Platycodin D attenuates bile duct ligation-induced hepatic injury and fibrosis in mice

Food and Chemical Toxicology

Volumn 51, Issue 1, 2013, Pages 364-369

  Kim, Tae Won ^a   Lee, Hong Ki ^a   Song, In Bae ^a   Lim, Jong Hwan ^b   Cho, Eun Sang ^a   Son, Hwa Young ^a   Jung, Ju Young ^a   Yun, Hyo In ^a  

^a Chungnam National University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Bile duct ligation; Cholestasis; Liver fibrosis; Platycodin d

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MALONALDEHYDE; NITRIC OXIDE; PLATYCODIN; SAPONIN DERIVATIVE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE DUCT LIGATION; BILIRUBIN BLOOD LEVEL; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INTRAHEPATIC CHOLESTASIS; LIPID PEROXIDATION; LIVER FIBROSIS; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; TREATMENT DURATION;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BILE DUCTS; BILIRUBIN; CHOLESTASIS; DISEASE MODELS, ANIMAL; FIBROSIS; GLUTATHIONE; LIGATION; LIVER; MALE; MICE; MICE, INBRED ICR; NF-KAPPA B; OXIDATIVE STRESS; PROTECTIVE AGENTS; SAPONINS; SUPEROXIDE DISMUTASE; TRITERPENES;

MUS; PLATYCODON GRANDIFLORUM;

EID: 84868682436     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.10.017     Document Type: Article

References (29)

