Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients

American journal of respiratory and critical care medicine

Volumn 191, Issue 10, 2015, Pages 1126-1138

  Hooijman, Pleuni E ^a   Beishuizen, Albertus ^a   Witt, Christian C ^a   de Waard, Monique C ^a   Girbes, Armand R J ^a   Spoelstra de Man, Angelique M E ^a   Niessen, Hans W M ^a   Manders, Emmy ^a   van Hees, Hieronymus W H ^a   van den Brom, Charissa E ^a   Silderhuis, Vera ^a   Lawlor, Michael W ^a   Labeit, Siegfried ^a   Stienen, Ger J M ^a   Hartemink, Koen J ^a   Paul, Marinus A ^a   Heunks, Leo M A ^a   Ottenheijm, Coen A C ^a  

^a 1 Department of Physiology   (United States)

Author keywords

diaphragm weakness; mechanical ventilation; single muscle fiber; weaning failure

Indexed keywords

MUSCLE PROTEIN; PROTEASOME; TRIM63 PROTEIN, MOUSE; UBIQUITIN; UBIQUITIN PROTEIN LIGASE;

ADULT; ADVERSE EFFECTS; AGED; ANIMAL; ARTIFICIAL VENTILATION; BIOPSY; CASE CONTROL STUDY; CRITICAL ILLNESS; DIAPHRAGM; DISEASE MODEL; FEMALE; HUMAN; KNOCKOUT MOUSE; LENGTH OF STAY; MALE; METABOLISM; MIDDLE AGED; MOUSE; MUSCLE WEAKNESS; MUSCULAR ATROPHY; NETHERLANDS; PATHOLOGY; PATHOPHYSIOLOGY; SKELETAL MUSCLE CELL; VERY ELDERLY; WESTERN BLOTTING; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; BIOPSY; BLOTTING, WESTERN; CASE-CONTROL STUDIES; CRITICAL ILLNESS; DIAPHRAGM; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; LENGTH OF STAY; MALE; MICE; MICE, KNOCKOUT; MIDDLE AGED; MUSCLE FIBERS, SKELETAL; MUSCLE PROTEINS; MUSCLE WEAKNESS; MUSCULAR ATROPHY; NETHERLANDS; PROTEASOME ENDOPEPTIDASE COMPLEX; RESPIRATION, ARTIFICIAL; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES; YOUNG ADULT;

EID: 84989782434     PISSN: None     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201412-2214OC     Document Type: Article

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