메뉴 건너뛰기




Volumn 23, Issue 11, 2015, Pages 2199-2206

TLR9 regulates adipose tissue inflammation and obesity-related metabolic disorders

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYTOKINE; GAMMA INTERFERON; GLUCOSE; INSULIN; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA; TLR9 PROTEIN, MOUSE;

EID: 84946496158     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.21215     Document Type: Article
Times cited : (40)

References (40)
  • 1
    • 84864118287 scopus 로고    scopus 로고
    • Immunological complications of obesity
    • Kanneganti TD, Dixit VD., Immunological complications of obesity. Nat Immunol 2012; 13: 707-712.
    • (2012) Nat Immunol , vol.13 , pp. 707-712
    • Kanneganti, T.D.1    Dixit, V.D.2
  • 2
    • 77951918926 scopus 로고    scopus 로고
    • Macrophages, inflammation, and insulin resistance
    • Olefsky JM, Glass CK., Macrophages, inflammation, and insulin resistance. Ann Rev Physiol 2010; 72: 219-246.
    • (2010) Ann Rev Physiol , vol.72 , pp. 219-246
    • Olefsky, J.M.1    Glass, C.K.2
  • 3
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • Lumeng CN, Bodzin JL, Saltiel AR., Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Investig 2007; 117: 175-184.
    • (2007) J Clin Investig , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 4
    • 68349150756 scopus 로고    scopus 로고
    • CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
    • Nishimura S, Manabe I, Nagasaki M, et al., CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med 2009; 15: 914-920.
    • (2009) Nat Med , vol.15 , pp. 914-920
    • Nishimura, S.1    Manabe, I.2    Nagasaki, M.3
  • 5
    • 68349160704 scopus 로고    scopus 로고
    • Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice
    • Liu J, Divoux A, Sun J, et al., Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med 2009; 15: 940-945.
    • (2009) Nat Med , vol.15 , pp. 940-945
    • Liu, J.1    Divoux, A.2    Sun, J.3
  • 6
    • 79953815551 scopus 로고    scopus 로고
    • Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis
    • Wu D, Molofsky AB, Liang HE, et al., Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science 2011; 332: 243-247.
    • (2011) Science , vol.332 , pp. 243-247
    • Wu, D.1    Molofsky, A.B.2    Liang, H.E.3
  • 7
    • 85027938385 scopus 로고    scopus 로고
    • B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies
    • Winer DA, Winer S, Shen L, et al., B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat Med 2011; 17: 610-617.
    • (2011) Nat Med , vol.17 , pp. 610-617
    • Winer, D.A.1    Winer, S.2    Shen, L.3
  • 8
    • 84868671526 scopus 로고    scopus 로고
    • Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase
    • Talukdar S, Oh da Y, Bandyopadhyay G, et al., Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase. Nat Med 2012; 18: 1407-1412.
    • (2012) Nat Med , vol.18 , pp. 1407-1412
    • Talukdar, S.1    Oh Da, Y.2    Bandyopadhyay, G.3
  • 9
    • 84865992180 scopus 로고    scopus 로고
    • Natural killer T cells in adipose tissue prevent insulin resistance
    • Schipper HS, Rakhshandehroo M, van de Graaf SF, et al., Natural killer T cells in adipose tissue prevent insulin resistance. J Clin Investig 2012; 122: 3343-3354.
    • (2012) J Clin Investig , vol.122 , pp. 3343-3354
    • Schipper, H.S.1    Rakhshandehroo, M.2    Van De Graaf, S.F.3
  • 10
    • 84866520055 scopus 로고    scopus 로고
    • Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production
    • Lynch L, Nowak M, Varghese B, et al., Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production. Immunity 2012; 37: 574-587.
