Polyphyllin i induced-apoptosis is enhanced by inhibition of autophagy in human hepatocellular carcinoma cells

Phytomedicine

Volumn 22, Issue 13, 2015, Pages 1139-1149

  Shi, Ya Min ^a   Yang, Lei ^a   Geng, Ya Di ^a   Zhang, Chao ^a   Kong, Ling Yi ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Antiproliferation; Apoptosis; Autophagy; Human hepatocellular carcinoma cell; Polyphyllin I

Indexed keywords

AUTOPHAGY PROTEIN 5; BECLIN 1; CASPASE 3; CASPASE 9; CHLOROQUINE; ERLOTINIB; GEFITINIB; MAMMALIAN TARGET OF RAPAMYCIN; PLANT MEDICINAL PRODUCT; POLYPHYLLIN I; PROCASPASE 3; PROCASPASE 9; PROTEIN KINASE B; SORAFENIB; TAMOXIFEN; UNCLASSIFIED DRUG; CASPASE; DIOSGENIN; SAPONIN;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CHEMOTHERAPY; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HEPG2 CELL LINE; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MTT ASSAY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; CHEMICAL STRUCTURE; DRUG EFFECTS; DRUG POTENTIATION; LIVER TUMOR; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

APOPTOSIS; AUTOPHAGY; CARCINOMA, HEPATOCELLULAR; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; CHLOROQUINE; DIOSGENIN; DRUG SYNERGISM; HUMANS; LIVER NEOPLASMS; MOLECULAR STRUCTURE; SAPONINS; SIGNAL TRANSDUCTION;

EID: 84946559147     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2015.08.014     Document Type: Article

References (28)

