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Volumn 11, Issue 11, 2015, Pages 663-669

Pathogenesis and targeted treatment of skin injury in SLE

Author keywords

[No Author keywords available]

Indexed keywords

ANTINUCLEAR ANTIBODY; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE IV; GAMMA INTERFERON; INTERFERON; INTERLEUKIN 1; INTERLEUKIN 12; INTERLEUKIN 17; LA ANTIBODY; PROTEIN KINASE SYK; RO ANTIBODY; TRANSCRIPTION FACTOR NFAT; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR 1;

EID: 84946485146     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2015.106     Document Type: Review
Times cited : (52)

References (101)
  • 1
    • 82555196095 scopus 로고    scopus 로고
    • Systemic lupus erythematosus
    • Tsokos, G. C. Systemic lupus erythematosus. N. Engl. J. Med. 365, 2110-2121 (2011).
    • (2011) N. Engl. J. Med. , vol.365 , pp. 2110-2121
    • Tsokos, G.C.1
  • 2
    • 84946476691 scopus 로고    scopus 로고
    • T cell signaling abnormalities in systemic autoimmunity explain aberrant immune cell function and provide rational targets for treatment
    • (in press)
    • Moulton, V. & Tsokos, G. C. T cell signaling abnormalities in systemic autoimmunity explain aberrant immune cell function and provide rational targets for treatment. J. Clin. Invest. (in press).
    • J. Clin. Invest.
    • Moulton, V.1    Tsokos, G.C.2
  • 3
    • 0027537389 scopus 로고
    • Systemic lupus erythematosus: Clinical and immunologic patterns of disease expression in a cohort of 1,000 patients
    • The European Working Party on Systemic Lupus Erythematosus
    • Cervera, R. et al. The European Working Party on Systemic Lupus Erythematosus. Systemic lupus erythematosus: clinical and immunologic patterns of disease expression in a cohort of 1,000 patients. Medicine (Baltimore) 72, 113-124 (1993).
    • (1993) Medicine (Baltimore) , vol.72 , pp. 113-124
    • Cervera, R.1
  • 4
    • 33750067967 scopus 로고    scopus 로고
    • Cutaneous lupus erythematosus: Understanding of clinical features, genetic basis, and pathobiology of disease guides therapeutic strategies
    • Lee, H. J. & Sinha, A. A. Cutaneous lupus erythematosus: understanding of clinical features, genetic basis, and pathobiology of disease guides therapeutic strategies. Autoimmunity 39, 433-444 (2006).
    • (2006) Autoimmunity , vol.39 , pp. 433-444
    • Lee, H.J.1    Sinha, A.A.2
  • 5
    • 84895871942 scopus 로고    scopus 로고
    • The classification and diagnosis of cutaneous lupus erythematosus
    • Kuhn, A. & Landmann, A. The classification and diagnosis of cutaneous lupus erythematosus. J. Autoimmun. 48-49, 14-19 (2014).
    • (2014) J. Autoimmun. , vol.48-49 , pp. 14-19
    • Kuhn, A.1    Landmann, A.2
  • 6
    • 84881541291 scopus 로고    scopus 로고
    • Update on pathogenesis and treatment of CLE
    • Privette, E. D. & Werth, V. P. Update on pathogenesis and treatment of CLE. Curr. Opin. Rheumatol. 25, 584-590 (2013).
    • (2013) Curr. Opin. Rheumatol. , vol.25 , pp. 584-590
    • Privette, E.D.1    Werth, V.P.2
  • 7
    • 85027948004 scopus 로고    scopus 로고
    • Cutaneous lupus erythematosus: Diagnosis and treatment
    • Okon, L. G. & Werth, V. P. Cutaneous lupus erythematosus: diagnosis and treatment. Best Pract. Res. Clin. Rheumatol. 27, 391-404 (2013).
    • (2013) Best Pract. Res. Clin. Rheumatol. , vol.27 , pp. 391-404
    • Okon, L.G.1    Werth, V.P.2
  • 8
    • 84872381512 scopus 로고    scopus 로고
    • Cutaneous lupus erythematosus: First multicenter database analysis of 1002 patients from the European Society of Cutaneous Lupus Erythematosus (EUSCLE)
    • Biazar, C. et al. Cutaneous lupus erythematosus: first multicenter database analysis of 1002 patients from the European Society of Cutaneous Lupus Erythematosus (EUSCLE). Autoimmun. Rev. 12, 444-454 (2013).
    • (2013) Autoimmun. Rev. , vol.12 , pp. 444-454
    • Biazar, C.1
  • 9
    • 0019831847 scopus 로고
    • Distinctive cutaneous subsets in the spectrum of lupus erythematosus
    • Gilliam, J. N. & Sontheimer, R. D. Distinctive cutaneous subsets in the spectrum of lupus erythematosus. J. Am. Acad. Dermatol. 4, 471-475 (1981).
    • (1981) J. Am. Acad. Dermatol. , vol.4 , pp. 471-475
    • Gilliam, J.N.1    Sontheimer, R.D.2
  • 10
    • 72749114579 scopus 로고    scopus 로고
    • Comparative analysis of subacute cutaneous lupus erythematosus and chronic cutaneous lupus erythematosus: Clinical and immunological study of 270 patients
    • Vera-Recabarren, M. A., Garcia-Carrasco, M., Ramos-Casals, M. & Herrero, C. Comparative analysis of subacute cutaneous lupus erythematosus and chronic cutaneous lupus erythematosus: clinical and immunological study of 270 patients. Br. J. Dermatol. 162, 91-101 (2010).
    • (2010) Br. J. Dermatol. , vol.162 , pp. 91-101
    • Vera-Recabarren, M.A.1    Garcia-Carrasco, M.2    Ramos-Casals, M.3    Herrero, C.4
  • 11
    • 65549085072 scopus 로고    scopus 로고
    • The 100th anniversary of lupus erythematosus tumidus
    • Kuhn, A., Bein, D. & Bonsmann, G. The 100th anniversary of lupus erythematosus tumidus. Autoimmun. Rev. 8, 441-448 (2009).
