Role of mitochondria in apoptotic and necroptotic cell death in the developing brain

Clinica Chimica Acta

Volumn 451, Issue , 2015, Pages 35-38

  Thornton, Claire ^a   Hagberg, Henrik ^a,b  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Apoptosis; Hypoxia ischemia; Mitochondria; Necroptosis; Necrosis; Perinatal brain injury

Indexed keywords

ADAPTOR PROTEIN; CASPASE 8; DEATH RECEPTOR; FAS LIGAND; MIXED LINEAGE KINASE; MIXED LINEAGE KINASE DOMAIN LIKE PROTEIN; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; RIP1 PROTEIN; RIP3 PROTEIN; TOLL LIKE RECEPTOR AGONIST; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TWEAK PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BIOACCUMULATION; BRAIN DEVELOPMENT; BRAIN MITOCHONDRION; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; HYPOTHERMIA; HYPOXIC ISCHEMIC ENCEPHALOPATHY; INFLAMMATION; MALE; MITOCHONDRIAL PERMEABILITY; MITOCHONDRIAL RESPIRATION; MOUSE; NECROPTOSIS; NERVE CELL; NEWBORN; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN SECRETION; ANIMAL; APOPTOSIS; CELL DEATH; HUMAN; METABOLISM; MITOCHONDRION; NECROSIS; PATHOLOGY;

ANIMALS; APOPTOSIS; CELL DEATH; HUMANS; HYPOXIA-ISCHEMIA, BRAIN; MITOCHONDRIA; NECROSIS; NEURONS;

EID: 84945442810     PISSN: 00098981     EISSN: 18733492     Source Type: Journal    
DOI: 10.1016/j.cca.2015.01.026     Document Type: Article

References (53)

