Induction of centrosome amplification and chromosome instability in p53-null cells by transient exposure to subtoxic levels of S-phase-targeting anticancer drugs

Oncogene

Volumn 23, Issue 40, 2004, Pages 6823-6829

  Bennett, Richard A ^a   Izumi, Hideki ^a   Fukasawa, Kenji ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Anticancer drug; Centrosome amplification; Chromosome instability; DNA synthesis; p53

Indexed keywords

ANTINEOPLASTIC AGENT; APHIDICOLIN; CYTARABINE; DACTINOMYCIN; DNA; FLUOROURACIL; HYDROXYUREA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; CELL CYCLE S PHASE; CENTROSOME; CHROMOSOMAL INSTABILITY; CHROMOSOME STRUCTURE; CONTROLLED STUDY; DISEASE COURSE; DNA SYNTHESIS; GENE AMPLIFICATION; GENE MUTATION; GENE TARGETING; GENETIC STABILITY; HUMAN; HUMAN CELL; MALE; MITOSIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TUMOR RECURRENCE;

ANTINEOPLASTIC AGENTS; CENTROSOME; CHROMOSOME ABERRATIONS; DNA REPLICATION; GENE AMPLIFICATION; HUMANS; S PHASE;

ANIMALIA;

EID: 4644259577     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1207561     Document Type: Article

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