Inhibition of the ubiquitin-proteasome pathway does not protect against ventilator-induced accelerated proteolysis or atrophy in the diaphragm

Anesthesiology

Volumn 121, Issue 1, 2014, Pages 115-126

  Smuder, Ashley J ^a   Nelson, W Bradley ^b   Hudson, Matthew B ^c   Kavazis, Andreas N ^d   Powers, Scott K ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b OHIO DOMINICAN UNIVERSITY   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d AUBURN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATROGIN 1; CALPAIN; CASPASE 3; EPOXOMICIN; MUSCLE RING FINGER 1 PROTEIN; PROTEASOME; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3;

ACUTE RESPIRATORY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; DIAPHRAGM DISEASE; DIAPHRAGM MUSCLE; DRUG EFFECT; DRUG MECHANISM; FEMALE; MUSCLE ATROPHY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANESTHESIA; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ATROPHY; BLOTTING, WESTERN; BORONIC ACIDS; CASPASE 3; DIAPHRAGM; DNA, COMPLEMENTARY; FEMALE; MUSCLE CONTRACTION; MUSCLE PROTEINS; OLIGOPEPTIDES; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; PYRAZINES; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; RESPIRATION, ARTIFICIAL; SKP CULLIN F-BOX PROTEIN LIGASES; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES; VENTILATOR-INDUCED LUNG INJURY;

EID: 84902870086     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0000000000000245     Document Type: Article

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