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Volumn 58, Issue 1, 2015, Pages 10-18

The time has come to test the beta cell preserving effects of exercise in patients with new onset type 1 diabetes

Author keywords

Beta cell; Exercise; Immune intervention; Type 1 diabetes

Indexed keywords

EXENDIN 4; GEVOKIZUMAB; GLUCOSE; INSULIN; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; STREPTOZOCIN;

EID: 84916607677     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3412-8     Document Type: Editorial
Times cited : (27)

References (68)
  • 1
    • 0035928391 scopus 로고    scopus 로고
    • Type 1 diabetes: new perspectives on disease pathogenesis and treatment
    • COI: 1:CAS:528:DC%2BD3MXltlymsr0%3D, PID: 11476858
    • Atkinson MA, Eisenbarth GS (2001) Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet 358:221–229
    • (2001) Lancet , vol.358 , pp. 221-229
    • Atkinson, M.A.1    Eisenbarth, G.S.2
  • 2
    • 31844443691 scopus 로고    scopus 로고
    • Natural history of beta-cell function in type 1 diabetes
    • COI: 1:CAS:528:DC%2BD2MXht12gs7nM, PID: 16306337
    • Sherry NA, Tsai EB, Herold KC (2005) Natural history of beta-cell function in type 1 diabetes. Diabetes 54(Suppl 2):S32–S39
    • (2005) Diabetes , vol.54 , pp. S32-S39
    • Sherry, N.A.1    Tsai, E.B.2    Herold, K.C.3
  • 3
    • 84890999355 scopus 로고    scopus 로고
    • The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells
    • COI: 1:CAS:528:DC%2BC3sXhs1WhsrrL, PID: 24121625
    • Oram RA, Jones AG, Besser REJ et al (2014) The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells. Diabetologia 57:187–191
    • (2014) Diabetologia , vol.57 , pp. 187-191
    • Oram, R.A.1    Jones, A.G.2    Besser, R.E.J.3
  • 4
    • 0041666293 scopus 로고    scopus 로고
    • Beta-cell function and the development of diabetes-related complications in the diabetes control and complications trial
    • PID: 12610045
    • Steffes MW, Sibley S, Jackson M, Thomas W (2003) Beta-cell function and the development of diabetes-related complications in the diabetes control and complications trial. Diabetes Care 26:832–836
    • (2003) Diabetes Care , vol.26 , pp. 832-836
    • Steffes, M.W.1    Sibley, S.2    Jackson, M.3    Thomas, W.4
  • 5
    • 84876089704 scopus 로고    scopus 로고
    • Progress in immune-based therapies for type 1 diabetes
    • von Herrath M, Peakman M, Roep B (2013) Progress in immune-based therapies for type 1 diabetes. Clin Exp Immunol 172:186–202
    • (2013) Clin Exp Immunol , vol.172 , pp. 186-202
    • von Herrath, M.1    Peakman, M.2    Roep, B.3
  • 6
    • 84876960512 scopus 로고    scopus 로고
    • Reactivation of latent viruses in individuals receiving rituximab for new onset type 1 diabetes
    • COI: 1:CAS:528:DC%2BC3sXis1Oru70%3D, PID: 23422292
    • Kroll JL, Beam C, Li S et al (2013) Reactivation of latent viruses in individuals receiving rituximab for new onset type 1 diabetes. J Clin Virol 57:115–119
    • (2013) J Clin Virol , vol.57 , pp. 115-119
    • Kroll, J.L.1    Beam, C.2    Li, S.3
  • 7
    • 77949513969 scopus 로고    scopus 로고
    • Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients
    • COI: 1:CAS:528:DC%2BC3cXisFyrt7c%3D, PID: 20007541
    • Keymeulen B, Candon S, Fafi-Kremer S et al (2010) Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients. Blood 115:1145–1155
    • (2010) Blood , vol.115 , pp. 1145-1155
    • Keymeulen, B.1    Candon, S.2    Fafi-Kremer, S.3
