Gastrodin ameliorates anxiety-like behaviors and inhibits IL-1β level and p38 MAPK phosphorylation of hippocampus in the rat model of posttraumatic stress disorder

Physiological Research

Volumn 62, Issue 5, 2013, Pages 537-545

  Peng, Z ^a   Wang, H ^a   Zhang, R ^a   Chen, Y ^a   Xue, F ^a   Nie, H ^a   Wu, D ^a   Wang, Y ^a   Tan, Q ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Gastrodin; IL 1 ; IL 6; iNOS; p38; PTSD

Indexed keywords

ANXIOLYTIC AGENT; BENZYL ALCOHOL DERIVATIVE; GASTRODIN; GLUCOSIDE; HERBACEOUS AGENT; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE P38; NOS2 PROTEIN, RAT;

ANIMAL; ANIMAL BEHAVIOR; ARTICLE; DISEASE MODEL; DRUG EFFECT; ENZYMOLOGY; HIPPOCAMPUS; MALE; METABOLISM; MOTOR ACTIVITY; ORAL DRUG ADMINISTRATION; PHOSPHORYLATION; POSTTRAUMATIC STRESS DISORDER; PSYCHOLOGICAL ASPECT; RAT; SPRAGUE DAWLEY RAT; TIME;

ADMINISTRATION, ORAL; ANIMALS; ANTI-ANXIETY AGENTS; BEHAVIOR, ANIMAL; BENZYL ALCOHOLS; DISEASE MODELS, ANIMAL; DRUGS, CHINESE HERBAL; GLUCOSIDES; HIPPOCAMPUS; INTERLEUKIN-1BETA; INTERLEUKIN-6; MALE; MOTOR ACTIVITY; NITRIC OXIDE SYNTHASE TYPE II; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; STRESS DISORDERS, POST-TRAUMATIC; TIME FACTORS;

