Turning the headlights on novel cancer biomarkers: Inspection of mechanics underlying intratumor heterogeneity

Molecular Aspects of Medicine

Volumn 45, Issue , 2015, Pages 3-13

  McBride, Michelle ^a   Rida, Padmashree C G ^a,b   Aneja, Ritu ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b Novazoi Theranostics   (United States)

Author keywords

Biomarker; Centrosomes; Chromosomal instability; Intratumoral heterogeneity; Mitotic propensity

Indexed keywords

TUMOR MARKER;

CANCER PROGNOSIS; CANCER RISK; CENTROMERE; CENTROSOME; CENTROSOME AMPLIFICATION; CHROMOSOMAL INSTABILITY; CHROMOSOMES AND CHROMOSOMAL PHENOMENA; CHROMOTHRIPSIS; GENE MUTATION; HUMAN; INTRATUMORAL HETEROGENEITY; M PHASE CELL CYCLE CHECKPOINT; MITOSIS RATE; ONCOLOGICAL PARAMETERS; PREDICTION; REVIEW; RISK ASSESSMENT; CELL PROLIFERATION; DISEASE COURSE; GENETICS; METABOLISM; MITOSIS; NEOPLASMS; PROGNOSIS; TUMOR CELL LINE;

BIOMARKERS, TUMOR; CELL LINE, TUMOR; CELL PROLIFERATION; CENTROSOME; CHROMOSOMAL INSTABILITY; DISEASE PROGRESSION; HUMANS; MITOSIS; NEOPLASMS; PROGNOSIS;

EID: 84946500126     PISSN: 00982997     EISSN: 18729452     Source Type: Journal    
DOI: 10.1016/j.mam.2015.05.001     Document Type: Review

References (90)

