Discovery of selective menaquinone biosynthesis inhibitors against Mycobacterium tuberculosis

Journal of Medicinal Chemistry

Volumn 55, Issue 8, 2012, Pages 3739-3755

  Debnath, Joy ^a   Siricilla, Shajila ^a   Wan, Bajoie ^b   Crick, Dean C ^c   Lenaerts, Anne J ^c   Franzblau, Scott G ^b   Kurosu, Michio ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [4 [[3 [(4 CHLOROPHENYL)(METHOXYIMINO)METHYL]PHENOXY]METHYL]PIPERIDIN 1 YL]OCTAN 2 YL CARBAMATE; ANTIMYCOBACTERIAL AGENT; MENAQUINONE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BIOASSAY; BIOSYNTHESIS; CHIRALITY; CONTROLLED STUDY; DRUG DEVELOPMENT; DRUG SYNTHESIS; GROWTH INHIBITION; IN VITRO STUDY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHARMACOPHORE;

ALKYL AND ARYL TRANSFERASES; ANAEROBIOSIS; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; ELECTRON TRANSPORT; ENZYME INHIBITORS; ESCHERICHIA COLI; HYDROXYLAMINES; MYCOBACTERIUM TUBERCULOSIS; QUINOLONES; STEREOISOMERISM; VITAMIN K 2;

EID: 84860308064     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201608g     Document Type: Article

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