Childhood maltreatment and transition to psychotic disorder independently predict long-term functioning in young people at ultra-high risk for psychosis

Psychological Medicine

Volumn 45, Issue 16, 2015, Pages 3453-3465

  Yung, A R ^a   Cotter, J ^a   Wood, S J ^b   McGorry, P ^c   Thompson, A D ^d   Nelson, B ^c   Lin, A ^e  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d UNIVERSITY OF WARWICK   (United Kingdom)

^e UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

At risk mental state; childhood trauma; clinical high risk; prodrome; psychosis; schizophrenia; ultra high risk

Indexed keywords

ADOLESCENT; ADULT; ANXIETY; CHILDHOOD TRAUMA SURVIVOR; COGNITION; DEPRESSION; FEMALE; HUMAN; LONGITUDINAL STUDY; MALE; MULTIVARIATE ANALYSIS; NEUROPSYCHOLOGICAL TEST; PROGNOSIS; PSYCHOLOGICAL RATING SCALE; PSYCHOLOGY; RISK ASSESSMENT; SCHIZOPHRENIA; STATISTICAL MODEL; YOUNG ADULT;

ADOLESCENT; ADULT; ADULT SURVIVORS OF CHILD ADVERSE EVENTS; ANXIETY; COGNITION; DEPRESSION; FEMALE; HUMANS; LINEAR MODELS; LONGITUDINAL STUDIES; MALE; MULTIVARIATE ANALYSIS; NEUROPSYCHOLOGICAL TESTS; PROGNOSIS; PSYCHIATRIC STATUS RATING SCALES; RISK ASSESSMENT; SCHIZOPHRENIA; YOUNG ADULT;

EID: 84945487749     PISSN: 00332917     EISSN: 14698978     Source Type: Journal    
DOI: 10.1017/S003329171500135X     Document Type: Article

References (86)

