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Volumn 52, Issue 7, 2008, Pages 772-779

Gauging the clinical significance of P-glycoprotein-mediated herb-drug interactions: Comparative effects of St. John's wort, Echinacea, clarithromycin, and rifampin on digoxin pharmacokinetics

Author keywords

Digoxin; Echinacea; Herb drug interactions; Pharmacokinetics; St. John's wort

Indexed keywords

CLARITHROMYCIN; DIGOXIN; FLAVONOID; GLYCOPROTEIN P; RIFAMPICIN;

EID: 53249094298     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.200700081     Document Type: Article
Times cited : (123)

References (53)
  • 1
    • 0033104547 scopus 로고    scopus 로고
    • Herbal remedies: Adverse effects and drug interactions
    • Cupp, M. J., Herbal remedies: adverse effects and drug interactions, Am. Fam. Phys. 1999, 59, 1239-1244.
    • (1999) Am. Fam. Phys , vol.59 , pp. 1239-1244
    • Cupp, M.J.1
  • 2
    • 0036304016 scopus 로고    scopus 로고
    • Pharmacokinetic interactions between herbal remedies and medicinal drugs
    • Ioannides, C., Pharmacokinetic interactions between herbal remedies and medicinal drugs, Xenobiotica 2002, 32, 451-478.
    • (2002) Xenobiotica , vol.32 , pp. 451-478
    • Ioannides, C.1
  • 3
    • 0037286803 scopus 로고    scopus 로고
    • Interactions of herbs with cytochrome P450
    • Zhou, S., Gao, Y., Jiang, W., Huang, M., et al., Interactions of herbs with cytochrome P450, Drug Metab. Rev. 2003, 35, 35-98.
    • (2003) Drug Metab. Rev , vol.35 , pp. 35-98
    • Zhou, S.1    Gao, Y.2    Jiang, W.3    Huang, M.4
  • 4
    • 1642360726 scopus 로고    scopus 로고
    • Herbal modulation of P-glycoprotein
    • Zhou, S., Lim, L. Y., Chowbay, B., Herbal modulation of P-glycoprotein, Drug Metab. Rev. 2004, 36, 57-104.
    • (2004) Drug Metab. Rev , vol.36 , pp. 57-104
    • Zhou, S.1    Lim, L.Y.2    Chowbay, B.3
  • 5
    • 26444461625 scopus 로고    scopus 로고
    • Natural health product-drug interactions: A systematic review of clinical trials
    • Mills, E., Wu, P., Johnston, B. C., Galliacano, K., Natural health product-drug interactions: a systematic review of clinical trials, Ther. Drug Monit. 2005, 27, 549-557.
    • (2005) Ther. Drug Monit , vol.27 , pp. 549-557
    • Mills, E.1    Wu, P.2    Johnston, B.C.3    Galliacano, K.4
  • 6
    • 22844441147 scopus 로고    scopus 로고
    • Herb-drug interactions: A literature review
    • Hu, Z., Yang, X., Ho, P. C. L., Chan, S. Y., et al., Herb-drug interactions: a literature review. Drugs. 2005, 65, 1239-1282.
    • (2005) Drugs , vol.65 , pp. 1239-1282
    • Hu, Z.1    Yang, X.2    Ho, P.C.L.3    Chan, S.Y.4
  • 7
    • 33646735774 scopus 로고    scopus 로고
    • Clinical drug interactions with medicinal herbs
    • Johne, A., Roots, I., Clinical drug interactions with medicinal herbs, Evid. Based Integrative Med. 2005, 2, 207-228.
    • (2005) Evid. Based Integrative Med , vol.2 , pp. 207-228
    • Johne, A.1    Roots, I.2
  • 9
    • 33747471447 scopus 로고    scopus 로고
    • An evidence-based systematic review of herb and supplement interactions by the Natural Standard Research Collaboration
    • Ulbricht, C., Basch, E., Weissner, W., Hackman, D., An evidence-based systematic review of herb and supplement interactions by the Natural Standard Research Collaboration, Expert Opin. Drug Saf. 2006, 5, 719-728.
