-
1
-
-
84865070369
-
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
-
Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA, et al. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science. 2012;337:816-21.
-
(2012)
Science
, vol.337
, pp. 816-821
-
-
Jinek, M.1
Chylinski, K.2
Fonfara, I.3
Hauer, M.4
Doudna, J.A.5
-
2
-
-
84913594397
-
The new frontier of genome engineering with CRISPR-Cas9
-
Doudna JA, Charpentier E. The new frontier of genome engineering with CRISPR-Cas9. Science. 2014;346:1258096.
-
(2014)
Science
, vol.346
, pp. 1258096
-
-
Doudna, J.A.1
Charpentier, E.2
-
3
-
-
84902096048
-
Development and applications of CRISPR-Cas9 for genome engineering
-
Hsu PD, Lander ES, Zhang F. Development and applications of CRISPR-Cas9 for genome engineering. Cell. 2014;157:1262-78.
-
(2014)
Cell
, vol.157
, pp. 1262-1278
-
-
Hsu, P.D.1
Lander, E.S.2
Zhang, F.3
-
5
-
-
84902185906
-
Genome engineering with targetable nucleases
-
Carroll D. Genome engineering with targetable nucleases. Annu Rev Biochem. 2014;83:409-39.
-
(2014)
Annu Rev Biochem
, vol.83
, pp. 409-439
-
-
Carroll, D.1
-
6
-
-
84898778301
-
A guide to genome engineering with programmable nucleases
-
Kim H, Kim JS. A guide to genome engineering with programmable nucleases. Nat Rev Genet. 2014;15:321-34.
-
(2014)
Nat Rev Genet
, vol.15
, pp. 321-334
-
-
Kim, H.1
Kim, J.S.2
-
7
-
-
84938739634
-
Measuring and reducing off-target activities of programmable nucleases including CRISPR-Cas9
-
Koo T, Lee J, Kim JS. Measuring and reducing off-target activities of programmable nucleases including CRISPR-Cas9. Mol Cells. 2015;38:475-81.
-
(2015)
Mol Cells
, vol.38
, pp. 475-481
-
-
Koo, T.1
Lee, J.2
Kim, J.S.3
-
8
-
-
80054981256
-
Solutions for a cultivated planet
-
Foley JA, Ramankutty N, Brauman KA, Cassidy ES, Gerber JS, Johnston M, et al. Solutions for a cultivated planet. Nature. 2011;478:337-42.
-
(2011)
Nature
, vol.478
, pp. 337-342
-
-
Foley, J.A.1
Ramankutty, N.2
Brauman, K.A.3
Cassidy, E.S.4
Gerber, J.S.5
Johnston, M.6
-
9
-
-
84921594086
-
Enabling plant synthetic biology through genome engineering
-
Baltes NJ, Voytas DF. Enabling plant synthetic biology through genome engineering. Trends Biotechnol. 2015;33:120-31.
-
(2015)
Trends Biotechnol
, vol.33
, pp. 120-131
-
-
Baltes, N.J.1
Voytas, D.F.2
-
10
-
-
84867688971
-
Precision editing of large animal genomes
-
Tan WS, Carlson DF, Walton MW, Fahrenkrug SC, Hackett PB. Precision editing of large animal genomes. Adv Genet. 2012;80:37-97.
-
(2012)
Adv Genet
, vol.80
, pp. 37-97
-
-
Tan, W.S.1
Carlson, D.F.2
Walton, M.W.3
Fahrenkrug, S.C.4
Hackett, P.B.5
-
11
-
-
84862660573
-
Bovine polledness - an autosomal dominant trait with allelic heterogeneity
-
Medugorac I, Seichter D, Graf A, Russ I, Blum H, Göpel KH, et al. Bovine polledness - an autosomal dominant trait with allelic heterogeneity. PLoS One. 2012;7, e39477.
