Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy

Structure

Volumn 23, Issue 11, 2015, Pages 2076-2086

  Pobbati, Ajaybabu V ^a   Han, Xiao ^b,c   Hung, Alvin W ^d   Weiguang, Seetoh ^d   Huda, Nur ^d   Chen, Guo Ying ^d   Kang, CongBao ^d   Chia, Cheng San Brian ^d   Luo, Xuelian ^c   Hong, Wanjin ^a   Poulsen, Anders ^d  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b JILIN UNIVERSITY   (China)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d Agency for Science   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; FLUFENAMIC ACID; NIFLUMIC ACID; PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TEAD1; TRANSCRIPTION FACTOR TEAD2; TRANSCRIPTION FACTOR TEAD3; TRANSCRIPTION FACTOR TEAD4; UNCLASSIFIED DRUG; YAP BINDING DOMAIN; ANTINEOPLASTIC AGENT; DNA BINDING PROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEIN BINDING; TEAD2 PROTEIN, HUMAN;

ARTICLE; BINDING AFFINITY; BINDING SITE; BIOCHEMICAL ANALYSIS; CANCER THERAPY; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; CHEMISTRY; GENETICS; HEK293 CELL LINE; METABOLISM; MOLECULAR DOCKING; MOLECULAR GENETICS;

AMINO ACID SEQUENCE; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTINEOPLASTIC AGENTS; BINDING SITES; DNA-BINDING PROTEINS; HEK293 CELLS; HUMANS; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; TRANSCRIPTION FACTORS;

EID: 84946121238     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2015.09.009     Document Type: Article

References (47)

