Altered bax expression and decreased apoptosis in bone marrow cells of lupus-susceptible NZB/W mice

Lupus

Volumn 10, Issue 11, 2001, Pages 785-793

  Nazareth, M ^a   Fanti, P ^a   Schwach, C ^a   Poppenberg, K ^a   Janis, K ^a   Aronica, S M ^a  

^a CANISIUS COLLEGE   (United States)

Author keywords

Apoptosis; Bax; Estrogen; Lupus; Murine

Indexed keywords

ESTROGEN; PROTEIN BAX; PROTEIN BCL 2; THROMBOPOIETIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL CULTURE; CELL ISOLATION; CONTROLLED STUDY; IMMUNOPATHOLOGY; MOUSE; MOUSE STRAIN; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 0035665057     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1177/096120330101001105     Document Type: Article

References (54)

1. Systemic lupus erythematosus: Immunopathogenesis and the card game analogy
2. Apoptosis in systemic lupus erythematosus. Clinical implications
3. Systemic lupus erythematosus: Demographics, prognosis, and outcome
4. B lymphocyte precursors and myeloid progenitors survive in diffusion chamber cultures but B cell differentiation requires close association with stromal cells
5. A primer on cytokines: Sources, receptors, effects, and inducers
6. Defects of B-cell lymphopoiesis and bone marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
7. General review: Effects of gender and sex steroids on the immune response
8. Gonadal steroids and immunity
9. Estrogens, the immune response and autoimmunity
10. Hemopoetic cell dysfunction in murine lupus
11. Increased osteoclast development after estrogen loss: Mediation by interleukin-6
12. Estrogen loss upregulates hematopoiesis in the mouse: A mediating role of IL-6
13. Estrogen deficiency stimulates B lymphopoiesis in mouse bone marrow
14. Increased B-lymphopoiesis by interleukin-7 induces bone loss in mice with intact ovarian function: Similarity to estrogen deficiency
15. Involvement of different second messengers in parathyroid hormone- and interleukin-1-induced interleukin-6 and interleukin-11 production in human bone marrow stromal cells
16. Estradiol down-regulates LPS-induced cytokine production and NFκβ activation in murine macrophages
17. Regulation of the gp80 and gp130 subunits of the IL-6 receptor by sex steroids in the murine bone marrow
18. Hormonal regulation of tumor necrosis factor-alpha, interleukin-12 and interleukin-10 production by activated macrophages. A disease-modifying mechanism in rheumatoid arthritis and systemic lupus erythematosus?
19. Complexities in the treatment of autoimmune disease
20. Estrogen up-regulates Bcl-2 and blocks tolerance induction of naïve B cells
21. Role of Bcl-2 family proteins in apoptosis: Apoptosomes or mitochondria?
22. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
23. Analyses of the role of Bcl-2 in apoptosis
24. The proto-oncogene Bcl-2 and its role in regulating apoptosis
25. Bcl-2 family: Regulators of cell death
26. The relationship between Bcl-2, Bax, and p53: Consequences for cell cycle progression and cell death
27. Stromal cells regulate Bcl-2 and Bax expression in pro-B cells
28. Cytokine regulation of apoptosis in hematopoietic precursor cells
29. L regulates apoptosis by heterodimerization-dependent and -independent mechanisms
30. Differential oncogene and TNF-α mRNA expression in bone marrow cells from systemic lupus erythematosus patients
31. Sex hormone modulation of autoimmunity in NZB/NZW mice
32. The immunology and pathology of NZB mice
33. Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains
34. B-cell hyperreactivity in murine lupus. I. Immunological abnormalities in lupus-prone strains and the activation of normal B cells
35. B-cell hyperreactivity in murine lupus. II. Defects in response to and production of accessory signals in lupus-prone mice
36. Pathogenesis of the glomerulonephritis of NZB/W mice
37. Resting B cells from New Zealand black mice demonstrate a defect in apoptosis induction following surface IgM ligation
38. Enhancing and suppressing effects of recombinant murine macrophage inflammatory proteins on colony formation in vitro by bone marrow myeloid progenitor cells
39. Estrogen receptor null mice: What have we learned and where will they lead us?
40. Altered bone marrow cell sensitivity in the lupus-prone NZB/W mouse: Regulation of CFU-GM colony formation by estrogen, tamoxifen, and thrombopoietin
41. Spontaneous and induced apoptosis in systemic lupus erythematosus: Multiple assays fail to reveal consistent abnormalities
42. Bcl-2 gene family and related proteins in mammary gland involution and breast cancer
43. Control of apoptosis in hematopoiesis and leukemia by cytokines tumor suppressor and oncogenes
44. Cytokines and the regulation of apoptosis in reproductive tissues: A review
45. Lymphocyte apoptosis - Mechanisms and implications in disease
46. Cell death in the myeloid lineage
47. Estrogen enhancement of antidouble-stranded DNA antibody and immunoglobulin G production in peripheral blood mononuclear cells from patients with systemic lupus erythematosus
48. Autostimulatory effects of IL-6 on excessive B cell differentiation in patients with systemic lupus erythematosus: Analysis of IL-6 production and IL-6R expression
49. New therapies for systemic lupus erythematosus
50. Antibodies to DNA
51. Bcl-2 oncogene (B cell lymphoma/leukemia-2) levels correlate with systemic lupus erythematosus disease activity
52. Thrombopoietin suppresses apoptosis and behaves as a survival factor for the human growth factor-dependent cell line MO7e
53. Oestrogen is a potent disease accelerator in SLE-prone MRL Ipr/Ipr mice
54. Sex hormone involvement in the induction of experimental systemic lupus erythematosus by a pathogenic anti-DNA idiotype in naïve mice