    • (2006) Expert Opin. Drug Saf , vol.5 , pp. 719-728
    • Ulbricht, C.1    Basch, E.2    Weissner, W.3    Hackman, D.4
  • 11
    • 11344250258 scopus 로고    scopus 로고
    • Increasing trends in elderly persons' use of nonvitamin, nonmineral dietary supplements and concurrent use of medications
    • Wold, R. S., Lopez, S. T., Yau, L., Butler, L. M., et al., Increasing trends in elderly persons' use of nonvitamin, nonmineral dietary supplements and concurrent use of medications, J. Am. Diet. Assoc. 2005, 105, 54-63.
    • (2005) J. Am. Diet. Assoc , vol.105 , pp. 54-63
    • Wold, R.S.1    Lopez, S.T.2    Yau, L.3    Butler, L.M.4
  • 12
    • 20744432510 scopus 로고    scopus 로고
    • Elderly herbal supplement users less satisfied with medical care than nonusers
    • Shahrokh, L. E., Lukaszuk, J. M., Prawitz, A. D., Elderly herbal supplement users less satisfied with medical care than nonusers. J. Am. Diet. Assoc. 2005, 105, 1138-1140.
    • (2005) J. Am. Diet. Assoc , vol.105 , pp. 1138-1140
    • Shahrokh, L.E.1    Lukaszuk, J.M.2    Prawitz, A.D.3
  • 13
  • 14
    • 33644929029 scopus 로고    scopus 로고
    • In vitro and in vivo assessment of herb drug interactions
    • Venkataramanan, R., Komoroski, B., Strom, S., In vitro and in vivo assessment of herb drug interactions. Life Sci. 2006, 78, 2105-2115.
    • (2006) Life Sci , vol.78 , pp. 2105-2115
    • Venkataramanan, R.1    Komoroski, B.2    Strom, S.3
  • 15
    • 33846431610 scopus 로고    scopus 로고
    • Effect of goldenseal (Hydrastis Canadensis) and kava kava (Piper methysticum) supplementation on digoxin pharmacokinetics in humans
    • Gurley, B. J., Swain, A., Barone, G., Williams, D. K., et al., Effect of goldenseal (Hydrastis Canadensis) and kava kava (Piper methysticum) supplementation on digoxin pharmacokinetics in humans, Drug Metab. Dispos. 2007, 35, 240-245.
    • (2007) Drug Metab. Dispos , vol.35 , pp. 240-245
    • Gurley, B.J.1    Swain, A.2    Barone, G.3    Williams, D.K.4
  • 16
    • 31444435037 scopus 로고    scopus 로고
    • Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: Comparison of a milk thistle and black cohosh product to rifampin and clarithromycin
    • Gurley, B., Hubbard, M. A., Williams, D. K., Thaden, J., et al., Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: comparison of a milk thistle and black cohosh product to rifampin and clarithromycin, J. Clin Pharmacol. 2006, 46, 201-213.
    • (2006) J. Clin Pharmacol , vol.46 , pp. 201-213
    • Gurley, B.1    Hubbard, M.A.2    Williams, D.K.3    Thaden, J.4
  • 17
    • 30044432615 scopus 로고    scopus 로고
    • Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans
    • Gurley, B. J., Barone, G. W., Williams, D. K., Carrier, J. C., et al., Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans, Drug Metab. Dispos. 2006, 34, 69-74.
    • (2006) Drug Metab. Dispos , vol.34 , pp. 69-74
    • Gurley, B.J.1    Barone, G.W.2    Williams, D.K.3    Carrier, J.C.4
  • 18
    • 0038336620 scopus 로고    scopus 로고
    • Contribution of increased oral bioavailability and reduced nonglomerular renal clearance of digoxin to the digoxin-clarithromycin interaction
    • Rengelshausen, J., Goggelmann, C., Burhenne, J., Riedel, K.-D., et al., Contribution of increased oral bioavailability and reduced nonglomerular renal clearance of digoxin to the digoxin-clarithromycin interaction. Br. J. Clin. Pharmacol. 2003, 56, 32-38.
    • (2003) Br. J. Clin. Pharmacol , vol.56 , pp. 32-38
    • Rengelshausen, J.1    Goggelmann, C.2    Burhenne, J.3    Riedel, K.-D.4
  • 19
    • 0032754284 scopus 로고    scopus 로고
    • The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin
    • Greiner, B., Eichelbaum, M., Fritz, P., Kreichgauer, H.-P., et al., The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin, J. Clin. Invest. 1999, 104, 147-153.