-
(2012)
PLoS One
, vol.7
-
-
Medugorac, I.1
Seichter, D.2
Graf, A.3
Russ, I.4
Blum, H.5
Göpel, K.H.6
-
12
-
-
84885358161
-
Efficient nonmeiotic allele introgression in livestock using custom endonucleases
-
Tan W, Carlson DF, Lancto CA, Garbe JR, Webster DA, Hackett PB, et al. Efficient nonmeiotic allele introgression in livestock using custom endonucleases. Proc Natl Acad Sci U S A. 2013;110:16526-31.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 16526-16531
-
-
Tan, W.1
Carlson, D.F.2
Lancto, C.A.3
Garbe, J.R.4
Webster, D.A.5
Hackett, P.B.6
-
13
-
-
0030840359
-
Double muscling in cattle due to mutations in the myostatin gene
-
McPherron AC, Lee SJ. Double muscling in cattle due to mutations in the myostatin gene. Proc Natl Acad Sci U S A. 1994;94:12457-61.
-
(1994)
Proc Natl Acad Sci U S A
, vol.94
, pp. 12457-12461
-
-
McPherron, A.C.1
Lee, S.J.2
-
14
-
-
84901419785
-
Disruption of the myostatin gene in porcine primary fibroblasts and embryos using zinc-finger nucleases
-
Huang X-J, Zhang H-X, Wang H, Xiong K, Qin L, Liu H. Disruption of the myostatin gene in porcine primary fibroblasts and embryos using zinc-finger nucleases. Mol Cells. 2014;37:302-6.
-
(2014)
Mol Cells
, vol.37
, pp. 302-306
-
-
Huang, X.-J.1
Zhang, H.-X.2
Wang, H.3
Xiong, K.4
Qin, L.5
Liu, H.6
-
15
-
-
84899683227
-
Efficient generation of myostatin (MSTN) biallelic mutations in cattle using zinc finger nucleases
-
Luo J, Song Z, Yu S, Cui D, Wang B, Ding F, et al. Efficient generation of myostatin (MSTN) biallelic mutations in cattle using zinc finger nucleases. PLoS One. 2014;9, e95225.
-
(2014)
PLoS One
, vol.9
-
-
Luo, J.1
Song, Z.2
Yu, S.3
Cui, D.4
Wang, B.5
Ding, F.6
-
16
-
-
84938494195
-
Super-muscly pigs created by small genetic tweak
-
Cyranoski D. Super-muscly pigs created by small genetic tweak. Nature. 2015;523:13-4.
-
(2015)
Nature
, vol.523
, pp. 13-14
-
-
Cyranoski, D.1
-
18
-
-
2942650626
-
Why are US and EU policies toward GMOs so different?
-
Anderson K, Jackson LA. Why are US and EU policies toward GMOs so different? AgBioForum. 2003;6:95-100.
-
(2003)
AgBioForum
, vol.6
, pp. 95-100
-
-
Anderson, K.1
Jackson, L.A.2
-
19
-
-
84946420496
-
Restrictions on genetically modified organisms: European Union
-
Papademetriou T. Restrictions on genetically modified organisms: European Union. Law Library of Congress. 2015. http://www.loc.gov/law/help/restrictions-on-gmos/eu.php.
-
(2015)
Law Library of Congress
-
-
Papademetriou, T.1
-
20
-
-
61849121315
-
Lessons learned from the gene therapy trial for ornithine transcarbamylase deficiency
-
Wilson JM. Lessons learned from the gene therapy trial for ornithine transcarbamylase deficiency. Mol Genet Metab. 2009;96:151-7.
-
(2009)
Mol Genet Metab
, vol.96
, pp. 151-157
-
-
Wilson, J.M.1
-
21
-
-
0037129435
-
Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy
-
Hacein-Bey-Abina S, Le Deist F, Carlier F, Bouneaud C, Hue C, De Villartay JP, et al. Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy. N Engl J Med. 2002;346:1185-93.
-
(2002)
N Engl J Med
, vol.346
, pp. 1185-1193
-
-
Hacein-Bey-Abina, S.1
Deist, F.2
Carlier, F.3
Bouneaud, C.4
Hue, C.5
De Villartay, J.P.6
-
22
-
-
0142084745
-
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
-
Hacein-Bey-Abina S, Von Kalle C, Schmidt M, McCormack MP, Wulffraat N, Leboulch P, et al. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science. 2003;302:415-9.
-
(2003)
Science
, vol.302
, pp. 415-419
-
-
Hacein-Bey-Abina, S.1
Kalle, C.2
Schmidt, M.3
McCormack, M.P.4
Wulffraat, N.5
Leboulch, P.6
-
23
-
-
84866899464
-
Endgame: glybera finally recommended for approval as the first gene therapy drug in the European union
-
Yla-Herttuala S. Endgame: glybera finally recommended for approval as the first gene therapy drug in the European union. Mol Ther. 2012;20:1831-2.