  • 8
    • 84930763863 scopus 로고    scopus 로고
    • The rise, fall, and resurgence of immunotherapy in type 1 diabetes
    • Ben Nasr M, D’Addio F, Usuelli V et al (2014) The rise, fall, and resurgence of immunotherapy in type 1 diabetes. Pharmacol Res. doi:10.1016/j.phrs.2014.07.004
    • (2014) Pharmacol Res
    • Ben Nasr, M.1    D’Addio, F.2    Usuelli, V.3
  • 9
    • 0024586904 scopus 로고
    • Growth hormone is a growth factor for the differentiated pancreatic beta-cell
    • COI: 1:CAS:528:DyaL1MXhtVylsrw%3D, PID: 2644530
    • Nielsen JH, Linde S, Welinder BS et al (1989) Growth hormone is a growth factor for the differentiated pancreatic beta-cell. Mol Endocrinol 3:165–173
    • (1989) Mol Endocrinol , vol.3 , pp. 165-173
    • Nielsen, J.H.1    Linde, S.2    Welinder, B.S.3
  • 10
    • 27644571687 scopus 로고    scopus 로고
    • STAT5 activation by human GH protects insulin-producing cells against interleukin-1β, interferon-γ and tumour necrosis factor-α-induced apoptosis independent of nitric oxide production
    • COI: 1:CAS:528:DC%2BD2MXhtF2itLrK, PID: 16214938
    • Jensen J, Galsgaard ED, Karlsen AE et al (2005) STAT5 activation by human GH protects insulin-producing cells against interleukin-1β, interferon-γ and tumour necrosis factor-α-induced apoptosis independent of nitric oxide production. J Endocrinol 187:25–36
    • (2005) J Endocrinol , vol.187 , pp. 25-36
    • Jensen, J.1    Galsgaard, E.D.2    Karlsen, A.E.3
  • 11
    • 33747884524 scopus 로고    scopus 로고
    • Exercise and dexamethasone oppositely modulate beta-cell function and survival via independent pathways in 90% pancreatectomized rats
    • COI: 1:CAS:528:DC%2BD28Xpt1Wjtbk%3D, PID: 16899580
    • Choi SB, Jang JS, Hong SM et al (2006) Exercise and dexamethasone oppositely modulate beta-cell function and survival via independent pathways in 90% pancreatectomized rats. J Endocrinol 190:471–482
    • (2006) J Endocrinol , vol.190 , pp. 471-482
    • Choi, S.B.1    Jang, J.S.2    Hong, S.M.3
  • 12
    • 35649016075 scopus 로고    scopus 로고
    • Exercise improves glucose homeostasis that has been impaired by a high-fat diet by potentiating pancreatic beta-cell function and mass through IRS2 in diabetic rats
    • COI: 1:CAS:528:DC%2BD2sXhtlyrtr3O, PID: 17761790
    • Park S, Hong SM, Lee JE, Sung SR (2007) Exercise improves glucose homeostasis that has been impaired by a high-fat diet by potentiating pancreatic beta-cell function and mass through IRS2 in diabetic rats. J Appl Physiol 103:1764–1771
    • (2007) J Appl Physiol , vol.103 , pp. 1764-1771
    • Park, S.1    Hong, S.M.2    Lee, J.E.3    Sung, S.R.4
  • 13
    • 81255157471 scopus 로고    scopus 로고
    • Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
    • COI: 1:CAS:528:DC%2BC3MXhtlyisL%2FN, PID: 22037645
    • Ellingsgaard H, Hauselmann I, Schuler B et al (2011) Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nat Med 17:1481–1489
    • (2011) Nat Med , vol.17 , pp. 1481-1489
    • Ellingsgaard, H.1    Hauselmann, I.2    Schuler, B.3
  • 14
    • 0036085225 scopus 로고    scopus 로고
    • Enhanced plasma IL-6 and IL-1ra responses to repeated vs. single bouts of prolonged cycling in elite athletes
    • COI: 1:CAS:528:DC%2BD38Xks1aisro%3D
    • Ronsen O, Lea T, Bahr R, Pedersen BK (2002) Enhanced plasma IL-6 and IL-1ra responses to repeated vs. single bouts of prolonged cycling in elite athletes. J Appl Physiol (1985) 92:2547–2553