1. V. Almendro, Cheng Y.-K., A. Randles, S. Itzkovitz, A. Marusyk, E. Ametller, and et al. Inference of tumor evolution during chemotherapy by computational modeling and in situ analysis of genetic and phenotypic cellular diversity Cell Rep 6 3 2014 514 527
2. V. Almendro, H.J. Kim, Cheng Y.-K., M. Gönen, S. Itzkovitz, P. Argani, and et al. Genetic and phenotypic diversity in breast tumor metastases Cancer Res 74 5 2014 1338 1348
3. K. Anderson, C. Lutz, F.W. van Delft, C.M. Bateman, Guo Y., S.M. Coleman, and et al. Genetic variegation of clonal architecture and propagating cells in leukaemia Nature 469 7330 2011 356 361
4. S.F. Bakhoum, G. Genovese, and D.A. Compton Deviant kinetochore microtubule dynamics underlie chromosomal instability Curr. Biol 19 22 2009 1937 1942
5. P.L. Bedard, A.R. Hansen, M.J. Ratain, and L.L. Siu Tumour heterogeneity in the clinic Nature 501 7467 2013 355 364
6. R.A. Bennett, H. Izumi, and K. Fukasawa Induction of centrosome amplification and chromosome instability in p53-null cells by transient exposure to subtoxic levels of S-phase-targeting anticancer drugs Oncogene 23 40 2004 6823 6829
7. T.M. Bezemer, and W.H. van der Putten Ecology: diversity and stability in plant communities Nature 446 7135 2007 E6 E7
8. K. Blighe, L. Kenny, N. Patel, D.S. Guttery, K. Page, J.H. Gronau, and et al. Whole genome sequence analysis suggests intratumoral heterogeneity in dissemination of breast cancer to lymph nodes PLoS ONE 9 12 2014 e115346
9. M. Breuer, A. Kolano, M. Kwon, Li C.-C., T.-F. Tsai, D. Pellman, and et al. HURP permits MTOC sorting for robust meiotic spindle bipolarity, similar to extra centrosome clustering in cancer cells J. Cell Biol 191 7 2010 1251 1260
10. B.R. Brinkley Managing the centrosome numbers game: from chaos to stability in cancer cell division Trends Cell Biol 11 1 2001 18 21
11. R.A. Burrell, and C. Swanton The evolution of the unstable cancer genome Curr. Opin. Genet. Dev 24 2014 61 67
12. R.A. Burrell, and C. Swanton Tumour heterogeneity and the evolution of polyclonal drug resistance Mol. Oncol 8 6 2014 1095 1111
13. D.P. Cahill, C. Lengauer, Yu J., G.J. Riggins, J.K. Willson, S.D. Markowitz, and et al. Mutations of mitotic checkpoint genes in human cancers Nature 392 6673 1998 300 303
14. B.J. Cardinale Biodiversity improves water quality through niche partitioning Nature 472 7341 2011 86 89
15. S.L. Carter, A.C. Eklund, I.S. Kohane, L.N. Harris, and Z. Szallasi A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers Nat. Genet 38 9 2006 1043 1048
16. D.V.T. Catenacci Next-generation clinical trials: novel strategies to address the challenge of tumor molecular heterogeneity Mol. Oncol 9 2015 967 996 10.1016/j.molonc.2014.09.011 S1574-7891(14)00235-X [pii]
17. J.Y. Chan A clinical overview of centrosome amplification in human cancers Int. J. Biol. Sci 7 8 2011 1122 1144
18. S.H. Choi, and D. McCollum A role for metaphase spindle elongation forces in correction of merotelic kinetochore attachments Curr. Biol 22 3 2012 225 230
19. D. Cimini Merotelic kinetochore orientation, aneuploidy, and cancer Biochim. Biophys. Acta 1786 1 2008 32 40
20. A.S. Cleary, T.L. Leonard, S.A. Gestl, and E.J. Gunther Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers Nature 508 7494 2014 113 117
21. K. Crasta, N.J. Ganem, R. Dagher, A.B. Lantermann, E.V. Ivanova, Pan Y., and et al. DNA breaks and chromosome pulverization from errors in mitosis Nature 482 7383 2012 53 58
22. B. Crespi, and K. Summers Evolutionary biology of cancer Trends Ecol. Evol 20 10 2005 545 552
23. A.B. D'Assoro, W.L. Lingle, and J.L. Salisbury Centrosome amplification and the development of cancer Oncogene 21 40 2002 6146 6153