    • (2012) Immunity , vol.37 , pp. 574-587
    • Lynch, L.1    Nowak, M.2    Varghese, B.3
  • 11
    • 33847183077 scopus 로고    scopus 로고
    • Cooperation of Toll-like receptor signals in innate immune defence
    • Trinchieri G, Sher A., Cooperation of Toll-like receptor signals in innate immune defence. Nat Rev Immunol 2007; 7: 179-190.
    • (2007) Nat Rev Immunol , vol.7 , pp. 179-190
    • Trinchieri, G.1    Sher, A.2
  • 12
    • 77950250064 scopus 로고    scopus 로고
    • Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5
    • Vijay-Kumar M, Aitken JD, Carvalho FA, et al., Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science 2010; 328: 228-231.
    • (2010) Science , vol.328 , pp. 228-231
    • Vijay-Kumar, M.1    Aitken, J.D.2    Carvalho, F.A.3
  • 13
    • 34547602916 scopus 로고    scopus 로고
    • Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance
    • Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, et al., Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 2007; 56: 1986-1998.
    • (2007) Diabetes , vol.56 , pp. 1986-1998
    • Tsukumo, D.M.1    Carvalho-Filho, M.A.2    Carvalheira, J.B.3
  • 14
    • 77952315676 scopus 로고    scopus 로고
    • Tlr2 is critical for diet-induced metabolic syndrome in a murine model
    • Himes RW, Smith CW., Tlr2 is critical for diet-induced metabolic syndrome in a murine model. FASEB J 2010; 24: 731-739.
    • (2010) FASEB J , vol.24 , pp. 731-739
    • Himes, R.W.1    Smith, C.W.2
  • 15
    • 0034619794 scopus 로고    scopus 로고
    • A Toll-like receptor recognizes bacterial DNA
    • Hemmi H, Takeuchi O, Kawai T, et al., A Toll-like receptor recognizes bacterial DNA. Nature 2000; 408: 740-745.
    • (2000) Nature , vol.408 , pp. 740-745
    • Hemmi, H.1    Takeuchi, O.2    Kawai, T.3
  • 16
    • 12144286763 scopus 로고    scopus 로고
    • Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
    • Tabeta K, Georgel P, Janssen E, et al., Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc Natl Acad Sci USA 2004; 101: 3516-3521.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 3516-3521
    • Tabeta, K.1    Georgel, P.2    Janssen, E.3
  • 17
    • 33846898975 scopus 로고    scopus 로고
    • Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection
    • Albiger B, Dahlberg S, Sandgren A, et al., Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection. Cell Microbiol 2007; 9: 633-644.
    • (2007) Cell Microbiol , vol.9 , pp. 633-644
    • Albiger, B.1    Dahlberg, S.2    Sandgren, A.3
  • 18
    • 34447128388 scopus 로고    scopus 로고
    • Antiinfective applications of toll-like receptor 9 agonists
    • Krieg AM., Antiinfective applications of toll-like receptor 9 agonists. Proc Am Thorac Soc 2007; 4: 289-294.
    • (2007) Proc Am Thorac Soc , vol.4 , pp. 289-294
    • Krieg, A.M.1
  • 19
    • 48549088455 scopus 로고    scopus 로고
    • Antimicrobial peptides and self-DNA in autoimmune skin inflammation
    • Gilliet M, Lande R., Antimicrobial peptides and self-DNA in autoimmune skin inflammation. Curr Opin Immunol 2008; 20: 401-407.
    • (2008) Curr Opin Immunol , vol.20 , pp. 401-407
    • Gilliet, M.1    Lande, R.2
  • 20
    • 84866735326 scopus 로고    scopus 로고
    • TLR7 and TLR9 in SLE: When sensing self goes wrong
    • Celhar T, Magalhaes R, Fairhurst AM., TLR7 and TLR9 in SLE: When sensing self goes wrong. Immunol Res 2012; 53: 58-77.
    • (2012) Immunol Res , vol.53 , pp. 58-77
    • Celhar, T.1    Magalhaes, R.2    Fairhurst, A.M.3
  • 21
    • 10744233159 scopus 로고    scopus 로고
    • Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis
    • Rachmilewitz D, Katakura K, Karmeli F, et al., Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology 2004; 126: 520-528.