    • (2002) J Appl Physiol (1985) , vol.92 , pp. 2547-2553
    • Ronsen, O.1    Lea, T.2    Bahr, R.3    Pedersen, B.K.4
  • 15
    • 0041846867 scopus 로고    scopus 로고
    • IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans
    • COI: 1:CAS:528:DC%2BD3sXmsVahtr4%3D, PID: 12857678
    • Steensberg A, Fischer CP, Keller C et al (2003) IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans. Am J Physiol Endocrinol Metab 285:E433–E437
    • (2003) Am J Physiol Endocrinol Metab , vol.285 , pp. E433-E437
    • Steensberg, A.1    Fischer, C.P.2    Keller, C.3
  • 16
    • 84878300647 scopus 로고    scopus 로고
    • Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials
    • COI: 1:CAS:528:DC%2BC3sXls1Sit7s%3D, PID: 23562090
    • Moran A, Bundy B, Becker DJ et al (2013) Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials. Lancet 381:1905–1915
    • (2013) Lancet , vol.381 , pp. 1905-1915
    • Moran, A.1    Bundy, B.2    Becker, D.J.3
  • 17
    • 84864386088 scopus 로고    scopus 로고
    • Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetes
    • COI: 1:CAS:528:DC%2BC38XhsFCqsLfI, PID: 22699287
    • Cavelti-Weder C, Babians-Brunner A, Keller C et al (2012) Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetes. Diabetes Care 35:1654–1662
    • (2012) Diabetes Care , vol.35 , pp. 1654-1662
    • Cavelti-Weder, C.1    Babians-Brunner, A.2    Keller, C.3
  • 18
    • 79151484704 scopus 로고    scopus 로고
    • Adipokines in inflammation and metabolic disease
    • COI: 1:CAS:528:DC%2BC3MXotlSgsg%3D%3D, PID: 21252989
    • Ouchi N, Parker JL, Lugus JJ, Walsh K (2011) Adipokines in inflammation and metabolic disease. Nat Rev Immunol 11:85–97
    • (2011) Nat Rev Immunol , vol.11 , pp. 85-97
    • Ouchi, N.1    Parker, J.L.2    Lugus, J.J.3    Walsh, K.4
  • 19
    • 69949085015 scopus 로고    scopus 로고
    • Two-month effects of individualized exercise training with or without caloric restriction on plasma adipocytokine levels in obese female adolescents
    • COI: 1:CAS:528:DC%2BD1MXhsVWgs7vL
    • Ben Ounis O, Elloumi M, Lac G et al (2009) Two-month effects of individualized exercise training with or without caloric restriction on plasma adipocytokine levels in obese female adolescents. Ann Endocrinol (Paris) 70:235–241
    • (2009) Ann Endocrinol (Paris) , vol.70 , pp. 235-241
    • Ben Ounis, O.1    Elloumi, M.2    Lac, G.3
  • 20
    • 84874919268 scopus 로고    scopus 로고
    • Inhibition of islet immunoreactivity by adiponectin is attenuated in human type 1 diabetes
    • COI: 1:CAS:528:DC%2BC3sXksFylsLw%3D, PID: 23386639
    • Pang TTL, Chimen M, Goble E et al (2013) Inhibition of islet immunoreactivity by adiponectin is attenuated in human type 1 diabetes. J Clin Endocrinol Metab 98:E418–E428
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. E418-E428
    • Pang, T.T.L.1    Chimen, M.2    Goble, E.3
  • 21
    • 77953540785 scopus 로고    scopus 로고
    • The influence of prolonged cycling on monocyte Toll-like receptor 2 and 4 expression in healthy men
    • COI: 1:CAS:528:DC%2BC3cXovVGntL8%3D, PID: 20063104
    • Oliveira M, Gleeson M (2010) The influence of prolonged cycling on monocyte Toll-like receptor 2 and 4 expression in healthy men. Eur J Appl Physiol 109:251–257
    • (2010) Eur J Appl Physiol , vol.109 , pp. 251-257
    • Oliveira, M.1    Gleeson, M.2
  • 23
    • 84873841346 scopus 로고    scopus 로고