    • (2009) Autoimmun. Rev. , vol.8 , pp. 441-448
    • Kuhn, A.1    Bein, D.2    Bonsmann, G.3
  • 12
    • 0019793706 scopus 로고
    • Lupus band test
    • Provost, T. T. Lupus band test. Int. J. Dermatol. 20, 475-481 (1981).
    • (1981) Int. J. Dermatol. , vol.20 , pp. 475-481
    • Provost, T.T.1
  • 13
    • 0021059263 scopus 로고
    • Usefulness of direct immunofluorescence in patients with lupus erythematosus
    • Dahl, M. V. Usefulness of direct immunofluorescence in patients with lupus erythematosus. Arch. Dermatol. 119, 1010-1017 (1983).
    • (1983) Arch. Dermatol. , vol.119 , pp. 1010-1017
    • Dahl, M.V.1
  • 14
    • 0021220719 scopus 로고
    • Dermatopathological studies on skin lesions of MRL mice
    • Furukawa, F. et al. Dermatopathological studies on skin lesions of MRL mice. Arch. Dermatol. Res. 276, 186-194 (1984).
    • (1984) Arch. Dermatol. Res. , vol.276 , pp. 186-194
    • Furukawa, F.1
  • 15
    • 56149099718 scopus 로고    scopus 로고
    • Cholera toxin B accelerates disease progression in lupus-prone mice by promoting lipid raft aggregation
    • Deng, G. M. & Tsokos, G. C. Cholera toxin B accelerates disease progression in lupus-prone mice by promoting lipid raft aggregation. J. Immunol. 181, 4019-4026 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 4019-4026
    • Deng, G.M.1    Tsokos, G.C.2
  • 16
    • 0025828067 scopus 로고
    • Characterization of cutaneous infiltrates in MRL/lpr mice monitored from onset to the full development of lupus erythematosus-like skin lesions
    • Kanauchi, H., Furukawa, F. & Imamura, S. Characterization of cutaneous infiltrates in MRL/lpr mice monitored from onset to the full development of lupus erythematosus-like skin lesions. J. Invest. Dermatol. 96, 478-483 (1991).
    • (1991) J. Invest. Dermatol. , vol.96 , pp. 478-483
    • Kanauchi, H.1    Furukawa, F.2    Imamura, S.3
  • 17
    • 58149182883 scopus 로고    scopus 로고
    • Sunlight triggers cutaneous lupus through a CSF-1-dependent mechanism in MRL-Faslpr mice
    • Menke, J. et al. Sunlight triggers cutaneous lupus through a CSF-1-dependent mechanism in MRL-Faslpr mice. J. Immunol. 181, 7367-7379 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 7367-7379
    • Menke, J.1
  • 18
    • 84904384644 scopus 로고    scopus 로고
    • Ultraviolet light protection by a sunscreen prevents interferon-driven skin inflammation in cutaneous lupus erythematosus
    • Zahn, S. et al. Ultraviolet light protection by a sunscreen prevents interferon-driven skin inflammation in cutaneous lupus erythematosus. Exp. Dermatol. 23, 516-518 (2014).
    • (2014) Exp. Dermatol. , vol.23 , pp. 516-518
    • Zahn, S.1
  • 19
    • 84891776162 scopus 로고    scopus 로고
    • Photosensitivity, apoptosis, and cytokines in the pathogenesis of lupus erythematosus: A critical review
    • Kuhn, A., Wenzel, J. & Weyd, H. Photosensitivity, apoptosis, and cytokines in the pathogenesis of lupus erythematosus: a critical review. Clin. Rev. Allergy Immunol. 47, 148-162 (2014).
    • (2014) Clin. Rev. Allergy Immunol. , vol.47 , pp. 148-162
    • Kuhn, A.1    Wenzel, J.2    Weyd, H.3
  • 20
    • 84875919149 scopus 로고    scopus 로고
    • Immunologic and genetic considerations of cutaneous lupus erythematosus: A comprehensive review
    • Yu C., Chang, C. & Zhang, J. Immunologic and genetic considerations of cutaneous lupus erythematosus: a comprehensive review. J. Autoimmun. 41, 34-45 (2013).
    • (2013) J. Autoimmun. , vol.41 , pp. 34-45
    • Yu, C.1    Chang, C.2    Zhang, J.3
  • 21
    • 84900429291 scopus 로고    scopus 로고
    • Ultraviolet B irradiation induces skin accumulation of plasmacytoid dendritic cells: A possible role for chemerin
    • Yin, Q. et al. Ultraviolet B irradiation induces skin accumulation of plasmacytoid dendritic cells: a possible role for chemerin. Autoimmunity 47, 185-192 (2014).
    • (2014) Autoimmunity , vol.47 , pp. 185-192
    • Yin, Q.1
  • 22
    • 84881097754 scopus 로고    scopus 로고
    • Anti-interferon α treatment in SLE
    • Kirou, K. A. & Gkrouzman, E. Anti-interferon α treatment in SLE. Clin. Immunol. 148, 303-312 (2013).
    • (2013) Clin. Immunol. , vol.148 , pp. 303-312
    • Kirou, K.A.1    Gkrouzman, E.2
  • 23
    • 37749027829 scopus 로고    scopus 로고
    • Type i interferons are involved in the development of ultraviolet B-induced inflammatory skin lesions in systemic lupus erythematosus patients
    • Reefman, E., Kuiper, H., Limburg, P. C., Kallenberg, C. G. & Bijl, M. Type I interferons are involved in the development of ultraviolet B-induced inflammatory skin lesions in systemic lupus erythematosus patients. Ann. Rheum. Dis. 67, 11-18 (2008).
    • (2008) Ann. Rheum. Dis. , vol.67 , pp. 11-18
    • Reefman, E.1    Kuiper, H.2    Limburg, P.C.3    Kallenberg, C.G.4    Bijl, M.5
  • 24
    • 84907867967 scopus 로고    scopus 로고
    • Relevant new insights into the effects of photoprotection in cutaneous lupus erythematosus
    • Kreuter, A. & Lehmann, P. Relevant new insights into the effects of photoprotection in cutaneous lupus erythematosus. Exp. Dermatol. 23, 712-713 (2014).
