Deficiency of hyaluronan synthase 1 (Has1) results in chronic joint inflammation and widespread intra-articular fibrosis in a murine model of knee joint cartilage damage

Osteoarthritis and Cartilage

Volumn 23, Issue 11, 2015, Pages 1879-1889

  Chan, D D ^a   Xiao, W F ^b   Li, J ^a   de la Motte, C A ^c   Sandy, J D ^a   Plaas, A ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Cartilage; Fibrotic scar; Hyaluronan synthases; Inflammation; Injury; Synovium

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; CARISOPRODOL; CD40 ANTIGEN; COLLAGEN TYPE 3; COLLAGENASE 3; CXCL1 CHEMOKINE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; FAS ANTIGEN; FAS LIGAND; FIBROMODULIN; GELATINASE A; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HYALURONAN SYNTHASE 1; HYALURONIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 17; INTERLEUKIN 6; MANGANESE SUPEROXIDE DISMUTASE; MATRIX METALLOPROTEINASE 14; MYELOID DIFFERENTIATION FACTOR 88; NEUTROPHIL COLLAGENASE; PROTEIN BCL 2; RESERPINE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TRANSFORMING GROWTH FACTOR BETA3; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UNCLASSIFIED DRUG; GLUCURONOSYLTRANSFERASE; HYALURONAN SYNTHASE; RNA;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTHRITIS; ARTICLE; CARTILAGE DEGENERATION; CARTILAGE INJURY; CELL HYPERPLASIA; CHRONIC INFLAMMATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME DEFICIENCY; EXTRACELLULAR MATRIX; FIBROSIS; GENE EXPRESSION; HISTOPATHOLOGY; INJURY; INTRAARTICULAR FIBROSIS; KNEE OSTEOARTHRITIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SCAR FORMATION; SYNOVIUM; WOUND HEALING; ANIMAL; ARTICULAR CARTILAGE; BIOSYNTHESIS; C57BL MOUSE; CHRONIC DISEASE; DEFICIENCY; DISEASE MODEL; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; INFLAMMATION; INJURIES; KNEE; PATHOLOGY; POLYMERASE CHAIN REACTION;

ANIMALS; CARTILAGE, ARTICULAR; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; FIBROSIS; GENE EXPRESSION REGULATION; GLUCURONOSYLTRANSFERASE; INFLAMMATION; KNEE JOINT; MALE; MICE; MICE, INBRED C57BL; OSTEOARTHRITIS, KNEE; POLYMERASE CHAIN REACTION; RNA;

EID: 84945293491     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2015.06.021     Document Type: Article

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