Independent and combined effects of physical activity and weight loss on inflammatory biomarkers in overweight and obese older adults

Journal of the American Geriatrics Society

Volumn 61, Issue 7, 2013, Pages 1089-1094

  Beavers, Kristen M ^a   Ambrosius, Walter T ^a   Nicklas, Barbara J ^a   Rejeski, W Jack ^b  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b WAKE FOREST UNIVERSITY   (United States)

Author keywords

aging; inflammation; physical activity; weight loss

Indexed keywords

ADIPONECTIN; INTERLEUKIN 6; INTERLEUKIN 8; LEPTIN; TUMOR NECROSIS FACTOR RECEPTOR 1;

ADULT; AGED; AGING; ARTICLE; BODY MASS; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; FEMALE; GERIATRIC PATIENT; HEALTH EDUCATION; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; OBESITY; PHYSICAL ACTIVITY; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; WEIGHT REDUCTION;

AGING; INFLAMMATION; PHYSICAL ACTIVITY; WEIGHT LOSS;

ADIPONECTIN; AGED; ANALYSIS OF VARIANCE; BIOLOGICAL MARKERS; COMMUNITY HEALTH CENTERS; DIET, REDUCING; EXERCISE; FEMALE; HUMANS; INFLAMMATION; INTERLEUKIN-6; INTERLEUKIN-8; INTERVENTION STUDIES; LEPTIN; MALE; MIDDLE AGED; NORTH CAROLINA; OBESITY; OVERWEIGHT; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; TREATMENT OUTCOME; WEIGHT LOSS;

EID: 84880272767     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/jgs.12321     Document Type: Article

References (30)

