Protective effect of gastrodin on bile duct ligation-induced hepatic fibrosis in rats

Food and Chemical Toxicology

Volumn 86, Issue , 2015, Pages 202-207

  Zhao, Shuangshuang ^a   Li, Naren ^a   Zhen, Yongzhan ^b   Ge, Maoxu ^a   Li, Yi ^a   Yu, Bin ^a   He, Hongwei ^a   Shao, Rong Guang ^a  

^a INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

^b HEBEI UNITED UNIVERSITY   (China)

Author keywords

Bile duct ligation; Gastrodin; Inflammation; Liver fibrosis; Oxidative stress

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILE ACID; BILIRUBIN; CD68 ANTIGEN; COLLAGEN; GASTRODIN; HIGH DENSITY LIPOPROTEIN; HYDROXYPROLINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MALONALDEHYDE; NITRIC OXIDE; SUPEROXIDE DISMUTASE; BENZYL ALCOHOL DERIVATIVE; GLUCOSIDE;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE ACID BLOOD LEVEL; BILE DUCT; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIPOPROTEIN BLOOD LEVEL; LIVER FIBROSIS; LIVER PROTECTION; MALE; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PROTEIN CONTENT; PROTEIN EXPRESSION; RAT; URINE LEVEL; ANIMAL; BILE; BLOOD; BLOOD ANALYSIS; CHEMISTRY; CHOLESTASIS; COMPLICATION; LIGATION; LIVER; LIVER CIRRHOSIS; METABOLISM; URINALYSIS;

ANIMALS; BENZYL ALCOHOLS; BILE; BLOOD CHEMICAL ANALYSIS; CHOLESTASIS; GLUCOSIDES; LIGATION; LIVER; LIVER CIRRHOSIS; RATS; URINALYSIS;

EID: 84945292453     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2015.10.010     Document Type: Article

References (26)