    • (2004) Gastroenterology , vol.126 , pp. 520-528
    • Rachmilewitz, D.1    Katakura, K.2    Karmeli, F.3
  • 22
    • 84876412015 scopus 로고    scopus 로고
    • Topical treatment with the Toll-like receptor agonist DIMS0150 has potential for lasting relief of symptoms in patients with chronic active ulcerative colitis by restoring glucocorticoid sensitivity
    • Musch E, Lutfi T, von Stein P, et al., Topical treatment with the Toll-like receptor agonist DIMS0150 has potential for lasting relief of symptoms in patients with chronic active ulcerative colitis by restoring glucocorticoid sensitivity. Inflamm Bowel Dis 2013; 19: 283-292.
    • (2013) Inflamm Bowel Dis , vol.19 , pp. 283-292
    • Musch, E.1    Lutfi, T.2    Von Stein, P.3
  • 23
    • 33745834319 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
    • Kadowaki T, Yamauchi T, Kubota N, et al., Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Investig 2006; 116: 1784-1792.
    • (2006) J Clin Investig , vol.116 , pp. 1784-1792
    • Kadowaki, T.1    Yamauchi, T.2    Kubota, N.3
  • 24
    • 84903531205 scopus 로고    scopus 로고
    • CXCL12 secreted from adipose tissue recruits macrophages and induces insulin resistance in mice
    • Kim D, Kim J, Yoon JH, et al., CXCL12 secreted from adipose tissue recruits macrophages and induces insulin resistance in mice. Diabetologia 2014; 57: 1456-1465.
    • (2014) Diabetologia , vol.57 , pp. 1456-1465
    • Kim, D.1    Kim, J.2    Yoon, J.H.3
  • 25
    • 68349137821 scopus 로고    scopus 로고
    • Normalization of obesity-associated insulin resistance through immunotherapy
    • Winer S, Chan Y, Paltser G, et al., Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med 2009; 15: 921-929.
    • (2009) Nat Med , vol.15 , pp. 921-929
    • Winer, S.1    Chan, Y.2    Paltser, G.3
  • 26
    • 84857985148 scopus 로고    scopus 로고
    • The cellular and signaling networks linking the immune system and metabolism in disease
    • Osborn O, Olefsky JM., The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med 2012; 18: 363-374.
    • (2012) Nat Med , vol.18 , pp. 363-374
    • Osborn, O.1    Olefsky, J.M.2
  • 27
    • 68349148211 scopus 로고    scopus 로고
    • Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
    • Feuerer M, Herrero L, Cipolletta D, et al., Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med 2009; 15: 930-939.
    • (2009) Nat Med , vol.15 , pp. 930-939
    • Feuerer, M.1    Herrero, L.2    Cipolletta, D.3
  • 28
    • 54049086276 scopus 로고    scopus 로고
    • Interferon-gamma, a Th1 cytokine, regulates fat inflammation: A role for adaptive immunity in obesity
    • Rocha VZ, Folco EJ, Sukhova G, et al., Interferon-gamma, a Th1 cytokine, regulates fat inflammation: A role for adaptive immunity in obesity. Circulation Res 2008; 103: 467-476.
    • (2008) Circulation Res , vol.103 , pp. 467-476
    • Rocha, V.Z.1    Folco, E.J.2    Sukhova, G.3
  • 29
    • 84872166765 scopus 로고    scopus 로고
    • Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis
    • Odegaard JI, Chawla A., Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis. Science 2013; 339: 172-177.
    • (2013) Science , vol.339 , pp. 172-177
    • Odegaard, J.I.1    Chawla, A.2
  • 30
    • 56749164791 scopus 로고    scopus 로고
    • Nutrient sensing and inflammation in metabolic diseases
    • Hotamisligil GS, Erbay E., Nutrient sensing and inflammation in metabolic diseases. Nature Rev Immunol 2008; 8: 923-934.
