Effects of polyphyllin i on growth inhibition of human non-small lung cancer cells and in xenograft

Acta Biochimica et Biophysica Sinica

Volumn 42, Issue 11, 2010, Pages 827-833

  Kong, Minjian ^a   Fan, Junqiang ^a   Dong, Aiqiang ^a   Cheng, Haifeng ^a   Xu, Rongzhen ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

apoptosis; non small cell lung cancer; polyphyllin I; xenograft

Indexed keywords

CASPASE 3; DIOSGENIN; DRUG DERIVATIVE; PLANT EXTRACT; POLYPHYLLIN I; PROTEIN BCL 2;

ANIMAL; APOPTOSIS; ARTICLE; BAGG ALBINO MOUSE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; DRUG SCREENING; HUMAN; IC 50; LUNG NON SMALL CELL CANCER; LUNG TUMOR; MALE; METABOLISM; MOUSE; NUDE MOUSE; PATHOLOGY; RHIZOME; TIME; TUMOR CELL LINE; TUMOR VOLUME; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, NON-SMALL-CELL LUNG; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; DIOSGENIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; HUMANS; INHIBITORY CONCENTRATION 50; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MOLECULAR STRUCTURE; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-BCL-2; RHIZOME; TIME FACTORS; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS MUSCULUS;

EID: 78049473665     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1093/abbs/gmq091     Document Type: Article

References (19)

1. Crino L, Foglietta J and Hamzaj A. Lung cancer. J Thorac Oncol 2007, 2 (5 Suppl): S24-S26.
2. Yang L, Parkin DM, Ferlay J and Chen Y. Estimates of cancer incidence in China for 2000 and projections for 2005. Cancer Epidemiol Biomarkers Prev 2005, 14:243-250.
3. Bria E, Cuppone F, Cecere FL, Milella M, Nisticò C, Cognetti F and Terzoli E. Adjuvant chemotherapy for non-small cell lung cancer. J Thorac Oncol 2007, 2 (5 Suppl): S7-S11.
4. Li B, Yu B, Hui Y, Li M, Han X and Fung KP. An improved synthesis of the saponin, polyphyllin D. Carbohydr Res 2001, 331:1-7.
5. Lee MS, Yuet-Wa JC, Kong SK, Yu B, Eng-Choon VO, Nai-Ching HW and Chung-Wai TM, et al. Effects of polyphyllin D, a steroidal saponin in Paris polyphylla, in growth inhibition of human breast cancer cells and in xenograft. Cancer Biol Ther 2005, 4:1248-1254.
6. Ong RC, Lei J, Lee RK, Cheung JY, Fung KP, Lin C and Ho HP, et al. Polyphyllin D induces mitochondrial fragmentation and acts directly on the mitochondria to induce apoptosis in drug-resistant HepG2 cells. Cancer Lett 2008, 261:158-164.
7. Sun J, Liu BR, Hu WJ, Yu LX and Qian XP. In vitro anticancer activity of aqueous extracts and ethanol extracts of fifteen traditional Chinese medicines on human digestive tumor cell lines. Phytother Res 2007, 21:1102-1104.
8. Siu FM, Ma DL, Cheung YW, Lok CN, Yan K, Yang Z and Yang M, et al. Proteomic and transcriptomic study on the action of a cytotoxic saponin (polyphyllin D) induction of endoplasmic reticulum stress and mitochondriamediated apoptotic pathways. Proteomics 2008, 15:3105-3117.
9. Dong AQ, Kong MJ, Ma ZY, Qian JF and Xu XH. Down-regulation of IGF-IR using small, interfering, hairpin RNA (siRNA) inhibits growth of human lung cancer cell line A549 in vitro and in nude mice. Cell Biol Int 2007, 31:500-507.
10. Dong A, Kong M, Ma Z, Qian J, Cheng H and Xu X. Knockdown of the insulin-like growth factor 1 receptor enhances the chemosensitivity to cisplatin in human lung adenocarcinoma A549 cells. Acta Biochim Biophys Sin 2008, 40:497-504.
11. Morgensztern D and Govindan R. Adjuvant chemotherapy for lung cancer: cisplatin doublets only? J Natl Compr Canc Netw 2008, 6:277-284.
12. Mendoza L. Targeted therapies in the treatment of advanced non-small-cell lung cancer: update. Klin Onkol 2009, 22:131-138.
13. Hansen HH. Treatment of advanced non-small cell lung cancer. BMJ 2002, 325:452-453.
14. Viktorsson K, Lewensohn R and Zhivotovsky B. Apoptotic pathways and therapy resistance in human malignancies. Adv Cancer Res 2005, 94:143-196.
15. Salvesen GS and Abrams JM. Caspase activation-stepping on the gas or releasing the brakes? Lessons from humans and files. Oncogene 2004, 23:2774-2784.
16. Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol 2007, 35:495-516.
17. Cozzi P. The discovery of a new potential anticancer drug: a case history. Farmaco 2003, 58:213-220.
18. Bigioni M, Benzo A, Irrissuto C, Lopez G, Curatella B, Maggi CA and Manzini S, et al. Antitumour effect of combination treatment with Sabarubicin (MEN 10755) and cis-platin (DDP) in human lung tumor xenograft. Cancer Chemother Pharmacol 2008, 62:621-629.
19. Schulze-Bergkamen H and Krammer PH. Apoptosis in cancer-implications for therapy. Semin Oncol 2004, 31:90-119.