A Yeast/Drosophila Screen to Identify New Compounds Overcoming Frataxin Deficiency

Oxidative Medicine and Cellular Longevity

Volumn 2015, Issue , 2015, Pages

  Seguin, Alexandra ^a   Monnier, Véronique ^b   Palandri, Amandine ^b   Bihel, Frédéric ^c   Rera, Michael ^b   Schmitt, Martine ^c   Camadro, Jean Michel ^a   Tricoire, Hervé ^b   Lesuisse, Emmanuel ^a  

^a INSTITUT JACQUES MONOD   (France)

^b Groupe Hospitalier Pitié Salpêtrière   (France)

^c UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

YEAST;

ACTIVE COMPOUNDS; CHEMICAL LIBRARIES; DROSOPHILA MELANOGASTER; FRIEDREICH'S ATAXIAS; GENETIC DEFECTS; LARVAL DEVELOPMENT; PRIMARY SCREEN; THERAPEUTIC TREATMENTS;

NEURODEGENERATIVE DISEASES;

4 HYDROXYPHENAZONE; CHICAGO SKY BLUE; DEFEROXAMINE MESYLATE; FRATAXIN; LPGS 02 C06; LPS 01 03 L F03; LPS 01 04 L G10; LPS 02 13 L E04; LPS 02 14 L B11; LPS 02 23 L C05; LPS 02 25 L E10; LPS 02 30 L H10; MENADIONE; NEW DRUG; RAFFINOSE; UNCLASSIFIED DRUG; DROSOPHILA PROTEIN; IRON BINDING PROTEIN; MOLECULAR LIBRARY; SACCHAROMYCES CEREVISIAE PROTEIN;

ADULT; ANIMAL EXPERIMENT; ARTICLE; CARBON SOURCE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; DRUG SCREENING; FEMALE; FRIEDREICH ATAXIA; GENE DELETION; HEART DILATATION; HEART FUNCTION; HEART MUSCLE CELL; LARVAL DEVELOPMENT; NONHUMAN; PHENOTYPE; PROTEIN DEPLETION; PROTEIN EXPRESSION; ANIMAL; CELL PROLIFERATION; CHEMISTRY; DISEASE MODEL; DROSOPHILA; DRUG EFFECTS; GENETICS; GROWTH, DEVELOPMENT AND AGING; HEART; LARVA; METABOLISM; MOLECULAR LIBRARY; PHARMACOLOGY; SACCHAROMYCES CEREVISIAE; VIDEO MICROSCOPY;

ANIMALS; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DROSOPHILA; DROSOPHILA PROTEINS; HEART; IRON-BINDING PROTEINS; LARVA; MICROSCOPY, VIDEO; RAFFINOSE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SMALL MOLECULE LIBRARIES;

EID: 84946064255     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2015/565140     Document Type: Article

References (42)

