Associations between serum levels of inflammatory markers and change in knee pain over 5 years in older adults: A prospective cohort study

Annals of the Rheumatic Diseases

Volumn 72, Issue 4, 2013, Pages 535-540

  Stannus, Oliver P ^a   Jones, Graeme ^a   Blizzard, Leigh ^a   Cicuttini, Flavia M ^b   Ding, Changhai ^a,b  

^a UNIVERSITY OF TASMANIA   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CARTILAGE DEGENERATION; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MARKER; FEMALE; HUMAN; JOINT EFFUSION; KNEE OSTEOARTHRITIS; KNEE PAIN; KNEE RADIOGRAPHY; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; SITTING; STANDING;

AGE DISTRIBUTION; AGED; ARTHRALGIA; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CARTILAGE, ARTICULAR; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTERLEUKIN-6; KNEE JOINT; LOGISTIC MODELS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; QUESTIONNAIRES; RISK FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84874445047     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2011-201047     Document Type: Article

References (49)

1. Zhai G, Blizzard L, Srikanth V, et al. Correlates of knee pain in older adults: Tasmanian Older Adult Cohort Study. Arthritis Rheum 2006;55:264-71.
2. Peat G, McCarney R, Croft P. Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care. Ann Rheum Dis 2001;60:91-7. (Pubitemid 32102197)
3. Dore D, Quinn S, Ding C, et al. Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: a prospective study in community dwelling older adults. Arthritis Res Ther 2010;12:R223.
4. Hill CL, Hunter DJ, Niu J, et al. Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis. Ann Rheum Dis 2007;66:1599-603. (Pubitemid 350205447)
5. Torres L, Dunlop DD, Peterfy C, et al. The relationship between specific tissue lesions and pain severity in persons with knee osteoarthritis. Osteoarthr Cartil 2006;14:1033-40. (Pubitemid 44321374)
6. Yusuf E, Kortekaas MC, Watt I, et al. Do knee abnormalities visualised on MRI explain knee pain in knee osteoarthritis? A systematic review. Ann Rheum Dis 2011;70:60-7.
7. Zhai G, Cicuttini F, Ding C, et al. Correlates of knee pain in younger subjects. Clin Rheumatol 2007;26:75-80. (Pubitemid 46020026)
8. Bondeson J, Wainwright SD, Lauder S, et al. The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis. Arthritis Res Ther 2006;8:R187.
9. Doss F, Menard J, Hauschild M, et al. Elevated IL-6 levels in the synovial fluid of osteoarthritis patients stem from plasma cells. Scand J Rheumatol 2007;36:136-9. (Pubitemid 46685758)
10. Fontana L, Eagon JC, Trujillo ME, et al. Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 2007;56:1010-13. (Pubitemid 46525079)
11. Goldring SR, Goldring MB. The role of cytokines in cartilage matrix degeneration in osteoarthritis. Clin Orthop Relat Res 2004;427:S27-36. (Pubitemid 39362798)
12. Klein-Wieringa IR, Kloppenburg M, Bastiaansen-Jenniskens YM, et al. The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype. Ann Rheum Dis 2011;70:851-7.
13. Ushiyama T, Chano T, Inoue K, et al. Cytokine production in the infrapatellar fat pad: another source of cytokines in knee synovial fluids. Ann Rheum Dis 2003;62:108-12. (Pubitemid 36135384)
14. Stannus O, Jones G, Cicuttini F, et al. Circulating levels of IL-6 and TNF-a are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults. Osteoarthr Cartil 2010;18:1441-7.
15. Stannus OP, Jones G, Quinn SJ, et al. The association between leptin, interleukin-6, and hip radiographic osteoarthritis in older people: a cross-sectional study. Arthritis Res Ther 2010;12:R95.
16. Livshits G, Zhai G, Hart DJ, et al. Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: the Chingford Study. Arthritis Rheum 2009;60:2037-45.
17. Ershler WB, Keller ET. Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu Rev Med 2000;51:245-70. (Pubitemid 30216036)
18. Spector TD, Hart DJ, Nandra D, et al. Low-level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease. Arthritis Rheum 1997;40:723-7. (Pubitemid 27157579)
19. Sharif M, Shepstone L, Elson CJ, et al. Increased serum C reactive protein may reflect events that precede radiographic progression in osteoarthritis of the knee. Ann Rheum Dis 2000;59:71-4. (Pubitemid 30303902)
20. Hanna FS, Bell RJ, Cicuttini FM, et al. High sensitivity C-reactive protein is associated with lower tibial cartilage volume but not lower patella cartilage volume in healthy women at mid-life. Arthritis Res Ther 2008;10:R27.
21. Brenner SS, Klotz U, Alscher DM, et al. Osteoarthritis of the knee - clinical assessments and inflammatory markers. Osteoarthr Cartil 2004;12:469-75. (Pubitemid 38696947)
22. Penninx BW, Abbas H, Ambrosius W, et al. Inflammatory markers and physical function among older adults with knee osteoarthritis. J Rheumatol 2004;31:2027-31. (Pubitemid 39336730)
23. Stürmer T, Brenner H, Koenig W, et al. Severity and extent of osteoarthritis and low grade systemic inflammation as assessed by high sensitivity C reactive protein. Ann Rheum Dis 2004;63:200-5. (Pubitemid 38122141)
24. Ding C, Parameswaran V, Udayan R, et al. Circulating levels of inflammatory markers predict change in bone mineral density and resorption in older adults: a longitudinal study. J Clin Endocrinol Metab 2008;93:1952-8. (Pubitemid 351656543)