-
(2012)
Mol Ther
, vol.20
, pp. 1831-1832
-
-
Yla-Herttuala, S.1
-
24
-
-
84895487305
-
Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV
-
Tebas P, Stein D, Tang WW, Frank I, Wang SQ, Lee G, et al. Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. N Engl J Med. 2014;370:901-10.
-
(2014)
N Engl J Med
, vol.370
, pp. 901-910
-
-
Tebas, P.1
Stein, D.2
Tang, W.W.3
Frank, I.4
Wang, S.Q.5
Lee, G.6
-
25
-
-
0004040771
-
The Ethics of Human Gene Therapy
-
New York: Oxford University Press
-
Walters L, Palmer JG. The Ethics of Human Gene Therapy. New York: Oxford University Press; 1997.
-
(1997)
-
-
Walters, L.1
Palmer, J.G.2
-
26
-
-
84928775846
-
A prudent path forward for genomic engineering and germline gene modification
-
Baltimore D, Berg P, Botchan M, Carroll D, Charo RA, Church G, et al. A prudent path forward for genomic engineering and germline gene modification. Science. 2015;348:36-8.
-
(2015)
Science
, vol.348
, pp. 36-38
-
-
Baltimore, D.1
Berg, P.2
Botchan, M.3
Carroll, D.4
Charo, R.A.5
Church, G.6
-
27
-
-
84928775204
-
Don't edit the human germ line
-
Lanphier E, Urnov F, Haecker SE, Werner M, Smolenski J. Don't edit the human germ line. Nature. 2015;519:410-1.
-
(2015)
Nature
, vol.519
, pp. 410-411
-
-
Lanphier, E.1
Urnov, F.2
Haecker, S.E.3
Werner, M.4
Smolenski, J.5
-
28
-
-
84937544686
-
Responsible use of human gene-editing technologies
-
Dzau VJ, Cicerone RJ. Responsible use of human gene-editing technologies. Hum Gene Ther. 2015;26:411-2.
-
(2015)
Hum Gene Ther
, vol.26
, pp. 411-412
-
-
Dzau, V.J.1
Cicerone, R.J.2
-
29
-
-
84896142186
-
TALEN-mediated gene mutagenesis in rhesus and cynomolgus monkeys
-
Liu H, Chen Y, Niu Y, Zhang K, Kang Y, Ge W, et al. TALEN-mediated gene mutagenesis in rhesus and cynomolgus monkeys. Cell Stem Cell. 2014;14:323-8.
-
(2014)
Cell Stem Cell
, vol.14
, pp. 323-328
-
-
Liu, H.1
Chen, Y.2
Niu, Y.3
Zhang, K.4
Kang, Y.5
Ge, W.6
-
30
-
-
84894081986
-
Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos
-
Niu Y, Shen B, Cui Y, Chen Y, Wang J, Wang L, et al. Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos. Cell. 2014;156:836-43.
-
(2014)
Cell
, vol.156
, pp. 836-843
-
-
Niu, Y.1
Shen, B.2
Cui, Y.3
Chen, Y.4
Wang, J.5
Wang, L.6
-
31
-
-
84936765320
-
Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9
-
Chen Y, Zheng Y, Kang Y, Yang W, Niu Y, Guo X, et al. Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9. Hum Mol Genet. 2015;24:3764-74.
-
(2015)
Hum Mol Genet
, vol.24
, pp. 3764-3774
-
-
Chen, Y.1
Zheng, Y.2
Kang, Y.3
Yang, W.4
Niu, Y.5
Guo, X.6
-
32
-
-
84930618439
-
CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
-
Liang P, Xu Y, Zhang X, Ding C, Huang R, Zhang Z, et al. CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Prot Cell. 2015;6:363-72.
-
(2015)
Prot Cell
, vol.6
, pp. 363-372
-
-
Liang, P.1
Xu, Y.2
Zhang, X.3
Ding, C.4
Huang, R.5
Zhang, Z.6
-
34
-
-
27144443269
-
The precautionary principle: a legal and policy history
-
In: Martuzzi M, Tickner JA, editors
-
Jordan A, O'Riordan T. The precautionary principle: a legal and policy history. In: Martuzzi M, Tickner JA, editors. The precautionary principle: protecting public health, the environment and the future of our children. Rome: World Health Organization; 2004. p. 31-48.
