Schizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotype

Psychological Medicine

Volumn 42, Issue 9, 2012, Pages 1865-1871

  Dennison, U ^a   McKernan, D ^b   Cryan, J ^a,b   Dinan, T ^a,b  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Childhood trauma; inflammation; schizophrenia

Indexed keywords

AUTACOID; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CASE CONTROL STUDY; CHILD; CHILD ABUSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IMMUNOLOGY; INFLAMMATION; MALE; MENTAL STRESS; MIDDLE AGED; PARENTAL DEPRIVATION; PHENOTYPE; PSYCHOLOGICAL ASPECT; PSYCHOLOGY; PSYCHOSIS; SCHIZOPHRENIA;

ADULT; CASE-CONTROL STUDIES; CHILD; CHILD ABUSE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; INTERLEUKIN-6; INTERLEUKIN-8; MALE; MIDDLE AGED; PARENTAL DEATH; PHENOTYPE; PSYCHOTIC DISORDERS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; STRESS, PSYCHOLOGICAL; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84864561098     PISSN: 00332917     EISSN: 14698978     Source Type: Journal    
DOI: 10.1017/S0033291712000074     Document Type: Article

References (46)

1. Addington D, Addington J, Maticka-Tyndale E (1993). Assessing depression in schizophrenia : The Calgary Depression Scale. British Journal of Psychiatry. Supplement 39-44.
2. Addington D, Addington J, Maticka-Tyndale E, Joyce J (1992). Reliability and validity of a depression rating scale for schizophrenics. Schizophrenia Research 6, 201-208.
3. APA (1994). Diagnostic and Statistical Manual of Mental Disorders, 4th edn. American Psychiatric Association : Washington, DC.
4. Bernstein D, Fink L, Handelsman L, Foote J, Lovejoy M, Wenzel K, Sapareto E, Ruggiero J (1994). Initial reliability and validity of a new retrospective measure of child abuse and neglect. American Journal of Psychiatry 151, 1132-1136.
5. Boynton-Jarrett R, Fargnoli J, Suglia SF, Zuckerman B, Wright RJ (2010). Association between maternal intimate partner violence and incident obesity in preschool-aged children : Results from the Fragile Families and Child Well-being Study. Archives of Paediatric and Adolescent Medicine 164, 540-546.
6. Braehler C, Holowka D, Brunet A, Beaulieu S, Baptista T, Debruille JB, Walker CD, King S (2005). Diurnal cortisol in schizophrenia patients with childhood trauma. Schizophrenia Research 79, 353-354.
7. Bremner JD (2005). Effects of traumatic stress on brain structure and function : Relevance to early responses to trauma. Journal of Trauma and Dissociation 6, 51-68.
8. Brown AS (2011). The environment and susceptibility to schizophrenia. Progress in Neurobiology 93, 23-58.
9. Brydon L, Wright CE, O'Donnell K, Zachary I, Wardle J, Steptoe A (2008). Stress-induced cytokine responses and central adiposity in young women. International Journal of Obesity 32, 443-450.
10. Carpenter LL, Gawuga CE, Tyrka AR, Lee JK, Anderson GM, Price LH (2010). Association between plasma IL-6 response to acute stress and early-life adversity in healthy adults. Neuropsychopharmacology 35, 2617-2623.
11. Carpenter LL, Tyrka AR, Ross NS, Khoury L, Anderson GM, Price LH (2009). Effect of childhood emotional abuse and age on cortisol responsivity in adulthood. Biological Psychiatry 66, 69-75.
12. Cicchetti D, Walker EF (2001). Stress and development: Biological and psychological consequences. Development and Psychopathology 13, 413-418.
13. Commins SP, Borish L, Steinke JW (2010). Immunologic messenger molecules : Cytokines, interferons, and chemokines. Journal of Allergy and Clinical Immunology 125, S53-S72.
14. Danese A, Moffitt TE, Pariante CM, Ambler A, Poulton R, Caspi A (2008). Elevated inflammation levels in depressed adults with a history of childhood maltreatment. Archives of General Psychiatry 65, 409-415.
15. Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW (2008). From inflammation to sickness and depression : When the immune system subjugates the brain. Nature Reviews Neuroscience 9, 46-56.
16. Frank M, Baratta M, Sprunger D, Watkins L, Maier S (2007). Microglia serve as a neuroimmune substrate for stress induced potentiation of CNS pro-inflammatory cytokine responses. Brain, Behavior and Immunity 21, 47-59.
17. Galletly C, van Hooff M, McFarlane A (2011). Psychotic symptoms in young adults exposed to childhood trauma-a 20 year follow-up study. Schizophrenia Research 127, 76-82.
18. Hall F, Wilkinson L, Humby T, Robbins T (1999). Maternal deprivation of neonatal rats produces enduring changes in dopamine function. Synapse 32, 37-43.
19. Hardt J, Rutter M (2004). Validity of adult retrospective reports of adverse childhood experiences : Review of the evidence. Journal of Child Psychology and Psychiatry 45, 260-273.
20. Heim C, Mletzko T, Purselle D, Musselman DL, Nemeroff CB (2008a). The dexamethasone/corticotropinreleasing factor test in men with major depression : Role of childhood trauma. Biological Psychiatry 63, 398-405.
21. Heim C, Newport DJ, Mletzko T, Miller AH, Nemeroff CB (2008b). The link between childhood trauma and depression : Insights from HPA axis studies in humans. Psychoneuroendocrinology 33, 693-710.
