Partial support ventilation and mitochondrial-targeted antioxidants protect against ventilator-induced decreases in diaphragm muscle protein synthesis

PLoS ONE

Volumn 10, Issue 9, 2015, Pages

  Hudson, Matthew B ^a   Smuder, Ashley J ^b   Nelson, W Bradley ^c   Wiggs, Michael P ^b   Shimkus, Kevin L ^d   Fluckey, James D ^d   Szeto, Hazel H ^e   Powers, Scott K ^b  

^a TEMPLE UNIVERSITY   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c OHIO DOMINICAN UNIVERSITY   (United States)

^d TEXAS A AND M UNIVERSITY   (United States)

^e WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; MUSCLE PROTEIN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; PROTEIN KINASE B; TARGET OF RAPAMYCIN KINASE;

ADULT; ANIMAL EXPERIMENT; ARTICLE; ARTIFICIAL VENTILATION; BREATHING; CONTROLLED STUDY; DIAPHRAGM MUSCLE; FEMALE; IN VIVO STUDY; LUNG VENTILATION; MITOCHONDRION; MUSCLE ATROPHY; MUSCLE WEAKNESS; NONHUMAN; OXIDATIVE STRESS; PRESSURE SUPPORT VENTILATION; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; WESTERN BLOTTING; ADVERSE EFFECTS; ANIMAL; DIAPHRAGM; DISEASE MODEL; DRUG EFFECTS; MECHANICAL VENTILATOR; METABOLISM; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION; TIME FACTOR;

ANIMALS; ANTIOXIDANTS; DIAPHRAGM; DISEASE MODELS, ANIMAL; FEMALE; MITOCHONDRIA; MULTIPROTEIN COMPLEXES; MUSCLE WEAKNESS; OXIDATIVE STRESS; PROTEIN BIOSYNTHESIS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RESPIRATION; RESPIRATION, ARTIFICIAL; SIGNAL TRANSDUCTION; TIME FACTORS; TOR SERINE-THREONINE KINASES; VENTILATORS, MECHANICAL;

EID: 84945397595     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0137693     Document Type: Article

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