    • (2014) Exp. Dermatol. , vol.23 , pp. 712-713
    • Kreuter, A.1    Lehmann, P.2
  • 25
    • 84877837895 scopus 로고    scopus 로고
    • Therapeutic strategies evaluated by the European Society of Cutaneous Lupus Erythematosus (EUSCLE) Core Set Questionnaire in more than 1000 patients with cutaneous lupus erythematosus
    • Sigges, J. et al. Therapeutic strategies evaluated by the European Society of Cutaneous Lupus Erythematosus (EUSCLE) Core Set Questionnaire in more than 1000 patients with cutaneous lupus erythematosus. Autoimmun. Rev. 12, 694-702 (2013).
    • (2013) Autoimmun. Rev. , vol.12 , pp. 694-702
    • Sigges, J.1
  • 26
    • 84925248644 scopus 로고    scopus 로고
    • Influence of smoking on disease severity and antimalarial therapy in cutaneous lupus erythematosus: Analysis of 1002 patients from the EUSCLE database
    • Kuhn, A. et al. Influence of smoking on disease severity and antimalarial therapy in cutaneous lupus erythematosus: analysis of 1002 patients from the EUSCLE database. Br. J. Dermatol. 171, 571-579 (2014).
    • (2014) Br. J. Dermatol. , vol.171 , pp. 571-579
    • Kuhn, A.1
  • 27
    • 84876282977 scopus 로고    scopus 로고
    • Recent insights into the genetic basis of systemic lupus erythematosus
    • Rullo, O. J. & Tsao, B. P. Recent insights into the genetic basis of systemic lupus erythematosus. Ann. Rheum. Dis. 72 (Suppl. 2), ii56-ii61 (2013).
    • (2013) Ann. Rheum. Dis. , vol.72 , pp. ii56-ii61
    • Rullo, O.J.1    Tsao, B.P.2
  • 28
    • 80052461085 scopus 로고    scopus 로고
    • Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus
    • Sanchez, E. et al. Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus. Ann. Rheum. Dis. 70, 1752-1757 (2011).
    • (2011) Ann. Rheum. Dis. , vol.70 , pp. 1752-1757
    • Sanchez, E.1
  • 29
    • 84863326630 scopus 로고    scopus 로고
    • Inherited or de novo mutation affecting aspartate 18 of TREX1 results in either familial chilblain lupus or Aicardi-Gouti?res syndrome
    • Tongler, V., Silver, R. M., Walkenhorst, H., G?nther, C. & Lee-Kirsch, M. A. Inherited or de novo mutation affecting aspartate 18 of TREX1 results in either familial chilblain lupus or Aicardi-Gouti?res syndrome. Br. J. Dermatol. 167, 212-214 (2012).
    • (2012) Br. J. Dermatol. , vol.167 , pp. 212-214
    • Tongler, V.1    Silver, R.M.2    Walkenhorst, H.3    Ginther, C.4    Lee-Kirsch, M.A.5
  • 30
    • 84862777442 scopus 로고    scopus 로고
    • Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity
    • Jiang, X. et al. Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity. Nature 483, 227-231 (2012).
    • (2012) Nature , vol.483 , pp. 227-231
    • Jiang, X.1
  • 31
    • 0029968324 scopus 로고    scopus 로고
    • Murine lupus in the absence of αβ T cells
    • Peng, S. L. et al. Murine lupus in the absence of αβ T cells. J. Immunol. 156, 4041-4049 (1996).
    • (1996) J. Immunol. , vol.156 , pp. 4041-4049
    • Peng, S.L.1
  • 32
    • 0030589323 scopus 로고    scopus 로고
    • Propagation and regulation of systemic autoimmunity by γδ T cells
    • Peng, S. L., Madaio, M. P., Hayday, A. C. & Craft, J. Propagation and regulation of systemic autoimmunity by γδ T cells. J. Immunol. 157, 5689-5698 (1996).
    • (1996) J. Immunol. , vol.157 , pp. 5689-5698
    • Peng, S.L.1    Madaio, M.P.2    Hayday, A.C.3    Craft, J.4
  • 33
    • 84885166972 scopus 로고    scopus 로고
    • T cell CD3ζ deficiency enables multiorgan tissue inflammation
    • Deng, G. M., Beltran, J., Chen, C., Terhorst, C. & Tsokos, G. C. T cell CD3ζ deficiency enables multiorgan tissue inflammation. J. Immunol. 191, 3563-3567 (2013).
    • (2013) J. Immunol , vol.191 , pp. 3563-3567
    • Deng, G.M.1    Beltran, J.2    Chen, C.3    Terhorst, C.4    Tsokos, G.C.5
  • 34
    • 0032036481 scopus 로고    scopus 로고
    • Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor ζ chain
    • Liossis, S. N., Ding, X. Z., Dennis, G. J. & Tsokos, G. C. Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor ζ chain. J. Clin. Invest. 101, 1448-1457 (1998).
    • (1998) J. Clin. Invest. , vol.101 , pp. 1448-1457
    • Liossis, S.N.1    Ding, X.Z.2    Dennis, G.J.3    Tsokos, G.C.4
  • 35
    • 33846536952 scopus 로고    scopus 로고
    • Phosphorylated ERM is responsible for increased T cell polarization, adhesion, and migration in patients with systemic lupus erythematosus
    • Li, Y. et al. Phosphorylated ERM is responsible for increased T cell polarization, adhesion, and migration in patients with systemic lupus erythematosus. J. Immunol. 178, 1938-1947 (2007).
    • (2007) J. Immunol. , vol.178 , pp. 1938-1947
    • Li, Y.1
  • 36
    • 46949104431 scopus 로고    scopus 로고
    • Differential roles of ICAM-1 and VCAM-1 in leukocyte-endothelial cell interactions in skin and brain of MRL/faslpr mice
    • Norman, M. U., James, W. G. & Hickey, M. J. Differential roles of ICAM-1 and VCAM-1 in leukocyte-endothelial cell interactions in skin and brain of MRL/faslpr mice. J. Leukoc. Biol. 84, 68-76 (2008).
    • (2008) J. Leukoc. Biol. , vol.84 , pp. 68-76
    • Norman, M.U.1    James, W.G.2    Hickey, M.J.3
  • 37
    • 0031092710 scopus 로고    scopus 로고
    • αβ T cell regulation and CD40 ligand dependence in murine systemic autoimmunity
    • Peng, S. L. et al. αβ T cell regulation and CD40 ligand dependence in murine systemic autoimmunity. J. Immunol. 158, 2464-2470 (1997).
