BDNF val66met modulates the association between childhood trauma, cognitive and brain abnormalities in psychoses

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 46, Issue , 2013, Pages 181-188

  Aas, Monica ^a,b   Haukvik, Unn K ^a,c   Djurovic, Srdjan ^a,b   Bergmann, Ørjan ^a   Athanasiu, Lavinia ^b   Tesli, Martin S ^b   Hellvin, Tone ^a   Steen, Nils Eiel ^b   Agartz, Ingrid ^a,c   Lorentzen, Steinar ^a,b   Sundet, Kjetil ^a   Andreassen, Ole A ^a,b   Melle, Ingrid ^a,b  

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c DIAKONHJEMMET HOSPITAL   (Norway)

Author keywords

BDNF val66met; Cognition; Early trauma; Gene environmental interaction; Psychoses; SMRI

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; METHIONINE; VALINE;

ADULT; ARTICLE; BDNF GENE; BIPOLAR DISORDER; BRAIN DYSFUNCTION; BRAIN SIZE; CHILD ABUSE; CHILD SEXUAL ABUSE; CHILDHOOD TRAUMA QUESTIONNAIRE; COGNITIVE DEFECT; CONTROLLED STUDY; DNA POLYMORPHISM; DSM-IV; EMOTIONAL ABUSE; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC REGULATION; GENETIC VARIABILITY; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSICAL ABUSE; PSYCHOSIS; SCHIZOPHRENIA;

BDNF; BDNF VAL66MET; BIPOLAR NOS; BIPOLAR NOT OTHERWISE SPECIFIED; BRAIN DERIVED NEUROTROPHIC FACTOR; CHILDHOOD TRAUMA QUESTIONNAIRE; COGNITION; CTQ; D-KEFS; DELIS-KAPLAN EXECUTIVE FUNCTION SCALE; DEOXYRIBONUCLEIC ACID; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS, FOURTH EDITION; DNA; DSM-IV; EA; EARLY TRAUMA; EMOTIONAL ABUSE; EMOTIONAL NEGLECT; EN; GENE×ENVIRONMENTAL INTERACTION; GLUCOCORTICOID RECEPTOR; GR; INTELLIGENCE QUOTIENT; IQ; MET; METHIONINE; PA; PANSS; PASW; PHYSICAL ABUSE; PHYSICAL NEGLECT; PN; POSITIVE AND NEGATIVE SYNDROME SCALE; PRECURSOR OF BRAIN-DERIVED NEUROTROPHIC FACTOR; PREDICTIVE ANALYTIC SOFTWARE; PROBDNF; PSYCHOSES; PSYCHOSIS NOS; PSYCHOSIS NOT OTHERWISE SPECIFIED; RIBONUCLEIC ACID; RNA; SA; SCID; SEXUAL ABUSE; SINGLE-NUCLEOTIDE POLYMORPHISM; SMRI; SNP; STRUCTURAL MAGNETIC RESONANCE IMAGING; STRUCTURED CLINICAL INTERVIEW FOR DSM DISORDERS; THEMATICALLY ORGANIZED PSYCHOSIS RESEARCH STUDY; TOP STUDY; VAL; VALINE; WASI; WECHSLER ABBREVIATED SCALE OF INTELLIGENCE;

ADOLESCENT; ADULT; BIPOLAR DISORDER; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHILD ABUSE; COGNITION DISORDERS; HIPPOCAMPUS; HUMANS; LATERAL VENTRICLES; METHIONINE; PSYCHOTIC DISORDERS; VALINE; YOUNG ADULT;

EID: 84882780371     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2013.07.008     Document Type: Article

References (70)