1. Aas M, Dazzan P, Fisher HL, Morgan C, Morgan K, Reichenberg A, Zanelli J, Fearon P, Jones PB, Murray RM, Pariante CM (2011). Childhood trauma and cognitive function in first-episode affective and non-affective psychosis. Schizophrenia Research 129, 12-19.
2. Aas M, Dazzan P, Mondelli V, Melle I, Murray RM, Pariante CM (2014). A systematic review of cognitive function in first-episode psychosis, including a discussion on childhood trauma, stress, and inflammation. Frontiers in Psychiatry 4, 182.
3. Aas M, Haukvik UK, Djurovic S, Bergmann ∅, Athanasiu L, Tesli MS, Hellvin T, Steen NE, Agartz I, Lorentzen S, Sundet K, Andreassen OA, Melle I (2013). BDNF val66met modulates the association between childhood trauma, cognitive and brain abnormalities in psychoses. Progress in Neuro-Psychopharmacology & Biological Psychiatry 46, 181-188.
4. Aas M, Navari S, Gibbs A, Mondelli V, Fisher HL, Morgan C, Morgan K, MacCabe J, Reichenberg A, Zanelli J, Fearon P, Jones PB, Murray RM, Pariante CM, Dazzan P (2012). Is there a link between childhood trauma, cognition, and amygdala and hippocampus volume in first-episode psychosis? Schizophrenia Research 137, 73-79.
5. Addington J, Cornblatt BA, Cadenhead KS, Cannon TD, McGlashan TH, Perkins DO, Seidman LJ, Tsuang MT, Walker EF, Woods SW, Heinssen R (2011). At clinical high risk for psychosis: outcome for nonconverters. American Journal of Psychiatry 168, 800-805.
6. Addington J, Stowkowy J, Cadenhead KS, Cornblatt BA, McGlashan TH, Perkins DO, Seidman LJ, Tsuang MT, Walker EF,Woods SW, Cannon TD (2013). Early traumatic experiences in those at clinical high risk for psychosis. Early Intervention in Psychiatry 7, 300-305.
7. Andreasen N (1984). Scale for the Assessment of Negative Symptoms (SANS). University of Iowa: Iowa.
8. Auther AM, McLaughlin D, Carrión RE, Nagachandran P, Correll CU, Cornblatt BA (2012). Prospective study of cannabis use in adolescents at clinical high risk for psychosis: impact on conversion to psychosis and functional outcome. Psychological Medicine 42, 2485-2497.
9. Ball JS, Links PS (2009). Borderline personality disorder and childhood trauma: evidence for a causal relationship. Current Psychiatry Reports 11, 63-68.
10. Barbato M, Liu L, Penn DL, Keefe RS, Perkins DO, Woods SW, Addington J (2013). Social cognition as a mediator between neurocognition and functional outcome in individuals at clinical high risk for psychosis. Schizophrenia Research 150, 542-546.
11. Bernstein DP, Stein JA, Newcomb MD, Walker E, Pogge D, Ahluvalia T, Stokes J, Handelsman L, Medrano M, Desmond D, Zule W (2003). Development and validation of a brief screening version of the Childhood Trauma Questionnaire. Child Abuse & Neglect 27, 169-190.
12. Bohus M, Dyer AS, Priebe K, Krüger A, Kleindienst N, Schmahl C, Niedtfeld I, Steil R (2013). Dialectical behaviour therapy for post-traumatic stress disorder after childhood sexual abuse in patients with and without borderline personality disorder: a randomised controlled trial. Psychotherapy and Psychosomatics 82, 221-233.
13. Brandizzi M, Valmaggia L, Byrne M, Jones C, Iwegbu N, Badger S, McGuire P, Fusar-Poli P (2015). Predictors of functional outcome in individuals at high clinical risk for psychosis at six years follow-up. Journal of Psychiatric Research 65, 115-123.
14. Cannon TD, Cadenhead K, Cornblatt B, Woods SW, Addington J, Walker E, Seidman LJ, Perkins D, Tsuang M, McGlashan T, Heinssen R (2008). Prediction of psychosis in youth at high clinical risk: a multisite longitudinal study in North America. Archives of General Psychiatry 65, 28-37.
15. Carrión RE, McLaughlin D, Goldberg TE, Auther AM, Olsen RH, Olvet DM, Correll CU, Cornblatt BA (2013). Prediction of functional outcome in individuals at clinical high risk for psychosis. JAMA Psychiatry 70, 1133-1142.
16. Chapman DP, Whitfield CL, Felitti VJ, Dube SR, Edwards VJ, Anda RF (2004). Adverse childhood experiences and the risk of depressive disorders in adulthood. Journal of Affective Disorders 82, 217-225.