    • (1997) J. Immunol. , vol.158 , pp. 2464-2470
    • Peng, S.L.1
  • 38
    • 0034041205 scopus 로고    scopus 로고
    • Costimulation by B7-1 and B7-2 is required for autoimmune disease in MRL-Faslpr mice
    • Kinoshita, K. et al. Costimulation by B7-1 and B7-2 is required for autoimmune disease in MRL-Faslpr mice. J. Immunol. 164, 6046-6056 (2000).
    • (2000) J. Immunol. , vol.164 , pp. 6046-6056
    • Kinoshita, K.1
  • 39
    • 0032769336 scopus 로고    scopus 로고
    • The central and multiple roles of B cells in lupus pathogenesis
    • Chan, O. T., Madaio, M. P. & Shlomchik, M. J. The central and multiple roles of B cells in lupus pathogenesis. Immunol. Rev. 169, 107-121 (1999).
    • (1999) Immunol. Rev. , vol.169 , pp. 107-121
    • Chan, O.T.1    Madaio, M.P.2    Shlomchik, M.J.3
  • 40
    • 4644304228 scopus 로고    scopus 로고
    • Negative role of colony-stimulating factor-1 in macrophage, T cell, and B cell mediated autoimmune disease in MRL-Faslpr mice
    • Lenda, D. M., Stanley, E. R. & Kelley, V. R. Negative role of colony-stimulating factor-1 in macrophage, T cell, and B cell mediated autoimmune disease in MRL-Faslpr mice. J. Immunol. 173, 4744-4754 (2004).
    • (2004) J. Immunol. , vol.173 , pp. 4744-4754
    • Lenda, D.M.1    Stanley, E.R.2    Kelley, V.R.3
  • 41
    • 78650108453 scopus 로고    scopus 로고
    • Dendritic cells in lupus are not required for activation of T and B cells but promote their expansion, resulting in tissue damage
    • Teichmann, L. L. et al. Dendritic cells in lupus are not required for activation of T and B cells but promote their expansion, resulting in tissue damage. Immunity 33, 967-978 (2010).
    • (2010) Immunity , vol.33 , pp. 967-978
    • Teichmann, L.L.1
  • 42
    • 0034913451 scopus 로고    scopus 로고
    • Presence of cutaneous interferon-α producing cells in patients with systemic lupus erythematosus
    • Blomberg, S. et al. Presence of cutaneous interferon-α producing cells in patients with systemic lupus erythematosus. Lupus 10, 484-490 (2001).
    • (2001) Lupus , vol.10 , pp. 484-490
    • Blomberg, S.1
  • 43
    • 0035403969 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells (natural interferon-α/β-producing cells) accumulate in cutaneous lupus erythematosus lesions
    • Farkas, L., Beiske, K., Lund-Johansen, F., Brandtzaeg, P. & Jahnsen, F. L. Plasmacytoid dendritic cells (natural interferon-α/β-producing cells) accumulate in cutaneous lupus erythematosus lesions. Am. J. Pathol. 159, 237-243 (2001).
    • (2001) Am. J. Pathol. , vol.159 , pp. 237-243
    • Farkas, L.1    Beiske, K.2    Lund-Johansen, F.3    Brandtzaeg, P.4    Jahnsen, F.L.5
  • 44
    • 78650315462 scopus 로고    scopus 로고
    • Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9
    • Guiducci, C. et al. Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9. J. Exp. Med. 207, 2931-2942 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 2931-2942
    • Guiducci, C.1
  • 45
    • 84907212548 scopus 로고    scopus 로고
    • Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus
    • Sisirak, V. et al. Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus. J. Exp. Med. 211, 1969-1976 (2014).
    • (2014) J. Exp. Med. , vol.211 , pp. 1969-1976
    • Sisirak, V.1
  • 46
    • 84907195497 scopus 로고    scopus 로고
    • Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model
    • Rowland, S. L. et al. Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model. J. Exp. Med. 211, 1977-1991 (2014).
    • (2014) J. Exp. Med. , vol.211 , pp. 1977-1991
    • Rowland, S.L.1
  • 47
    • 3242734150 scopus 로고    scopus 로고
    • CD1d deficiency exacerbates inflammatory dermatitis in MRL-lpr/lpr mice
    • Yang, J. Q. et al. CD1d deficiency exacerbates inflammatory dermatitis in MRL-lpr/lpr mice. Eur. J. Immunol. 34, 1723-1732 (2004).
    • (2004) Eur. J. Immunol. , vol.34 , pp. 1723-1732
    • Yang, J.Q.1
  • 48
    • 71849119015 scopus 로고    scopus 로고
    • Cutting edge: Migration of Langerhans dendritic cells is impaired in autoimmune dermatitis
    • Eriksson, A. U. & Singh, R. R. Cutting edge: migration of Langerhans dendritic cells is impaired in autoimmune dermatitis. J. Immunol. 181, 7468-7472 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 7468-7472
    • Eriksson, A.U.1    Singh, R.R.2
  • 49
    • 0036929868 scopus 로고    scopus 로고
    • Human and mouse plasmacytoid dendritic cells
    • Hochrein, H., O'Keeffe, M. & Wagner, H. Human and mouse plasmacytoid dendritic cells. Hum. Immunol. 63, 1103-1110 (2002).
    • (2002) Hum. Immunol. , vol.63 , pp. 1103-1110
    • Hochrein, H.1    O'Keeffe, M.2    Wagner, H.3
  • 50
    • 77953648072 scopus 로고    scopus 로고
    • Lupus serum IgG induces skin inflammation through the TNFR1 signaling pathway
    • Deng, G. M., Liu, L., Kyttaris, V. C. & Tsokos, G. C. Lupus serum IgG induces skin inflammation through the TNFR1 signaling pathway. J. Immunol. 184, 7154-7161 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 7154-7161
    • Deng, G.M.1    Liu, L.2    Kyttaris, V.C.3    Tsokos, G.C.4
  • 51
    • 0033038486 scopus 로고    scopus 로고
    • Intra-articularly localized bacterial DNA containing CpG motifs induces arthritis
    • Deng, G. M., Nilsson, M., Verdrengh, M., Collins, L. V. & Tarkowski, A. Intra-articularly localized bacterial DNA containing CpG motifs induces arthritis. Nat. Med. 5, 702-705 (1999).
