Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism

Arthritis Research and Therapy

Volumn 14, Issue 3, 2012, Pages

  Li, Jun ^a   Gorski, Daniel J ^a   Anemaet, Wendy ^a,b   Velasco, Jennifer ^a   Takeuchi, Jun ^c   Sandy, John D ^a   Plaas, Anna ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b REGIS UNIVERSITY   (United States)

^c SEIKAGAKU CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; AGGRECANASE 2; CD44V ANTIGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 10; COLLAGEN TYPE 2; COLLAGEN TYPE 3; COLLAGEN TYPE 5; COLLAGENASE 3; HYALURONIC ACID; TRANSFORMING GROWTH FACTOR BETA1; ADAM PROTEIN; ADAMTS5 PROTEIN, MOUSE; BETAIG H3 PROTEIN; BETAIG-H3 PROTEIN; HERMES ANTIGEN; SCLEROPROTEIN; TRANSCRIPTOME; TRANSFORMING GROWTH FACTOR BETA; VISCOSUPPLEMENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE INJURY; CONTROLLED STUDY; FIBROSIS; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; KINETICS; KNEE MENISCUS; KNEE OSTEOARTHRITIS; MALE; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; OSTEOARTHRITIS; POLYMERASE CHAIN REACTION; TREADMILL; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DISEASE MODEL; DRUG EFFECT; INTRAARTERIAL DRUG ADMINISTRATION; METABOLISM; MOUSE MUTANT; PATHOLOGY; SYNOVIUM; VASCULARIZATION;

ADAM PROTEINS; ANIMALS; ANTIGENS, CD44; CARTILAGE, ARTICULAR; DISEASE MODELS, ANIMAL; EXTRACELLULAR MATRIX PROTEINS; FIBROSIS; HYALURONIC ACID; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRA-ARTERIAL; MALE; MATRIX METALLOPROTEINASE 13; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOVASCULARIZATION, PATHOLOGIC; OSTEOARTHRITIS; POLYMERASE CHAIN REACTION; SYNOVIAL MEMBRANE; TRANSCRIPTOME; TRANSFORMING GROWTH FACTOR BETA; VISCOSUPPLEMENTS;

EID: 84862499349     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3887     Document Type: Article

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