-
1
-
-
0022297190
-
Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related
-
C.W. Wong, V. Quaranta, and G.G. Glenner Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related Proc Natl Acad Sci U S A 82 1984 8729 8732
-
(1984)
Proc Natl Acad Sci U S A
, vol.82
, pp. 8729-8732
-
-
Wong, C.W.1
Quaranta, V.2
Glenner, G.G.3
-
3
-
-
84875354777
-
2013 Alzheimer's disease facts and figures
-
Alzheimer's Association
-
W. Thies, L. Bleiler Alzheimer's Association 2013 Alzheimer's disease facts and figures Alzheimers Dement 9 2013 208 245
-
(2013)
Alzheimers Dement
, vol.9
, pp. 208-245
-
-
Thies, W.1
Bleiler, L.2
-
4
-
-
77952312969
-
Regulation of the activity of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis
-
O. Radmark, and B. Samuelsson Regulation of the activity of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis Biochem Biophys Res Commun 396 2010 105 110
-
(2010)
Biochem Biophys Res Commun
, vol.396
, pp. 105-110
-
-
Radmark, O.1
Samuelsson, B.2
-
5
-
-
77649172085
-
5-Lipoxygenase inhibitors: A review of recent developments and patents
-
C. Pergola, and O. Werz 5-Lipoxygenase inhibitors: a review of recent developments and patents Expert Opin Ther Pat 2010 355 375
-
(2010)
Expert Opin Ther Pat
, pp. 355-375
-
-
Pergola, C.1
Werz, O.2
-
6
-
-
0023664462
-
Regional distribution of leukotriene and mono-hydroxyeicosatetraenoic acid production in the rat brain. Highest leukotriene C4 formation in the hypothalamus
-
T. Miyamoto, J.A. Lindgren, T. Hokfelt, and B. Samuelsson Regional distribution of leukotriene and mono-hydroxyeicosatetraenoic acid production in the rat brain. Highest leukotriene C4 formation in the hypothalamus FEBS Lett 216 1987 123 127
-
(1987)
FEBS Lett
, vol.216
, pp. 123-127
-
-
Miyamoto, T.1
Lindgren, J.A.2
Hokfelt, T.3
Samuelsson, B.4
-
7
-
-
0010608154
-
Leukotrienes in the rat central nervous system
-
DOI 10.1073/pnas.81.19.6212
-
J.A. Lindgren, T. Hokfelt, S.E. Dahlen, C. Patrono, and B. Samuelsson Leukotrienes in the rat central nervous system Proc Natl Acad Sci U S A 81 1984 6212 6216 (Pubitemid 15220810)
-
(1984)
Proceedings of the National Academy of Sciences of the United States of America
, vol.81
, Issue.19
, pp. 6212-6216
-
-
Lindgren, J.A.1
Hokfelt, T.2
Dahlen, S.-E.3
-
8
-
-
34447565153
-
The 5-lipoxygenase enzymatic pathway in the mouse brain: Young versus old
-
DOI 10.1016/j.neurobiolaging.2006.06.007, PII S0197458006002193
-
C.M. Chinnici, Y. Yao, and D. Praticò The 5-lipoxygenase enzymatic pathway in the mouse brain: young versus old Neurobiol Aging 28 2007 1457 1462 (Pubitemid 47081230)
-
(2007)
Neurobiology of Aging
, vol.28
, Issue.9
, pp. 1457-1462
-
-
Chinnici, C.M.1
Yao, Y.2
Pratico, D.3
-
9
-
-
0034991806
-
5-Lipoxygenase (5-LOX) promoter polymorphism in patients with early-onset and late-onset Alzheimer's disease [4]
-
DOI 10.1176/appi.neuropsych.13.2.304
-
T. Qu, R. Manev, and H. Manev 5-lipoxygenase (5-LOX) promotor polymorphism in patients with early-onset and late-onset Alzheimer's disease J Neuropsychiatr Clin Neurosci 13 2001 304 305 (Pubitemid 32499684)
-
(2001)
Journal of Neuropsychiatry and Clinical Neurosciences
, vol.13
, Issue.2