    • The effects of free-living interval-walking training on glycemic control, body composition, and physical fitness in type 2 diabetic patients: a randomized, controlled trial
    • PID: 23002086
    • Karstoft K, Winding K, Knudsen SH et al (2013) The effects of free-living interval-walking training on glycemic control, body composition, and physical fitness in type 2 diabetic patients: a randomized, controlled trial. Diabetes Care 36:228–236
    • (2013) Diabetes Care , vol.36 , pp. 228-236
    • Karstoft, K.1    Winding, K.2    Knudsen, S.H.3
  • 24
    • 68049105042 scopus 로고    scopus 로고
    • Effects of exercise training and diet on lipid kinetics during free fatty acid-induced insulin resistance in older obese humans with impaired glucose tolerance
    • COI: 1:CAS:528:DC%2BD1MXhtVahtr7O, PID: 19531640
    • Solomon TPJ, Haus JM, Marchetti CM et al (2009) Effects of exercise training and diet on lipid kinetics during free fatty acid-induced insulin resistance in older obese humans with impaired glucose tolerance. Am J Physiol Endocrinol Metab 297:E552–E559
    • (2009) Am J Physiol Endocrinol Metab , vol.297 , pp. E552-E559
    • Solomon, T.P.J.1    Haus, J.M.2    Marchetti, C.M.3
  • 25
    • 0033034807 scopus 로고    scopus 로고
    • Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes
    • COI: 1:CAS:528:DyaK1MXitFCqt7w%3D, PID: 10102689
    • Donath MY, Gross DJ, Cerasi E, Kaiser N (1999) Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes. Diabetes 48:738–744
    • (1999) Diabetes , vol.48 , pp. 738-744
    • Donath, M.Y.1    Gross, D.J.2    Cerasi, E.3    Kaiser, N.4
  • 26
    • 0021990787 scopus 로고
    • The effect of insulin treatment on insulin secretion and insulin action in type II diabetes mellitus
    • COI: 1:STN:280:DyaL2M7ivVSnsg%3D%3D, PID: 3882489
    • Garvey WT, Olefsky JM, Griffin J et al (1985) The effect of insulin treatment on insulin secretion and insulin action in type II diabetes mellitus. Diabetes 34:222–234
    • (1985) Diabetes , vol.34 , pp. 222-234
    • Garvey, W.T.1    Olefsky, J.M.2    Griffin, J.3
  • 27
    • 41149088656 scopus 로고    scopus 로고
    • Near normalisation of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 2 diabetes
    • COI: 1:CAS:528:DC%2BD1cXjsFGhsr4%3D, PID: 18292985
    • Hojberg PV, Zander M, Vilsboll T et al (2008) Near normalisation of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 2 diabetes. Diabetologia 51:632–640
    • (2008) Diabetologia , vol.51 , pp. 632-640
    • Hojberg, P.V.1    Zander, M.2    Vilsboll, T.3
  • 28
    • 0028849148 scopus 로고
    • Opposite effects of short- and long-term fatty acid infusion on insulin secretion in healthy subjects
    • COI: 1:CAS:528:DyaK28XitlOhsg%3D%3D, PID: 8582538
    • Paolisso G, Gambardella A, Amato L et al (1995) Opposite effects of short- and long-term fatty acid infusion on insulin secretion in healthy subjects. Diabetologia 38:1295–1299
    • (1995) Diabetologia , vol.38 , pp. 1295-1299
    • Paolisso, G.1    Gambardella, A.2    Amato, L.3
  • 29
    • 0027303165 scopus 로고
    • Chronic perifusion of rat islets with palmitate suppresses glucose-stimulated insulin release
    • COI: 1:CAS:528:DyaK3sXmtVWjsL8%3D, PID: 8319569
    • Elks ML (1993) Chronic perifusion of rat islets with palmitate suppresses glucose-stimulated insulin release. Endocrinology 133:208–214
    • (1993) Endocrinology , vol.133 , pp. 208-214
    • Elks, M.L.1
  • 30
    • 0036797785 scopus 로고    scopus 로고
    • Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress
    • COI: 1:CAS:528:DC%2BD38XnvFGru78%3D, PID: 12370856
    • Piro S, Anello M, Di Pietro C et al (2002) Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress. Metab Clin Exp 51:1340–1347
    • (2002) Metab Clin Exp , vol.51 , pp. 1340-1347
    • Piro, S.1    Anello, M.2    Di Pietro, C.3
  • 31
    • 84858631179 scopus 로고    scopus 로고
    • Improved preservation of residual beta cell function by atorvastatin in patients with recent onset type 1 diabetes and high CRP levels (DIATOR trial)
    • COI: 1:CAS:528:DC%2BC38XltVeru7g%3D, PID: 22448235
    • Strom A, Kolb H, Martin S et al (2012) Improved preservation of residual beta cell function by atorvastatin in patients with recent onset type 1 diabetes and high CRP levels (DIATOR trial). PLoS One 7:e33108
    • (2012) PLoS One , vol.7 , pp. e33108
    • Strom, A.1    Kolb, H.2    Martin, S.3
  • 32
    • 4444271002 scopus 로고    scopus 로고
    • Exercise training prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas
    • COI: 1:CAS:528:DC%2BD2cXmtFGmtbs%3D, PID: 15240923
    • Coskun O, Ocakci A, Bayraktaroglu T, Kanter M (2004) Exercise training prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas. Tohoku J Exp Med 203:145–154
    • (2004) Tohoku J Exp Med , vol.203 , pp. 145-154
    • Coskun, O.1    Ocakci, A.2    Bayraktaroglu, T.3    Kanter, M.4
  • 33
    • 81555201127 scopus 로고    scopus 로고
    • Exercise increases insulin content and basal secretion in pancreatic islets in type 1 diabetic mice
    • PID: 21912535
    • Huang H-H, Farmer K, Windscheffel J et al (2011) Exercise increases insulin content and basal secretion in pancreatic islets in type 1 diabetic mice. Exp Diabetes Res 2011:481427
    • (2011) Exp Diabetes Res , vol.2011 , pp. 481427
    • Huang, H.-H.1    Farmer, K.2    Windscheffel, J.3
  • 34
    • 0031079718 scopus 로고    scopus 로고
    • Exercise training in Otsuka Long-Evans Tokushima Fatty rat, a model of spontaneous non-insulin-dependent diabetes mellitus: effects on the B-cell mass, insulin content and fibrosis in the pancreas
    • COI: 1:CAS:528:DyaK2sXis1SjsL8%3D, PID: 9113470
    • Shima K, Zhu M, Noma Y et al (1997) Exercise training in Otsuka Long-Evans Tokushima Fatty rat, a model of spontaneous non-insulin-dependent diabetes mellitus: effects on the B-cell mass, insulin content and fibrosis in the pancreas. Diabetes Res Clin Pract 35:11–19
    • (1997) Diabetes Res Clin Pract , vol.35 , pp. 11-19
    • Shima, K.1    Zhu, M.2    Noma, Y.3
  • 35
    • 20144386698 scopus 로고    scopus 로고
    • Long-term AICAR administration and exercise prevents diabetes in ZDF rats
    • COI: 1:CAS:528:DC%2BD2MXjtFWntrc%3D, PID: 15793229
    • Pold R, Jensen LS, Jessen N et al (2005) Long-term AICAR administration and exercise prevents diabetes in ZDF rats. Diabetes 54:928–934
    • (2005) Diabetes , vol.54 , pp. 928-934
    • Pold, R.1    Jensen, L.S.2    Jessen, N.3
  • 36
    • 34248366080 scopus 로고    scopus 로고
    • Attenuation of type 2 diabetes mellitus in the male Zucker diabetic fatty rat: the effects of stress and non-volitional exercise
    • PID: 17512304
    • Király MA, Bates HE, Yue JTY et al (2007) Attenuation of type 2 diabetes mellitus in the male Zucker diabetic fatty rat: the effects of stress and non-volitional exercise. Metab Clin Exp 56:732–744
    • (2007) Metab Clin Exp , vol.56 , pp. 732-744
    • Király, M.A.1    Bates, H.E.2    Yue, J.T.Y.3
  • 37
    • 38949092116 scopus 로고    scopus 로고