1. Aas M., Dazzan P., Mondelli V., Toulopoulou T., Reichenberg A., Di F.M., et al. Abnormal cortisol awakening response predicts worse cognitive function in patients with first-episode psychosis. Psychol Med 2010, 1-14.
2. Aas M., Dazzan P., Fisher H.L., Morgan C., Morgan K., Reichenberg A., et al. Childhood trauma and cognitive function in first-episode affective and non-affective psychosis. Schizophr Res 2011, 129:12-19.
3. Aas M., Djurovic S., Athanasiu L., Steen N.E., Agartz I., Lorentzen S., et al. Serotonin transporter gene polymorphism, childhood trauma, and cognition in patients with psychotic disorders. Schizophr Bull 2012, 38:15-22.
4. Alemany S., Arias B., Aguilera M., Villa H., Moya J., Ibanez M.I., et al. Childhood abuse, the BDNF-Val66Met polymorphism and adult psychotic-like experiences. Br J Psychiatry 2011, 199:38-42.
5. Allen D.N., Goldstein G., Warnick E. A consideration of neuropsychologically normal schizophrenia. J Int Neuropsychol Soc 2003, 9:56-63.
6. Andersen S.L., Tomada A., Vincow E.S., Valente E., Polcari A., Teicher M.H. Preliminary evidence for sensitive periods in the effect of childhood sexual abuse on regional brain development. J Neuropsychiatry Clin Neurosci 2008, 20:292-301.
7. Arnone D., Cavanagh J., Gerber D., Lawrie S.M., Ebmeier K.P., McIntosh A.M. Magnetic resonance imaging studies in bipolar disorder and schizophrenia: meta-analysis. Br J Psychiatry 2009, 195:194-201.
8. Bernstein D.P., Stein J.A., Newcomb M.D., Walker E., Pogge D., Ahluvalia T., et al. Development and validation of a brief screening version of the Childhood Trauma Questionnaire. Child Abuse Negl 2003, 27:169-190.
9. Brickman A.M., Buchsbaum M.S., Bloom R., Bokhoven P., Paul-Odouard R., Haznedar M.M., et al. Neuropsychological functioning in first-break, never-medicated adolescents with psychosis. J Nerv Ment Dis 2004, 192:615-622.
10. Buckley P.F., Pillai A., Evans D., Stirewalt E., Mahadik S. Brain derived neurotropic factor in first-episode psychosis. Schizophr Res 2007, 91:1-5.
11. Bueller J.A., Aftab M., Sen S., Gomez-Hassan D., Burmeister M., Zubieta J.K. BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects. Biol Psychiatry 2006, 59:812-815.
12. Calabrese F., Molteni R., Racagni G., Riva M.A. Neuronal plasticity: a link between stress and mood disorders. Psychoneuroendocrinology 2009, 34(Suppl. 1):S208-S216.
13. Champagne F.A., Curley J.P. Epigenetic mechanisms mediating the long-term effects of maternal care on development. Neurosci Biobehav Rev 2009, 33:593-600.
14. De Bellis M.D., Keshavan M.S., Clark D.B., Casey B.J., Giedd J.N., Boring A.M., et al. A.E. Bennett Research Award. Developmental traumatology. Part II: Brain development. Biol Psychiatry 1999, 45:1271-1284.
15. Delis D.C., Kaplan E., Kramer J.H. The Delis-Kaplan Executive Function System: D-KEFS 2005, Pearson Assessment, Stockholm, Sweden.
16. Delis D.C., Kramer J.H., Kaplan E., Ober B.A. California Verbal Learning Test-Second edition (CVLT-II). Norwegian Manual Supplement 2004, Pearson Assessment, Stockholm.
17. Djurovic S., Gustafsson O., Mattingsdal M., Athanasiu L., Bjella T., Tesli M., et al. A genome-wide association study of bipolar disorder in Norwegian individuals, followed by replication in Icelandic sample. J Affect Disord 2010, 126:312-316.
18. Durany N., Michel T., Zochling R., Boissl K.W., Cruz-Sanchez F.F., Riederer P., et al. Brain-derived neurotrophic factor and neurotrophin 3 in schizophrenic psychoses. Schizophr Res 2001, 52:79-86.
19. Egan M.F., Kojima M., Callicott J.H., Goldberg T.E., Kolachana B.S., Bertolino A., et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003, 112:257-269.
20. Faerden A., Vaskinn A., Finset A., Agartz I., Ann B.E., Friis S., et al. Apathy is associated with executive functioning in first episode psychosis. BMC Psychiatry 2009, 9:1.
21. Fischl B., Salat D.H., Busa E., Albert M., Dieterich M., Haselgrove C., et al. Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 2002, 33:341-355.
22. Fisher H.L., Craig T.K., Fearon P., Morgan K., Dazzan P., Lappin J., et al. Reliability and comparability of psychosis patients' retrospective reports of childhood abuse. Schizophr Bull 2011, 37:546-553.
23. Flashman L.A., Green M.F. Review of cognition and brain structure in schizophrenia: profiles, longitudinal course, and effects of treatment. Psychiatr Clin North Am 2004, 27:1-18. [vii].