, pp. 304-305
-
-
Qu, T.1
Manev, R.2
Manev, H.3
-
10
-
-
42049114647
-
5-Lipoxygenase gene disruption reduces amyloid-β pathology in a mouse model of Alzheimer's disease
-
DOI 10.1096/fj.07-9131.com
-
O. Firuzi, J. Zhou, C.M. Chinnici, T. Wisniewski, and D. Praticò 5-Lipoxygenase gene disruption reduces amyloid-beta pathology in a mouse model of Alzheimer's disease FASEB J 22 2008 1169 1178 (Pubitemid 351519971)
-
(2008)
FASEB Journal
, vol.22
, Issue.4
, pp. 1169-1178
-
-
Firuzi, O.1
Zhuo, J.2
Chinnici, C.M.3
Wisniewski, T.4
Pratico, D.5
-
11
-
-
56449106689
-
Increased 5-lipoxygenase immunoreactivity in the hippocampus of patients with Alzheimer's disease
-
M.D. Ikonomovic, E.E. Abrahamson, T. Uz, H. Manev, and S.T. Dekovsky Increased 5-lipoxygenase immunoreactivity in the hippocampus of patients with Alzheimer's disease J Histochem Cytochem 56 2008 1065 1073
-
(2008)
J Histochem Cytochem
, vol.56
, pp. 1065-1073
-
-
Ikonomovic, M.D.1
Abrahamson, E.E.2
Uz, T.3
Manev, H.4
Dekovsky, S.T.5
-
12
-
-
84883142421
-
Involvement of 5-lipoxygenase in Alzheimer's disease: A role for DNA methylation
-
A. Di Francesco, B. Arosio, C. Gussago, E. Dainese, D. Mari, and C. D'Addario et al. Involvement of 5-lipoxygenase in Alzheimer's disease: a role for DNA methylation J. Alzheimers Dis 37 2013 3 8
-
(2013)
J. Alzheimers Dis
, vol.37
, pp. 3-8
-
-
Di Francesco, A.1
Arosio, B.2
Gussago, C.3
Dainese, E.4
Mari, D.5
D'Addario, C.6
-
13
-
-
0038652102
-
γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2
-
DOI 10.1073/pnas.1037392100
-
W.T. Kimberly, M.J. LaVoie, B.L. Ostaszewski, W. Ye, M.S. Wolfe, and D.J. Selkoe Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2 Proc Natl Acad Sci U S A 100 2003 6382 6387 (Pubitemid 36666590)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.11
, pp. 6382-6387
-
-
Kimberly, W.T.1
LaVoie, M.J.2
Ostaszewski, B.L.3
Ye, W.4
Wolfe, M.S.5
Selkoe, D.J.6
-
14
-
-
84880759156
-
Neurotoxicity of amyloid beta-protein: Synaptic and network dysfunction
-
L. Mucke, and D.J. Selkoe Neurotoxicity of amyloid beta-protein: synaptic and network dysfunction Cold Spring Harb Prespect Med 2 2012 a006338
-
(2012)
Cold Spring Harb Prespect Med
, vol.2
, pp. 006338
-
-
Mucke, L.1
Selkoe, D.J.2
-
15
-
-
77957927865
-
The genetics of Alzheimer disease: Back to the future
-
L. Bertram, C.M. Lill, and R.E. Tanzi The genetics of Alzheimer disease: back to the future Neuron 68 2010 270 281
-
(2010)
Neuron
, vol.68
, pp. 270-281
-
-
Bertram, L.1
Lill, C.M.2
Tanzi, R.E.3
-
16
-
-
79953660461
-
Pharmacologic blockade of 5-lipoxygenase improves the amyloidotic phenotype of an Alzheimer's disease transgenic mouse model: Involvement of gamma-secretase
-
J. Chu, and D. Praticò Pharmacologic blockade of 5-lipoxygenase improves the amyloidotic phenotype of an Alzheimer's disease transgenic mouse model: involvement of gamma-secretase Am J Pathol 178 2011 1762 1769
-
(2011)
Am J Pathol
, vol.178
, pp. 1762-1769
-
-
Chu, J.1
Praticò, D.2
-
17
-
-
84891099134
-
Mk886 reduces cerebral amyloid angiopathy severity in TgCRND8 mice
-
[Epub ahead of print]
-