1. J. B. Schulz, S. Boesch, K. Bürk et al., "Diagnosis and treatment of Friedreich ataxia: a European perspective," Nature Reviews Neurology, vol. 5, no. 4, pp. 222-234, 2009.
2. V. Campuzano, L. Montermini, M. D. Moltò et al., "Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion," Science, vol. 271, no. 5254, pp. 1423-1427, 1996.
3. A. Bayot, S. Reichman, S. Lebon et al., "Cis-silencing of PIP5K1B evidenced in Friedreich's ataxia patient cells results in cytoskeleton anomalies," Human Molecular Genetics, vol. 22, no. 14, pp. 2894-2904, 2013.
4. M. Pandolfo and A. Pastore, "The pathogenesis of Friedreich ataxia and the structure and function of frataxin," Journal of Neurology, vol. 256, supplement 1, pp. 9-17, 2009.
5. R. Santos, S. Lefevre, D. Sliwa, A. Seguin, J.-M. Camadro, and E. Lesuisse, "Friedreich ataxia:molecular mechanisms, redox considerations, and therapeutic opportunities," Antioxidants and Redox Signaling, vol. 13, no. 5, pp. 651-690, 2010.
6. S. Schmucker, A. Martelli, F. Colin et al., "Mammalian frataxin: an essential function for cellular viability through an interaction with a preformed ISCU/NFS1/ISD11 iron-sulfur assembly complex," PLoS ONE, vol. 6, no. 1, Article ID e16199, 2011.
7. F. Prischi, P. V. Konarev, C. Iannuzzi et al., "Structural bases for the interaction of frataxin with the central components of ironsulphur cluster assembly," Nature communications, vol. 1, article 95, 2010.
8. O. Gakh, T. Bedekovics, S. F. Duncan IIII, D. Y. Smith IV, D. S. Berkholz, and G. Isaya, "Normal and Friedreich ataxia cells express different isoforms of frataxin with complementary roles in iron-sulfur cluster assembly," The Journal of Biological Chemistry, vol. 285, no. 49, pp. 38486-38501, 2010.
9. T. L. Stemmler, E. Lesuisse, D. Pain, and A. Dancis, "Frataxin and mitochondrial FeS cluster biogenesis," The Journal of Biological Chemistry, vol. 285, no. 35, pp. 26737-26743, 2010.
10. H. A. O'Neill, O. Gakh, S. Park et al., "Assembly of human frataxin is a mechanism for detoxifying redox-active iron," Biochemistry, vol. 44, no. 2, pp. 537-545, 2005.
11. A.-L. Bulteau, H. A. O'Neill, M. C. Kennedy, M. Ikeda-Saito, G. Isaya, and L. I. Szweda, "Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity," Science, vol. 305, no. 5681, pp. 242-245, 2004.
12. S. Adinolfi, C. Iannuzzi, F. Prischi et al., "Bacterial frataxin CyaY is the gatekeeper of iron-sulfur cluster formation catalyzed by IscS," Nature Structural and Molecular Biology, vol. 16, no. 4, pp. 390-396, 2009.
13. C.-L. Tsai and D. P. Barondeau, "Human frataxin is an allosteric switch that activates the Fe-S cluster biosynthetic complex," Biochemistry, vol. 49, no. 43, pp. 9132-9139, 2010.
14. A.-L. Bulteau, A. Dancis, M. Gareil, J.-J. Montagne, J.-M. Camadro, and E. Lesuisse, "Oxidative stress and protease dysfunction in the yeast model of Friedreich ataxia," Free Radical Biology and Medicine, vol. 42, no. 10, pp. 1561-1570, 2007.
15. J. Bridwell-Rabb, N. G. Fox, C.-L. Tsai, A. M. Winn, and D. P. Barondeau, "Human frataxin activates Fe-S cluster biosynthesis by facilitating sulfur transfer chemistry," Biochemistry, vol. 53, no. 30, pp. 4904-4913, 2014.
16. H. Yoon, R. Golla, E. Lesuisse et al., "Mutation in the Fe-S scaffold protein Isu bypasses frataxin deletion," The Biochemical Journal, vol. 441, no. 1, pp. 473-480, 2012.
17. A. Wong, J. Yang, P. Cavadini et al., "The Friedreich's ataxia mutation confers cellular sensitivity to oxidant stress which is rescued by chelators of iron and calcium and inhibitors of apoptosis," Human Molecular Genetics, vol. 8, no. 3, pp. 425-430, 1999.
18. K. Chantrel-Groussard, V. Geromel, H. Puccio et al., "Disabled early recruitment of antioxidant defenses in Friedreich's ataxia," Human Molecular Genetics, vol. 10, no. 19, pp. 2061-2067, 2001.
19. S. Jiralerspong, B. Ge, T. J. Hudson, and M. Pandolfo, "Manganese superoxide dismutase induction by iron is impaired in Friedreich ataxia cells," FEBS Letters, vol. 509, no. 1, pp. 101-105, 2001.
20. F. Auchère, R. Santos, S. Planamente, E. Lesuisse, and J.-M. Camadro, "Glutathione-dependent redox status of frataxindeficient cells in a yeast model of Friedreich's ataxia," Human Molecular Genetics, vol. 17, no. 18, pp. 2790-2802, 2008.
21. V. Paupe, E. P. Dassa, S. Goncalves et al., "Impaired nuclear Nrf2 translocation undermines the oxidative stress response in Friedreich ataxia," PLoS ONE, vol. 4, no. 1, Article ID e4253, 2009.
