Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke

Journal of Cerebral Blood Flow and Metabolism

Volumn 35, Issue 11, 2015, Pages 1711-1721

  Zinnhardt, Bastian ^a   Viel, Thomas ^a,b   Wachsmuth, Lydia ^a   Vrachimis, Alexis ^a   Wagner, Stefan ^a   Breyholz, Hans Jörg ^a   Faust, Andreas ^a   Hermann, Sven ^a   Kopka, Klaus ^a,g   Faber, Cornelius ^a   Dollé, Frédéric ^c   Pappata, Sabina ^d   Planas, Anna M ^e   Tavitian, Bertrand ^b   Schäfers, Michael ^a   Sorokin, Lydia M ^a   Kuhlmann, Michael T ^a   Jacobs, Andreas H ^a,f  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b PARIS CARDIOVASCULAR RESEARCH CENTER   (France)

^c SERVICE HOSPITALIER FRÉDÉRIC JOLIOT   (France)

^d CNR   (Italy)

^e INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^f Johanniter Krankenhaus   (Germany)

^g GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

matrix metalloproteases; microglia; perfusion; positron emission tomography; stroke

Indexed keywords

2 [N (4 METHOXYSULFONYL)(3 PYRIDINYLMETHYL)AMINO] 3 METHYLBUTYROHYDROXAMIC ACID; 2 [N BENZYL 4 (2 FLUOROETHOXY)PHENYLSULPHONAMIDO] N HYDROXY 3 METHYLBUTANAMIDE F 18; GELATINASE B; HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M; N,N DIETHYL 2 [2 [4 (2 FLUOROETHOXY)PHENYL] 5,7 DIMETHYLPYRAZOLO[1,5 A]PYRIMIDIN 3 YL]ACETAMIDE F 18; TRACER; UNCLASSIFIED DRUG; MATRIX METALLOPROTEINASE; N,N-DIETHYL-2-(2-(4-(2-FLUOROETHOXY)PHENYL)-5,7-DIMETHYLPYRAZOLO(1,5-A)PYRIMIDIN-3-YL)ACETAMIDE; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; RADIOPHARMACEUTICAL AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN INFARCTION; CELL ACTIVATION; CONTROLLED STUDY; ENCEPHALITIS; ENZYME ACTIVITY; EXPERIMENTAL STROKE; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; MULTIMODAL IMAGING; NEUROIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PET SCANNER; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOCHEMISTRY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; THROMBECTOMY DEVICE; ANIMAL; C57BL MOUSE; CEREBRAL ARTERY DISEASE; CEREBROVASCULAR ACCIDENT; DIAGNOSTIC IMAGING; ENZYMOLOGY; IMMUNOHISTOCHEMISTRY; METABOLISM; PATHOLOGY; PROCEDURES; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY;

ANIMALS; IMMUNOHISTOCHEMISTRY; INFARCTION, MIDDLE CEREBRAL ARTERY; MAGNETIC RESONANCE IMAGING; MATRIX METALLOPROTEINASES; MICE; MICE, INBRED C57BL; MICROGLIA; MULTIMODAL IMAGING; NEUROIMAGING; POSITRON-EMISSION TOMOGRAPHY; PYRAZOLES; PYRIMIDINES; RADIOPHARMACEUTICALS; STROKE; TECHNETIUM TC 99M EXAMETAZIME; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 84946501242     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2015.149     Document Type: Article

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