25. Stratford PW, Kennedy DM, Woodhouse LJ, et al. Measurement properties of the WOMAC LK 3.1 pain scale. Osteoarthr Cartil 2007;15:266-72. (Pubitemid 46238250)
26. Jones G, Ding C, Scott F, et al. Early radiographic osteoarthritis is associated with substantial changes in cartilage volume and tibial bone surface area in both males and females. Osteoarthr Cartil 2004;12:169-74. (Pubitemid 38181124)
27. Bellamy N, Buchanan WW, Goldsmith CH, et al. Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol 1988;15:1833-40. (Pubitemid 19037656)
28. Angst F, Aeschlimann A, Stucki G. Smallest detectable and minimal clinically important differences of rehabilitation intervention with their implications for required sample sizes using WOMAC and SF-36 quality of life measurement instruments in patients with osteoarthritis of the lower extremities. Arthritis Rheum 2001;45:384-91. (Pubitemid 32738745)
29. Ding C, Garnero P, Cicuttini F, et al. Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen breakdown. Osteoarthr Cartil 2005;13:198-205. (Pubitemid 40277277)
30. Hunter DJ, Lo GH, Gale D, et al. The reliability of a new scoring system for knee osteoarthritis MRI and the validity of bone marrow lesion assessment: BLOKS (Boston Leeds Osteoarthritis Knee Score). Ann Rheum Dis 2008;67:206-11. (Pubitemid 351183309)
31. Hochberg Y. A sharper bonferroni procedure for multiple tests of significance. Biometrika 1988;75:800-2.
32. Richette P, Poitou C, Garnero P, et al. Benefits of massive weight loss on symptoms, systemic inflammation and cartilage turnover in obese patients with knee osteoarthritis. Ann Rheum Dis 2011;70:139-44.
33. Pelletier JP, Raynauld J P, Caron J, et al. Decrease in serum level of matrix metalloproteinases is predictive of the disease-modifying effect of osteoarthritis drugs assessed by quantitative MRI in patients with knee osteoarthritis. Ann Rheum Dis 2010;69:2095-101.
34. Shamsuzzaman AS, Winnicki M, Wolk R, et al. Independent association between plasma leptin and C-reactive protein in healthy humans. Circulation 2004;109:2181-5. (Pubitemid 38625394)
35. Kerkhof HJ, Bierma-Zeinstra SM, Castano-Betancourt MC, et al. Serum C reactive protein levels and genetic variation in the CRP gene are not associated with the prevalence, incidence or progression of osteoarthritis independent of body mass index. Ann Rheum Dis 2010;69:1976-82.
36. Pearle AD, Scanzello CR, George S, et al. Elevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings in patients with osteoarthritis. Osteoarthr Cartil 2007;15:516-23. (Pubitemid 46667712)
37. Felson DT. The sources of pain in knee osteoarthritis. Curr Opin Rheumatol 2005;17:624-8.
38. Wluka AE, Wolfe R, Stuckey S, et al. How does tibial cartilage volume relate to symptoms in subjects with knee osteoarthritis? Ann Rheum Dis 2004;63:264-8. (Pubitemid 38250668)
39. Rai MF, Rachakonda PS, Manning K, et al. Quantification of cytokines and inflammatory mediators in a three-dimensional model of inflammatory arthritis. Cytokine 2008;42:8-17.
40. Ning L, Ishijima M, Kaneko H, et al. Correlations between both the expression levels of inflammatory mediators and growth factor in medial perimeniscal synovial tissue and the severity of medial knee osteoarthritis. Int Orthop 2011;35:831-8.
41. Fernandes JC, Martel-Pelletier J, Pelletier J P. The role of cytokines in osteoarthritis pathophysiology. Biorheology 2002;39:237-46. (Pubitemid 34626067)
42. Attur MG, Patel IR, Patel RN, et al. Autocrine production of IL-1 beta by human osteoarthritis-affected cartilage and differential regulation of endogenous nitric oxide, IL-6, prostaglandin E2, and IL-8. Proc Assoc Am Physicians 1998;110:65-72. (Pubitemid 28051639)
43. Porée B, Kypriotou M, Chadjichristos C, et al. Interleukin-6 (IL-6) and/or soluble IL-6 receptor down-regulation of human type II collagen gene expression in articular chondrocytes requires a decrease of Sp1. Sp3 ratio and of the binding activity of both factors to the COL2A1 promoter. J Biol Chem 2008;283:4850-65.
44. Lo GH, McAlindon TE, Niu J, et al. Bone marrow lesions and joint effusion are strongly and independently associated with weight-bearing pain in knee osteoarthritis: data from the osteoarthritis initiative. Osteoarthr Cartil 2009;17:1562-9.
45. Uçeyler N, Schäfers M, Sommer C. Mode of action of cytokines on nociceptive neurons. Exp Brain Res 2009;196:67-78.
46. Andratsch M, Mair N, Constantin CE, et al. A key role for gp130 expressed on peripheral sensory nerves in pathological pain. J Neurosci 2009;29:13473-83.
47. Richter F, Natura G, Löser S, et al. Tumor necrosis factor causes persistent sensitization of joint nociceptors to mechanical stimuli in rats. Arthritis Rheum 2010;62:3806-14.
48. Brenn D, Richter F, Schaible HG. Sensitization of unmyelinated sensory fibers of the joint nerve to mechanical stimuli by interleukin-6 in the rat: an inflammatory mechanism of joint pain. Arthritis Rheum 2007;56:351-9. (Pubitemid 46106209)
49. Kumon Y, Suehiro T, Nishiya K, et al. Ferritin correlates with C-reactive protein and acute phase serum amyloid A in synovial fluid, but not in serum. Amyloid 1999;6:130-5. (Pubitemid 29362036)