    • (1999) J. Clin. Invest , vol.104 , pp. 147-153
    • Greiner, B.1    Eichelbaum, M.2    Fritz, P.3    Kreichgauer, H.-P.4
  • 20
    • 33751160865 scopus 로고    scopus 로고
    • Elucidating the effect of final-day dosing of rifampin in induction studies on hepatic drug disposition and metabolism
    • Lam, J. L., Shugarts, S. B., Okochi, H., Benet, L. Z., Elucidating the effect of final-day dosing of rifampin in induction studies on hepatic drug disposition and metabolism, J. Pharmacol Exp. Ther. 2006, 319, 864-870.
    • (2006) J. Pharmacol Exp. Ther , vol.319 , pp. 864-870
    • Lam, J.L.1    Shugarts, S.B.2    Okochi, H.3    Benet, L.Z.4
  • 21
    • 0034604841 scopus 로고    scopus 로고
    • Evaluation of major active components in St. John's wort dietary supplements by high-performance liquid chromatography with photodiode array detection and electrospray mass spectrometric confirmation
    • Liu, F. F., Ang, C. Y. W., Heinze, T. M., Rankin, J. D., et al., Evaluation of major active components in St. John's wort dietary supplements by high-performance liquid chromatography with photodiode array detection and electrospray mass spectrometric confirmation, J. Chromatogr. A 2000, 888, 85-92.
    • (2000) J. Chromatogr. A , vol.888 , pp. 85-92
    • Liu, F.F.1    Ang, C.Y.W.2    Heinze, T.M.3    Rankin, J.D.4
  • 22
    • 0242439522 scopus 로고    scopus 로고
    • HPLC method validated for the simultaneous analysis of cichoric acid and alkamides in Echinacea purpurea planta and products
    • Molgaard, P., Johnsen, S., Christensen, P., Cornett, C., HPLC method validated for the simultaneous analysis of cichoric acid and alkamides in Echinacea purpurea planta and products. J. Agric. Food Chem. 2003, 51, 6922-6933.
    • (2003) J. Agric. Food Chem , vol.51 , pp. 6922-6933
    • Molgaard, P.1    Johnsen, S.2    Christensen, P.3    Cornett, C.4
  • 23
    • 54549124926 scopus 로고    scopus 로고
    • Disintegration and dissolution of dietary supplements
    • United States Pharmacopeial Convention, Rockville, 22 nd edn, pp, Anonymous
    • nd edn., pp. 2645-2646.
    • (2004) th revision , pp. 2645-2646
  • 24
    • 0003577917 scopus 로고    scopus 로고
    • Statistical Power Analysis for the Behavioral Sciences
    • nd edn.
    • nd edn
    • Cohen, J.1
  • 25
    • 0000006828 scopus 로고    scopus 로고
    • Pharmacokinetic interaction of digoxin with an herbal extract from St. John's wort (Hypericum perforatum)
    • Johne, A., Brockmöller, J., Bauer, S., Maurer, A. et al., Pharmacokinetic interaction of digoxin with an herbal extract from St. John's wort (Hypericum perforatum), Clin. Pharmacol. Ther. 1999, 66, 338-345.
    • (1999) Clin. Pharmacol. Ther , vol.66 , pp. 338-345
    • Johne, A.1    Brockmöller, J.2    Bauer, S.3    Maurer, A.4
  • 26
    • 0034520267 scopus 로고    scopus 로고
    • St. John's wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4
    • Dürr, D., Stieger, B., Kullak-Ublick, G. A., Rentsch, K. M., et al., St. John's wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4, Clin. Pharmacol. Ther. 2000, 68, 598-604.
    • (2000) Clin. Pharmacol. Ther , vol.68 , pp. 598-604
    • Dürr, D.1    Stieger, B.2    Kullak-Ublick, G.A.3    Rentsch, K.M.4
  • 27
    • 2942625789 scopus 로고    scopus 로고
    • Effect of St. John's wort dose and preparations on the pharmacokinetics of digoxin
    • Mueller, S. C., Uehleke, B., Woehling, H., Petzsch, M., et al., Effect of St. John's wort dose and preparations on the pharmacokinetics of digoxin. Clin. Pharmacol. Ther. 2004, 75, 546-557.