17. Chen LP, Murad MH, Paras ML, Colbenson KM, Sattler AL, Goranson EN, Elamin MB, Seime RJ, Shinozaki G, Prokop LJ, Zirakzadeh A (2010). Sexual abuse and lifetime diagnosis of psychiatric disorders: systematic review and meta-analysis. Mayo Clinic Proceedings 85, 618-629.
18. Cotter J, Drake RJ, Bucci S, Firth J, Edge D, Yung AR (2014). What drives poor functioning in the at-risk mental state? A systematic review. Schizophrenia Research 159, 267-277.
19. Cotter J, Kaess M, Yung AR (2015). Childhood trauma and functional disability in psychosis, bipolar disorder and borderline personality disorder: a review of the literature. Irish Journal of Psychological Medicine 32, 21-30.
20. Day FL, Valmaggia LR, Mondelli V, Papadopoulos A, Papadopoulos I, Pariante CM, McGuire P (2014). Blunted cortisol awakening response in people at ultra high risk of developing psychosis. Schizophrenia Research 158, 25-31.
21. Dennison U, McKernan D, Cryan J, Dinan T (2012). Schizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotype. Psychological Medicine 42, 1865-1871.
22. Elzinga BM, Roelofs K, Tollenaar MS, Bakvis P, van Pelt J, Spinhoven P (2008). Diminished cortisol responses to psychosocial stress associated with lifetime adverse events a study among healthy young subjects. Psychoneuroendocrinology 33, 227-237.
23. Fisher HL, Craig TK, Fearon P, Morgan K, Dazzan P, Lappin J, Hutchinson G, Doody GA, Jones PB, McGuffin P, Murray RM, Leff J, Morgan C (2011). Reliability and comparability of psychosis patients' retrospective reports of childhood abuse. Schizophrenia Bulletin 37, 546-553.
24. Fowke A, Ross S, Ashcroft K (2012). Childhood maltreatment and internalized shame in adults with a diagnosis of bipolar disorder. Clinical Psychology & Psychotherapy 19, 450-457.
25. Frodl T, O'Keane V (2013). How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans. Neurobiology of Disease 52, 24-37.
26. Fusar-Poli P, Bechdolf A, Taylor MJ, Bonoldi I, Carpenter WT, Yung AR, McGuire P (2013a). At risk for schizophrenic or affective psychoses? A meta-analysis of DSM/ICD diagnostic outcomes in individuals at high clinical risk. Schizophrenia Bulletin 39, 923-932.
27. Fusar-Poli P, Borgwardt S, Bechdolf A, Addington J, Riecher-Rössler A, Schultze-Lutter F, Keshavan M, Wood S, Ruhrmann S, Seidman LJ, Valmaggia L, Cannon T, Velthorst E, De Haan L, Cornblatt B, Bonoldi I, Birchwood M, McGlashan T, Carpenter W, McGorry P, Klosterkötter J, McGuire P, Yung A (2013b). The psychosis high-risk state: a comprehensive state-of-the-art review. JAMA Psychiatry 70, 107-120.
28. Fusar-Poli P, Meneghelli A, Valmaggia L, Allen P, Galvan F, McGuire P, Cocchi A (2009). Duration of untreated prodromal symptoms and 12-month functional outcome of individuals at risk of psychosis. British Journal of Psychiatry 194, 181-182.
29. Goldman H, Skodol A, Lave T (1992). Revising Axis V for DSM-IV: a review of measures of social functioning. American Journal of Psychiatry 149, 1148-1156.
30. Green MF, Kern RS, Braff DL, Mintz J (2000). Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the 'right stuff'? Schizophrenia Bulletin 26, 119-136.
31. Hall RC (1995). Global assessment of functioning. A modified scale. Psychosomatics 36, 267-275.
32. Henry LP, Harris MG, Amminger GP, Yuen HP, Harrigan SM, Lambert M, Conus P, Schwartz O, Prosser A, Farrelly S, Purcell R, Herrman H, Jackson HJ, McGorry PD (2007). Early Psychosis Prevention and Intervention Centre long-term follow-up study of first-episode psychosis: methodology and baseline characteristics. Early Intervention in Psychiatry 1, 49-60.
33. Hill M, Crumlish N, ClarkeM, Whitty P, Owens E, Renwick L, Browne S, Macklin EA, Kinsella A, Larkin C, Waddington JL, O'Callaghan E (2012). Prospective relationship of duration of untreated psychosis to psychopathology and functional outcome over 12 years. Schizophrenia Research 141, 215-221.
34. Hoy K, Barrett S, Shannon C, Campbell C,Watson D, Rushe T, Shevlin M, Bai F, Cooper S, Mulholland C (2012). Childhood trauma and hippocampal and amygdalar volumes in first-episode psychosis. Schizophrenia Bulletin 38, 1162-1169.