1. P.D. Adams, P.V. Afonine, G. Bunkoczi, V.B. Chen, I.W. Davis, N. Echols, J.J. Headd, L.W. Hung, G.J. Kapral, R.W. Grosse-Kunstleve, and et al. PHENIX: a comprehensive Python-based system for macromolecular structure solution Acta Crystallogr. D Biol. Crystallogr. 66 2010 213 221
2. Y. Bao, K. Nakagawa, Z. Yang, M. Ikeda, K. Withanage, M. Ishigami-Yuasa, Y. Okuno, S. Hata, H. Nishina, and Y. Hata A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription J. Biochem. 150 2011 199 208
3. D.W. Begley, S.O. Moen, P.G. Pierce, and E.R. Zartler Saturation transfer difference NMR for fragment screening Curr. Protoc. Chem. Biol. 5 2013 251 268
4. S.W. Chan, C.J. Lim, K. Guo, C.P. Ng, I. Lee, W. Hunziker, Q. Zeng, and W. Hong A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells Cancer Res. 68 2008 2592 2598
5. L. Chen, S.W. Chan, X. Zhang, M. Walsh, C.J. Lim, W. Hong, and H. Song Structural basis of YAP recognition by TEAD4 in the hippo pathway Genes Dev. 24 2010 290 300
6. I.W. Davis, A. Leaver-Fay, V.B. Chen, J.N. Block, G.J. Kapral, X. Wang, L.W. Murray, W.B. Arendall 3rd, J. Snoeyink, J.S. Richardson, and et al. MolProbity: all-atom contacts and structure validation for proteins and nucleic acids Nucleic Acids Res. 35 2007 W375 W383
7. M. Diepenbruck, L. Waldmeier, R. Ivanek, P. Berninger, P. Arnold, E. van Nimwegen, and G. Christofori Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition J. Cell Sci. 127 2014 1523 1536
8. J. Dong, G. Feldmann, J. Huang, S. Wu, N. Zhang, S.A. Comerford, M.F. Gayyed, R.A. Anders, A. Maitra, and D. Pan Elucidation of a universal size-control mechanism in Drosophila and mammals Cell 130 2007 1120 1133
9. S. Dupont, L. Morsut, M. Aragona, E. Enzo, S. Giulitti, M. Cordenonsi, F. Zanconato, J. Le Digabel, M. Forcato, S. Bicciato, and et al. Role of YAP/TAZ in mechanotransduction Nature 474 2011 179 183
10. P. Emsley, B. Lohkamp, W.G. Scott, and K. Cowtan Features and development of Coot Acta Crystallogr. D Biol. Crystallogr. 66 2010 486 501
11. R. Fan, N.G. Kim, and B.M. Gumbiner Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1 Proc. Natl. Acad. Sci. USA 110 2013 2569 2574
12. T.A. Halgren Identifying and characterizing binding sites and assessing druggability J. Chem. Inf. Model 49 2009 377 389
13. D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
14. C.G. Hansen, T. Moroishi, and K.L. Guan YAP and TAZ: a nexus for Hippo signaling and beyond Trends Cell Biol 25 2015 499 513
15. W. Hong, and K.L. Guan The YAP and TAZ transcription co-activators: key downstream effectors of the mammalian Hippo pathway Semin. Cell Dev. Biol. 23 2012 785 793
16. T. Hucl, J.R. Brody, E. Gallmeier, C.A. Iacobuzio-Donahue, I.K. Farrance, and S.E. Kern High cancer-specific expression of mesothelin (MSLN) is attributable to an upstream enhancer containing a transcription enhancer factor dependent MCAT motif Cancer Res. 67 2007 9055 9065
17. A.W. Hung, H.L. Silvestre, S. Wen, A. Ciulli, T.L. Blundell, and C. Abell Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase Angew. Chem. Int. Ed. Engl. 48 2009 8452 8456
18. S. Jiao, H. Wang, Z. Shi, A. Dong, W. Zhang, X. Song, F. He, Y. Wang, Z. Zhang, W. Wang, and et al. A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer Cancer Cell 25 2014 166 180
19. R. Johnson, and G. Halder The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment Nat. Rev. Drug Discov. 13 2014 63 79
20. A. Kapoor, W. Yao, H. Ying, S. Hua, A. Liewen, Q. Wang, Y. Zhong, C.J. Wu, A. Sadanandam, B. Hu, and et al. Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer Cell 158 2014 185 197
21. J.F. Knight, C.J. Shepherd, S. Rizzo, D. Brewer, S. Jhavar, A.R. Dodson, C.S. Cooper, R. Eeles, A. Falconer, G. Kovacs, and et al. TEAD1 and c-Cbl are novel prostate basal cell markers that correlate with poor clinical outcome in prostate cancer Br. J. Cancer 99 2008 1849 1858
22. J.M. Lamar, P. Stern, H. Liu, J.W. Schindler, Z.G. Jiang, and R.O. Hynes The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain Proc. Natl. Acad. Sci. USA 109 2012 E2441 E2450
23. Q.Y. Lei, H. Zhang, B. Zhao, Z.Y. Zha, F. Bai, X.H. Pei, S. Zhao, Y. Xiong, and K.L. Guan TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway Mol. Cell Biol. 28 2008 2426 2436