EID: 84888772112     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. AHN EK, JEON HJ, LIM EJ, JUNG HJ, PARK EH: Anti-inflammatory and anti-angiogenic activities of Gastrodia elata Blume. J Ethnopharmacol 110: 476-482, 2007.
2. BAKER DG, EKHATOR NN, KASCKOW JW, HILL KK, ZOUMAKIS E, DASHEVSKY BA, CHROUSOS GP, GERACIOTI TD JR: Plasma and cerebrospinal fluid interleukin-6 concentrations in posttraumatic stress disorder. Neuroimmunomodulation 9: 209-217, 2001.
3. BASTERZI AD, AYDEMIR C, KISA C, AKSARAY S, TUZER V, YAZICI K, GÖKA E: IL-6 levels decrease with SSRI treatment in patients with major depression. Hum Psychopharmacol 20: 473-476, 2005.
4. BERGER W, MENDLOWICZ MV, MARQUES-PORTELLA C, KINRYS G, FONTENELLE LF, MARMAR CR, FIGUEIRA I: Pharmacologic alternatives to antidepressants in posttraumatic stress disorder: a systematic review. Prog Neuropsychopharmacol Biol Psychiatry 33: 169-180, 2009.
5. BESEDOVSKY HO, DEL REY A: Central and peripheral cytokines mediate immune-brain connectivity. Neurochem Res 36: 1-6, 2011.
6. BREMNER JD, ELZINGA B, SCHMAHL C, VERMETTEN E: Structural and functional plasticity of the human brain in posttraumatic stress disorder. Prog Brain Res 167: 171-186, 2008.
7. CHAE HJ, KIM SC, CHAE SW, AN NH, KIM HH, LEE ZH, KIM HR: Blockade of the p38 mitogen-activated protein kinase pathway inhibits inducible nitric oxide synthase and interleukin-6 expression in MC3T3E-1 osteoblasts. Pharmacol Res 43: 275-283, 2001.
8. CORCHS F, NUTT DJ, HOOD S, BERNIK M: Serotonin and sensitivity to trauma-related exposure in selective serotonin reuptake inhibitors-recovered posttraumatic stress disorder. Biol Psychiatry 66: 17-24, 2009.
9. CUNHA JM, MASUR J: Evaluation of psychotropic drugs with a modified open field test. Pharmacology 16: 259-267, 1978.
10. DA SILVA J, PIERRAT B, MARY JL, LESSLAUER W: Blockade of p38 mitogen-activated protein kinase pathway inhibits inducible nitric-oxide synthase expression in mouse astrocytes. J Biol Chem 272: 28373-28380, 1997.
11. DAI JN, ZONG Y, ZHONG LM, LI YM, ZHANG W, BIAN LG, AI QL, LIU YD, SUN J, LU D: Gastrodin inhibits expression of inducible NO synthase, cyclooxygenase-2 and proinflammatory cytokines in cultured LPS-stimulated microglia via MAPK pathways. PLoS One 6: e21891, 2011.
12. DEAK T, BORDNER KA, MCELDERRY NK, BARNUM CJ, BLANDINO P JR, DEAK MM, TAMMARIELLO SP: Stress-induced increases in hypothalamic IL-1: a systematic analysis of multiple stressor paradigms. Brain Res Bull 64: 541-556, 2005.
13. GILL J, VYTHILINGAM M, PAGE GG: Low cortisol, high DHEA, and high levels of stimulated TNF-alpha, and IL-6 in women with PTSD. J Trauma Stress 21: 530-539, 2008.
14. GUAN Z, BUCKMAN SY, SPRINGER LD, MORRISON AR: Both p38alpha(MAPK) and JNK/SAPK pathways are important for induction of nitric-oxide synthase by interleukin-1beta in rat glomerular mesangial cells. J Biol Chem 274: 36200-36206, 1999.
15. HARVEY BH, OOSTHUIZEN F, BRAND L, WEGENER G, STEIN DJ: Stress-restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus. Psychopharmacology (Berl) 175: 494-502, 2004.
16. HSIEH MT, WU CR, CHEN CF: Gastrodin and p-hydroxybenzyl alcohol facilitate memory consolidation and retrieval, but not acquisition, on the passive avoidance task in rats. J Ethnopharmacol 56: 45-54, 1997.
17. HUANG NK, LIN YL, CHENG JJ, LAI WL: Gastrodia elata prevents rat pheochromocytoma cells from serumdeprived apoptosis: the role of the MAPK family. Life Sci 75: 1649-1657, 2004.
18. JUNG JW, YOON BH, OH HR, AHN JH, KIM SY, PARK SY, RYU JH: Anxiolytic-like effects of Gastrodia elata and its phenolic constituents in mice. Biol Pharm Bull 29: 261-265, 2006.
19. KIM JJ, LEE HJ, WELDAY AC, SONG E, CHO J, SHARP PE, JUNG MW, BLAIR HT: Stress-induced alterations in hippocampal plasticity, place cells, and spatial memory. Proc Natl Acad Sci USA 104: 18297-18302, 2007.
20. KITAYAMA N, VACCARINO V, KUTNER M, WEISS P, BREMNER JD: Magnetic resonance imaging (MRI) measurement of hippocampal volume in posttraumatic stress disorder: a meta-analysis. J Affect Disord 88: 79-86, 2005.
21. KOO JW, DUMAN RS: IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress. Proc Natl Acad Sci USA 105: 751-756, 2008.
22. LIBERT S, POINTER K, BELL EL, DAS A, COHEN DE, ASARA JM, KAPUR K, BERGMANN S, PREISIG M, OTOWA T, KENDLER KS, CHEN X, HETTEMA JM, VAN DEN OORD EJ, RUBIO JP, GUARENTE L: SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive. Cell 147: 1459-1472, 2011.
23. LIN LC, CHEN YF, LEE WC, WU YT, TSAI TH: Pharmacokinetics of gastrodin and its metabolite p-hydroxybenzyl alcohol in rat blood, brain and bile by microdialysis coupled to LC-MS/MS. J Pharm Biomed Anal 48: 909-917, 2008.
24. LINDAUER RJ, OLFF M, VAN MEIJEL EP, CARLIER IV, GERSONS BP: Cortisol, learning, memory, and attention in relation to smaller hippocampal volume in police officers with posttraumatic stress disorder. Biol Psychiatry 59: 171-177, 2006.
25. LIU X, YANG LE J, FAN SJ, JIANG H, PAN F: Swimming exercise effects on the expression of HSP70 and iNOS in hippocampus and prefrontal cortex in combined stress. Neurosci Lett 476: 99-103, 2010.