35. Janssen I, Krabbendam L, Bak M, Hanssen M, Vollebergh W, de Graaf R, van Os J (2004). Childhood abuse as a risk factor for psychotic experiences. Acta Psychiatrica Scandinavica 109, 38-45.
36. Jones P, Rodgers B, Murray R, Marmot M (1994). Child development risk factors for adult schizophrenia in the British 1946 birth cohort. Lancet 344, 1398-1402.
37. Kerfoot KE, Rosenheck RA, Petrakis IL, Swartz MS, Keefe RS, McEvoy JP, Stroup TS, CATIE Investigators (2011). Substance use and schizophrenia: adverse correlates in the CATIE study sample. Schizophrenia Research 132, 177-182.
38. Klosterkotter J, Ebel H, Schultze-Lutter F, Steinmeyer EM (1996). Diagnostic validity of basic symptoms. European Archives of Psychiatry and Clinical Neuroscience 246, 147-154.
39. Kraan T, Velthorst E, Smit F, de Haan L, van der Gaag M (2015). Trauma and recent life events in individuals at ultra high risk for psychosis: review and meta-analysis. Schizophrenia Research 161, 143-149.
40. Lardinois M, Lataster T, Mengelers R, Van Os J, Myin Germeys I (2011). Childhood trauma and increased stress sensitivity in psychosis. Acta Psychiatrica Scandinavica 123, 28-35.
41. Lin A, Brewer WJ, Yung AR, Nelson B, Pantelis C, Wood SJ (2015a). Olfactory identification deficits at identification as ultra-high risk for psychosis are associated with poor functional outcome. Schizophrenia Research 161, 156-162.
42. Lin A, Reniers RL,Wood SJ (2013a). Clinical staging in severe mental disorder: evidence from neurocognition and neuroimaging. British Journal of Psychiatry 54, s11-s17.
43. Lin A, Wood SJ, Nelson B, Beavan A, McGorry P, Yung AR (2015b). Outcomes of nontransitioned cases in a sample at ultra-high risk for psychosis. American Journal of Psychiatry 172, 249-258.
44. Lin A, Wood SJ, Nelson B, Brewer WJ, Spiliotacopoulos D, Bruxner A, Broussard C, Pantelis C, Yung AR (2011). Neurocognitive predictors of functional outcome two to 13 years after identification as ultra-high risk for psychosis. Schizophrenia Research 132, 1-7.
45. Lin A, Wood SJ, Yung AR (2013b). Measuring psychosocial outcome is good. Current Opinion in Psychiatry 26, 138-143.
46. Linehan MM (1993). Cognitive-Behavioral Treatment of Borderline Personality Disorder. Guilford: New York.
47. Lovatt A, Mason O, Brett C, Peters E (2010). Psychotic-like experiences, appraisals, and trauma. Journal of Nervous and Mental Disease 198, 813-819.
48. Lysaker PH,Wright DE, Clements CA, Plascak-Hallberg CD (2002). Neurocognitive and psychosocial correlates of hostility among persons in a post-acute phase of schizophrenia spectrum disorders. Comprehensive Psychiatry 43, 319-324.
49. Meyer EC, Carrión RE, Cornblatt BA, Addington J, Cadenhead KS, Cannon TD, McGlashan TH, Perkins DO, Tsuang MT,Walker EF,Woods SW, Heinssen R, Seidman LJ, NAPLS group (2014). The relationship of neurocognition and negative symptoms to social and role functioning over time in individuals at clinical high risk in the first phase of the North American Prodrome Longitudinal Study. Schizophrenia Bulletin 40, 1452-1461.
50. Miller TJ, McGlashan TH, Rosen JL, Somjee L, Markovich PJ, Stein K, Woods SW (2002). Prospective diagnosis of the initial prodrome for schizophrenia based on the Structured Interview for Prodromal Syndromes: preliminary evidence of interrater reliability and predictive validity. American Journal of Psychiatry 159, 863-865.
51. Mills R, Alati R, O'CallaghanM, Najman JM,Williams GM, Bor W, Strathearn L (2011). Child abuse and neglect and cognitive functioning at 14 years of age: findings from a birth cohort. Pediatrics 127, 4-10.
52. Mondelli V, Cattaneo A, Belvederi Murri M, Di Forti M, Handley R, Hepgul N, Miorelli A, Navari S, Papadopoulos AS, Aitchison KJ, Morgan C, Murray RM, Dazzan P, Pariante CM (2011). Stress and inflammation reduce brain-derived neurotrophic factor expression in first-episode psychosis: a pathway to smaller hippocampal volume. Journal of Clinical Psychiatry 72, 1677-1684.