24. Ding L., T.J. Ley, D.E. Larson, C.A. Miller, D.C. Koboldt, J.S. Welch, and et al. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing Nature 481 7382 2012 506 510
25. S. Duensing, L.Y. Lee, A. Duensing, J. Basile, S. Piboonniyom, S. Gonzalez, and et al. The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle Proc. Natl. Acad. Sci. U.S.A. 18 2000 10002 10007
26. P. Duesberg, Li R., A. Fabarius, and R. Hehlmann Aneuploidy and cancer: from correlation to causation Contrib. Microbiol 13 2006 16 44
27. I.J. Fidler, and I.R. Hart Biological diversity in metastatic neoplasms: origins and implications Science 217 4564 1982 998 1003
28. J.V. Forment, A. Kaidi, and S.P. Jackson Chromothripsis and cancer: causes and consequences of chromosome shattering Nat. Rev. Cancer 12 10 2012 663 670
29. K. Fukasawa Oncogenes and tumour suppressors take on centrosomes Nat. Rev. Cancer 7 12 2007 911 924
30. K. Fukasawa P53, cyclin-dependent kinase and abnormal amplification of centrosomes Biochim. Biophys. Acta 1786 1 2008 15 23
31. K. Fukasawa, T. Choi, R. Kuriyama, S. Rulong, and G.F. Vande Woude Abnormal centrosome amplification in the absence of p53 Science 271 5256 1996 1744 1747
32. N.J. Ganem, S.A. Godinho, and D. Pellman A mechanism linking extra centrosomes to chromosomal instability Nature 460 7252 2009 278 282
33. R.A. Gatenby, A.S. Silva, R.J. Gillies, and B.R. Frieden Adaptive therapy Cancer Res 69 11 2009 4894 4903
34. M. Giehl, A. Fabarius, O. Frank, A. Hochhaus, M. Hafner, R. Hehlmann, and et al. Centrosome aberrations in chronic myeloid leukemia correlate with stage of disease and chromosomal instability Leukemia 19 7 2005 1192 1197
35. S.A. Godinho, and D. Pellman Causes and consequences of centrosome abnormalities in cancer Philos. Trans. R. Soc. B. Biol. Sci 369 1650 2014
36. M.B. Gordon, L. Howard, and D.A. Compton Chromosome movement in mitosis requires microtubule anchorage at spindle poles J. Cell Biol 152 3 2001 425 434
37. M.K. Harrison, A.M. Adon, and H.I. Saavedra The G1 phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification Cell Div 6 2011 2
38. I.R. Hart New evidence for tumour embolism as a mode of metastasis J. Pathol 219 3 2009 275 276
39. Y. Hautier, E.W. Seabloom, E.T. Borer, P.B. Adler, W.S. Harpole, H. Hillebrand, and et al. Eutrophication weakens stabilizing effects of diversity in natural grasslands Nature 508 7497 2014 521 525
40. A. Hector Ecology: diversity favours productivity Nature 472 7341 2011 45 46
41. S. Heim Boveri at 100: Boveri, chromosomes and cancer J. Pathol 234 2 2014 138 141
42. Heng H.H., S.W. Bremer, J.B. Stevens, S.D. Horne, Liu G., B.Y. Abdallah, and et al. Chromosomal instability (CIN): what it is and why it is crucial to cancer evolution Cancer Metastasis Rev 32 3-4 2013 325 340
43. A.J. Holland, D. Fachinetti, Zhu Q., M. Bauer, I.M. Verma, E.A. Nigg, and et al. The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle Genes Dev 26 24 2012 2684 2689
44. L.C. Hsu, and R.L. White BRCA1 is associated with the centrosome during mitosis Proc. Natl. Acad. Sci. U.S.A. 95 22 1998 12983 12988
45. A. Khodjakov Centrosomes enhance the fidelity of cytokinesis in vertebrates and are required for cell cycle progression J. Cell Biol 153 1 2001 237 242
46. M. Kwon, S.A. Godinho, N.S. Chandhok, N.J. Ganem, A. Azioune, M. Thery, and et al. Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes Genes Dev 22 16 2008 2189 2203
47. D.A. Landau, S.L. Carter, G. Getz, and Wu C.J. Clonal evolution in hematological malignancies and therapeutic implications Leukemia 28 1 2014 34 43
48. A.J.X. Lee, and C. Swanton Tumour heterogeneity and drug resistance: personalising cancer medicine through functional genomics Biochem. Pharmacol 83 8 2012 1013 1020