26. MA X, LIU X, HU X, QIU C, WANG Y, HUANG Y, WANG Q, ZHANG W, LI T: Risk indicators for post-traumatic stress disorder in adolescents exposed to the 5.12 Wenchuan earthquake in China. Psychiatry Res 189: 385-391, 2011.
27. MAES M, DELMEIRE L, MYLLE J, ALTAMURA C: Risk and preventive factors of post-traumatic stress disorder (PTSD): alcohol consumption and intoxication prior to a traumatic event diminishes the relative risk to develop PTSD in response to that trauma. J Affect Disord 63: 113-121, 2001.
28. MCAFOOSE J, BAUNE BT: Evidence for a cytokine model of cognitive function. Neurosci Biobehav Rev 33: 355-366, 2009.
29. MONTEZUMA K, BIOJONE C, LISBOA SF, CUNHA FQ, GUIMARAES FS, JOCA SR: Inhibition of iNOS induces antidepressant-like effects in mice: pharmacological and genetic evidence. Neuropharmacology 62: 485-491, 2012.
30. OJEMANN LM, NELSON WL, SHIN DS, ROWE AO, BUCHANAN RA: Tian ma, an ancient Chinese herb, offers new options for the treatment of epilepsy and other conditions. Epilepsy Behav 8: 376-83, 2006.
31. ROSENBROCK H, KOROS E, BLOCHING A, PODHORNA J, BORSINI F: Effect of chronic intermittent restraint stress on hippocampal expression of marker proteins for synaptic plasticity and progenitor cell proliferation in rats. Brain Res 1040: 55-63, 2005.
32. SCHNEIER FR, NERIA Y, PAVLICOVA M, HEMBREE E, SUH EJ, AMSEL L, MARSHALL RD: Combined prolonged exposure therapy and paroxetine for PTSD related to the World Trade Center attack: a randomized controlled trial. Am J Psychiatry 169: 80-88, 2012.
33. SCHWARTZ M, SHECHTER R: Protective autoimmunity functions by intracranial immunosurveillance to support the mind: The missing link between health and disease. Mol Psychiatry 15: 342-354, 2010.
34. SKURLOVA M, STOFKOVA A, JURCOVICOVA J: Anxiety-like behavior in the elevated-plus maze tests and enhanced IL-1beta, IL-6, NADPH oxidase-1, and iNOS mRNAs in the hippocampus during early stage of adjuvant arthritis in rats. Neurosci Lett 487: 250-254, 2011.
35. STEIN MB, KLINE NA, MATLOFF JL: Adjunctive olanzapine for SSRI-resistant combat-related PTSD: a doubleblind, placebo-controlled study. Am J Psychiatry 159: 1777-1779, 2002.
36. TUCKER P, RUWE WD, MASTERS B, PARKER DE, HOSSAIN A, TRAUTMAN RP, WYATT DB: Neuroimmune and cortisol changes in selective serotonin reuptake inhibitor and placebo treatment of chronic posttraumatic stress disorder. Biol Psychiatry 56: 121-128, 2004.
37. VON KANEL R, HEPP U, KRAEMER B, TRABER R, KEEL M, MICA L, SCHNYDER U: Evidence for low-grade systemic proinflammatory activity in patients with posttraumatic stress disorder. J Psychiatr Res 41: 744-752, 2007.
38. WANG HN, PENG Y, TAN QR, CHEN YC, ZHANG RG, QIAO YT, WANG HH, LIU L, KUANG F, WANG BR, ZHANG ZJ: Quetiapine ameliorates anxiety-like behavior and cognitive impairments in stressed rats: implications for the treatment of posttraumatic stress disorder. Physiol Res 59: 263-271, 2010.
39. WANG HN, PENG Y, TAN QR, WANG HH, CHEN YC, ZHANG RG, WANG ZZ, GUO L, LIU Y, ZHANG ZJ: Free and Easy Wanderer Plus (FEWP), a polyherbal preparation, ameliorates PTSD-like behavior and cognitive impairments in stressed rats. Prog Neuropsychopharmacol Biol Psychiatry 33: 1458-1463, 2009.
40. WANG W, LIU Y, ZHENG H, WANG HN, JIN X, CHEN YC, ZHENG LN, LUO XX, TAN QR: A modified singleprolonged stress model for post-traumatic stress disorder. Neurosci Lett 441: 237-241, 2008.
41. XIA Z, DICKENS M, RAINGEAUD J, DAVIS RJ, GREENBERG ME: Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 1326-1331, 1995.
42. XU X, LU Y, BIE X: Protective effects of gastrodin on hypoxia-induced toxicity in primary cultures of rat cortical neurons. Planta Med 73: 650-654, 2007.
43. YANG J, HOU C, MA N, LIU J, ZHANG Y, ZHOU J, XU L, LI L: Enriched environment treatment restores impaired hippocampal synaptic plasticity and cognitive deficits induced by prenatal chronic stress. Neurobiol Learn Mem 87: 257-263, 2007.
44. YIRMIYA R, GOSHEN I: Immune modulation of learning, memory, neural plasticity and neurogenesis. Brain Behav Immun 25: 181-213, 2011.
45. YOSHIMURA R, HORI H, IKENOUCHI-SUGITA A, UMENE-NAKANO W, UEDA N, NAKAMURA J: Higher plasma interleukin-6 (IL-6) level is associated with SSRI-or SNRI-refractory depression. Prog Neuropsychopharmacol Biol Psychiatry 33: 722-726, 2009.
46. ZENG X, ZHANG S, ZHANG L, ZHANG K, ZHENG X: A study of the neuroprotective effect of the phenolic glucoside gastrodin during cerebral ischemia in vivo and in vitro. Planta Med 72: 1359-1365, 2006.
47. ZHAO X, ZOU Y, XU H, FAN L, GUO H, LI X, LI G, ZHANG X, DONG M: Gastrodin protect primary cultured rat hippocampal neurons against amyloid-beta peptide-induced neurotoxicity via ERK1/2-Nrf2 pathway. Brain Res 1482: 13-21, 2012.
48. ZHOU D, KUSNECOV AW, SHURIN MR, DEPAOLI M, RABIN BS: Exposure to physical and psychological stressors elevates plasma interleukin 6: relationship to the activation of hypothalamic-pituitary-adrenal axis. Endocrinology 133: 2523-2530, 1993.
49. ZOHAR J, AMITAL D, MIODOWNIK C, KOTLER M, BLEICH A, LANE RM, AUSTIN C: Double-blind placebocontrolled pilot study of sertraline in military veterans with posttraumatic stress disorder. J Clin Psychopharmacol 22: 190-195, 2002.