    • (1999) Nat. Med. , vol.5 , pp. 702-705
    • Deng, G.M.1    Nilsson, M.2    Verdrengh, M.3    Collins, L.V.4    Tarkowski, A.5
  • 52
    • 0035888028 scopus 로고    scopus 로고
    • Intracisternally localized bacterial DNA containing CpG motifs induces meningitis
    • Deng, G. M., Liu, Z. Q. & Tarkowski, A. Intracisternally localized bacterial DNA containing CpG motifs induces meningitis. J. Immunol. 167, 4616-4626 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 4616-4626
    • Deng, G.M.1    Liu, Z.Q.2    Tarkowski, A.3
  • 53
    • 0033788042 scopus 로고    scopus 로고
    • The major role of macrophages and their product tumor necrosis factor α in the induction of arthritis triggered by bacterial DNA containing CpG motifs
    • Deng, G. M., Verdrengh, M., Liu, Z. Q. & Tarkowski, A. The major role of macrophages and their product tumor necrosis factor α in the induction of arthritis triggered by bacterial DNA containing CpG motifs. Arthritis Rheum. 43, 2283-2289 (2000).
    • (2000) Arthritis Rheum. , vol.43 , pp. 2283-2289
    • Deng, G.M.1    Verdrengh, M.2    Liu, Z.Q.3    Tarkowski, A.4
  • 54
    • 0032813046 scopus 로고    scopus 로고
    • Role of nucleosomes for induction and glomerular binding of autoantibodies in lupus nephritis
    • Berden, J. H., Licht, R., van Bruggen, M. C. & Tax, W. J. Role of nucleosomes for induction and glomerular binding of autoantibodies in lupus nephritis. Curr. Opin. Nephrol. Hypertens. 8, 299-306 (1999).
    • (1999) Curr. Opin. Nephrol. Hypertens. , vol.8 , pp. 299-306
    • Berden, J.H.1    Licht, R.2    Van Bruggen, M.C.3    Tax, W.J.4
  • 55
    • 33947660078 scopus 로고    scopus 로고
    • Glomerular apoptotic nucleosomes are central target structures for nephritogenic antibodies in human SLE nephritis
    • Kalaaji, M. et al. Glomerular apoptotic nucleosomes are central target structures for nephritogenic antibodies in human SLE nephritis. Kidney Int. 71, 664-672 (2007).
    • (2007) Kidney Int. , vol.71 , pp. 664-672
    • Kalaaji, M.1
  • 56
    • 33744756400 scopus 로고    scopus 로고
    • Nephritogenic lupus antibodies recognize glomerular basement membrane-associated chromatin fragments released from apoptotic intraglomerular cells
    • Kalaaji, M., Mortensen, E., Jorgensen, L., Olsen, R. & Rekvig, O. P. Nephritogenic lupus antibodies recognize glomerular basement membrane-associated chromatin fragments released from apoptotic intraglomerular cells. Am. J. Pathol. 168, 1779-1792 (2006).
    • (2006) Am. J. Pathol. , vol.168 , pp. 1779-1792
    • Kalaaji, M.1    Mortensen, E.2    Jorgensen, L.3    Olsen, R.4    Rekvig, O.P.5
  • 57
    • 0035060979 scopus 로고    scopus 로고
    • Lupus anti-DNA autoantibodies cross-react with a glomerular structural protein: A case for tissue injury by molecular mimicry
    • Mostoslavsky, G. et al. Lupus anti-DNA autoantibodies cross-react with a glomerular structural protein: a case for tissue injury by molecular mimicry. Eur. J. Immunol. 31, 1221-1227 (2001).
    • (2001) Eur. J. Immunol. , vol.31 , pp. 1221-1227
    • Mostoslavsky, G.1
  • 58
    • 0037087262 scopus 로고    scopus 로고
    • α-actinin is a cross-reactive renal target for pathogenic anti-DNA antibodies
    • Deocharan, B., Qing, X., Lichauco, J. & Putterman, C. α-Actinin is a cross-reactive renal target for pathogenic anti-DNA antibodies. J. Immunol. 168, 3072-3078 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 3072-3078
    • Deocharan, B.1    Qing, X.2    Lichauco, J.3    Putterman, C.4
  • 59
    • 0035173156 scopus 로고    scopus 로고
    • A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus
    • DeGiorgio, L. A. et al. A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus. Nat. Med. 7, 1189-1193 (2001).
    • (2001) Nat. Med. , vol.7 , pp. 1189-1193
    • DeGiorgio, L.A.1
  • 60
    • 0024577759 scopus 로고
    • Pattern of cutaneous immunoglobulin G deposition in subacute cutaneous lupus erythematosus is reproduced by infusing purified anti-Ro (SSA) autoantibodies into human skin-grafted mice
    • Lee, L. A., Gaither, K. K., Coulter, S. N., Norris, D. A. & Harley, J. B. Pattern of cutaneous immunoglobulin G deposition in subacute cutaneous lupus erythematosus is reproduced by infusing purified anti-Ro (SSA) autoantibodies into human skin-grafted mice. J. Clin. Invest. 83, 1556-1562 (1989).
    • (1989) J. Clin. Invest. , vol.83 , pp. 1556-1562
    • Lee, L.A.1    Gaither, K.K.2    Coulter, S.N.3    Norris, D.A.4    Harley, J.B.5
  • 61
    • 84919883414 scopus 로고    scopus 로고
    • Association of anti-acidic ribosomal protein p0 and anti-galectin 3 antibodies with the development of skin lesions in systemic lupus erythematosus
    • Shi, Z. R. et al. Association of anti-acidic ribosomal protein p0 and anti-galectin 3 antibodies with the development of skin lesions in systemic lupus erythematosus. Arthritis Rheumatol. 67, 193-203 (2015).