1. Hagberg H., Mallard C., Rousset C.I., Thornton C. Mitochondria: hub of injury responses in the developing brain. Lancet Neurol 2014, 13:217-232.
2. Blumberg R.M., Cady E.B., Wigglesworth J.S., McKenzie J.E., Edwards A.D. Relation between delayed impairment of cerebral energy metabolism and infarction following transient focal hypoxia-ischaemia in the developing brain. Exp Brain Res 1997, 113:130-137.
3. Johnston M.V., Fatemi A., Wilson M.A., Northington F. Treatment advances in neonatal neuroprotection and neurointensive care. Lancet Neurol 2011, 10:372-382.
4. Puka-Sundvall M., Gajkowska B., Cholewinski M., Blomgren K., Lazarewicz J.W., Hagberg H. Subcellular distribution of calcium and ultrastructural changes after cerebral hypoxia-ischemia in immature rats. Brain Res Dev Brain Res 2000, 125:31-41.
5. Blomgren K., Hagberg H. Free radicals, mitochondria, and hypoxia-ischemia in the developing brain. Free Radic Biol Med 2006, 40:388-397.
6. Perrone S., Negro S., Tataranno M.L., Buonocore G. Oxidative stress and antioxidant strategies in newborns. J Matern Fetal Neonatal Med 2010, 23(Suppl. 3):63-65.
7. Bernardi P., Krauskopf A., Basso E., et al. The mitochondrial permeability transition from in vitro artifact to disease target. FEBS J 2006, 273:2077-2099.
8. Schinzel A.C., Takeuchi O., Huang Z., et al. Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia. Proc Natl Acad Sci U S A 2005, 102:12005-12010.
9. Wang X., Carlsson Y., Basso E., et al. Developmental shift of cyclophilin D contribution to hypoxic-ischemic brain injury. J Neurosci 2009, 29:2588-2596.
10. Zhu C., Wang X., Deinum J., et al. Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia. J Exp Med 2007, 204:1741-1748.
11. Blomgren K., Zhu C., Wang X., et al. Synergistic activation of caspase-3 by m-calpain after neonatal hypoxia-ischemia: a mechanism of "pathological apoptosis"?. J Biol Chem 2001, 276:10191-10198.
12. Zhu C., Wang X., Xu F., et al. The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia. Cell Death Differ 2005, 12:162-176.
13. Thornton C., Rousset C.I., Kichev A., et al. Molecular mechanisms of neonatal brain injury. Neurol Res Int 2012, 2012:506320.
14. Merry D.E., Veis D.J., Hickey W.F., Korsmeyer S.J. bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS. Development 1994, 120:301-311.
15. Vekrellis K., McCarthy M.J., Watson A., Whitfield J., Rubin L.L., Ham J. Bax promotes neuronal cell death and is downregulated during the development of the nervous system. Development 1997, 124:1239-1249.
16. Wang X., Han W., Du X., et al. Neuroprotective effect of Bax-inhibiting peptide on neonatal brain injury. Stroke 2010, 41:2050-2055.
17. Vousden K.H., Lu X. Live or let die: the cell's response to p53. Nat Rev Cancer 2002, 2:594-604.
18. Nijboer C.H., Heijnen C.J., van der Kooij M.A., et al. Targeting the p53 pathway to protect the neonatal ischemic brain. Ann Neurol 2011, 70:255-264.
19. Lassus P., Opitz-Araya X., Lazebnik Y. Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization. Science 2002, 297:1352-1354.
20. Carlsson Y., Schwendimann L., Vontell R., et al. Genetic inhibition of caspase-2 reduces hypoxic-ischemic and excitotoxic neonatal brain injury. Ann Neurol 2011, 70:781-789.
21. Carlsson Y., Wang X., Schwendimann L., et al. Combined effect of hypothermia and caspase-2 gene deficiency on neonatal hypoxic-ischemic brain injury. Pediatr Res 2012, 71:566-572.
22. Chauvier D., Renolleau S., Holifanjaniaina S., et al. Targeting neonatal ischemic brain injury with a pentapeptide-based irreversible caspase inhibitor. Cell Death Dis 2011, 2:e203.
23. Sifringer M., Bendix I., Borner C., et al. Prevention of neonatal oxygen-induced brain damage by reduction of intrinsic apoptosis. Cell Death Dis 2012, 3:e250.
24. Galluzzi L., Vanden Berghe T., Vanlangenakker N., et al. Programmed necrosis from molecules to health and disease. Int Rev Cell Mol Biol 2011, 289:1-35.
25. Lu J.V., Chen H.C., Walsh C.M. Necroptotic signaling in adaptive and innate immunity. Semin Cell Dev Biol 2014, 35C:33-39.
26. Vandenabeele P., Galluzzi L., Vanden Berghe T., Kroemer G. Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol 2010, 11:700-714.
27. Northington F.J., Chavez-Valdez R., Graham E.M., Razdan S., Gauda E.B., Martin L.J. Necrostatin decreases oxidative damage, inflammation, and injury after neonatal HI. J Cereb Blood Flow Metab 2011, 31:178-189.
28. Wu J., Huang Z., Ren J., et al. Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis. Cell Res 2013, 23:994-1006.