24. Z. Li, B. Zhao, P. Wang, F. Chen, Z. Dong, H. Yang, K.L. Guan, and Y. Xu Structural insights into the YAP and TEAD complex Genes Dev. 24 2010 235 240
25. Y. Liu-Chittenden, B. Huang, J.S. Shim, Q. Chen, S.J. Lee, R.A. Anders, J.O. Liu, and D. Pan Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP Genes Dev. 26 2012 1300 1305
26. M.C. Lo, A. Aulabaugh, G. Jin, R. Cowling, J. Bard, M. Malamas, and G. Ellestad Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery Anal. Biochem. 332 2004 153 159
27. A.J. McCoy, R.W. Grosse-Kunstleve, P.D. Adams, M.D. Winn, L.C. Storoni, and R.J. Read Phaser crystallographic software J. Appl. Crystallogr. 40 2007 658 674
28. T. Moroishi, C.G. Hansen, and K.L. Guan The emerging roles of YAP and TAZ in cancer Nat. Rev. Cancer 15 2015 73 79
29. M. Overholtzer, J. Zhang, G.A. Smolen, B. Muir, W. Li, D.C. Sgroi, C.X. Deng, J.S. Brugge, and D.A. Haber Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon Proc. Natl. Acad. Sci. USA 103 2006 12405 12410
30. H.W. Park, and K.L. Guan Regulation of the Hippo pathway and implications for anticancer drug development Trends Pharmacol. Sci. 34 2013 581 589
31. E.F. Pettersen, T.D. Goddard, C.C. Huang, G.S. Couch, D.M. Greenblatt, E.C. Meng, and T.E. Ferrin UCSF Chimera - a visualization system for exploratory research and analysis J. Comput. Chem. 25 2004 1605 1612
32. A.V. Pobbati, and W. Hong Emerging roles of TEAD transcription factors and its coactivators in cancers Cancer Biol. Ther. 14 2013
33. A.V. Pobbati, S.W. Chan, I. Lee, H. Song, and W. Hong Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes Structure 20 2012 1135 1140
34. A. Sawada, H. Kiyonari, K. Ukita, N. Nishioka, Y. Imuta, and H. Sasaki Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival Mol. Cell Biol. 28 2008 3177 3189
35. I. Serrano, P.C. McDonald, F. Lock, W.J. Muller, and S. Dedhar Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase Nat. Commun. 4 2013 2976
36. G. Sorrentino, N. Ruggeri, V. Specchia, M. Cordenonsi, M. Mano, S. Dupont, A. Manfrin, E. Ingallina, R. Sommaggio, S. Piazza, and et al. Metabolic control of YAP and TAZ by the mevalonate pathway Nat. Cell Biol. 16 2014 357 366
37. W. Tian, J. Yu, D.R. Tomchick, D. Pan, and X. Luo Structural and functional analysis of the YAP-binding domain of human TEAD2 Proc. Natl. Acad. Sci. USA 107 2010 7293 7298
38. D.F. Tschaharganeh, X. Chen, P. Latzko, M. Malz, M.M. Gaida, K. Felix, S. Ladu, S. Singer, F. Pinna, N. Gretz, and et al. Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma Gastroenterology 144 2013 1530 1542.e12
39. D.F. Veber, S.R. Johnson, H.Y. Cheng, B.R. Smith, K.W. Ward, and K.D. Kopple Molecular properties that influence the oral bioavailability of drug candidates J. Med. Chem. 45 2002 2615 2623
40. H. Wackerhage, D.P. Del Re, R.N. Judson, M. Sudol, and J. Sadoshima The Hippo signal transduction network in skeletal and cardiac muscle Sci. Signal. 7 2014 re4
41. M.Z. Xu, S.W. Chan, A.M. Liu, K.F. Wong, S.T. Fan, J. Chen, R.T. Poon, L. Zender, S.W. Lowe, W. Hong, and et al. AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma Oncogene 30 2011 1229 1240
42. F.X. Yu, Y. Zhang, H.W. Park, J.L. Jewell, Q. Chen, Y. Deng, D. Pan, S.S. Taylor, Z.C. Lai, and K.L. Guan Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation Genes Dev. 27 2013 1223 1232
43. Z. Zhang, Z. Lin, Z. Zhou, H.C. Shen, S.F. Yan, A.V. Mayweg, Z. Xu, N. Qin, J.C. Wong, Y. Rong, and et al. Structure-based design and synthesis of potent cyclic peptides inhibiting the YAP-TEAD protein-protein interaction ACS Med. Chem. Lett. 5 2014 993 998
44. B. Zhao, X. Wei, W. Li, R.S. Udan, Q. Yang, J. Kim, J. Xie, T. Ikenoue, J. Yu, L. Li, and et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control Genes Dev. 21 2007 2747 2761
45. B. Zhao, X. Ye, J. Yu, L. Li, W. Li, S. Li, J.D. Lin, C.Y. Wang, A.M. Chinnaiyan, Z.C. Lai, and et al. TEAD mediates YAP-dependent gene induction and growth control Genes Dev. 22 2008 1962 1971
46. B. Zhao, L. Li, L. Wang, C.Y. Wang, J. Yu, and K.L. Guan Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis Genes Dev. 26 2012 54 68
47. G. Zimmermann, B. Papke, S. Ismail, N. Vartak, A. Chandra, M. Hoffmann, S.A. Hahn, G. Triola, A. Wittinghofer, P.I. Bastiaens, and et al. Small molecule inhibition of the KRAS-PDEdelta interaction impairs oncogenic KRAS signalling Nature 497 2013 638 642