    • Swim training prevents hyperglycemia in ZDF rats: mechanisms involved in the partial maintenance of beta-cell function
    • PID: 18029442
    • Király MA, Bates HE, Kaniuk NA et al (2008) Swim training prevents hyperglycemia in ZDF rats: mechanisms involved in the partial maintenance of beta-cell function. Am J Physiol Endocrinol Metab 294:E271–E283
    • (2008) Am J Physiol Endocrinol Metab , vol.294 , pp. E271-E283
    • Király, M.A.1    Bates, H.E.2    Kaniuk, N.A.3
  • 38
    • 84855326549 scopus 로고    scopus 로고
    • Voluntary running exercise prevents beta-cell failure in susceptible islets of the Zucker diabetic fatty rat
    • COI: 1:CAS:528:DC%2BC38XhvVKqtLc%3D, PID: 22045312
    • Delghingaro-Augusto V, Decary S, Peyot M-L et al (2012) Voluntary running exercise prevents beta-cell failure in susceptible islets of the Zucker diabetic fatty rat. Am J Physiol Endocrinol Metab 302:E254–E264
    • (2012) Am J Physiol Endocrinol Metab , vol.302 , pp. E254-E264
    • Delghingaro-Augusto, V.1    Decary, S.2    Peyot, M.-L.3
  • 39
    • 80054885196 scopus 로고    scopus 로고
    • Short-term exercise training early in life restores deficits in pancreatic beta-cell mass associated with growth restriction in adult male rats
    • COI: 1:CAS:528:DC%2BC3MXhsFaksbjK, PID: 21810930
    • Laker RC, Gallo LA, Wlodek ME et al (2011) Short-term exercise training early in life restores deficits in pancreatic beta-cell mass associated with growth restriction in adult male rats. Am J Physiol Endocrinol Metab 301:E931–E940
    • (2011) Am J Physiol Endocrinol Metab , vol.301 , pp. E931-E940
    • Laker, R.C.1    Gallo, L.A.2    Wlodek, M.E.3
  • 40
    • 0023137608 scopus 로고
    • Basal and 24-h C-peptide and insulin secretion rate in normal man
    • COI: 1:CAS:528:DyaL2sXhsV2qtbo%3D, PID: 3552817
    • Kruszynska YT, Home PD, Hanning I, Alberti KG (1987) Basal and 24-h C-peptide and insulin secretion rate in normal man. Diabetologia 30:16–21
    • (1987) Diabetologia , vol.30 , pp. 16-21
    • Kruszynska, Y.T.1    Home, P.D.2    Hanning, I.3    Alberti, K.G.4
  • 41
    • 9144268894 scopus 로고    scopus 로고
    • C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop, 21-22 October 2001
    • COI: 1:CAS:528:DC%2BD2cXitlaltQ%3D%3D, PID: 14693724
    • Palmer JP, Fleming GA, Greenbaum CJ et al (2004) C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop, 21-22 October 2001. Diabetes 53:250–264
    • (2004) Diabetes , vol.53 , pp. 250-264
    • Palmer, J.P.1    Fleming, G.A.2    Greenbaum, C.J.3
  • 42
    • 70549111807 scopus 로고    scopus 로고
    • Evaluation of proposed oral disposition index measures in relation to the actual disposition index
    • COI: 1:CAS:528:DC%2BC3cXnvFCqsg%3D%3D, PID: 20002470
    • Retnakaran R, Qi Y, Goran MI, Hamilton JK (2009) Evaluation of proposed oral disposition index measures in relation to the actual disposition index. Diabet Med 26:1198–1203
    • (2009) Diabet Med , vol.26 , pp. 1198-1203
    • Retnakaran, R.1    Qi, Y.2    Goran, M.I.3    Hamilton, J.K.4
  • 43
    • 33644673386 scopus 로고    scopus 로고
    • Two-hour seven-sample oral glucose tolerance test and meal protocol: minimal model assessment of beta-cell responsivity and insulin sensitivity in nondiabetic individuals
    • COI: 1:CAS:528:DC%2BD2MXht1Shsr7L, PID: 16249454
