MUS; SCUTELLARIA BAICALENSIS;

EID: 84867843761     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4644     Document Type: Article

References (32)

1. Asahi M, Asahi K, Jung JC, del Zoppo GJ, Fini ME, Lo EH,. 2000. Role for matrix metalloproteinase 9 in focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94. J Cereb Blood Flow Metab 20: 1681-1689.
2. Asahi M, Wang X, Mori T, et al., 2001a. Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood brain barrier and white matter components after cerebral ischemia. J Neurosci, 21: 7724-7732.
3. Asahi M, Sumii T, Fini ME, Itohara S, Lo EH,. 2001b. Matrix metalloproteinase 2 gene knockout has no effect on acute brain injury after focal ischemia. Neuroreport 12: 3003-3007.
4. Bondy SC,. 1995. The relation of oxidative stress and hyperexcitation to neurological disease. Proc Soc Exp Biol Med 208: 337-345.
5. Chen J, Zhu RL, Nakayama M, et al., 1996. Expression of the apoptosis-effector gene, Bax, is up-regulated in vulnerable hippocampal CA1 neurons following global ischemia. J Neurochem 67: 64-71.
6. Chen J, Nagayama T, Jin K, et al., 1998. Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia. J Neurosci 18: 4914-4928.
7. Cheng Y, He G, Mu X, et al., 2008. Neuroprotective effect of baicalein against MPTP neurotoxicity: behavioral, biochemical and immunohistochemical profile. Neurosci Lett 441: 16-20.
8. Choi DW,. 1996. Ischemia-induced neuronal apoptosis. Curr Opin Neurobiol 6: 667-672.
9. Cui L, Zhang X, Yang R, et al., 2010. Baicalein is neuroprotective in rat MCAO model: role of 12/15-lipoxygenase, mitogen-activated protein kinase and cytosolic phospholipase A2. Pharmacol Biochem Behav 96: 469-75.
10. Gidday JM, Gasche YG, Copin JC, et al., 2005. Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia. Am J Physiol Heart Circ Physiol 289: H558-568.
11. Guo Z, Sun X, He Z, Jiang Y, Zhang X,. 2010. Role of matrix metalloproteinase-9 in apoptosis of hippocampal neurons in rats during early brain injury after subarachnoid hemorrhage. Neurol Sci 31: 143-149.
12. Kirino T, Sano K,. 1984. Selective vulnerability in the gerbil hippocampus following transient ischemia. Acta Neuropathol 62: 201-208.
13. Lee SR, Tsuji K, Lee SR, Lo EH,. 2004. Role of matrix metalloproteinases in delayed neuronal damage after transient global cerebral ischemia. J Neurosci 24: 671-678.
14. Li FQ, Wang T, Pei Z, Liu B, Hong JS,. 2005. Inhibition of microglial activation by the herbal flavonoid baicalein attenuates inflammation-mediated degeneration of dopaminergic neurons. J Neural Transm 112: 331-347.
15. Lin CC, Shieh DE,. 1996. The anti-inflammatory activity of Scutellaria rivularis extracts and its active components, baicalin, baicalein and wogonin. Am J Chin Med 24: 31-36.
16. Lin HY, Shen SC, Lin CW, Yang LY, Chen YC,. 2007. Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression. Biochim Biophys Acta 1773: 1073-1086.
17. Lipton P, 1999. Ischemic cell death in brain neurons. Physiol Rev 79: 1431-1568.
18. Liu C, Wu J, Gu J, et al., 2007. Baicalein improves cognitive deficits induced by chronic cerebral hypoperfusion in rats. Pharmacol Biochem Behav 86: 423-430.
19. 2-induced oxidative stress by scavenging reactive oxygen species and downregulating the expression of matrix metalloproteinase-9 and vascular endothelial growth factor. J Ocul Pharmacol Ther 26: 421-429.
20. Lo EH, Wang X, Cuzner ML,. 2002. Extracellular proteolysis in brain injury and inflammation: role for plasminogen activators and matrix metalloproteinases. J Neurosci Res 69: 1-9.
21. Mun-Bryce S, Rosenberg GA,. 1998. Gelatinase B modulates selective opening of the blood-brain barrier during inflammation. Am J Physiol 274: R1203-1211.
22. Nitatori T, Sato N, Waguri S, et al., 1995. Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis. J Neurosci 15: 1001-1011.
23. Pulsinelli WA, Brierley JB, Plum F,. 1982. Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol 11: 491-498.
24. Shang YZ, Gong MY, Zhou XX, Li ST, Wang BY,. 2001. Improving effects of SSF on memory deficits and pathological changes of neural and immunological systems in senescent mice. Acta Pharmacol Sin 22: 1078-1083.
25. Shang Y, Cheng J, Qi J, Miao H,. 2005. Scutellaria flavonoid reduced memory dysfunction and neuronal injury caused by permanent global ischemia in rats. Pharmacol Biochem Behav 82: 67-73.
26. Shao ZH, Vanden Hoek TL, Qin Y, et al., 2002. Baicalein attenuates oxidant stress in cardiomyocytes. Am J Physiol Heart Circ Physiol 282: H999-1006.
27. Shieh DE, Liu LT, Lin CC,. 2000. Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin. Anticancer Res 20: 2861-2865.
28. Tsirka SE, Rogove AD, Bugge TH, Degen JL, Strickland S,. 1997. An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus. J Neurosci 17: 543-552.
29. Van Leyen K, Kim HY, Lee SR, Jin G, Arai K, Lo EH,. 2006. Baicalein and 12/15-lipoxygenase in the ischemic brain. Stroke 37: 3014-3018.
30. Wang Z, Du Q, Wang F, et al., 2007. Large scale analysis of genes contributing to the herbal preparation dependent hippocampal plasticity in postischemic rehabilitation. Vascul Pharmacol 47: 319-327.
31. Yong VW,., Power C, Forsyth P, Edwards DR,. 2001. Metalloproteinases in biology and pathology of the nervous system. Nat Rev Neurosci 2: 502-511.
32. Zalewska T, Ziemka-Nalecz M, Sarnowska A, Domanska-Janik K,. 2002. Involvement of MMPs in delayed neuronal death after global ischemia. Acta Neurobiol Exp (Wars) 62: 53-61.