C.A. Hawkes, J.E. Shaw, M. Brown, A.P. Sampson, J. McLaurin, and R.O. Carare Mk886 reduces cerebral amyloid angiopathy severity in TgCRND8 mice Neurodegener Dis 2013 [Epub ahead of print]
-
(2013)
Neurodegener Dis
-
-
Hawkes, C.A.1
Shaw, J.E.2
Brown, M.3
Sampson, A.P.4
McLaurin, J.5
Carare, R.O.6
-
18
-
-
79551473183
-
5-Lipoxygenase as an endogenous modulator of amyloid beta in vivo
-
J. Chu, and D. Praticò 5-Lipoxygenase as an endogenous modulator of amyloid beta in vivo Ann Neurol 69 2011 34 46
-
(2011)
Ann Neurol
, vol.69
, pp. 34-46
-
-
Chu, J.1
Praticò, D.2
-
19
-
-
84855414647
-
Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice
-
10.1186/1750-1326-7-1
-
J. Chu, P.F. Giannopoulos, C. Ceballos-Diaz, T.E. Gold, and D. Praticò Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice Mol Neurodegener 7 2012 1 10.1186/1750-1326-7-1
-
(2012)
Mol Neurodegener
, vol.7
, pp. 1
-
-
Chu, J.1
Giannopoulos, P.F.2
Ceballos-Diaz, C.3
Gold, T.E.4
Praticò, D.5
-
20
-
-
6944231363
-
Gene structure and organization of the human β-secretase (BACE) promoter
-
DOI 10.1096/fj.03-1378fje
-
K. Sambamurti, R. Kinsey, B. Maloney, Y.W. Ge, and D.K. Lahiri Gene structure and organization of the human beta-secretase (BACE) promotor FASEB J 18 9 2004 1034 1036 (Pubitemid 39561516)
-
(2004)
FASEB Journal
, vol.18
, Issue.9
, pp. 1034-1036
-
-
Sambamurti, K.1
Kinsey, R.2
Maloney, B.3
Ge, Y.-W.4
Lahiri, D.K.5
-
21
-
-
84880712325
-
A phase 3 trial of semagacestat for treatment of Alzheimer's disease
-
R.S. Doody, R. Raman, M. Farlow, T. Iwatsubo, B. Vellas, and S. Joffe et al. A phase 3 trial of semagacestat for treatment of Alzheimer's disease New Engl J Med 369 2013 341 350
-
(2013)
New Engl J Med
, vol.369
, pp. 341-350
-
-
Doody, R.S.1
Raman, R.2
Farlow, M.3
Iwatsubo, T.4
Vellas, B.5
Joffe, S.6
-
22
-
-
46749097518
-
Inhibition and Modulation of γ-Secretase for Alzheimer's Disease
-
DOI 10.1016/j.nurt.2008.05.010, PII S1933721308000986
-
M.S. Wolfe Inhibition and modulation of gamma-secretase for Alzheimer's disease Neurotherapeutics 5 2008 391 398 (Pubitemid 351952492)
-
(2008)
Neurotherapeutics
, vol.5
, Issue.3
, pp. 391-398
-
-
Wolfe, M.S.1
-
23
-
-
84867608068
-
Tau protein kinases: Involvement in Alzheimer's disease
-
L. Martin, X. Latypova, C.M. Wilson, A. Magnaudeix, M.L. Perrin, and C. Yardin et al. Tau protein kinases: involvement in Alzheimer's disease Ageing Res Rev 12 2013 289 309
-
(2013)
Ageing Res Rev
, vol.12
, pp. 289-309
-
-
Martin, L.1
Latypova, X.2
Wilson, C.M.3
Magnaudeix, A.4
Perrin, M.L.5
Yardin, C.6
-
24
-
-
84867339738
-
Tau protein phosphatases in Alzheimer's disease: The leading role of PP2A
-
L. Martin, X. Latypova, C.M. Wilson, A. Magnaudeix, M.L. Perrin, and C. Yardin et al. Tau protein phosphatases in Alzheimer's disease: the leading role of PP2A Ageing Res Rev 12 2013 39 49
-
(2013)
Ageing Res Rev
, vol.12
, pp. 39-49
-
-
Martin, L.1
Latypova, X.2
Wilson, C.M.3
Magnaudeix, A.4
Perrin, M.L.5
Yardin, C.6
-
25
-
-
33748752882
-
The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation
-
DOI 10.1074/jbc.M603469200
-
F. Plattner, M. Angelo, and K.P. Giese The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation J Biol Chem 281 35 2006 25457 25465 (Pubitemid 44401934)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.35
