Bortezomib enhances expression of effector molecules in antitumor CD8+T lymphocytes by promoting Notch-nuclear factor-κB crosstalk

Oncotarget

Volumn 6, Issue 32, 2015, Pages 32439-32455

  Thounaojam, Menaka C ^a   Dudimah, Duafalia F ^a   Pellom, Samuel T ^a   Uzhachenko, Roman V ^a   Carbone, David P ^b   Dikov, Mikhail M ^b   Shanker, Anil ^a,c  

^a MEHARRY MEDICAL COLLEGE   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c VANDERBILT INGRAM CANCER CENTER   (United States)

Author keywords

Cancer immunosuppression; Immune response; Immunity; Immunology and Microbiology Section; NF B; Notch signaling; Proteasome inhibition; T cell Immunotherapy

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; BORTEZOMIB; EOMESODERMIN; GAMMA INTERFERON; GRANZYME B; I KAPPA B ALPHA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NOTCH RECEPTOR; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; PERFORIN; PHOSPHOPROTEIN; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR HES 1; TRANSFORMING GROWTH FACTOR BETA; ANTINEOPLASTIC AGENT; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CELL CYCLE PROTEIN; EOMES PROTEIN, MOUSE; GRANZYME; GZMB PROTEIN, MOUSE; HES1 PROTEIN, MOUSE; HEY1 PROTEIN, MOUSE; HOMEODOMAIN PROTEIN; PERFORIN, MOUSE; PORE FORMING CYTOTOXIC PROTEIN; PROTEASOME INHIBITOR; PROTEIN P53; T BOX TRANSCRIPTION FACTOR; TP53 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CD8+ T LYMPHOCYTE; CELL NUCLEUS; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOPLASM; DOWN REGULATION; GENE; HES1 GENE; HEY1 GENE; LYMPHATIC SYSTEM TUMOR; LYMPHOID TISSUE; MOUSE; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; BREAST NEOPLASMS; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; FEMALE; GENETICS; HUMAN; IMMUNOLOGY; KIDNEY NEOPLASMS; LUNG NEOPLASMS; METABOLISM; MUTATION; NEURONAL CEROID LIPOFUSCINOSIS; ONCOGENE RAS; PATHOLOGY; TRANSGENIC MOUSE; TUMOR ASSOCIATED LEUKOCYTE; TUMOR CELL LINE; TUMOR ESCAPE; TUMOR MICROENVIRONMENT;

ANIMALS; ANTINEOPLASTIC AGENTS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BORTEZOMIB; BREAST NEOPLASMS; CD8-POSITIVE T-LYMPHOCYTES; CELL CYCLE PROTEINS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENES, RAS; GRANZYMES; HOMEODOMAIN PROTEINS; HUMANS; KIDNEY NEOPLASMS; LUNG NEOPLASMS; LYMPHOCYTES, TUMOR-INFILTRATING; MICE, INBRED BALB C; MICE, TRANSGENIC; MUTATION; NEURONAL CEROID-LIPOFUSCINOSES; NF-KAPPA B; PORE FORMING CYTOTOXIC PROTEINS; PROTEASOME INHIBITORS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; T-BOX DOMAIN PROTEINS; TRANSCRIPTION FACTOR HES-1; TUMOR ESCAPE; TUMOR MICROENVIRONMENT; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84946079077     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.5857     Document Type: Article

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