Association between cardiorespiratory fitness and the determinants of glycemic control across the entire glucose tolerance continuum

Diabetes Care

Volumn 38, Issue 5, 2015, Pages 921-929

  Solomon, Thomas P J ^a,b   Malin, Steven K ^c   Karstoft, Kristian ^b   Knudsen, Sine H ^b   Haus, Jacob M ^d   Laye, Matthew J ^b   Kirwan, John P ^c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b University of Copenhagen   (Denmark)

^c LERNER RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; GLUCOSE; HEMOGLOBIN A1C; INSULIN; TRIACYLGLYCEROL; GLUCOSE BLOOD LEVEL;

AGE DISTRIBUTION; ARTICLE; BODY COMPOSITION; BODY FAT; BODY MASS; BODY WEIGHT; CARDIORESPIRATORY FITNESS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISPOSITION INDEX; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLYCEMIC CONTROL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN SENSITIVITY; METABOLIC PARAMETERS; ORAL GLUCOSE TOLERANCE TEST; PROTEIN BLOOD LEVEL; SEX DIFFERENCE; TRIACYLGLYCEROL BLOOD LEVEL; ANALYSIS OF VARIANCE; BLOOD; COHORT ANALYSIS; DIABETES MELLITUS, TYPE 2; DIET RESTRICTION; FEMALE; GLUCOSE TOLERANCE TEST; HYPERGLYCEMIA; INSULIN RESISTANCE; MALE; METABOLISM; MIDDLE AGED; OXYGEN CONSUMPTION; PANCREAS ISLET BETA CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; SECRETION (PROCESS);

ANALYSIS OF VARIANCE; BLOOD GLUCOSE; COHORT STUDIES; DIABETES MELLITUS, TYPE 2; FASTING; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; HYPERGLYCEMIA; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; MALE; MIDDLE AGED; OXYGEN CONSUMPTION;

EID: 84945279452     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc14-2813     Document Type: Article

References (33)