1. Ahn K.S., Noh E.J., Zhao H.L., Jung S.H., Kang S.S., Kim Y.S. Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-kappaB activation in RAW 264.7 cells. Life Sci. 2005, 76:2315-2328.
2. Aller M.A., Arias J.L., Garcia-Dominguez J., Arias J.I., Duran M., Arias J. Experimental obstructive cholestasis: the wound-like inflammatory liver response. Fibrogenesis Tissue Repair 2008, 1:6.
3. Arrese M., Trauner M. Molecular aspects of bile formation and cholestasis. Trends Mol. Med. 2003, 9:558-564.
4. Bogdan C. Nitric oxide and the immune response. Nat. Immunol. 2001, 2:907-916.
5. Clavien P.A., Petrowsky H., DeOliveira M.L., Graf R. Strategies for safer liver surgery and partial liver transplantation. N. Engl. J. Med. 2007, 356:1545-1559.
6. Copple B.L., Jaeschke H., Klaassen C.D. Oxidative stress and the pathogenesis of cholestasis. Semin. Liver Dis. 2010, 30:195-204.
7. Davis K.L., Martin E., Turko I.V., Murad F. Novel effects of nitric oxide. Annu. Rev. Pharmacol. Toxicol. 2001, 41:203-236.
8. Demirbilek S., Tas E., Gurunluoglu K., Akin M., Aksoy R.T., Emre M.H., Aydin N.E., Ay S., Ozatay N. Fluvastatin reduced liver injury in rat model of extrahepatic cholestasis. Pediatr. Surg. Int. 2007, 23:155-162.
9. Georgiev P., Jochum W., Heinrich S., Jang J.H., Nocito A., Dahm F., Clavien P.A. Characterization of time-related changes after experimental bile duct ligation. Br. J. Surg. 2008, 95:646-656.
10. Heinrich S., Georgiev P., Weber A., Vergopoulos A., Graf R., Clavien P.A. Partial bile duct ligation in mice: a novel model of acute cholestasis. Surgery 2010, 149:445-451.
11. Ishak K., Baptista A., Bianchi L., Callea F., De Groote J., Gudat F., Denk H., Desmet V., Korb G., MacSween R.N., et al. Histological grading and staging of chronic hepatitis. J. Hepatol. 1995, 22:696-699.
12. Khanal T., Choi J.H., Hwang Y.P., Chung Y.C., Jeong H.G. Saponins isolated from the root of Platycodon grandiflorum protect against acute ethanol-induced hepatotoxicity in mice. Food Chem. Toxicol. 2009, 47:530-535.
13. Kim Y.P., Lee E.B., Kim S.Y., Li D., Ban H.S., Lim S.S., Shin K.H., Ohuchi K. Inhibition of prostaglandin E2 production by platycodin D isolated from the root of Platycodon grandiflorum. Planta Med. 2001, 67:362-364.
14. Knodell R.G., Ishak K.G., Black W.C., Chen T.S., Craig R., Kaplowitz N., Kiernan T.W., Wollman J. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981, 1:431-435.
15. Kolouchova G., Brcakova E., Hirsova P., Sispera L., Tomsik P., Cermanova J., Hyspler R., Slanarova M., Fuksa L., Lotkova H., Micuda S. Pravastatin modulates liver bile acid and cholesterol homeostasis in rats with chronic cholestasis. J. Gastroenterol. Hepatol. 2011, 26:1544-1551.
16. Lee K.J., Choi J.H., Kim H.G., Han E.H., Hwang Y.P., Lee Y.C., Chung Y.C., Jeong H.G. Protective effect of saponins derived from the roots of Platycodon grandiflorum against carbon tetrachloride induced hepatotoxicity in mice. Food Chem. Toxicol. 2008, 46:1778-1785.
17. Lee K.J., You H.J., Park S.J., Kim Y.S., Chung Y.C., Jeong T.C., Jeong H.G. Hepatoprotective effects of Platycodon grandiflorum on acetaminophen-induced liver damage in mice. Cancer Lett. 2001, 174:73-81.
18. Lim J.H., Kim T.W., Park S.J., Song I.B., Kim M.S., Kwon H.J., Cho E.S., Son H.Y., Lee S.W., Suh J.W., Kim J.W., Yun H.I. Protective effects of Platycodon grandiflorum aqueous extract on thioacetamide-induced fulminant hepatic failure in mice. J. Toxicol. Pathol. 2011, 24:223-228.
19. Lin Y.L., Hsu Y.C., Chiu Y.T., Huang Y.T. Antifibrotic effects of a herbal combination regimen on hepatic fibrotic rats. Phytother. Res. 2008, 22:69-76.
20. Maillette de Buy Wenniger L., Beuers U. Bile salts and cholestasis. Dig. Liver Dis. 2010, 42:409-418.
21. Pastor A., Collado P.S., Almar M., GonzalezGallego J. Antioxidant enzyme status in biliary obstructed rats: effects of N-acetylcysteine. J. Hepatol. 1997, 27:363-370.
22. Ryu C.S., Kim C.H., Lee S.Y., Lee K.S., Choung K.J., Song G.Y., Kim B.H., Ryu S.Y., Lee H.S., Kim S.K. Evaluation of the total oxidant scavenging capacity of saponins isolated from Platycodon grandiflorum. Food Chem. 2012, 132:333-337.
23. Staels B., Fonseca V.A. Bile acids and metabolic regulation: mechanisms and clinical responses to bile acid sequestration. Diabetes Care 2009, 32(Suppl. 2):S237-S245.
24. Takagi K., Lee E.B. Pharmacological studies on Platycodon grandiflorum A. DC. 3. Activities of crude platycodin on respiratory and circulatory systems and its other pharmacological activities. Yakugaku Zasshi 1972, 92:969-973.
25. Wu J.T., Yang G.W., Wen W.J., Zhang F.M., An L.G. Cholesterol metabolism regulation and antioxidant effect of platycodin D on hyperlipidemic emulsion-reduced rats. Afr. J. Pharm. Pharmacol. 2011, 5:2444-2453.
26. Xie Q.W., Kashiwabara Y., Nathan C. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J. Biol. Chem. 1994, 269:4705-4708.
27. Xie Y., Sun H.X., Li D. Platycodin D is a potent adjuvant of specific cellular and humoral immune responses against recombinant hepatitis B antigen. Vaccine 2009, 27:757-764.
28. Yu J.S., Kim A.K. Platycodin D induces apoptosis in MCF-7 human breast cancer cells. J. Med. Food 2010, 13:298-305.
29. Zhao H.L., Cho K.H., Ha Y.W., Jeong T.S., Lee W.S., Kim Y.S. Cholesterol-lowering effect of platycodin D in hypercholesterolemic ICR mice. Eur. J. Pharmacol. 2006, 537:166-173.