, pp. 25457-25465
-
-
Plattner, F.1
Angelo, M.2
Giese, K.P.3
-
26
-
-
84875271571
-
5-lipoxygenase pharmacological blockade decreases tau phosphorylation in vivo: Involvement of the cyclin-dependent kinase-5
-
J. Chu, and D. Praticò 5-lipoxygenase pharmacological blockade decreases tau phosphorylation in vivo: involvement of the cyclin-dependent kinase-5 Neurobiol Aging 34 2013 1549 1554
-
(2013)
Neurobiol Aging
, vol.34
, pp. 1549-1554
-
-
Chu, J.1
Praticò, D.2
-
27
-
-
84882256181
-
The influence of 5-lipoxygenase on Alzheimer's disease-related tau pathology: In vivo and in vitro evidence
-
J. Chu, G. Li, C. Ceballos-Diaz, T. Golde, and D. Praticò The influence of 5-lipoxygenase on Alzheimer's disease-related tau pathology: in vivo and in vitro evidence Biol Psychiatry 74 5 2013 321 328
-
(2013)
Biol Psychiatry
, vol.74
, Issue.5
, pp. 321-328
-
-
Chu, J.1
Li, G.2
Ceballos-Diaz, C.3
Golde, T.4
Praticò, D.5
-
28
-
-
0042697305
-
Triple-transgenic model of Alzheimer's Disease with plaques and tangles: Intracellular Aβ and synaptic dysfunction
-
DOI 10.1016/S0896-6273(03)00434-3
-
S. Oddo, A. Caccamo, J.D. Shepherd, M.P. Murphy, T.E. Gold, and R. Kayed et al. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction Neuron 39 2003 409 421 (Pubitemid 36937044)
-
(2003)
Neuron
, vol.39
, Issue.3
, pp. 409-421
-
-
Oddo, S.1
Caccamo, A.2
Shepherd, J.D.3
Murphy, M.P.4
Golde, T.E.5
Kayed, R.6
Metherate, R.7
Mattson, M.P.8
Akbari, Y.9
LaFerla, F.M.10
-
29
-
-
84897110156
-
Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease
-
10.1038/mp.2013.23
-
P.F. Giannopoulos, J. Chu, Y.B. Joshi, M. Sperow, G. Li, and L.G. Kirby et al. Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease Mol Psychiatry 12 2013 10.1038/mp.2013.23
-
(2013)
Mol Psychiatry
, vol.12
-
-
Giannopoulos, P.F.1
Chu, J.2
Joshi, Y.B.3
Sperow, M.4
Li, G.5
Kirby, L.G.6
-
30
-
-
84881353249
-
Zileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer's disease with plaques and tangles
-
J. Chu, J.G. Li, and D. Praticò Zileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer's disease with plaques and tangles PLoS ONE 8 2013 e70991
-
(2013)
PLoS ONE
, vol.8
, pp. 70991
-
-
Chu, J.1
Li, J.G.2
Praticò, D.3
-
31
-
-
84867095666
-
5-Lipoxygenase gene transfer worsens memory, amyloid and tau brain pathologies in a mouse model of Alzheimer's disease
-
J. Chu, P.F. Giannopoulos, C. Ceballos-Diaz, T. Golde, and D. Praticò 5-Lipoxygenase gene transfer worsens memory, amyloid and tau brain pathologies in a mouse model of Alzheimer's disease Ann Neurol 72 2012 442 454
-
(2012)
Ann Neurol
, vol.72
, pp. 442-454
-
-
Chu, J.1
Giannopoulos, P.F.2
Ceballos-Diaz, C.3
Golde, T.4
Praticò, D.5
-
32
-
-
49149124343
-
Amyloid-beta dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
-
G.M. Shankar, S. Li, T.H. Mehta, A. Garcia-Munoz, N.E. Shepardson, and I. Smith et al. Amyloid-beta dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory Nat Med 14 2008 837 842
-
(2008)
Nat Med
, vol.14
, pp. 837-842
-
-
Shankar, G.M.1
Li, S.2
Mehta, T.H.3
Garcia-Munoz, A.4
Shepardson, N.E.5
Smith, I.6
|