49. A.J.X. Lee, D. Endesfelder, A.J. Rowan, A. Walther, N.J. Birkbak, P.A. Futreal, and et al. Chromosomal instability confers intrinsic multidrug resistance Cancer Res 71 5 2011 1858 1870
50. L. Lentini, A. Amato, T. Schillaci, and A. Di Leonardo Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype BMC Cancer 7 2007 212
51. W.L. Lingle, W.H. Lutz, J.N. Ingle, N.J. Maihle, and J.L. Salisbury Centrosome hypertrophy in human breast tumors: implications for genomic stability and cell polarity Proc. Natl. Acad. Sci. U.S.A. 95 6 1998 2950 2955
52. W.L. Lingle, S.L. Barrett, V.C. Negron, A.B. D'Assoro, K. Boeneman, Liu W., and et al. Centrosome amplification drives chromosomal instability in breast tumor development Proc. Natl. Acad. Sci. U.S.A. 99 4 2002 1978 1983
53. J.G. Lohr, P. Stojanov, S.L. Carter, P. Cruz-Gordillo, M.S. Lawrence, D. Auclair, and et al. Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy Cancer Cell 25 1 2014 91 101
54. C.S. Lopes, and C.E. Sunkel The spindle checkpoint: from normal cell division to tumorigenesis Arch. Med. Res 34 3 2003 155 165
55. C.C. Maley, P.C. Galipeau, J.C. Finley, V.J. Wongsurawat, Li X., C.A. Sanchez, and et al. Genetic clonal diversity predicts progression to esophageal adenocarcinoma Nat. Genet 38 4 2006 468 473
56. S.E. McClelland, R.A. Burrell, and C. Swanton Chromosomal instability: a composite phenotype that influences sensitivity to chemotherapy Cell Cycle 8 20 2009 3262 3266
57. F. Michor, Y. Iwasa, B. Vogelstein, C. Lengauer, and M.A. Nowak Can chromosomal instability initiate tumorigenesis? Semin. Cancer Biol 15 1 2005 43 49
58. E. Montagna, G. Cancello, S. Dellapasqua, E. Munzone, and M. Colleoni Metronomic therapy and breast cancer: a systematic review Cancer Treat. Rev 40 8 2014 942 950
59. V.B. Morris, J. Brammall, J. Noble, and R. Reddel p53 localizes to the centrosomes and spindles of mitotic cells in the embryonic chick epiblast, human cell lines, and a human primary culture: an immunofluorescence study Exp. Cell Res 256 1 2000 122 130
60. V. Mountain, C. Simerly, L. Howard, A. Ando, G. Schatten, and D.A. Compton The kinesin-related protein, HSET, opposes the activity of Eg5 and cross-links microtubules in the mammalian mitotic spindle J. Cell Biol 147 2 1999 351 366
61. N. Navin, A. Krasnitz, L. Rodgers, K. Cook, J. Meth, J. Kendall, and et al. Inferring tumor progression from genomic heterogeneity Genome Res 20 1 2010 68 80
62. R.B. Nicklas, and S.C. Ward Elements of error correction in mitosis: microtubule capture, release, and tension J. Cell Biol 126 5 1994 1241 1253
63. E.A. Nigg Origins and consequences of centrosome aberrations in human cancers Int. J. Cancer 119 12 2006 2717 2723
64. A. Ogden, P.C.G. Rida, and R. Aneja Let's huddle to prevent a muddle: centrosome declustering as an attractive anticancer strategy Cell Death Differ 19 8 2012 1255 1267
65. A. Ogden, P.C.G. Rida, and R. Aneja Heading off with the herd: how cancer cells might maneuver supernumerary centrosomes for directional migration Cancer Metastasis Rev 32 1-2 2013 269 287
66. V. Pannu, P.C.G. Rida, B. Celik, R.C. Turaga, A. Ogden, G. Cantuaria, and et al. Centrosome-declustering drugs mediate a two-pronged attack on interphase and mitosis in supercentrosomal cancer cells Cell Death Dis 5 11 2014 e1538
67. L. Parast, and Cai T. Landmark risk prediction of residual life for breast cancer survival Stat. Med 32 20 2013 3459 3471
68. S.Y. Park, M. Gönen, H.J. Kim, F. Michor, and K. Polyak Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype J. Clin. Invest 120 2 2010 636 644
69. G.A. Pihan, J. Wallace, Zhou Y., and S.J. Doxsey Centrosome abnormalities and chromosome instability occur together in pre-invasive carcinomas Cancer Res 63 6 2003 1398 1404