    • (2008) Nature Rev Immunol , vol.8 , pp. 923-934
    • Hotamisligil, G.S.1    Erbay, E.2
  • 32
    • 84878812591 scopus 로고    scopus 로고
    • Innate immune receptors: Key regulators of metabolic disease progression
    • Jin C, Henao-Mejia J, Flavell RA., Innate immune receptors: Key regulators of metabolic disease progression. Cell Metab 2013; 17: 873-882.
    • (2013) Cell Metab , vol.17 , pp. 873-882
    • Jin, C.1    Henao-Mejia, J.2    Flavell, R.A.3
  • 33
    • 34347399563 scopus 로고    scopus 로고
    • Metabolic endotoxemia initiates obesity and insulin resistance
    • Cani PD, Amar J, Iglesias MA, et al., Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 2007; 56: 1761-1772.
    • (2007) Diabetes , vol.56 , pp. 1761-1772
    • Cani, P.D.1    Amar, J.2    Iglesias, M.A.3
  • 34
    • 33750584214 scopus 로고    scopus 로고
    • TLR4 links innate immunity and fatty acid-induced insulin resistance
    • Shi H, Kokoeva MV, Inouye K, et al., TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Investig 2006; 116: 3015-3025.
    • (2006) J Clin Investig , vol.116 , pp. 3015-3025
    • Shi, H.1    Kokoeva, M.V.2    Inouye, K.3
  • 35
    • 84855508991 scopus 로고    scopus 로고
    • Obesity activates toll-like receptor-mediated proinflammatory signaling cascades in the adipose tissue of mice
    • Kim SJ, Choi Y, Choi YH, et al., Obesity activates toll-like receptor-mediated proinflammatory signaling cascades in the adipose tissue of mice. J Nutr Biochem 2012; 23: 113-122.
    • (2012) J Nutr Biochem , vol.23 , pp. 113-122
    • Kim, S.J.1    Choi, Y.2    Choi, Y.H.3
  • 36
    • 77957108166 scopus 로고    scopus 로고
    • T cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 mice
    • Strissel KJ, DeFuria J, Shaul ME, et al., T cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 mice. Obesity 2010; 18: 1918-1925.
    • (2010) Obesity , vol.18 , pp. 1918-1925
    • Strissel, K.J.1    DeFuria, J.2    Shaul, M.E.3
  • 37
    • 0346157290 scopus 로고    scopus 로고
    • Innate immunity: An overview
    • 8 59
    • Beutler B., Innate immunity: An overview. Mol Immunol 2004; 40: 845 -8 59.
    • (2004) Mol Immunol , vol.40 , pp. 845
    • Beutler, B.1
  • 38
    • 84866058423 scopus 로고    scopus 로고
    • TLR9 is important for protection against intestinal damage and for intestinal repair
    • Rose WA, 2nd, Sakamoto K, Leifer CA., TLR9 is important for protection against intestinal damage and for intestinal repair. Sci Rep 2012; 2: 574.
    • (2012) Sci Rep , vol.2 , pp. 574
    • Rose, W.A.1    Sakamoto, K.2    Leifer, C.A.3
  • 39
    • 33751563152 scopus 로고    scopus 로고
    • Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals
    • Boonstra A, Rajsbaum R, Holman M, et al., Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals. J Immunol 2006; 177: 7551-7558.
    • (2006) J Immunol , vol.177 , pp. 7551-7558
    • Boonstra, A.1    Rajsbaum, R.2    Holman, M.3
  • 40
    • 84866461477 scopus 로고    scopus 로고
    • Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice
    • Ubeda C, Lipuma L, Gobourne A, et al., Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice. J Exp Med 2012; 209: 1445-1456.
    • (2012) J Exp Med , vol.209 , pp. 1445-1456
    • Ubeda, C.1    Lipuma, L.2    Gobourne, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.