1. Bao Z.Q., Hu C.F., Sun L.P. The effect of gastrodine on hepatitic cell line L02 injury induced by ethanol. Chin. J. Cell Mol. Immunol. 2010, 26(3):211-213.
2. Bataller R., Brenner D.A. Liver fibrosis. J. Clin. Investig. 2005, 115(2):209-218.
3. Buko V.U., Lukivskaya O.Y., Naruta E.E., Belonovskaya E.B., Tauschel H.D. Protective effects of norursodeoxycholic acid versus ursodeoxycholic acid on thioacetamide-induced rat liver fibrosis. J. Clin. Exp. Hepatol. 2014, 4(4):293-301.
4. Dai J.N., Zong Y., Zhong L.M., Li Y.M., Zhang W., Bian L.G., Ai Q.L., Liu Y.D., Sun J., Lu D. Gastrodin inhibits expression of inducible NO synthase, cyclooxygenase-2 and proinflammatory cytokines in cultured LPS-stimulated microglia via MAPK pathways. PloS One 2011, 6(7):e21891.
5. Friedman S.L. Hepatic fibrosis-overview. Toxicology 2008, 254(3):120-129.
6. Giannini E.G., Testa R., Savarino V. Liver enzyme alteration: a guide for clinicians. Can. Med. Assoc. J. 2005, 172(3):367-379.
7. Guo J., Friedman S.L. Hepatic fibrogenesis. Semin. Liver Dis. 2007, 27(4):413-426.
8. Jaeschke H. Reactive oxygen and mechanisms of inflammatory liver injury: present concepts. J. Gastroenterol. Hepatol. 2011, 26(Suppl. 1):173-179.
9. Jiang G., Hu Y., Liu L., Cai J., Peng C., Li Q. Gastrodin protects against MPP(+)-induced oxidative stress by up regulates heme oxygenase-1 expression through p38 MAPK/Nrf2 pathway in human dopaminergic cells. Neurochem. Int. 2014, 75:79-88.
10. Kim H.J., Moon K.D., Oh S.Y., Kim S.P., Lee S.R. Ether fraction of methanol extracts of Gastrodia elata, a traditional medicinal herb, protects against kainic acid-induced neuronal damage in the mouse hippocampus. Neurosci. Lett. 2001, 314:65-68.
11. Kim T.W., Lee H.K., Song I.B., Lim J.H., Cho E.S., Son H.Y., Jung J.Y., Yun H.I. Platycodin D attenuates bile duct ligation-induced hepatic injury and fibrosis in mice. Food Chem. Toxicol. 2013, 51:364-369.
12. Li J., Fan R., Zhao S., Liu L., Guo S., Wu N., Zhang W., Chen P. Reactive oxygen species released from hypoxic hepatocytes regulates MMP-2 expression in hepatic stellate cells. Int. J. Mol. Sci. 2011, 12(4):2434-2447.
13. Liu X., Xu J., Brenner D.A., Kisseleva T. Reversibility of liver fibrosis and inactivation of fibrogenic myofibroblasts. Curr. Pathobiol. Rep. 2013, 1(3):209-214.
14. Luedde T., Schwabe R.F. NF-kappaB in the liver-linking injury, fibrosis and hepatocellular carcinoma. Nat. Rev. Gastroenterol. Hepatol. 2011, 8(2):108-118.
15. Novo E., Cannito S., Paternostro C., Bocca C., Miglietta A., Parola M. Cellular and molecular mechanisms in liver fibrogenesis. Arch. Biochem. Biophys. 2014, 548:20-37.
16. Ojemann L.M., Nelson W.L., Shin D.S., Rowe A.O., Buchanan R.A. Tian ma, an ancient Chinese herb, offers new options for the treatment of epilepsy and other conditions. Epilepsy Behav. 2006, 8(2):376-383.
17. Pacana T., Sanyal A.J. Vitamin E and nonalcoholic fatty liver disease. Curr. Opin. Clin. Nutr. Metab. Care 2012, 15(6):641-648.
18. Pan P.H., Lin S.Y., Wang Y.Y., Chen W.Y., Chuang Y.H., Wu C.C., Chen C.J. Protective effects of rutin on liver injury induced by biliary obstruction in rats. Free Radic. Boil. Med. 2014, 73:106-116.
19. Peng Z., Wang H., Zhang R., Chen Y., Xue F., Nie H., Chen Y., Wu D., Wang Y., Wang H. Gastrodin ameliorates anxiety-like behaviors and inhibits IL-1β level and p38 MAPK phosphorylation of hippocampus in the rat model of posttraumatic stress disorder. Physiol. Res. 2013, 62:537-545.
20. Sánchez-Valle V., Chávez-Tapia N.C., Uribe M., Méndez-Sánchez N. Role of oxidative stress and molecular changes in liver fibrosis: a review. Curr. Med. Chem. 2012, 19:4850-4860.
21. Tag C.G., Sauer-Lehnen S., Weiskirchen S., Borkham-Kamphorst E., Tolba R.H., Tacke F., Weiskirchen R. Bile duct ligation in mice: induction of inflammatory liver injury and fibrosis by obstructive cholestasis. J. Vis. Exp. 2015, 96:e52438.
22. Wang Z.P., Fu L., Liu L., Gao Y.L. Protective effect of gastrodin on liver injury mice induced by CCl4. Acta Acad. Med. CP AF 2008, 17(9):762-764.
23. Wang X.L., Xing G.H., Hong B., Li X.M., Zou Y., Zhang X.J., Dong M.X. Gastrodin prevents motor deficits and oxidative stress in the MPTP mouse model of Parkinson's disease: involvement of ERK1/2-Nrf2 signaling pathway. Life Sci. 2014, 114(2):77-85.
24. Wang H., Zhang R., Qiao Y., Xue F., Nie H., Zhang Z., Wang Y., Peng Z., Tan Q. Gastrodin ameliorates depression-like behaviors and up-regulates proliferation of hippocampal-derived neural stem cells in rats: involvement of its anti-inflammatory action. Behav. Brain Res. 2014, 266:153-160.
25. Yang P., Han Y., Gui L., Sun J., Chen Y.L., Song R., Guo J.Z., Xie Y.N., Lu D., Sun L. Gastrodin attenuation of the inflammatory response in H9c2 cardiomyocytes involves inhibition of NF-kappaB and MAPKs activation via the phosphatidylinositol 3-kinase signaling. Biochem. Pharm. 2013, 85(8):1124-1133.
26. Zhao S.S., Wang J.X., Wang Y.C., Shao R.G., He H.W. Establishment and application of a high-throughput drug screening model based on COL1A1 promoter for anti-liver fibrosis. Acta Pharm. Sin. 2015, 50(2):169-173.