-
(2004)
The precautionary principle: protecting public health, the environment and the future of our children. Rome: World Health Organization
, pp. 31-48
-
-
Jordan, A.1
O'Riordan, T.2
-
35
-
-
0344035560
-
Is modern genetics the new eugenics?
-
Epstein CJ. Is modern genetics the new eugenics? Genet Med. 2003;5:469-75.
-
(2003)
Genet Med
, vol.5
, pp. 469-475
-
-
Epstein, C.J.1
-
36
-
-
84946420497
-
-
About human germline gene editing
-
Center for Genetics and Society. About human germline gene editing. 2015. http://www.geneticsandsociety.org/article.php?id=8711.
-
(2015)
-
-
-
37
-
-
10644288311
-
Mendel's dwarf
-
New York: Harmony Publishing
-
Mawer S. Mendel's dwarf. New York: Harmony Publishing; 1998.
-
(1998)
-
-
Mawer, S.1
-
38
-
-
84946420498
-
-
March 13
-
National Bioethics Advisory Commission meeting transcript. March 13, 1997. http://bioethics.georgetown.edu/nbac/transcripts/1997/3-13-97.pdf.
-
(1997)
-
-
-
39
-
-
84882372476
-
-
Pfleiderer G, Brahier G, Lindpaintner K, editors. GenEthics and Religion. Basel: Karger
-
Engelhardt Jr HT. Global bioethics, theology, and human genetic engineering: the challenge of refashioning human nature in the face of moral and religious pluralism. In: Pfleiderer G, Brahier G, Lindpaintner K, editors. GenEthics and Religion. Basel: Karger; 2010. p. 40-51.
-
(2010)
Global bioethics, theology, and human genetic engineering: the challenge of refashioning human nature in the face of moral and religious pluralism
, pp. 40-51
-
-
Engelhardt, H.T.1
-
40
-
-
16544362874
-
The dilemmas of German bioethics
-
Brown E. The dilemmas of German bioethics. The New Atlantis. 2004;5:37-53.
-
(2004)
The New Atlantis
, vol.5
, pp. 37-53
-
-
Brown, E.1
-
41
-
-
84873255987
-
Law, bioethics and practice in France: forging a new legislative pact
-
Berthiau T. Law, bioethics and practice in France: forging a new legislative pact. Med Health Care Philos. 2013;16:105-13.
-
(2013)
Med Health Care Philos
, vol.16
, pp. 105-113
-
-
Berthiau, T.1
-
42
-
-
84946420499
-
-
Human Fertilization and Embryology Authority (HFEA). http://www.hfea.gov.uk/.
-
-
-
-
45
-
-
84924410016
-
Concerning RNA-guided gene drives for the alteration of wild populations
-
Esvelt KE, Smidler AL, Catteruccia F, Church GM. Concerning RNA-guided gene drives for the alteration of wild populations. eLife. 2014;3, e03401.
-
(2014)
eLife
, vol.3
-
-
Esvelt, K.E.1
Smidler, A.L.2
Catteruccia, F.3
Church, G.M.4
-
46
-
-
0038027293
-
Site-specific selfish genes as tools for the control and genetic engineering of natural populations
-
Burt A. Site-specific selfish genes as tools for the control and genetic engineering of natural populations. Proc Biol Sci. 2003;270:921-8.
-
(2003)
Proc Biol Sci
, vol.270
, pp. 921-928
-
-
Burt, A.1
-
47
-
-
84905914560
-
Regulating gene drives
-
Oye KA, Esvelt K, Appleton E, Catteruccia F, Church G, Kuiken T, et al. Regulating gene drives. Science. 2014;345:626-8.
-
(2014)
Science
, vol.345
, pp. 626-628
-
-
Oye, K.A.1
Esvelt, K.2
Appleton, E.3
Catteruccia, F.4
Church, G.5
Kuiken, T.6
-
48
-
-
84928208828
-
The mutagenic chain reaction: a method for converting heterozygous to homozygous mutations
-
Gantz VM, Bier E. The mutagenic chain reaction: a method for converting heterozygous to homozygous mutations. Science. 2015;348:442-4.
-
(2015)
Science
, vol.348
, pp. 442-444
-
-
Gantz, V.M.1
Bier, E.2
|