Bacillus anthracis o-succinylbenzoyl-CoA synthetase: Reaction kinetics and a novel inhibitor mimicking its reaction intermediate

Biochemistry

Volumn 47, Issue 47, 2008, Pages 12434-12447

  Tian, Yang ^a   Suk, Dae Hwan ^a,b   Cai, Feng ^a,c   Crich, David ^a,c   Mesecar, Andrew D ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b Yonsei University   (South Korea)

^c WAYNE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDS; BACTERIOLOGY; CARBOXYLATION; ENZYMES; LEAD COMPOUNDS; SUBSTRATES; SULFUR COMPOUNDS;

ANTHRACIS; BACILLUS ANTHRACIS; BINDING STUDIES; BIOSYNTHETIC PATHWAYS; CARBOXYLATE GROUPS; E FORMS; FIRST ROUNDS; GENE KNOCKOUTS; INHIBITION CONSTANTS; INHIBITOR DESIGNS; KINETIC MECHANISMS; KINETIC STUDIES; REACTION INTERMEDIATES; SUBSTRATE SPECIFICITIES; SYNTHETASE; TRIFLUORO METHYLS;

REACTION KINETICS;

2 SUCCINYLBENZOYL COENZYME A SYNTHETASE; 4 [2 (TRIFLUOROMETHYL)PHENYL] 4 OXOBUTYRIC ACID; 5' O [N [2 (TRIFLUOROMETHYL)PHENYL] 4 OXOBUTYL]ADENOSINE SULFONAMIDE; BACTERIAL ENZYME; BUTYRIC ACID DERIVATIVE; CARBOXYL GROUP; COENZYME A; ENZYME INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BACILLUS ANTHRACIS; BINDING AFFINITY; CONTROLLED STUDY; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STABILITY; ENZYME SUBSTRATE; INHIBITION KINETICS; ISOMERISM; MOLECULAR MIMICRY; MOLECULAR PROBE; PRIORITY JOURNAL; STEADY STATE;

ADENOSINE TRIPHOSPHATE; BACILLUS ANTHRACIS; BIOMIMETIC MATERIALS; COENZYME A; ENZYME INHIBITORS; KINETICS; PHENOLS; PHENYLBUTYRATES; SUBSTRATE SPECIFICITY; SUCCINATE-COA LIGASES;

BACILLUS ANTHRACIS;

EID: 56749085478     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi801311d     Document Type: Article

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