53. Morandotti N, Dima D, Jogia J, Frangou S, Sala M, Vidovich GZ, Lazzaretti M, Gambini F, Marraffini E, d'Allio G, Barale F, Zappoli F, Caverzasi E, Brambilla P (2013). Childhood abuse is associated with structural impairment in the ventrolateral prefrontal cortex and aggressiveness in patients with borderline personality disorder. Psychiatry Research 213, 18-23.
54. Neigh GN, Gillespie CF, Nemeroff CB (2009). The neurobiological toll of child abuse and neglect. Trauma Violence Abuse 10, 389-410.
55. Nelson B, Yuen HP, Wood SJ, Lin A, Spiliotacopoulos D, Bruxner A, Broussard C, Simmons M, Foley DL, Brewer WJ, Francey SM, Amminger GP, Thompson A, McGorry PD, Yung AR (2013). Long term follow up of a group at ultra high risk ('prodromal') for psychosis: the PACE 400 study. JAMA Psychiatry 70, 793-802.
56. Overall JE, Gorham DR (1962). The brief psychiatric rating scale. Psychological Reports 10, 799-812.
57. Pruessner M, Béchard-Evans L, Boekestyn L, Iyer SN, Pruessner JC,Malla AK (2013). Attenuated cortisol response to acute psychosocial stress in individuals at ultra-high risk for psychosis. Schizophrenia Research 146, 79-86.
58. Ruhrmann S, Schultze-Lutter F, Salokangas RK, Heinimaa M, Linszen D, Dingemans P, Birchwood M, Patterson P, Juckel G, Heinz A, Morrison A, Lewis S, von Reventlow HG, Klosterkötter J (2010). Prediction of psychosis in adolescents and young adults at high risk: results from the prospective European Prediction of Psychosis Study. Archives of General Psychiatry 67, 241-251.
59. Salokangas RK, Heinimaa M, From T, Loÿttyniemi E, Ilonen T, Luutonen S, Hietala J, Svirskis T, von Reventlow HG, Juckel G, Linszen D, Dingemans P, Birchwood M, Patterson P, Schultze-Lutter F, Ruhrmann S, Klosterkötter J, EPOS group (2014). Short-term functional outcome and premorbid adjustment in clinical high-risk patients. Results of the EPOS project. European Psychiatry 29, 371-380.
60. Salokangas RK, Nieman DH, Heinimaa M, Svirskis T, Luutonen S, From T, von Reventlow HG, Juckel G, Linszen D, Dingemans P, Birchwood M, Patterson P, Schultze-Lutter F, Klosterkötter J, Ruhrmann S, EPOS group (2013). Psychosocial outcome in patients at clinical high risk of psychosis: a prospective follow-up. Social Psychiatry and Psychiatric Epidemiology 48, 303-311.
61. Sapolsky RM, Krey LC, McEwen BS (1986). The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis. Endocrine Reviews 7, 284-301.
62. Schenkel LS, Spaulding WD, DiLillo D, Silverstein SM (2005). Histories of childhood maltreatment in schizophrenia: relationships with premorbid functioning, symptomatology, and cognitive deficits. Schizophrenia Research 76, 273-286.
63. Schlosser DA, Jacobson S, Chen Q, Sugar CA, Niendam TA, Li G, Bearden CE, Cannon TD (2012). Recovery from an at-risk state: clinical and functional outcomes of putatively prodromal youth who do not develop psychosis. Schizophrenia Bulletin 38, 1225-1233.
64. Schmidt LM, Hesse M, Lykke J (2011). The impact of substance use disorders on the course of schizophrenia-a 15-year follow-up study: dual diagnosis over 15 years. Schizophrenia Research 130, 228-233.
65. Shannon C, Douse K, McCusker C, Feeney L, Barrett S, Mulholland C (2011). The association between childhood trauma and memory functioning in schizophrenia. Schizophrenia Bulletin 37, 531-537.
66. Sheffield JM, Williams LE, Woodward ND, Heckers S (2013). Reduced gray matter volume in psychotic disorder patients with a history of childhood sexual abuse. Schizophrenia Research 143, 185-191.
67. Sideli L, Fisher HL, Russo M, Murray RM, Stilo SA, Wiffen BD, O'Connor JA, Aurora Falcone M, Pintore SM, Ferraro L, Mule' A, La Barbera D, Morgan C, Di Forti M (2014). Failure to find association between childhood abuse and cognition in first-episode psychosis patients. European Psychiatry 29, 32-35.
68. Statucka M, Walder DJ (2013). Efficacy of social cognition remediation programs targeting facial affect recognition deficits in schizophrenia: a review and consideration of high-risk samples and sex differences. Psychiatry Research 206, 125-139.