    • (2004) Clin. Pharmacol. Ther , vol.75 , pp. 546-557
    • Mueller, S.C.1    Uehleke, B.2    Woehling, H.3    Petzsch, M.4
  • 29
    • 0042950000 scopus 로고    scopus 로고
    • Coordinate induction of both cytochrome P4503A and MDR1 by St. John's wort in healthy subjects
    • Dresser, G. K., Schwarz, U. I., Wilkinson, G. R., Kim, R. B., Coordinate induction of both cytochrome P4503A and MDR1 by St. John's wort in healthy subjects, Clin. Pharmacol. Ther. 2003, 73, 41-50.
    • (2003) Clin. Pharmacol. Ther , vol.73 , pp. 41-50
    • Dresser, G.K.1    Schwarz, U.I.2    Wilkinson, G.R.3    Kim, R.B.4
  • 30
    • 20144389498 scopus 로고    scopus 로고
    • CYP3A and P-glycoprotein activity induction with St. John's wort in healthy volunteers from 6 ethnic populations
    • Xie, R., Tan, L. H., Polasek, E. C., Hong, C., et al., CYP3A and P-glycoprotein activity induction with St. John's wort in healthy volunteers from 6 ethnic populations, J. Clin. Pharmacol. 2005, 45, 352-356.
    • (2005) J. Clin. Pharmacol , vol.45 , pp. 352-356
    • Xie, R.1    Tan, L.H.2    Polasek, E.C.3    Hong, C.4
  • 32
    • 10744232730 scopus 로고    scopus 로고
    • Alterations in cyclosporine A pharmacokinetics and metabolism during treatment with St. John's wort in renal transplant patients
    • Bauer, S., Störmer, E., Johne, A., Krüger, H., et al., Alterations in cyclosporine A pharmacokinetics and metabolism during treatment with St. John's wort in renal transplant patients. Br. J. Clin. Pharmacol. 2003, 55, 203-211.
    • (2003) Br. J. Clin. Pharmacol , vol.55 , pp. 203-211
    • Bauer, S.1    Störmer, E.2    Johne, A.3    Krüger, H.4
  • 33
    • 4744359869 scopus 로고    scopus 로고
    • Hyperforin content determines the magnitude of the St. John's wort-cyclosporine drug interaction
    • Mai, I., Bauer, S., Perloff, E., Johne, A., et al., Hyperforin content determines the magnitude of the St. John's wort-cyclosporine drug interaction, Clin. Pharmacol. Ther. 2004, 76, 330-340.
    • (2004) Clin. Pharmacol. Ther , vol.76 , pp. 330-340
    • Mai, I.1    Bauer, S.2    Perloff, E.3    Johne, A.4
  • 34
    • 0034691064 scopus 로고    scopus 로고
    • St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor
    • Moore, L. B., Goodwin, B., Jones, S. A., Wisely, G. B., et al., St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. Proc. Nalt. Acad. Sci. USA 2000, 97, 7500-7502.
    • (2000) Proc. Nalt. Acad. Sci. USA , vol.97 , pp. 7500-7502
    • Moore, L.B.1    Goodwin, B.2    Jones, S.A.3    Wisely, G.B.4
  • 36
    • 18744369624 scopus 로고    scopus 로고
    • Arold, G., Donath, F., Maurer, A., Diefenbach, K., et al., No relevant interaction with alprazolam, caffeine, tolbutamide, and digoxin by treatment with a low-hyperforin St. John's wort extract, Planta Med. 2005, 71, 331-337.
    • Arold, G., Donath, F., Maurer, A., Diefenbach, K., et al., No relevant interaction with alprazolam, caffeine, tolbutamide, and digoxin by treatment with a low-hyperforin St. John's wort extract, Planta Med. 2005, 71, 331-337.
  • 37
    • 0035805536 scopus 로고    scopus 로고
    • Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
    • Geick, A., Eichelbaum, M., Burk, O., Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin, J. Biol Chem. 2001, 276, 14581-14587.