22. Janssen I, Krabbendam L, Bak M, Hanssen M, Volleberg W, de Graaf R, van Os J (2004). Childhood abuse as a risk factor for psychotic experiences. Acta Psychiatrica Scandinavica 109, 38-45.
23. Kay S, Fiszbein A, Opler L (1987). The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin 13, 261-276.
24. Kvasnicka T, Kvasnicka J, Ceska R, Vrablik M (2003). Increase of inflammatory state in overweight adults with combined hyperlipidemia. Nutrition, Metabolism and Cardiovascular Diseases 13, 227-231.
25. LeMay LG, Vander AJ, Kluger MJ (1990). The effects of psychological stress on plasma interleukin-6 activity in rats. Physiology and Behavior 47, 957-961.
26. Leonard BE, Myint A (2009). The psychoneuroimmunology of depression. Human Psychopharmacology 24, 165-175.
27. Leucht S, Kane JM, Kissling W, Hamann J, Etschel E, Engel RR (2005). What does the PANSS mean? Schizophrenia Research 79, 231-238.
28. Liu D, Diorio J, Tannenbaum B, Caldji C, Francis D, Freedman A, Sharma S, Pearson D, Plotsky PM, Meaney MJ (1997).Maternal care, hippocampal glucocorticoid receptors, and hypothalamicpituitary-adrenal responses to stress. Science 277, 1659-1662.
29. Maes M, Delange J, Ranjan R, Meltzer HY, Desnyder R, Cooremans W, Scharpe S (1997). Acute phase proteins in schizophrenia, mania and major depression : Modulation by psychotropic drugs. Psychiatry Research 66, 1-11.
30. Mondelli V, Cattaneo A, Belvederi Murri M, Di Forti M, Handley R, Hepgul N, Miorelli A, Navari S, Papadopoulos A, Aitchinson K, Morgan C, Murray R, Dazzan P, Pariante C (2011). Stress and inflammation reduce brain-derived neurotrophic factor expression in first-episode psychosis : A pathway to smaller hippocampal volumes. Journal of Clinical Psychiatry. Published online : 18 May 2011. doi :10.4088/JCP.10m06745.
31. Mondelli V, Dazzan J, Hepgul N, Di Forti M, Aas M, D'Albenzio A, Di Nicola M, Fisher H, Handley R, Marques T, Morgan C, Navari S, Taylor H, Papadopoulos A, Aitchinson K, Murray R, Pariante C (2009). Abnormal cortisol levels during the day and cortisol awakening response in first-episode psychosis : The role of stress and of antipsychotic treatment. Schizophrenia Research 116, 234-242.
32. Morgan C, Fisher H (2007). Environmental factors in schizophrenia : Childhood trauma-a critical review. Schizophrenia Bulletin 33, 3-10.
33. O'Brien SM, Scully P, Scott LV, Dinan TG (2006). Cytokine profiles in bipolar affective disorder : Focus on acutely ill patients. Journal of Affective Disorders 90, 263-267.
34. O'Mahony SM, Marchesi JR, Scully P, Codling C, Ceolho AM, Quigley EM, Cryan JF, Dinan TG (2009). Early life stress alters behavior, immunity, and microbiota in rats : Implications for irritable bowel syndrome and psychiatric illnesses. Biological Psychiatry 65, 263-267.
35. Opler MG, Yang LH, Caleo S, Alberti P (2007). Statistical validation of the criteria for symptom remission in schizophrenia : Preliminary findings. BMC Psychiatry 7, 35.
36. Pace TWW, Mletzko TC, Alagbe O, Musselman DL, Nemeroff CB, Miller AH, Heim CM (2006). Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress. American Journal of Psychiatry 163, 1630-1633.
37. Potvin S, Stip E, Sepehry AA, Gendron A, Bah R, Kouassi E (2008). Inflammatory cytokine alterations in schizophrenia : A systematic quantitative review. Biological Psychiatry 63, 801-808.
38. Read J, Perry BD, Moskowitz A, Connolly J (2001). The contribution of early traumatic events to schizophrenia in some patients : A traumagenic neurodevelopmental model. Psychiatry 64, 319-345.
39. Read J, van Os J, Morrison AP, Ross CA (2005). Childhood trauma, psychosis and schizophrenia : A literature review with theoretical and clinical implications. Acta Psychiatrica Scandinavica 112, 330-350.
40. Shevlin M, Dorahy MJ, Adamson G (2007). Trauma and psychosis : An analysis of the National Comorbidity Survey. American Journal of Psychiatry 164, 166-169.
41. Sparkman N, Johnson R (2008). Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress. Neuroimmunomodulation 15, 323-330.
42. Strous RD, Shoenfeld Y (2006). Schizophrenia, autoimmunity and immune system dysregulation : A comprehensive model updated and revisited. Journal of Autoimmunity 27, 71-80.
43. Tandon R, Keshavan MS, Nasrallah HA (2008). Schizophrenia, ' just the facts ' what we know in 2008. 2. Epidemiology and etiology. Schizophrenia Research 102, 1-18.
44. Tienari P, Wynne LC, Sorri A, Lahti I, Läksy K, Moring J, Naarala M, Nieminen P, Wahlberg K-E (2004). Genotype-environment interaction in schizophreniaspectrum disorder. Long-term follow-up study of Finnish adoptees. British Journal of Psychiatry 184, 216-222.
45. Zarkovic M, Ignjatovic S, Dajak M, Ćirić J, Beleslin B, Savić S, Stojković M, Bulat P, Trbojević B (2008). Cortisol response to ACTH stimulation correlates with blood interleukin 6 concentration in healthy humans. European Journal of Endocrinology 159, 649-652.
46. Zhou D, Kusnecov A, Shurin M, Depaoli M, Rabin B (1993). Exposure to physical and psychological stressors elevates plasma interleukin 6 : Relationship to the activation of hypothalamic-pituitary-adrenal axis. Endocrinology 133, 2523-2530.