    • (2015) Arthritis Rheumatol. , vol.67 , pp. 193-203
    • Shi, Z.R.1
  • 62
    • 67651097514 scopus 로고    scopus 로고
    • High Ro52 expression in spontaneous and UV-induced cutaneous inflammation
    • Oke, V. et al. High Ro52 expression in spontaneous and UV-induced cutaneous inflammation. J. Invest. Dermatol. 129, 2000-2010 (2009).
    • (2009) J. Invest. Dermatol. , vol.129 , pp. 2000-2010
    • Oke, V.1
  • 63
    • 68149179247 scopus 로고    scopus 로고
    • Loss of the lupus autoantigen Ro52/TRIM21 induces tissue inflammation and systemic autoimmunity by dysregulating the IL-23-TH17 pathway
    • Espinosa, A. et al. Loss of the lupus autoantigen Ro52/TRIM21 induces tissue inflammation and systemic autoimmunity by dysregulating the IL-23-TH17 pathway. J. Exp. Med. 206, 1661-1671 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 1661-1671
    • Espinosa, A.1
  • 64
    • 0032522778 scopus 로고    scopus 로고
    • IFN-γ receptor deletion prevents autoantibody production and glomerulonephritis in lupus-prone (NZB ? NZW) F1 mice
    • Haas, C., Ryffel, B. & Le Hir, M. IFN-γ receptor deletion prevents autoantibody production and glomerulonephritis in lupus-prone (NZB ? NZW) F1 mice. J. Immunol. 160, 3713-3718 (1998).
    • (1998) J. Immunol. , vol.160 , pp. 3713-3718
    • Haas, C.1    Ryffel, B.2    Le Hir, M.3
  • 65
    • 0031831859 scopus 로고    scopus 로고
    • IFN-γ receptor signaling is essential for the initiation, acceleration, and destruction of autoimmune kidney disease in MRL-Faslpr mice
    • Schwarting, A., Wada, T., Kinoshita, K., Tesch, G. & Kelley, V. R. IFN-γ receptor signaling is essential for the initiation, acceleration, and destruction of autoimmune kidney disease in MRL-Faslpr mice. J. Immunol. 161, 494-503 (1998).
    • (1998) J. Immunol. , vol.161 , pp. 494-503
    • Schwarting, A.1    Wada, T.2    Kinoshita, K.3    Tesch, G.4    Kelley, V.R.5
  • 66
    • 0037378016 scopus 로고    scopus 로고
    • IL-12 deficiency in MRL-Faslpr mice delays nephritis and intrarenal IFN-γ expression, and diminishes systemic pathology
    • Kikawada, E., Lenda, D. M. & Kelley, V. R. IL-12 deficiency in MRL-Faslpr mice delays nephritis and intrarenal IFN-γ expression, and diminishes systemic pathology. J. Immunol. 170, 3915-3925 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 3915-3925
    • Kikawada, E.1    Lenda, D.M.2    Kelley, V.R.3
  • 67
    • 58149161860 scopus 로고    scopus 로고
    • Type i interferon-associated cytotoxic inflammation in cutaneous lupus erythematosus
    • Wenzel, J., Zahn, S., Bieber, T. & Toting, T. Type I interferon-associated cytotoxic inflammation in cutaneous lupus erythematosus. Arch. Dermatol. Res. 301, 83-86 (2009).
    • (2009) Arch. Dermatol. Res. , vol.301 , pp. 83-86
    • Wenzel, J.1    Zahn, S.2    Bieber, T.3    Toting, T.4
  • 68
    • 33645115417 scopus 로고    scopus 로고
    • Tumour necrosis factor α is expressed in refractory skin lesions from patients with subacute cutaneous lupus erythematosus
    • Zampieri, S. et al. Tumour necrosis factor α is expressed in refractory skin lesions from patients with subacute cutaneous lupus erythematosus. Ann. Rheum. Dis. 65, 545-548 (2006).
    • (2006) Ann. Rheum. Dis. , vol.65 , pp. 545-548
    • Zampieri, S.1
  • 69
    • 84857500358 scopus 로고    scopus 로고
    • Therapeutic blockade of TNF in patients with SLE-promising or crazy?
    • Aringer, M. & Smolen, J. S. Therapeutic blockade of TNF in patients with SLE-promising or crazy? Autoimmun. Rev. 11, 321-325 (2012).
    • (2012) Autoimmun. Rev. , vol.11 , pp. 321-325
    • Aringer, M.1    Smolen, J.S.2
  • 70
    • 81455154445 scopus 로고    scopus 로고
    • The role of tumor necrosis factor-α (TNF-α) in the pathogenesis of systemic lupus erythematosus
    • Postal, M. & Appenzeller, S. The role of tumor necrosis factor-α (TNF-α) in the pathogenesis of systemic lupus erythematosus. Cytokine 56, 537-543 (2011).
    • (2011) Cytokine , vol.56 , pp. 537-543
    • Postal, M.1    Appenzeller, S.2
  • 71
    • 27144479900 scopus 로고    scopus 로고
    • Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors
    • Deng, G. M., Zheng, L., Chan, F. K. & Lenardo, M. Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors. Nat. Med. 11, 1066-1072 (2005).
    • (2005) Nat. Med. , vol.11 , pp. 1066-1072
    • Deng, G.M.1    Zheng, L.2    Chan, F.K.3    Lenardo, M.4
  • 72
    • 0034733682 scopus 로고    scopus 로고
    • A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling
    • Chan, F. K. et al. A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science 288, 2351-2354 (2000).
    • (2000) Science , vol.288 , pp. 2351-2354
    • Chan, F.K.1
  • 73
    • 77955344294 scopus 로고    scopus 로고
    • Targeted tumor necrosis factor receptor i preligand assembly domain improves skin lesions in MRL/lpr mice
    • Deng, G. M., Liu, L. & Tsokos, G. C. Targeted tumor necrosis factor receptor I preligand assembly domain improves skin lesions in MRL/lpr mice. Arthritis Rheum. 62, 2424-2431 (2010).