1. Kritchevsky SB, Cesari M, Pahor M,. Inflammatory markers and cardiovascular health in older adults. Cardiovasc Res 2005; 66: 265-275.
2. Penninx BW, Kritchevsky SB, Newman AB, et al. Inflammatory markers and incident mobility limitation in the elderly. J Am Geriatr Soc 2004; 52: 1105-1113.
3. Beavers KM, Brinkley TE, Nicklas BJ,. Effect of exercise training on chronic inflammation. Clin Chim Acta 2010; 411: 785-793.
4. Goldhammer E, Tanchilevitch A, Maor I, et al. Exercise training modulates cytokines activity in coronary heart disease patients. Int J Cardiol 2005; 100: 93-99.
5. Larsen AI, Aukrust P, Aarsland T, et al. Effect of aerobic exercise training on plasma levels of tumor necrosis factor alpha in patients with heart failure. Am J Cardiol 2001; 88: 805-808.
6. Conraads VM, Beckers P, Bosmans J, et al. Combined endurance/resistance training reduces plasma TNF-alpha receptor levels in patients with chronic heart failure and coronary artery disease. Eur Heart J 2002; 23: 1854-1860.
7. Troseid M, Lappegard KT, Mollnes TE, et al. The effect of exercise on serum levels of interleukin-18 and components of the metabolic syndrome. Metab Syndr Relat Disord 2009; 7: 579-584.
8. Marcell TJ, McAuley KA, Traustadottir T, et al. Exercise training is not associated with improved levels of C-reactive protein or adiponectin. Metabolism 2005; 54: 533-541.
9. Hammett CJ, Oxenham HC, Baldi JC, et al. Effect of six months' exercise training on C-reactive protein levels in healthy elderly subjects. J Am Coll Cardiol 2004; 44: 2411-2413.
10. Nicklas BJ, Ambrosius W, Messier SP, et al. Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: A randomized controlled clinical trial. Am J Clin Nutr 2004; 79: 544-551.
11. Campbell KL, Campbell PT, Ulrich CM, et al. No reduction in C-reactive protein following a 12-month randomized controlled trial of exercise in men and women. Cancer Epidemiol Biomarkers Prev 2008; 17: 1714-1718.
12. Campbell PT, Campbell KL, Wener MH, et al. A yearlong exercise intervention decreases CRP among obese postmenopausal women. Med Sci Sports Exerc 2009; 41: 1533-1539.
13. Kadoglou NP, Iliadis F, Angelopoulou N, et al. The anti-inflammatory effects of exercise training in patients with type 2 diabetes mellitus. Eur J Cardiovasc Prev Rehabil 2007; 14: 837-843.
14. Tisi PV, Hulse M, Chulakadabba A, et al. Exercise training for intermittent claudication: Does it adversely affect biochemical markers of the exercise-induced inflammatory response? Eur J Vasc Endovasc Surg 1997; 14: 344-350.
15. Nicklas BJ, Hsu FC, Brinkley TJ, et al. Exercise training and plasma C-reactive protein and interleukin-6 in elderly people. J Am Geriatr Soc 2008; 56: 2045-2052.
16. Nawaz S, Walker RD, Wilkinson CH, et al. The inflammatory response to upper and lower limb exercise and the effects of exercise training in patients with claudication. J Vasc Surg 2001; 33: 392-399.
17. Kohut ML, McCann DA, Russell DW, et al. Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of beta-blockers, BMI, and psychosocial factors in older adults. Brain Behav Immun 2006; 20: 201-209.
18. Walther C, Mobius-Winkler S, Linke A, et al. Regular exercise training compared with percutaneous intervention leads to a reduction of inflammatory markers and cardiovascular events in patients with coronary artery disease. Eur J Cardiovasc Prev Rehabil 2008; 15: 107-112.
19. Beavers KM, Hsu FC, Isom S, et al. Long-term physical activity and inflammatory biomarkers in older adults. Med Sci Sports Exerc 2010; 42: 2189-2196.
20. Nicklas BJ, Beavers KM,. Exercise, weight loss, and effects on inflammation. Cardiovasc Risk Rep 2012; 4: 284-292.
21. Geffken DF, Cushman M, Burke GL, et al. Association between physical activity and markers of inflammation in a healthy elderly population. Am J Epidemiol 2001; 153: 242-250.
22. Pischon T, Hankinson SE, Hotamisligil GS, et al. Leisure-time physical activity and reduced plasma levels of obesity-related inflammatory markers. Obes Res 2003; 11: 1055-1064.
23. Colbert LH, Visser M, Simonsick EM, et al. Physical activity, exercise, and inflammatory markers in older adults: Findings from the Health, Aging and Body Composition Study. J Am Geriatr Soc 2004; 52: 1098-1104.
24. Rejeski WJ, Brubaker PH, Goff DC Jr., et al. Translating weight loss and physical activity programs into the community to preserve mobility in older, obese adults in poor cardiovascular health. Arch Intern Med 2011; 171: 880-886.
25. Simonsick EM, Montgomery PS, Newman AB, et al. Measuring fitness in healthy older adults: The Health ABC Long Distance Corridor Walk. J Am Geriatr Soc 2001; 49: 1544-1548.
26. Christiansen T, Paulsen SK, Bruun JM, et al. Exercise-training versus diet-induced weight-loss on metabolic risk factors and inflammatory markers in obese subjects. A 12-week randomized intervention-study. Am J Physiol Endocrinol Metab 2010; 298: E824-E831.
27. You T, Nicklas BJ,. Chronic inflammation: Role of adipose tissue and modulation by weight loss. Curr Diabetes Rev 2006; 2: 29-37.
28. Fain JN,. Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells. Vitam Horm 2006; 74: 443-477.
29. Alvarez-Llamas G, Szalowska E, de Vries MP, et al. Characterization of the human visceral adipose tissue secretome. Mol Cell Proteomics 2007; 6: 589-600.
30. Esposito K, Giugliano G, Scuderi N, et al. Role of adipokines in the obesity-inflammation relationship: The effect of fat removal. Plast Reconstr Surg 2006; 118: 1048-1057.