69. Stochl J, Khandaker GM, Lewis G, Perez J, Goodyer IM, Zammit S, Sullivan S, Croudace TJ, Jones PB (2015). Mood, anxiety and psychotic phenomena measure a common psychopathological factor. Psychological Medicine 45, 1483-1493.
70. Ten Velden Hegelstad W, Haahr U, Larsen TK, Auestad B, Barder H, Evensen J, Joa I, Johannessen JO, Langeveld J, Melle I, Opjordsmoen S, Rossberg JI, Rund BR, Simonsen E, Vaglum P, McGlashan T, Friis S (2013). Early detection, early symptom progression and symptomatic remission after ten years in a first episode of psychosis study. Schizophrenia Research 143, 337-343.
71. Thompson A, Nelson B, McNab C, Simmons M, Leicester S, McGorry PD, Bechdolf A, Yung AR (2010). Psychotic symptoms with sexual content in the 'ultra high risk' for psychosis population: frequency and association with sexual trauma. Psychiatry Research 177, 84-91.
72. Thompson AD, Nelson B, Yuen HP, Lin A, Amminger GP, McGorry PD, Wood SJ, Yung AR (2014). Sexual trauma increases the risk of developing psychosis in an ultra high-risk 'prodromal' population. Schizophrenia Bulletin 40, 697-706.
73. Tikka M, Luutonen S, Ilonen T, Tuominen L, Kotimäki M, Hankala J, Salokangas RK (2013). Childhood trauma and premorbid adjustment among individuals at clinical high risk for psychosis and normal control subjects. Early Intervention in Psychiatry 7, 51-57.
74. Tsuang MT, Stone WS, Gamma F, Faraone SV (2003). Schizotaxia: current status and future directions. Current Psychiatry Reports 5, 128-134.
75. van den Berg DP, van der Gaag M (2012). Treating trauma in psychosis with EMDR: a pilot study. Journal of Behavior Therapy and Experimental Psychiatry 43, 664-671.
76. Varese F, Smeets F, Drukker M, Lieverse R, Lataster T, Viechtbauer W, Read J, van Os J, Bentall RP (2012). Childhood adversities increase the risk of psychosis: a meta-analysis of patient-control, prospective-and crosssectional cohort studies. Schizophrenia Bulletin 38, 661-671.
77. Wigman JT, van NieropM, VolleberghWA, Lieb R, Beesdo-Baum K, Wittchen HU, van Os J (2012). Evidence that psychotic symptoms are prevalent in disorders of anxiety and depression, impacting on illness onset, risk, and severity-implications for diagnosis and ultra-high risk research. Schizophrenia Bulletin 38, 247-257.
78. Wood SJ, Yung AR, McGorry PD, Pantelis C (2011). Neuroimaging and treatment evidence for clinical staging in psychotic disorders: from the at-risk mental state to chronic schizophrenia. Biological Psychiatry 70, 619-625.
79. Wykes T, Huddy V, Cellard C, McGurk SR, Czobor P (2011). A meta-analysis of cognitive remediation for schizophrenia: methodology and effect sizes. American Journal of Psychiatry 168, 472-485.
80. Yung AR, McGorry PD, McFarlane CA, Jackson HJ, Patton GC, Rakkar A (1996). Monitoring and care of young people at incipient risk of psychosis. Schizophrenia Bulletin 22, 283-303.
81. Yung AR, Nelson B, Thompson A, Wood SJ (2010). The psychosis threshold in Ultra High Risk ('prodromal') research: is it valid? Schizophrenia Research 120, 1-6.
82. Yung AR, Phillips LJ, McGorry PD, McFarlane CA, Francey S, Harrigan S, Patton GC, Jackson HJ (1998). Prediction of psychosis: a step towards indicated prevention of schizophrenia. British Journal of Psychiatry 172, 14-20.
83. Yung AR, Phillips LJ, Yuen HP, Francey SM, McFarlane CA, Hallgren M, McGorry PD (2003). Psychosis prediction: 12-month follow up of a high-risk ('prodromal') group. Schizophrenia Research 60, 21-32.
84. Yung AR, Phillips LJ, Yuen HP, McGorry PD (2004). Risk factors for psychosis in an ultra high-risk group: psychopathology and clinical features. Schizophrenia Research 67, 131-142.
85. Yung AR, Yuen HP, McGorry PD, Phillips LJ, Kelly D, Dell'Olio M, Francey SM, Cosgrave EM, Killackey E, Stanford C, Godfrey K, Buckby J (2005). Mapping the onset of psychosis: the Comprehensive Assessment of At-Risk Mental States. Australian and New Zealand Journal of Psychiatry 39, 964-971.
86. Ziermans TB, Schothorst PF, Schnack HG, Koolschijn PC, Kahn RS, van Engeland H, Durston S (2012). Progressive structural brain changes during development of psychosis. Schizophrenia Bulletin 38, 519-530.