24. Goldstein G. Neuropsychological heterogeneity in schizophrenia: a consideration of abstraction and problem-solving abilities. Arch Clin Neuropsychol 1990, 5:251-264.
25. Hajek T., Kopecek M., Hoschl C. Reduced hippocampal volumes in healthy carriers of brain-derived neurotrophic factor Val66Met polymorphism: meta-analysis. World J Biol Psychiatry 2012, 13:178-187.
26. Hartberg C.B., Sundet K., Rimol L.M., Haukvik U.K., Lange E.H., Nesvag R., et al. Subcortical brain volumes relate to neurocognition in schizophrenia and bipolar disorder and healthy controls. Prog Neuropsychopharmacol Biol Psychiatry 2011, 35:1122-1130.
27. Heim C., Newport D.J., Heit S., Graham Y.P., Wilcox M., Bonsall R., et al. Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. JAMA 2000, 284:592-597.
28. Heim C., Mletzko T., Purselle D., Musselman D.L., Nemeroff C.B. The dexamethasone/corticotropin-releasing factor test in men with major depression: role of childhood trauma. Biol Psychiatry 2008, 63:398-405.
29. Heinrichs R.W., Awad A.G. Neurocognitive subtypes of chronic schizophrenia. Schizophr Res 1993, 9:49-58.
30. Hulshoff Pol H.E., Schnack H.G., Bertens M.G., van Haren N.E., van d.T., Staal W.G., et al. Volume changes in gray matter in patients with schizophrenia. Am J Psychiatry 2002, 159:244-250.
31. Ikeda Y., Yahata N., Ito I., Nagano M., Toyota T., Yoshikawa T., et al. Low serum levels of brain-derived neurotrophic factor and epidermal growth factor in patients with chronic schizophrenia. Schizophr Res 2008, 101:58-66.
32. Jensen C.L., Neugut Y.D., Champagne F.A. Sensitive periods for the impact of materinal care on offsprings behavior and region-specific gene expression. Soc Neurosci 2012, RR17:122.
33. Kauer-Sant'Anna M., Tramontina J., Andreazza A.C., Cereser K., da C.S., Santin A., et al. Traumatic life events in bipolar disorder: impact on BDNF levels and psychopathology. Bipolar Disord 2007, 9(Suppl. 1):128-135.
34. Kay S.R., Fiszbein A., Opler L.A. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987, 13:261-276.
35. Klengel T., Mehta D., Anacker C., Rex-Haffner M., Pruessner J.C., Pariante C.M., et al. Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nat Neurosci 2013, 16:33-41.
36. Lewin G.R., Barde Y.A. Physiology of the neurotrophins. Annu Rev Neurosci 1996, 19:289-317.
37. Miller S., Hallmayer J., Wang P.W., Hill S.J., Johnson S.L., Ketter T.A. Brain-derived neurotrophic factor val66met genotype and early life stress effects upon bipolar course. J Psychiatr Res 2013, 47:252-258.
38. Mondelli V., Dazzan P., Hepgul N., Di F.M., Aas M., D'Albenzio A., et al. Abnormal cortisol levels during the day and cortisol awakening response in first-episode psychosis: the role of stress and of antipsychotic treatment. Schizophr Res 2010, 116:234-242.
39. Mondelli V., Cattaneo A., Belvederi M.M., Di F.M., Handley R., Hepgul N., et al. Stress and inflammation reduce brain-derived neurotrophic factor expression in first-episode psychosis: a pathway to smaller hippocampal volume. J Clin Psychiatry 2011, 72:1677-1684.
40. Perez C.M., Widom C.S. Childhood victimization and long-term intellectual and academic outcomes. Child Abuse Negl 1994, 18:617-633.
41. Purcell S.M., Wray N.R., Stone J.L., Visscher P.M., O'Donovan M.C., Sullivan P.F., et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009, 460:748-752.
42. Read J., van O.J., Morrison A.P., Ross C.A. Childhood trauma, psychosis and schizophrenia: a literature review with theoretical and clinical implications. Acta Psychiatr Scand 2005, 112:330-350.
43. Reichenberg A., Harvey P.D. Neuropsychological impairments in schizophrenia: integration of performance-based and brain imaging findings. Psychol Bull 2007, 133:833-858.
44. Reichenberg A., Harvey P.D., Bowie C.R., Mojtabai R., Rabinowitz J., Heaton R.K., et al. Neuropsychological function and dysfunction in schizophrenia and psychotic affective disorders. Schizophr Bull 2009, 35:1022-1029.
45. Richter-Schmidinger T., Alexopoulos P., Horn M., Maus S., Reichel M., Rhein C., et al. Influence of brain-derived neurotrophic-factor and apolipoprotein E genetic variants on hippocampal volume and memory performance in healthy young adults. J Neural Transm 2011, 118:249-257.
46. Rimol L.M., Hartberg C.B., Nesvag R., Fennema-Notestine C., Hagler D.J., Pung C.J., et al. Cortical thickness and subcortical volumes in schizophrenia and bipolar disorder. Biol Psychiatry 2010, 68:41-50.
