Novel identification of the free fatty acid receptor FFAR1 that promotes contraction in airway smooth muscle

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 309, Issue 9, 2015, Pages L970-L982

  Mizuta, Kentaro ^a,b   Zhang, Yi ^a   Mizuta, Fumiko ^b   Hoshijima, Hiroshi ^b   Shiga, Toshiya ^c   Masaki, Eiji ^b   Emala, Charles W ^a  

^a College of Physicians and Surgeons of Columbia University ^*  (United States)

^b TOHOKU UNIVERSITY   (Japan)

^c International University of Health and Welfare Ichikawa Hospital   (Japan)

Author keywords

Airway smooth muscle; FFAR1; FFAR4; Free fatty acid; Gq coupled receptor

Indexed keywords

ACETYLCHOLINE; G PROTEIN COUPLED RECEPTOR 120; G PROTEIN COUPLED RECEPTOR 40; INOSITOL PHOSPHATE; ISOPRENALINE; LINOLEIC ACID; OLEIC ACID; SMALL INTERFERING RNA; 3-(4-((4-FLUORO-4'-METHYL-(1,1'-BIPHENYL)-2-YL)METHOXY)PHENYL)PROPANOIC ACID; BIPHENYL DERIVATIVE; FFAR1 PROTEIN, HUMAN; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GW9508; METHYLAMINE; PHENYLPROPIONIC ACID DERIVATIVE; PROPIONIC ACID DERIVATIVE;

ACTIN POLYMERIZATION; ADULT; AIRWAY SMOOTH MUSCLE CELL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM MOBILIZATION; CONTROLLED STUDY; EX VIVO STUDY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE TONE; STRESS FIBER; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CALCIUM SIGNALING; CELL LINE; DRUG EFFECTS; GUINEA PIG; METABOLISM; MUSCLE CONTRACTION; MUSCLE TONE; PHYSIOLOGY; SMOOTH MUSCLE;

ANIMALS; BIPHENYL COMPOUNDS; CALCIUM SIGNALING; CELL LINE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; GUINEA PIGS; HUMANS; LINOLEIC ACID; METHYLAMINES; MUSCLE CONTRACTION; MUSCLE TONUS; MUSCLE, SMOOTH; OLEIC ACID; PHENYLPROPIONATES; PROPIONATES; RECEPTORS, G-PROTEIN-COUPLED; STRESS FIBERS;

EID: 84946416932     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00041.2015     Document Type: Article

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