22. T. E. Richardson, H. N. Kelly, A. E. Yu, and J. W. Simpkins, "Therapeutic strategies in Friedreich's ataxia," Brain Research, vol. 1514, pp. 91-97, 2013.
23. C. J. Strawser, K. A. Schadt, and D. R. Lynch, "Therapeutic approaches for the treatment of Friedreich's ataxia," Expert Review of Neurotherapeutics, vol. 14, pp. 949-957, 2014.
24. N. Calmels, H. Seznec, P. Villa et al., "Limitations in a frataxin knockdown cell model for Friedreich ataxia in a highthroughput drug screen," BMC Neurology, vol. 9, article 46, 2009.
25. M. G. Cotticelli, L. Rasmussen, N. L. Kushner et al., "Primary and secondary drug screening assays for Friedreich ataxia," Journal of Biomolecular Screening, vol. 17, no. 3, pp. 303-313, 2012.
26. P. R. Anderson, K. Kirby, A. J. Hilliker, and J. P. Phillips, "RNAimediated suppression of the mitochondrial iron chaperone, frataxin, in Drosophila," Human Molecular Genetics, vol. 14, no. 22, pp. 3397-3405, 2005.
27. Y. Zhang, E. K. Lyver, S. A. B. Knight, E. Lesuisse, and A. Dancis, "Frataxin and mitochondrial carrier proteins, Mrs3p and Mrs4p, cooperate in providing iron for heme synthesis," The Journal of Biological Chemistry, vol. 280, no. 20, pp. 19794-19807, 2005.
28. F. Sherman, "Getting started with yeast," Methods in Enzymology, vol. 350, pp. 3-41, 2002.
29. C. Schwimmer, M. Rak, L. Lefebvre-Legendre, S. Duvezin-Caubet, G. Plane, and J.-P. di Rago, "Yeast models of human mitochondrial diseases: from molecular mechanisms to drug screening," Biotechnology Journal, vol. 1, no. 3, pp. 270-281, 2006.
30. V. Monnier, M. Iché-Torres, M. Rera et al., "dJun and Vri/dNFIL3 are major regulators of cardiac aging in Drosophila," PLoS Genetics, vol. 8, no. 11, Article ID e1003081, 2012.
31. H. Tricoire, A. Palandri, A. Bourdais, J.-M. Camadro, and V. Monnier, "Methylene blue rescues heart defects in a Drosophila model of Friedreich's ataxia," Human Molecular Genetics, vol. 23, no. 4, pp. 968-979, 2014.
32. E. Lesuisse, R. Santos, B. F. Matzanke, S. A. B. Knight, J.-M. Camadro, and A. Dancis, "Iron use for haeme synthesis is under control of the yeast frataxin homologue (Yfh1)," Human Molecular Genetics, vol. 12, no. 8, pp. 879-889, 2003.
33. A. Seguin, R. Sutak, A.-L. Bulteau et al., "Evidence that yeast frataxin is not an iron storage protein in vivo," Biochimica et Biophysica Acta, vol. 1802, no. 6, pp. 531-538, 2010.
34. E. Lesuisse, M. Simon-Casteras, and P. Labbe, "Siderophoremediated iron uptake in Saccharomyces cerevisiae: the SIT1 gene encodes a ferrioxamine B permease that belongs to the major facilitator superfamily," Microbiology, vol. 144, no. 12, pp. 3455-3462, 1998.
35. P. R. Anderson, K. Kirby, W. C. Orr, A. J. Hilliker, and J. P. Phillips, "Hydrogen peroxide scavenging rescues frataxin deficiency in a Drosophila model of Friedreich's ataxia," Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 2, pp. 611-616, 2008.
36. J. V. Llorens, J. A. Navarro, M. J. Martínez-Sebastían et al., "Causative role of oxidative stress in a Drosophilamodel of Friedreich ataxia," The FASEB Journal, vol. 21, no. 2, pp. 333-344, 2007.
37. J. A. Navarro, E. Ohmann, D. Sanchez et al., "Altered lipid metabolism in a Drosophila model of Friedreich's ataxia," Human Molecular Genetics, vol. 19, no. 14, Article ID ddq183, pp. 2828-2840, 2010.
38. H. Keberle, "The biochemistry of desferrioxamine and its relation to iron metabolism," Annals of the New York Academy of Sciences, vol. 119, pp. 758-768, 1964.
39. L. M. Canfield, L. A. Davy, and G. L. Thomas, "Anti-oxidant/pro-oxidant reactions of vitamin K," Biochemical and Biophysical Research Communications, vol. 128, no. 1, pp. 211-219, 1985.
40. F. A. V. Castro, D. Mariani, A. D. Panek, E. C. A. Eleutherio, and M. D. Pereira, "Cytotoxicity mechanism of two naphthoquinones (menadione and plumbagin) in Saccharomyces cerevisiae," PLoS ONE, vol. 3, no. 12, Article ID e3999, 2008.
41. F. A. V. Castro, R. S. Herdeiro, A. D. Panek, E. C. A. Eleutherio, and M. D. Pereira, "Menadione stress in Saccharomyces cerevisiae strains deficient in the glutathione transferases," Biochimica et Biophysica Acta: General Subjects, vol. 1770, no. 2, pp. 213-220, 2007.
42. R. Zadziński, A. Fortuniak, T. Biliński, M. Grey, and G. Bartosz, "Menadione toxicity in saccharomyces cerevisiae cells: activation by conjugation with glutathione," Biochemistry and Molecular Biology International, vol. 44, no. 4, pp. 747-759, 1998.