47. Ringen P.A., Lagerberg T.V., Birkenaes A.B.., Engn J., Faerden A., Jonsdottir H., et al. Differences in prevalence and patterns of substance use in schizophrenia and bipolar disorder. Psychol Med 2008, 38:1241-1249.
48. Roy A., Hu X.Z., Janal M.N., Goldman D. Interaction between childhood trauma and serotonin transporter gene variation in suicide. Neuropsychopharmacology 2007, 32:2046-2052.
49. Rund B.R., Melle I., Friis S., Larsen T.K., Midboe L.J., Opjordsmoen S., et al. Neurocognitive dysfunction in first-episode psychosis: correlates with symptoms, premorbid adjustment, and duration of untreated psychosis. Am J Psychiatry 2004, 161:466-472.
50. Rund B.R., Melle I., Friis S., Johannessen J.O., Larsen T.K., Midboe L.J., et al. The course of neurocognitive functioning in first-episode psychosis and its relation to premorbid adjustment, duration of untreated psychosis, and relapse. Schizophr Res 2007, 91:132-140.
51. Sapolsky R.M., Krey L.C., McEwen B.S. The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis. Endocr Rev 1986, 7:284-301.
52. Savitz J., van der Merwe L., Stein D.J., Solms M., Ramesar R. Genotype and childhood sexual trauma moderate neurocognitive performance: a possible role for brain-derived neurotrophic factor and apolipoprotein E variants. Biol Psychiatry 2007, 62:391-399.
53. Shenton M.E., Dickey C.C., Frumin M., McCarley R.W. A review of MRI findings in schizophrenia. Schizophr Res 2001, 49:1-52.
54. Shenton M.E., Whitford T.J., Kubicki M. Structural neuroimaging in schizophrenia: from methods to insights to treatments. Dialogues Clin Neurosci 2010, 12:317-332.
55. Shepherd A.M., Laurens K.R., Matheson S.L., Carr V.J., Green M.J. Systematic meta-review and quality assessment of the structural brain alterations in schizophrenia. Neurosci Biobehav Rev 2012, 36:1342-1356.
56. Shrout P.E., Fleiss J.L. Intraclass correlations: uses in assessing rater reliability. Psychol Bull 1979, 86:420-428.
57. Simon A.E., Cattapan-Ludewig K., Zmilacher S., Arbach D., Gruber K., Dvorsky D.N., et al. Cognitive functioning in the schizophrenia prodrome. Schizophr Bull 2007, 33:761-771.
58. Simonsen C., Sundet K., Vaskinn A., Birkenaes A.B.., Engh J.A., Faerden A., et al. Neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders depends on history of psychosis rather than diagnostic group. Schizophr Bull 2011, 37:73-83.
59. Steen R.G., Mull C., McClure R., Hamer R.M., Lieberman J.A. Brain volume in first-episode schizophrenia: systematic review and meta-analysis of magnetic resonance imaging studies. Br J Psychiatry 2006, 188:510-518.
60. Streiner D., Normann G. Health measurement scales: a practical guide to their development and use 1989, Oxford University Press.
61. Sun M.M., Yang L.M., Wang Y., Feng X., Cui K.Y., Liu L.F., et al. BDNF Val66Met polymorphism and anxiety/depression symptoms in schizophrenia in a Chinese Han population. Psychiatr Genet 2013, 23:124-129.
62. Teicher M.H. Scars that won't heal: the neurobiology of child abuse. Sci Am 2002, 286:68-75.
63. Teicher M.H., Anderson C.M., Polcari A. Childhood maltreatment is associated with reduced volume in the hippocampal subfields CA3, dentate gyrus, and subiculum. Proc Natl Acad Sci U S A 2012, 109:E563-E572.
64. van Os J., Kapur S. Psychosis: from diagnosis to syndrome. Ned Tijdschr Geneeskd 2010, 154:A1874.
65. Weaver I.C. Epigenetic programming by maternal behavior and pharmacological intervention. Nature versus nurture: let's call the whole thing off. Epigenetics 2007, 2:22-28.
66. Weaver I.C., Cervoni N., Champagne F.A., D'Alessio A.C., Sharma S., Seckl J.R., et al. Epigenetic programming by maternal behavior. Nat Neurosci 2004, 7:847-854.
67. Wechsler D. WAIS-III administration and scoring manual 1997, The Psychological Corporation, San Antonio, TX.
68. Wechsler D. Wechsler Appreviated Scale of Intelligence (WASI). Norwegian manual supplement 2007, Pearson Assessment, Stockholm.
69. Wolf O.T. HPA axis and memory. Best Pract Res Clin Endocrinol Metab 2003, 17:287-299.
70. Zanelli J., Reichenberg A., Morgan K., Fearon P., Kravariti E., Dazzan P., et al. Specific and generalized neuropsychological deficits: a comparison of patients with various first-episode psychosis presentations. Am J Psychiatry 2010, 167:78-85.