Mechanism of MenE Inhibition by Acyl-Adenylate Analogues and Discovery of Novel Antibacterial Agents

Biochemistry

Volumn 54, Issue 42, 2015, Pages 6514-6524

  Matarlo, Joe S ^a   Evans, Christopher E ^b   Sharma, Indrajeet ^b   Lavaud, Lubens J ^a   Ngo, Stephen C ^a   Shek, Roger ^a   Rajashankar, Kanagalaghatta R ^c   French, Jarrod B ^a   Tan, Derek S ^b   Tonge, Peter J ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c ARGONNE NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BACTERIA; BINS; BIOCHEMISTRY; CARBOXYLATION; CHAINS; CRYSTALLOGRAPHY; ENZYME INHIBITION; ENZYMES; ESCHERICHIA COLI; ISOMERS; PLANTS (BOTANY);

ANTI-BACTERIAL ACTIVITY; BIOSYNTHESIS PATHWAYS; ISOMERIC FORMS; MECHANISM OF ACTION; NEGATIVELY CHARGED; SITE DIRECTED MUTAGENESIS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIPS;

X RAY CRYSTALLOGRAPHY;

ACYL ADENYLATE DERIVATIVE; ADENOSINE DERIVATIVE; ANTIBIOTIC AGENT; MENAQUINONE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; ARGININE; ARYLBUTYRIC ACID DERIVATIVE; ESCHERICHIA COLI PROTEIN; FARNOQUINONE; O-SUCCINYLBENZOATE - COA LIGASE; O-SUCCINYLBENZOIC ACID; SUCCINATE COENZYME A LIGASE;

ALDOL REACTION; AMINO ACID SEQUENCE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIAL VIRULENCE; CIRCULAR DICHROISM; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; ENZYME INHIBITION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CHLOROCEBUS AETHIOPS; CONSERVED SEQUENCE; DRUG DEVELOPMENT; DRUG EFFECTS; ENZYME ACTIVE SITE; ENZYMOLOGY; ESCHERICHIA COLI K 12; GENETICS; METABOLISM; MICROBIAL SENSITIVITY TEST; MOLECULAR GENETICS; MOLECULAR MODEL; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY; STAPHYLOCOCCUS AUREUS; VERO CELL LINE;

AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; ARGININE; CATALYTIC DOMAIN; CERCOPITHECUS AETHIOPS; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; ESCHERICHIA COLI K12; ESCHERICHIA COLI PROTEINS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHENYLBUTYRATES; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; SUCCINATE-COA LIGASES; VERO CELLS; VITAMIN K 2;

EID: 84945556060     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.5b00966     Document Type: Article

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