70. S.M. Pockwinse, G. Krockmalnic, S.J. Doxsey, J. Nickerson, Lian J.B., A.J. van Wijnen, and et al. Cell cycle independent interaction of CDC2 with the centrosome, which is associated with the nuclear matrix-intermediate filament scaffold Proc. Natl. Acad. Sci. U.S.A. 94 7 1997 3022 3027
71. K. Polyak, and A. Marusyk Cancer: clonal cooperation Nature 508 7494 2014 52 53
72. S.L. Prosser, K.R. Straatman, and A.M. Fry Molecular dissection of the centrosome overduplication pathway in S-phase-arrested cells Mol. Cell. Biol 29 7 2009 1760 1773
73. B. Rebacz, T.O. Larsen, M.H. Clausen, M.H. Rønnest, H. Löffler, A.D. Ho, and et al. Identification of griseofulvin as an inhibitor of centrosomal clustering in a phenotype-based screen Cancer Res 67 13 2007 6342 6350
74. R.F. Schwarz, A. Trinh, B. Sipos, J.D. Brenton, N. Goldman, and F. Markowetz Phylogenetic quantification of intra-tumour heterogeneity PLoS Comput. Biol 10 4 2014 e1003535
75. R.F. Schwarz, C.K.Y. Ng, S.L. Cooke, S. Newman, J. Temple, A.M. Piskorz, and et al. Spatial and temporal heterogeneity in high-grade serous ovarian cancer: a phylogenetic analysis PLoS Med 12 2 2015 e1001789
76. W.T. Silkworth, I.K. Nardi, L.M. Scholl, and D. Cimini Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells PLoS ONE 4 8 2009 e6564
77. L.M. Starita, Y. Machida, S. Sankaran, J.E. Elias, K. Griffin, B.P. Schlegel, and et al. BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number Mol. Cell. Biol 24 19 2004 8457 8466
78. P.J. Stephens, P.S. Tarpey, H. Davies, P. Van Loo, C. Greenman, D.C. Wedge, and et al. The landscape of cancer genes and mutational processes in breast cancer Nature 486 7403 2012 400 404
79. C. Swanton Intratumor heterogeneity: evolution through space and time Cancer Res 72 19 2012 4875 4882
80. Tan A.L.C., P.C.G. Rida, and U. Surana Essential tension and constructive destruction: the spindle checkpoint and its regulatory links with mitotic exit Biochem. J. 386 Pt 1 2005 1 13
81. S.L. Thompson, and D.A. Compton Examining the link between chromosomal instability and aneuploidy in human cells J. Cell Biol 180 4 2008 665 672
82. Wang Y., J. Waters, M.L. Leung, A. Unruh, W. Roh, Shi X., and et al. Clonal evolution in breast cancer revealed by single nucleus genome sequencing Nature 512 7513 2014 155 160
83. B.A.A. Weaver, A.D. Silk, C. Montagna, P. Verdier-Pinard, and D.W. Cleveland Aneuploidy acts both oncogenically and as a tumor suppressor Cancer Cell 11 1 2007 25 36
84. A.C. Wolff, M.E. Hammond, D.G. Hicks, M. Dowsett, L.M. McShane, K.H. Allison, and et al. Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update J. Clin. Oncol 31 31 2013 3997 4013
85. Xu X., Z. Weaver, S.P. Linke, Li C., J. Gotay, Wang X.W., and et al. Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells Mol. Cell 3 3 1999 389 395
86. Y.M. Yamashita, and M.T. Fuller Asymmetric centrosome behavior and the mechanisms of stem cell division J. Cell Biol 180 2 2008 261 266
87. T.A. Yap, M. Gerlinger, P.A. Futreal, L. Pusztai, and C. Swanton Intratumor heterogeneity: seeing the wood for the trees Sci. Transl. Med 4 127 2012 127ps110
88. Ye C.J., J.B. Stevens, Liu G., S.W. Bremer, A.S. Jaiswal, Ye K.J., and et al. Genome based cell population heterogeneity promotes tumorigenicity: the evolutionary mechanism of cancer J. Cell. Physiol 219 2 2009 288 300
89. Zhai Y., P.J. Kronebusch, and G.G. Borisy Kinetochore microtubule dynamics and the metaphase-anaphase transition J. Cell Biol 131 3 1995 721 734
90. Zhang C.-Z., M.L. Leibowitz, and D. Pellman Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements Genes Dev 27 23 2013 2513 2530