    • (2001) J. Biol Chem , vol.276 , pp. 14581-14587
    • Geick, A.1    Eichelbaum, M.2    Burk, O.3
  • 38
    • 0029916534 scopus 로고    scopus 로고
    • P-glycoprotein: A major determinant of rifampin-inducible expression of cytochrome P4503A in mice and humans
    • Schuetz, E. G., Schinkel, A. H., Relling, M. V., Schuetz, J. D., P-glycoprotein: a major determinant of rifampin-inducible expression of cytochrome P4503A in mice and humans. Proc. Natl. Acad. Sci. USA 1996, 93, 4001-4005.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 4001-4005
    • Schuetz, E.G.1    Schinkel, A.H.2    Relling, M.V.3    Schuetz, J.D.4
  • 39
    • 22844438903 scopus 로고    scopus 로고
    • Echinacea species [Echinacea angustifolia (DC) Hell., Echinacea pallida (Nutt.) Nutt., Echinacea purpurea (L.) Moench]: A reviewof their chemistry, pharmacology and clinical properties
    • Barnes, J., Anderson, L. A., Gibbons, S., Phillipson, J. D., Echinacea species [Echinacea angustifolia (DC) Hell., Echinacea pallida (Nutt.) Nutt., Echinacea purpurea (L.) Moench]: a reviewof their chemistry, pharmacology and clinical properties, J. Pharm. Pharmacol. 2005, 57, 929-954.
    • (2005) J. Pharm. Pharmacol , vol.57 , pp. 929-954
    • Barnes, J.1    Anderson, L.A.2    Gibbons, S.3    Phillipson, J.D.4
  • 40
    • 0033868271 scopus 로고    scopus 로고
    • in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial extracts and tinctures
    • Budzinski, J. W., Foster, B. C., Vandenhoek, S., Arnason, J. T., An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial extracts and tinctures, Phytomedicine 2000, 7, 273-282.
    • (2000) Phytomedicine , vol.7 , pp. 273-282
    • Budzinski, J.W.1    Foster, B.C.2    Vandenhoek, S.3    Arnason, J.T.4    An5
  • 41
    • 0037911509 scopus 로고    scopus 로고
    • In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products
    • Foster, B. C., Vandenhoek, S., Hana, J., Krantis, A., In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products, Phytomedicine 2003, 10, 334-342.
    • (2003) Phytomedicine , vol.10 , pp. 334-342
    • Foster, B.C.1    Vandenhoek, S.2    Hana, J.3    Krantis, A.4
  • 42
    • 1542348613 scopus 로고    scopus 로고
    • An approach to the in vitro evaluation of potential for cytochrome P450 enzyme inhibition from herbals and other natural remedies
    • Strandell, J., Neil, A., Carlin, G., An approach to the in vitro evaluation of potential for cytochrome P450 enzyme inhibition from herbals and other natural remedies, Phytomedicine 2004, 11, 98-104.
    • (2004) Phytomedicine , vol.11 , pp. 98-104
    • Strandell, J.1    Neil, A.2    Carlin, G.3
  • 43
    • 20644447802 scopus 로고    scopus 로고
    • Echinacea alkamide disposition and pharmacokinetics in humans after tablet ingestion
    • Matthias, A., Gillam, E. M. J., Penman, K. G., Matovic, N. J. et al., Echinacea alkamide disposition and pharmacokinetics in humans after tablet ingestion, Chem. Biol. Interact. 2005, 155, 62-70.
    • (2005) Chem. Biol. Interact , vol.155 , pp. 62-70
    • Matthias, A.1    Gillam, E.M.J.2    Penman, K.G.3    Matovic, N.J.4
  • 44
    • 22244480328 scopus 로고    scopus 로고
    • Analysis of the inhibitory potential of Ginkgo biloba, Echinacea purpurea, and Serenoa repens on the metabolic activity of cytochrome P450 3A4, 2D6, and 2C9
    • Yale, S. H., Glurich, I., Analysis of the inhibitory potential of Ginkgo biloba, Echinacea purpurea, and Serenoa repens on the metabolic activity of cytochrome P450 3A4, 2D6, and 2C9, J. Altern. Complement. Med. 2005, 11, 433-439.
    • (2005) J. Altern. Complement. Med , vol.11 , pp. 433-439
    • Yale, S.H.1    Glurich, I.2
  • 45
    • 33845996201 scopus 로고    scopus 로고
    • The induction of CYP1A2, CYP2D6 and CYP3A4 by six trade herbal products in cultured primary human hepatocytes
    • Hellum, B. H., Hu, Z., Nilsen, O. D., The induction of CYP1A2, CYP2D6 and CYP3A4 by six trade herbal products in cultured primary human hepatocytes, Basic Clin. Pharmacol. Toxicol. 2007, 100, 23-30.