1. Jallut D, Golay A, Munger R, et al. Impaired glucose tolerance and diabetes in obesity: a 6-year follow-up study of glucose metabolism. Metabolism 1990;39:1068-1075
2. American Diabetes Association. Standards of medical care in diabetes - 2011. Diabetes Care 2011;34(Suppl. 1):S11-S61
3. Karstoft K, Winding K, Knudsen SH, et al. The effects of free-living interval-walking training on glycemic control, body composition, and physical fitness in type 2 diabetic patients: a randomized, controlled trial. Diabetes Care 2013;36:228-236
4. Balducci S, Zanuso S, Nicolucci A, et al, .; Italian Diabetes Exercise Study (IDES) Investigators. Effect of an intensive exercise intervention strategy on modifiable cardiovascular risk factors in subjects with type 2 diabetes mellitus: a randomized controlled trial: the Italian Diabetes and Exercise Study (IDES). Arch Intern Med 2010;170:1794-1803
5. 1c levels in patients with type 2 diabetes: a randomized controlled trial. JAMA 2010;304:2253-2262
6. Pan XR, Li GW, Hu YH, et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care 1997;20:537-544
7. Wei M, Gibbons LW, Mitchell TL, Kampert JB, Lee CD, Blair SN. The association between cardiorespiratory fitness and impaired fasting glucose and type 2 diabetes mellitus in men. Ann Intern Med 1999;130:89-96
8. Church TS, LaMonte MJ, Barlow CE, Blair SN. Cardiorespiratory fitness and body mass index as predictors of cardiovascular disease mortality among men with diabetes. Arch Intern Med 2005;165:2114-2120
9. Kirwan JP, Solomon TP, Wojta DM, Staten MA, Holloszy JO. Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2 diabetes mellitus. Am J Physiol Endocrinol Metab 2009;297:E151-E156
10. Solomon TP, Haus JM, Kelly KR, Rocco M, Kashyap SR, Kirwan JP. Improved pancreatic beta-cell function in type 2 diabetic patients after lifestyle-induced weight loss is related to glucose-dependent insulinotropic polypeptide. Diabetes Care 2010;33:1561-1566
11. Meex RC, Schrauwen-Hinderling VB, Moonen-Kornips E, et al. Restoration of muscle mitochondrial function and metabolic flexibility in type 2 diabetes by exercise training is paralleled by increased myocellular fat storage and improved insulin sensitivity. Diabetes 2010;59:572-579
12. O'Gorman DJ, Karlsson HK, McQuaid S, et al. Exercise training increases insulin-stimulated glucose disposal and GLUT4 (SLC2A4) protein content in patients with type 2 diabetes. Diabetologia 2006;49:2983-2992
13. Winnick JJ, Sherman WM, Habash DL, et al. Short-term aerobic exercise training in obese humans with type 2 diabetes mellitus improves whole-body insulin sensitivity through gains in peripheral, not hepatic insulin sensitivity. J Clin Endocrinol Metab 2008;93:771-778
14. Krotkiewski M, Lönnroth P, Mandroukas K, et al. The effects of physical training on insulin secretion and effectiveness and on glucose metabolism in obesity and type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1985;28:881-890
15. Dela F, von Linstow ME, Mikines KJ, Galbo H. Physical training may enhance beta-cell function in type 2 diabetes. Am J Physiol Endocrinol Metab 2004;287:E1024-E1031
16. Slentz CA, Tanner CJ, Bateman LA, et al. Effects of exercise training intensity on pancreatic beta-cell function. Diabetes Care 2009;32:1807-1811
17. Thamer C, Stumvoll M, Niess A, et al. Reduced skeletal muscle oxygen uptake and reduced beta-cell function: two early abnormalities in normal glucose-tolerant offspring of patients with type 2 diabetes. Diabetes Care 2003;26:2126-2132
18. Solomon TP, Sistrun SN, Krishnan RK, et al. Exercise and diet enhance fat oxidation and reduce insulin resistance in older obese adults. J Appl Physiol (1985) 2008;104:1313-1319
19. Solomon TP, Malin SK, Karstoft K, et al. Determining pancreatic β-cell compensation for changing insulin sensitivity using an oral glucose tolerance test. Am J Physiol Endocrinol Metab 2014;307:E822-E829
20. Meier JJ, Veldhuis JD, Butler PC. Pulsatile insulin secretion dictates systemic insulin delivery by regulating hepatic insulin extraction in humans. Diabetes 2005;54:1649-1656
21. Preacher KJ. Calculation for the test of the difference between two independent correlation coefficients [Internet], 2002. Available from http://quantpsy.org. Accessed 15 January 2015
22. Balducci S, Zanuso S, Cardelli P, et al, .; Italian Diabetes Exercise Study (IDES) Investigators. Changes in physical fitness predict improvements in modifiable cardiovascular risk factors independently of body weight loss in subjects with type 2 diabetes participating in the Italian Diabetes and Exercise Study (IDES). Diabetes Care 2012;35:1347-1354
23. Boulé NG, Weisnagel SJ, Lakka TA, et al, .; HERITAGE Family Study. Effects of exercise training on glucose homeostasis: the HERITAGE Family Study. Diabetes Care 2005;28:108-114
24. Maarbjerg SJ, Sylow L, Richter EA. Current understanding of increased insulin sensitivity after exercise - emerging candidates. Acta Physiol (Oxf) 2011;202:323-335
25. Holloszy JO. A forty-year memoir of research on the regulation of glucose transport into muscle. Am J Physiol Endocrinol Metab 2003;284:E453-E467
26. Rosenthal M, Haskell WL, Solomon R, Widstrom A, Reaven GM. Demonstration of a relationship between level of physical training and insulin-stimulated glucose utilization in normal humans. Diabetes 1983;32:408-411
27. Malin SK, Solomon TP, Blaszczak A, Finnegan S, Filion J, Kirwan JP. Pancreatic β-cell function increases in a linear dose-response manner following exercise training in adults with prediabetes. Am J Physiol Endocrinol Metab 2013;305:E1248-E1254
28. Chen Z, Black MH, Watanabe RM, et al. Self-reported physical activity is associated with β-cell function in Mexican American adults. Diabetes Care 2013;36:638-644
29. Bouchard C, An P, Rice T, et al. Familial aggregation of VO(2max) response to exercise training: results from the HERITAGE Family Study. J Appl Physiol (1985) 1999;87:1003-1008
30. Narendran P, Solomon TP, Kennedy A, Chimen M, Andrews RC. The time has come to test the beta cell preserving effects of exercise in patients with new onset type 1 diabetes. Diabetologia 2015;58:10-18
31. 1(c) in type 2 diabetes mellitus. Diabetologia 2011;54:93-102
32. Solomon TP, Malin SK, Karstoft K, Kashyap SR, Haus JM, Kirwan JP. Pancreatic β-cell function is a stronger predictor of changes in glycemic control after an aerobic exercise intervention than insulin sensitivity. J Clin Endocrinol Metab 2013;98:4176-4186
33. Eriksen L, Dahl-Petersen I, Haugaard SB, Dela F. Comparison of the effect of multiple short-duration with single long-duration exercise sessions on glucose homeostasis in type 2 diabetes mellitus. Diabetologia 2007;50:2245-2253