29. Chen W., Zhou Z., Li L., et al. Diverse sequence determinants control human and mouse receptor interacting protein 3 (RIP3) and mixed lineage kinase domain-like (MLKL) interaction in necroptotic signaling. J Biol Chem 2013, 288:16247-16261.
30. Wang Z., Jiang H., Chen S., Du F., Wang X. The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 2012, 148:228-243.
31. Tait S.W., Oberst A., Quarato G., et al. Widespread mitochondrial depletion via mitophagy does not compromise necroptosis. Cell Rep 2013, 5(4):878-885.
32. Feng S., Yang Y., Mei Y., et al. Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain. Cell Signal 2007, 19:2056-2067.
33. Oberst A., Green D.R. It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival. Nat Rev Mol Cell Biol 2011, 12:757-763.
34. Tait S.W., Ichim G., Green D.R. Die another way-non-apoptotic mechanisms of cell death. J Cell Sci 2014, 127:2135-2144.
35. Declercq W., Takahashi N., Vandenabeele P. Dual face apoptotic machinery: from initiator of apoptosis to guardian of necroptosis. Immunity 2011, 35:493-495.
36. Kichev A., Rousset C.I., Baburamani A.A., et al. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signaling and cell death in the immature central nervous system after hypoxia-ischemia and inflammation. J Biol Chem 2014, 289:9430-9439.
37. Nelson K.B., Dambrosia J.M., Grether J.K., Phillips T.M. Neonatal cytokines and coagulation factors in children with cerebral palsy. Ann Neurol 1998, 44:665-675.
38. Markus T., Cronberg T., Cilio C., Pronk C., Wieloch T., Ley D. Tumor necrosis factor receptor-1 is essential for LPS-induced sensitization and tolerance to oxygen-glucose deprivation in murine neonatal organotypic hippocampal slices. J Cereb Blood Flow Metab 2009, 29:73-86.
39. Kendall G.S., Hristova M., Horn S., et al. TNF gene cluster deletion abolishes lipopolysaccharide-mediated sensitization of the neonatal brain to hypoxic ischemic insult. Lab Invest 2011, 91:328-341.
40. Graham E.M., Sheldon R.A., Flock D.L., et al. Neonatal mice lacking functional Fas death receptors are resistant to hypoxic-ischemic brain injury. Neurobiol Dis 2004, 17:89-98.
41. Potrovita I., Zhang W., Burkly L., et al. Tumor necrosis factor-like weak inducer of apoptosis-induced neurodegeneration. J Neurosci 2004, 24:8237-8244.
42. Cui M., Wang L., Liang X., et al. Blocking TRAIL-DR5 signaling with soluble DR5 reduces delayed neuronal damage after transient global cerebral ischemia. Neurobiol Dis 2010, 39:138-147.
43. Feng Y., Fratkin J.D., LeBlanc M.H. Inhibiting caspase-8 after injury reduces hypoxic-ischemic brain injury in the newborn rat. Eur J Pharmacol 2003, 481:169-173.
44. Chavez-Valdez R., Martin L.J., Flock D.L., Northington F.J. Necrostatin-1 attenuates mitochondrial dysfunction in neurons and astrocytes following neonatal hypoxia-ischemia. Neuroscience 2012, 219:192-203.
45. Fang A.Y., Gonzalez F.F., Sheldon R.A., Ferriero D.M. Effects of combination therapy using hypothermia and erythropoietin in a rat model of neonatal hypoxia-ischemia. Pediatr Res 2013, 73:12-17.
46. Olivier P., Fontaine R.H., Loron G., et al. Melatonin promotes oligodendroglial maturation of injured white matter in neonatal rats. PLoS One 2009, 4:e7128.
47. Welin A.K., Svedin P., Lapatto R., et al. Melatonin reduces inflammation and cell death in white matter in the mid-gestation fetal sheep following umbilical cord occlusion. Pediatr Res 2007, 61:153-158.
48. Wang X., Svedin P., Nie C., et al. N-acetylcysteine reduces lipopolysaccharide-sensitized hypoxic-ischemic brain injury. Ann Neurol 2007, 61:263-271.
49. Nijboer C.H., Bonestroo H.J., Zijlstra J., Kavelaars A., Heijnen C.J. Mitochondrial JNK phosphorylation as a novel therapeutic target to inhibit neuroinflammation and apoptosis after neonatal ischemic brain damage. Neurobiol Dis 2013, 54:432-444.
50. Kannan S., Dai H., Navath R.S., et al. Dendrimer-based postnatal therapy for neuroinflammation and cerebral palsy in a rabbit model. Sci Transl Med 2012, 4:30ra146.
51. Ohls R.K., Kamath-Rayne B.D., Christensen R.D., et al. Cognitive outcomes of preterm infants randomized to darbepoetin, erythropoietin, or placebo. Pediatrics 2014, 133:1023-1030.
52. Leuchter R.H., Gui L., Poncet A., et al. Association between early administration of high-dose erythropoietin in preterm infants and brain MRI abnormality at term-equivalent age. JAMA 2014, 312:817-824.
53. Johnston M.V., Hagberg H. Sex and the pathogenesis of cerebral palsy. Dev Med Child Neurol 2007, 49:74-78.