Human brain imaging and radiation dosimetry of 11C-N-desmethyl- loperamide, a PET radiotracer to measure the function of P-glycoprotein

Journal of Nuclear Medicine

Volumn 50, Issue 5, 2009, Pages 807-813

  Seneca, Nicholas ^a   Zoghbi, Sami S ^a   Liow, Jeih San ^a   Kreisl, William ^a   Herscovitch, Peter ^b   Jenko, Kimberly ^a   Gladding, Robert L ^a   Taku, Andrew ^a   Pike, Victor W ^a   Innis, Robert B ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

N desmethyl loperamide; P glycoprotein; PET

Indexed keywords

CARBON N DESMETHYLLOPERAMIDE C 11; GLYCOPROTEIN P; TRACER; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN REGION; BRAIN SCINTISCANNING; COMPARTMENT MODEL; DOSIMETRY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG UPTAKE; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NEUROIMAGING; NORMAL HUMAN; PLASMA CLEARANCE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN FUNCTION; RADIOACTIVITY; TISSUE DISTRIBUTION;

ADULT; BODY BURDEN; BRAIN; FEMALE; HUMANS; LOPERAMIDE; MALE; METABOLIC CLEARANCE RATE; ORGAN SPECIFICITY; P-GLYCOPROTEIN; POSITRON-EMISSION TOMOGRAPHY; RADIATION DOSAGE; RADIOMETRY; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION;

EID: 66149123753     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.108.058453     Document Type: Article

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