Differing roles for urokinase and tissue-type plasminogen activator in collagen-induced arthritis

American Journal of Pathology

Volumn 160, Issue 3, 2002, Pages 917-926

  Cook, Andrew D ^a   Braine, Emma L ^a   Campbell, Ian K ^a   Hamilton, John A ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; COLLAGEN TYPE 2; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1BETA; TISSUE PLASMINOGEN ACTIVATOR; UROKINASE;

ADOLESCENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; FIBRIN DEPOSITION; KNOCKOUT MOUSE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIUM; T LYMPHOCYTE;

EID: 0036118456     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64914-0     Document Type: Article

References (46)

1. The plasminogen activator system: Biology and regulation
2. Urokinase-type plasminogen activator: Proenzyme, receptor, and inhibitors
3. Cell-associated plasminogen activation: Regulation and physiological functions
4. Membrane and matrix localization of proteinases: A common theme in tumor cell invasion and angiogenesis
5. Tissue plasminogen activator-mediated fibrinolysis protects against axonal degeneration and demyelination after sciatic nerve injury
6. Plasminogen activation in synovial tissues: Differences between normal, osteoarthritis, and rheumatoid arthritis joints
7. Stimulation of macrophage plasminogen activator by colony stimulating factors
8. Stimulation of human synovial fibroblast plasminogen activator production by mononuclear cell supernatants
9. Plasminogen activators and their inhibitors in arthritic disease
10. Fibrin: Metabolism, immunopathogenesis and significance in rheumatoid arthritis
11. Extravascular fibrin formation and dissolution in synovial tissue of patients with osteoarthritis and rheumatoid arthritis
12. Pathways of coagulation activation in situ in rheumatoid synovial tissue
13. Interleukin-1 beta and interleukin-1 alpha stimulate the plasminogen activator activity and prostaglandin E2 levels of human synovial cells
14. Recombinant human interleukin-1 stimulates human articular cartilage to undergo resorption and human chondrocytes to produce both tissue- and urokinase-type plasminogen activator
15. Recombinant human interleukin-1 inhibits plasminogen activator inhibitor-1 (PAI-1) production by human articular cartilage and chondrocytes
16. Independent regulation of plasminogen activator inhibitor 2 and plasminogen activator inhibitor 1 in human synovial fibroblasts
17. Physiological consequences of loss of plasminogen activator gene function in mice
18. Exacerbation of antigen-induced arthritis in urokinase-deficient mice
19. Collagen-induced arthritis, an animal model of autoimmunity
20. Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis
21. Anti-TNFα therapy of rheumatoid arthritis: What have we learned?
22. Protection from collagen-induced arthritis in granulocyte-macrophage colony-stimulating factor-deficient mice
23. b) mice: New insights into an important disease model of rheumatoid arthritis
24. Enhanced expression of genes involved in coagulation and fibrinolysis in murine arthritis
25. The colony-stimulating factors and collagen-induced arthritis: Exacerbation of disease by M-CSF and G-CSF and requirement for endogenous M-CSF
26. Blockade of collagen-induced arthritis post-onset by antibody to granulocytemacrophage colony-stimulating factor (GM-CSF): Requirement for GM-CSF in the effector phase of disease
27. IL-1αβ blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-α blockade only ameliorates joint inflammation
28. Amelioration of collagen-induced arthritis by thrombin inhibition
29. Clinical improvement and radiological deterioration in rheumatoid arthritis: Evidence that the pathogenesis of synovial inflammation and articular erosions may differ
30. Type II collagen-induced murine arthritis. I. Induction and perpetuation of arthritis require synergy between humoral and cell-mediated immunity
31. B cell-deficient mice do not develop type II collagen-induced arthritis (CIA)
32. Collagen-induced arthritis development requires alpha beta T cells but not gamma delta T cells: Studies with T cell-deficient (TCR mutant) mice
33. Genetic susceptibility to murine collagen II autoimmune arthritis. Proposed relationship to the IgG2 autoantibody subclass response, complement C5, major histocompatibility complex (MHC) and non-MHC loci
34. Attenuation of collagen-induced arthritis in 55-kDa TNF receptor type 1 (TNFR1)-IgG-treated and TNFR1-deficient mice
35. Tissue-type plasminogen activator deficiency exacerbates arthritis
36. Urokinase-dependent plasminogen activation is required for efficient skeletal muscle regeneration in vivo
37. Urokinase is required for the pulmonary inflammatory response to Cryptococcus neoformans. A murine transgenic model
38. Intracellular localization of human monocyte associated interleukin 1 (IL 1) activity and release of biologically active IL 1 from monocytes by trypsin and plasmin
39. Endogenously produced urokinase amplifies tumor necrosis factor-alpha secretion by THP-1 mononuclear phagocytes
40. Urokinase is required for T lymphocyte proliferation and activation in vitro
41. Relationship between Th1/Th2 cytokine patterns and the arthritogenic response in collagen-induced arthritis
42. Immunocytology in arthritic joints
43. Fibrin enhances the expression of IL-1 beta by human peripheral blood mononuclear cells. Implications in pulmonary inflammation
44. Plasminogen and plasminogen activators protect against renal injury in crescentic glomerulonephritis
45. Antiinflammatory activity of tissue plasminogen activator in the carrageenan rat footpad model