    • (2010) Arthritis Rheum. , vol.62 , pp. 2424-2431
    • Deng, G.M.1    Liu, L.2    Tsokos, G.C.3
  • 74
    • 0030584786 scopus 로고    scopus 로고
    • Greatly accelerated lymphadenopathy and autoimmune disease in lpr mice lacking tumor necrosis factor receptor i
    • Zhou, T. et al. Greatly accelerated lymphadenopathy and autoimmune disease in lpr mice lacking tumor necrosis factor receptor I. J. Immunol. 156, 2661-2665 (1996).
    • (1996) J. Immunol. , vol.156 , pp. 2661-2665
    • Zhou, T.1
  • 75
    • 0028355565 scopus 로고
    • Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling
    • Kurosaki, T. et al. Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling. J. Exp. Med. 179, 1725-1729 (1994).
    • (1994) J. Exp. Med. , vol.179 , pp. 1725-1729
    • Kurosaki, T.1
  • 76
    • 79959261430 scopus 로고    scopus 로고
    • Spleen tyrosine kinase inhibition in the treatment of autoimmune, allergic and autoinflammatory diseases
    • Pamuk, O. N. & Tsokos, G. C. Spleen tyrosine kinase inhibition in the treatment of autoimmune, allergic and autoinflammatory diseases. Arthritis Res. Ther. 12, 222 (2010).
    • (2010) Arthritis Res. Ther. , vol.12 , pp. 222
    • Pamuk, O.N.1    Tsokos, G.C.2
  • 77
    • 77954229590 scopus 로고    scopus 로고
    • Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus-prone mice
    • Deng, G. M., Liu, L., Bahjat, F. R., Pine, P. R. & Tsokos, G. C. Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus-prone mice. Arthritis Rheum. 62, 2086-2092 (2010).
    • (2010) Arthritis Rheum. , vol.62 , pp. 2086-2092
    • Deng, G.M.1    Liu, L.2    Bahjat, F.R.3    Pine, P.R.4    Tsokos, G.C.5
  • 78
    • 0035665057 scopus 로고    scopus 로고
    • Altered Bax expression and decreased apoptosis in bone marrow cells of lupus-susceptible NZB/W mice
    • Nazareth, M. et al. Altered Bax expression and decreased apoptosis in bone marrow cells of lupus-susceptible NZB/W mice. Lupus 10, 785-793 (2001).
    • (2001) Lupus , vol.10 , pp. 785-793
    • Nazareth, M.1
  • 79
    • 23844433945 scopus 로고    scopus 로고
    • Essential role of BAX, BAK in B cell homeostasis and prevention of autoimmune disease
    • Takeuchi, O. et al. Essential role of BAX, BAK in B cell homeostasis and prevention of autoimmune disease. Proc. Natl Acad. Sci. USA 102, 11272-11277 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 11272-11277
    • Takeuchi, O.1
  • 80
    • 65249187242 scopus 로고    scopus 로고
    • A retrospective seven-year analysis of the use of B cell depletion therapy in systemic lupus erythematosus at University College London Hospital: The first fifty patients
    • Lu, T. Y. et al. A retrospective seven-year analysis of the use of B cell depletion therapy in systemic lupus erythematosus at University College London Hospital: the first fifty patients. Arthritis Rheum. 61, 482-487 (2009).
    • (2009) Arthritis Rheum. , vol.61 , pp. 482-487
    • Lu, T.Y.1
  • 81
    • 77955379986 scopus 로고    scopus 로고
    • Safety and efficacy of rituximab in systemic lupus erythematosus: Results from 136 patients from the French AutoImmunity and Rituximab registry
    • Terrier, B. et al. Safety and efficacy of rituximab in systemic lupus erythematosus: results from 136 patients from the French AutoImmunity and Rituximab registry. Arthritis Rheum. 62, 2458-2466 (2010).
    • (2010) Arthritis Rheum. , vol.62 , pp. 2458-2466
    • Terrier, B.1
  • 82
    • 84880910638 scopus 로고    scopus 로고
    • Effects of rituximab-based B-cell depletion therapy on skin manifestations of lupus erythematosus-report of 17 cases and review of the literature
    • Hofmann, S. C., Leandro, M. J., Morris, S. D. & Isenberg, D. A. Effects of rituximab-based B-cell depletion therapy on skin manifestations of lupus erythematosus-report of 17 cases and review of the literature. Lupus 22, 932-939 (2013).
    • (2013) Lupus , vol.22 , pp. 932-939
    • Hofmann, S.C.1    Leandro, M.J.2    Morris, S.D.3    Isenberg, D.A.4
  • 83
    • 0035028435 scopus 로고    scopus 로고
    • Ca2+/CaM-dependent kinases: From activation to function
    • Hook, S. S. & Means, A. R. Ca2+/CaM-dependent kinases: from activation to function. Annu. Rev. Pharmacol. Toxicol. 41, 471-505 (2001).
    • (2001) Annu. Rev. Pharmacol. Toxicol. , vol.41 , pp. 471-505
    • Hook, S.S.1    Means, A.R.2
  • 84
    • 0033137329 scopus 로고    scopus 로고
    • The Ca-calmodulin-dependent protein kinase cascade
    • Soderling, T. R. The Ca-calmodulin-dependent protein kinase cascade. Trends Biochem. Sci. 24, 232-236 (1999).
    • (1999) Trends Biochem. Sci. , vol.24 , pp. 232-236
    • Soderling, T.R.1
  • 85
    • 16844376445 scopus 로고    scopus 로고
    • Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV
    • Juang, Y. T. et al. Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV. J. Clin. Invest. 115, 996-1005 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 996-1005
    • Juang, Y.T.1
  • 86
    • 79551680278 scopus 로고    scopus 로고
    • Suppression of autoimmunity and organ pathology in lupus-prone mice upon inhibition of calcium/calmodulin-dependent protein kinase type IV
    • Ichinose, K., Juang, Y. T., Crispin, J. C., Kis-Toth, K. & Tsokos, G. C. Suppression of autoimmunity and organ pathology in lupus-prone mice upon inhibition of calcium/calmodulin-dependent protein kinase type IV. Arthritis Rheum. 63, 523-529 (2011).
    • (2011) Arthritis Rheum. , vol.63 , pp. 523-529
    • Ichinose, K.1    Juang, Y.T.2    Crispin, J.C.3    Kis-Toth, K.4    Tsokos, G.C.5
  • 87
    • 77956175013 scopus 로고    scopus 로고
    • FAT, immunity and cancer: A transcription factor comes of age
    • Muller, M. R. & Rao, A. FAT, immunity and cancer: a transcription factor comes of age. Nat. Rev. Immunol. 10, 645-656 (2010).