    • (2007) Basic Clin. Pharmacol. Toxicol , vol.100 , pp. 23-30
    • Hellum, B.H.1    Hu, Z.2    Nilsen, O.D.3
  • 46
    • 0035671973 scopus 로고    scopus 로고
    • Absorption of dodeca-2E,4E,8Z,10E/Z- tetraenoic acid isobutylamides after oral application of Echinacea purpurea tincture
    • Dietz, B., Heilmann, J., Bauer, R., Absorption of dodeca-2E,4E,8Z,10E/Z- tetraenoic acid isobutylamides after oral application of Echinacea purpurea tincture, Planta Med. 2001, 67, 863-864.
    • (2001) Planta Med , vol.67 , pp. 863-864
    • Dietz, B.1    Heilmann, J.2    Bauer, R.3
  • 47
    • 23144449794 scopus 로고    scopus 로고
    • Echinacea alkamide disposition and pharmacokinetics in humans after tablet ingestion
    • Matthias, A., Addison, R. S., Penman, K. G., Dickinson, R. G. et al., Echinacea alkamide disposition and pharmacokinetics in humans after tablet ingestion, Life Sci. 2005, 77, 2018-2029.
    • (2005) Life Sci , vol.77 , pp. 2018-2029
    • Matthias, A.1    Addison, R.S.2    Penman, K.G.3    Dickinson, R.G.4
  • 48
    • 18844370636 scopus 로고    scopus 로고
    • Bioavailability and pharmacokinetics of alkamides from the roots of Echinacea angustifolia in humans
    • Woelkart, K., Koidl, C., Grisold, A., Gangemi, J. D., Bioavailability and pharmacokinetics of alkamides from the roots of Echinacea angustifolia in humans, J. Clin. Pharmacol. 2005, 45, 683-689.
    • (2005) J. Clin. Pharmacol , vol.45 , pp. 683-689
    • Woelkart, K.1    Koidl, C.2    Grisold, A.3    Gangemi, J.D.4
  • 49
    • 1642441388 scopus 로고    scopus 로고
    • The effect of Echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo
    • Gorski, J. C., Huang, S.-M., Pinto, A., Hamman, M. A., et al., The effect of Echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo, Clin. Pharmacol. Ther. 2004, 75, 89-100.
    • (2004) Clin. Pharmacol. Ther , vol.75 , pp. 89-100
    • Gorski, J.C.1    Huang, S.-M.2    Pinto, A.3    Hamman, M.A.4
  • 50
    • 7944225802 scopus 로고    scopus 로고
    • In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto
    • Gurley, B. J., Gardner, S. F., Hubbard, M. A., Williams, D. K., et al., In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto, Clin. Pharmacol. Ther., 2004, 76, 428-440.
    • (2004) Clin. Pharmacol. Ther , vol.76 , pp. 428-440
    • Gurley, B.J.1    Gardner, S.F.2    Hubbard, M.A.3    Williams, D.K.4
  • 51
    • 0037134631 scopus 로고    scopus 로고
    • Phytochemical variation in Echinacea from roots and flowerheads of wild and cultivated populations
    • Binns, S. E., Livesey, J. F., Arnason, J. T., Baum, B. R., Phytochemical variation in Echinacea from roots and flowerheads of wild and cultivated populations, J. Agric. Food Chem. 2002, 50, 3673-3687.
    • (2002) J. Agric. Food Chem , vol.50 , pp. 3673-3687
    • Binns, S.E.1    Livesey, J.F.2    Arnason, J.T.3    Baum, B.R.4
  • 53
    • 17344365616 scopus 로고    scopus 로고
    • Variability in the composition of anti-oxidant compounds in Echinacea species by HPLC
    • Pellati, F., Benvenuti, S., Melegari, M., Lasseigne, T., Variability in the composition of anti-oxidant compounds in Echinacea species by HPLC. Phytochem. Anal. 2005, 16, 77-85.
    • (2005) Phytochem. Anal , vol.16 , pp. 77-85
    • Pellati, F.1    Benvenuti, S.2    Melegari, M.3    Lasseigne, T.4


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