Improved pancreatic β-cell function in type 2 diabetic patients after lifestyle-induced weight loss is related to glucose-dependent insulinotropic polypeptide

Diabetes Care

Volumn 33, Issue 7, 2010, Pages 1561-1566

  Solomon, Thomas P J ^a   Haus, Jacob M ^a,b   Kelly, Karen R ^a,c   Rocco, Michael ^a   Kashyap, Sangeeta R ^a   Kirwan, John P ^a,b,c  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; GASTRIC INHIBITORY POLYPEPTIDE; INCRETIN; INSULIN; LEPTIN; TRIACYLGLYCEROL;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; BODY COMPOSITION; BODY MASS; CELL FUNCTION; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC PATIENT; DIET RESTRICTION; DIETARY INTAKE; EXERCISE; FEMALE; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE; HUMAN; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIFESTYLE MODIFICATION; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NUTRITIONAL COUNSELING; OBESITY; PANCREAS ISLET BETA CELL; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT REDUCTION; BLOOD; CLINICAL TRIAL; DIET THERAPY; FITNESS; GLUCOSE BLOOD LEVEL; HYPERINSULINISM; LIFESTYLE; LOW CALORY DIET; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY;

AGED; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DIET, REDUCING; EXERCISE; FEMALE; GASTRIC INHIBITORY POLYPEPTIDE; GLUCOSE CLAMP TECHNIQUE; HUMANS; HYPERINSULINISM; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; LIFE STYLE; MALE; MIDDLE AGED; OBESITY; PHYSICAL FITNESS; WEIGHT LOSS;

EID: 77955638311     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc09-2021     Document Type: Article

References (25)

1. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002;346:393-403
2. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2009;32(Suppl. 1):S62-S67
3. DeFronzo RA. Lilly Lecture 1987: The triumvirate: β-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 1988;37:667-687
4. Slentz CA, Tanner CJ, Bateman LA, Durheim MT, Huffman KM, Houmard JA, Kraus WE. Effects of exercise training intensity on pancreatic β-cell function. Diabetes Care 2009;32:1807-1811
5. Bloem CJ, Chang AM. Short-term exercise improves β-cell function and insulin resistance in older people with impaired glucose tolerance. J Clin Endocrinol Metab 2008;93:387-392
6. Kahn SE, Larson VG, Beard JC, Cain KC, Fellingham GW, Schwartz RS, Veith RC, Stratton JR, Cerqueira MD, Abrass IB. Effect of exercise on insulin action, glucose tolerance, and insulin secretion in aging. Am J Physiol 1990;258:E937-E943
7. Utzschneider KM, Carr DB, Barsness SM, Kahn SE, Schwartz RS. Diet-induced weight loss is associated with an improvement in β-cell function in older men. J Clin Endocrinol Metab 2004;89:2704-2710
8. O'Leary VB, Marchetti CM, Krishnan RK, Stetzer BP, Gonzalez F, Kirwan JP. Exercise-induced reversal of insulin resistance in obese elderly is associated with reduced visceral fat. J Appl Physiol 2006;100:1584-1589
9. Toledo FG, Menshikova EV, Ritov VB, Azuma K, Radikova Z, DeLany J, Kelley DE. Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in type 2 diabetes. Diabetes 2007;56:2142-2147
10. Bruce CR, Kriketos AD, Cooney GJ, Hawley JA. Disassociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with type 2 diabetes. Diabetologia 2004;47:23-30
11. Kelly KR, Brooks LM, Solomon TP, Kashyap SR, O'Leary VB, Kirwan JP. The glucose-dependent insulinotropic polypeptide and glucose-stimulated insulin response to exercise training and diet in obesity. Am J Physiol Endocrinol Metab 2009;296:E1269-E1274
12. Kashyap SR, Daud S, Kelly KR, Win H, Gastaldelli A, Kirwan JP, Brethuaer S, Schauer PS. Acute effects of gastric bypass vs. gastric restriction on pancreatic β-cell function and insulinotropic hormones in patients with type 2 diabetes. Int J Obes (Lond) 2010;34:462-471
13. Bunck MC, Diamant M, Cornér A, Eliasson B, Malloy JL, Shaginian RM, Deng W, Kendall DM, Taskinen MR, Smith U, Yki-Järvinen H, Heine RJ. One-year treatment with exenatide improves β-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: a randomized, controlled trial. Diabetes Care 2009;32:762-768
14. Abdul-Ghani MA, Williams K, DeFronzo R, Stern M. Risk of progression to type 2 diabetes based on relationship between postload plasma glucose and fasting plasma glucose. Diabetes Care 2006;29: 1613-1618
15. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979;237:E214-E223
16. Gastaldelli A, Ferrannini E, Miyazaki Y, Matsuda M, DeFronzo RA. β-Cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study. Diabetologia 2004;47:31-39
17. Henry RR, Brechtel G, Griver K. Secretion and hepatic extraction of insulin after weight loss in obese noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1988;66:979-986
18. Kelley DE, Wing R, Buonocore C, Sturis J, Polonsky K, Fitzsimmons M. Relative effects of calorie restriction and weight loss in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1993;77: 1287-1293
19. Gumbiner B, Polonsky KS, Beltz WF, Griver K, Wallace P, Brechtel G, Henry RR. Effects of weight loss and reduced hyperglycemia on the kinetics of insulin secretion in obese non-insulin dependent diabetes mellitus. J Clin Endocrinol Metab 1990;70:1594-1602
20. Bogardus C, Ravussin E, Robbins DC, Wolfe RR, Horton ES, Sims EA. Effects of physical training and diet therapy on carbohydrate metabolism in patients with glucose intolerance and non-insulin-dependent diabetes mellitus. Diabetes 1984; 33:311-318
21. Dela F, von Linstow ME, Mikines KJ, Galbo H. Physical training may enhance β-cell function in type 2 diabetes. Am J Physiol Endocrinol Metab 2004;287: E1024-E1031
22. Rossetti L, Shulman GI, Zawalich W, De-Fronzo RA. Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats. J Clin Invest 1987;80:1037-1044
23. Xu G, Kaneto H, Laybutt DR, Duvivier-Kali VF, Trivedi N, Suzuma K, King GL, Weir GC, Bonner-Weir S. Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes 2007;56:1551-1558
24. Mooney MH, Abdel-Wahab YH, Morgan LM, O'Harte FP, Flatt PR. Detection of glycated gastric inhibitory polypeptide within the intestines of diabetic obese (ob/ ob) mice. Endocrine 2001;16:167-171
25. Schauer PR, Burguera B, Ikramuddin S, Cottam D, Gourash W, Hamad G, Eid GM, Mattar S, Ramanathan R, Barinas-Mitchel E, Rao RH, Kuller L, Kelley D. Effect of laparoscopic Roux-en Y gastric bypass on type 2 diabetes mellitus. Ann Surg 2003;238:467-484; discussion 484-485