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 645-656
    • Muller, M.R.1    Rao, A.2
  • 88
    • 0023821516 scopus 로고
    • Identification of a putative regulator of early T cell activation genes
    • Shaw, J. P. et al. Identification of a putative regulator of early T cell activation genes. Science 241, 202-205 (1988).
    • (1988) Science , vol.241 , pp. 202-205
    • Shaw, J.P.1
  • 89
    • 0141483523 scopus 로고    scopus 로고
    • Transcriptional regulation by calcium, calcineurin, and NFAT
    • Hogan, P. G., Chen, L., Nardone, J. & Rao, A. Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev. 17, 2205-2232 (2003).
    • (2003) Genes Dev. , vol.17 , pp. 2205-2232
    • Hogan, P.G.1    Chen, L.2    Nardone, J.3    Rao, A.4
  • 90
    • 20644466433 scopus 로고    scopus 로고
    • NFAT proteins: Key regulators of T-cell development and function
    • Macian, F. NFAT proteins: key regulators of T-cell development and function. Nat. Rev. Immunol. 5, 472-484 (2005).
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 472-484
    • Macian, F.1
  • 91
    • 67650500800 scopus 로고    scopus 로고
    • CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation
    • Zanoni, I. et al. CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation. Nature 460, 264-268 (2009).
    • (2009) Nature , vol.460 , pp. 264-268
    • Zanoni, I.1
  • 92
    • 71749117376 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of 3BP2 regulates B cell receptor-mediated activation of NFAT
    • Shukla, U., Hatani, T., Nakashima, K., Ogi, K. & Sada, K. Tyrosine phosphorylation of 3BP2 regulates B cell receptor-mediated activation of NFAT. J. Biol. Chem. 284, 33719-33728 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 33719-33728
    • Shukla, U.1    Hatani, T.2    Nakashima, K.3    Ogi, K.4    Sada, K.5
  • 93
    • 43549095989 scopus 로고    scopus 로고
    • Nuclear factor of activated T cells (NFAT) mediates CD154 expression in megakaryocytes
    • Crist, S. A., Sprague, D. L. & Ratliff, T. L. Nuclear factor of activated T cells (NFAT) mediates CD154 expression in megakaryocytes. Blood 111, 3553-3561 (2008).
    • (2008) Blood , vol.111 , pp. 3553-3561
    • Crist, S.A.1    Sprague, D.L.2    Ratliff, T.L.3
  • 94
    • 33846518435 scopus 로고    scopus 로고
    • Increased levels of NF-ATc2 differentially regulate CD154 and IL-2 genes in T cells from patients with systemic lupus erythematosus
    • Kyttaris, V. C., Wang, Y., Juang, Y. T., Weinstein, A. & Tsokos, G. C. Increased levels of NF-ATc2 differentially regulate CD154 and IL-2 genes in T cells from patients with systemic lupus erythematosus. J. Immunol. 178, 1960-1966 (2007).
    • (2007) J. Immunol. , vol.178 , pp. 1960-1966
    • Kyttaris, V.C.1    Wang, Y.2    Juang, Y.T.3    Weinstein, A.4    Tsokos, G.C.5
  • 95
    • 79959852739 scopus 로고    scopus 로고
    • Calcium signaling in systemic lupus erythematosus T cells: A treatment target
    • Kyttaris, V. C., Zhang, Z., Kampagianni, O. & Tsokos, G. C. Calcium signaling in systemic lupus erythematosus T cells: a treatment target. Arthritis Rheum. 63, 2058-2066 (2011).
    • (2011) Arthritis Rheum. , vol.63 , pp. 2058-2066
    • Kyttaris, V.C.1    Zhang, Z.2    Kampagianni, O.3    Tsokos, G.C.4
  • 96
    • 0027491776 scopus 로고
    • The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun
    • Jain, J. et al. The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. Nature 365, 352-355 (1993).
    • (1993) Nature , vol.365 , pp. 352-355
    • Jain, J.1
  • 97
    • 0027432388 scopus 로고
    • Isolation of the cyclosporin-sensitive T cell transcription factor NFATp
    • McCaffrey, P. G. et al. Isolation of the cyclosporin-sensitive T cell transcription factor NFATp. Science 262, 750-754 (1993).
    • (1993) Science , vol.262 , pp. 750-754
    • McCaffrey, P.G.1
  • 98
    • 66149096223 scopus 로고    scopus 로고
    • Inhibiting the calcineurin-NFAT (nuclear factor of activated T cells) signaling pathway with a regulator of calcineurin-derived peptide without affecting general calcineurin phosphatase activity
    • Mulero, M. C. et al. Inhibiting the calcineurin-NFAT (nuclear factor of activated T cells) signaling pathway with a regulator of calcineurin-derived peptide without affecting general calcineurin phosphatase activity. J. Biol. Chem. 284, 9394-9401 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 9394-9401
    • Mulero, M.C.1
  • 100
    • 79958790928 scopus 로고    scopus 로고
    • Efficacy of tacrolimus 0.1% ointment in cutaneous lupus erythematosus: A multicenter, randomized, double-blind, vehicle-controlled trial
    • Kuhn A. et al. Efficacy of tacrolimus 0.1% ointment in cutaneous lupus erythematosus: a multicenter, randomized, double-blind, vehicle-controlled trial. J. Am. Acad. Dermatol. 65, 54-64 (2011).
    • (2011) J. Am. Acad. Dermatol. , vol.65 , pp. 54-64
    • Kuhn, A.1
  • 101
    • 84856463818 scopus 로고    scopus 로고
    • Treatment of systemic lupus erythematosus: New advances in targeted therapy
    • Lo, M. S. & Tsokos, G. C. Treatment of systemic lupus erythematosus: new advances in targeted therapy. Ann. NY Acad. Sci. 1247, 138-152 (2012).
    • (2012) Ann. NY Acad. Sci. , vol.1247 , pp. 138-152
    • Lo, M.S.1    Tsokos, G.C.2


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