1. Bahrami F., Pourgholami M.H., Mekkawy A.H., Rufener L., Morris D.L. Monepantel induces autophagy in human ovarian cancer cells through disruption of the mTOR/p70S6K signalling pathway Am. J. Cancer Res. 4 2014 558 571
2. Cheung J.Y., Ong R.C., Suen Y.K., Ooi V., Wong H.N., Mak T.C., Fung K.P., Yu B., Kong S.K. Polyphyllin D is a potent apoptosis inducer in drug-resistant HepG2 cells Cancer Lett. 217 2005 203 211
3. Feng Y., Ke C., Tang Q., Dong H., Zheng X., Lin W., Ke J., Huang J., Yeung S.C., Zhang H. Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling Cell Death Dis. 5 2014 e1088
4. Forner A., Llovet J.M., Bruix J. Hepatocellular carcinoma The Lancet 379 2012 1245 1255
5. 2+ rise and membrane permeabilization Arch. Toxicol. 86 2012 741 752
6. Geng Y.D., Yang L., Zhang C., Kong L.Y. Blockade of epidermal growth factor receptor/mammalian target of rapamycin pathway by Icariside II results in reduced cell proliferation of osteosarcoma cells Food Chem. Toxicol. 73 2014 7 16
7. Gozuacik D., Kimchi A. Autophagy as a cell death and tumor suppressor mechanism Oncogene 23 2004 2891 2906
8. Hu Y.L., Jahangiri A., Delay M., Aghi M.K. Tumor cell autophagy as an adaptive response mediating resistance to treatments such as antiangiogenic therapy Cancer Res. 72 2012 4294 4299
9. Hu F., Han J., Zhai B., Ming X., Zhuang L., Liu Y., Pan S., Liu T. Blocking autophagy enhances the apoptosis effect of bufalin on human hepatocellular carcinoma cells through endoplasmic reticulum stress and JNK activation Apoptosis 19 2014 210 223
10. Jain M.V., Paczulla A.M., Klonisch T., Dimgba F.N., Rao S.B., Roberg K., Schweizer F., Lengerke C., Davoodpour P., Palicharla V.R., Maddika S., Los M. Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development J. Cell. Mol. Med. 17 2013 12 29
11. Kimura T., Takabatake Y., Takahashi A., Isaka Y. Chloroquine in cancer therapy: a double-edged sword of autophagy Cancer Res. 73 2013 3 7
12. Kong M., Fan J., Dong A., Cheng H., Xu R. Effects of polyphyllin I on growth inhibition of human non-small lung cancer cells and in xenograft Acta Biochim. Biophys. Sin. 42 2010 827 833
13. Krishan A., Hamelik R.M. Click-iT proliferation assay with improved DNA histograms Curr. Protoc. Cytom. 7 2010 1 7
14. Lee M.S., Chan J.Y.W., Kong S.K., Yu B., Eng-Choon V.O., Nai-Ching H.W., Chung-Wai T.M., Fung K.P. Effects of polyphyllin D, a steroidal saponin in Paris Polyphylla, in growth inhibition of human breast cancer cells and in xenograft Cancer Biol. Ther. 4 2005 1248 1254
15. Lee S.W., Hong S.H., Kim H.K., Hong Y.K., Joe Y.A., Lee N.H., Yi H.Y., Kim H.S., Li C.J. The synergistic effect of combination temozolomide and chloroquine treatment is dependent on autophagy formation and p53 status in glioma cells Cancer Lett. 360 2015 195 204
16. Man S.L., Gao W.Y., Zhang Y.J., Ma C.Y., Yang L., Li Y.W. Paridis saponins inhibiting carcinoma growth and metastasis in vitro and in vivo Arch. Pharm. Res. 34 2011 43 50
17. Mathew R., Karp C.M., Beaudoin B., Vuong N., Chen G., Chen H.Y., Bray K., Reddy A., Bhanot G., Gelinas C., Dipaola R.S., Karantza-Wadsworth V., White E. Autophagy suppresses tumorigenesis through elimination of p62 Cell 137 2009 1062 1075
18. Mei L.F., Yu C.R., Chen Y.C., Liu X., Wang Z.M., Li W.H. Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21 Br. J. Pharmacol. 172 2015 2232 2245
19. Ong R.C., Lei J., Lee R.K., Cheung J.Y., Fung K.P., Lin C., Ho H.P., Yu B., Li M., Kong S.K. Polyphyllin D induces mitochondrial fragmentation and acts directly on the mitochondria to induce apoptosis in drug-resistant HepG2 cells Cancer Lett. 261 2008 158 164
20. Sarbassov Dos D., M,a.S.D M, A.S. Growing roles for the mTOR pathway Curr. Opin. Cell Biol. 17 2005 596 603
21. T. Shintani, Klionsky D.J. Autophagy in health and disease: a double-edged sword Science 306 2004 990 995
22. Wu L.N., Li Q., Liu Y. Polyphyllin D induces apoptosis in K562/A02 cells through G2/M phase arrest J. Pharm. Pharmacol. 66 2013 713 721
23. Wysocki P.J. Targeted therapy of hepatocellular cancer Expert Opin. Invest. Drugs 19 2010 265 274
24. Xia Y.Z., Yang L., Wang Z.D., Guo C., Zhang C., Geng Y.D., Kong L.Y. Schisandrin A enhances the cytotoxicity of doxorubicin by the inhibition of nuclear factor-kappa B signaling in a doxorubicin-resistant human osteosarcoma cell line RSC Adv. 5 2015 13972 13984
25. Xiao X., Bai P., Bui Nguyen T.M., Xiao J., Liu S., Yang G., Hu L., Chen X., Zhang X., Liu J., Wang H. The antitumoral effect of Paris Saponin I associated with the induction of apoptosis through the mitochondrial pathway Mol. Cancer Ther. 8 2009 1179 1188
26. Yang Z.J., Chee C.E., Huang S., Sinicrope F.A. The role of autophagy in cancer: therapeutic implications Mol. Cancer Ther. 10 2011 1533 1541
27. Zhang X., Chen L.X., Ouyang L., Cheng Y., Liu B. Plant natural compounds: targeting pathways of autophagy as anti-cancer therapeutic agents Cell Prolif. 45 2012 466 476
28. Zhang C., Yang L., Wang X.B., Wang J.S., Geng Y.D., Yang C.S., Kong L.Y. Calyxin Y induces hydrogen peroxide-dependent autophagy and apoptosis via JNK activation in human non-small cell lung cancer NCI-H460 cells Cancer Lett. 340 2013 51 62