    • Dalla Man C, Campioni M, Polonsky KS et al (2005) Two-hour seven-sample oral glucose tolerance test and meal protocol: minimal model assessment of beta-cell responsivity and insulin sensitivity in nondiabetic individuals. Diabetes 54:3265–3273
    • (2005) Diabetes , vol.54 , pp. 3265-3273
    • Dalla Man, C.1    Campioni, M.2    Polonsky, K.S.3
  • 44
    • 70349678813 scopus 로고    scopus 로고
    • Effects of exercise training intensity on pancreatic beta-cell function
    • COI: 1:CAS:528:DC%2BD1MXhtlehs7jJ, PID: 19592624
    • Slentz CA, Tanner CJ, Bateman LA et al (2009) Effects of exercise training intensity on pancreatic beta-cell function. Diabetes Care 32:1807–1811
    • (2009) Diabetes Care , vol.32 , pp. 1807-1811
    • Slentz, C.A.1    Tanner, C.J.2    Bateman, L.A.3
  • 45
    • 19944427874 scopus 로고    scopus 로고
    • Effects of exercise training on glucose homeostasis: the HERITAGE Family Study
    • PID: 15616242
    • Boule NG, Weisnagel SJ, Lakka TA et al (2005) Effects of exercise training on glucose homeostasis: the HERITAGE Family Study. Diabetes Care 28:108–114
    • (2005) Diabetes Care , vol.28 , pp. 108-114
    • Boule, N.G.1    Weisnagel, S.J.2    Lakka, T.A.3
  • 46
    • 39049102071 scopus 로고    scopus 로고
    • Short-term exercise improves beta-cell function and insulin resistance in older people with impaired glucose tolerance
    • COI: 1:CAS:528:DC%2BD1cXit1Snt7s%3D, PID: 18000089
    • Bloem CJ, Chang AM (2008) Short-term exercise improves beta-cell function and insulin resistance in older people with impaired glucose tolerance. J Clin Endocrinol Metab 93:387–392
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 387-392
    • Bloem, C.J.1    Chang, A.M.2
  • 47
    • 84887594589 scopus 로고    scopus 로고
    • Pancreatic beta-cell function increases in a linear dose-response manner following exercise training in adults with prediabetes
    • COI: 1:CAS:528:DC%2BC3sXhvFansLzE, PID: 24045867
    • Malin SK, Solomon TPJ, Blaszczak A et al (2013) Pancreatic beta-cell function increases in a linear dose-response manner following exercise training in adults with prediabetes. Am J Physiol Endocrinol Metab 305:E1248–E1254
    • (2013) Am J Physiol Endocrinol Metab , vol.305 , pp. E1248-E1254
    • Malin, S.K.1    Solomon, T.P.J.2    Blaszczak, A.3
  • 48
    • 0021145565 scopus 로고
    • Improvement of glucose homeostasis after exercise training in non-insulin-dependent diabetes
    • COI: 1:STN:280:DyaL2M%2FltVOjtA%3D%3D, PID: 6389057
    • Reitman JS, Vasquez B, Klimes I, Nagulesparan M (1984) Improvement of glucose homeostasis after exercise training in non-insulin-dependent diabetes. Diabetes Care 7:434–441
    • (1984) Diabetes Care , vol.7 , pp. 434-441
    • Reitman, J.S.1    Vasquez, B.2    Klimes, I.3    Nagulesparan, M.4
  • 49
    • 0022354818 scopus 로고
    • The effects of physical training on insulin secretion and effectiveness and on glucose metabolism in obesity and type 2 (non-insulin-dependent) diabetes mellitus
    • COI: 1:STN:280:DyaL287jslWgtw%3D%3D, PID: 3912243
    • Krotkiewski M, Lonnroth P, Mandroukas K et al (1985) The effects of physical training on insulin secretion and effectiveness and on glucose metabolism in obesity and type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 28:881–890
    • (1985) Diabetologia , vol.28 , pp. 881-890
    • Krotkiewski, M.1    Lonnroth, P.2    Mandroukas, K.3
  • 50
    • 0021127441 scopus 로고
    • Influence of physical training on blood glucose control, glucose tolerance, insulin secretion, and insulin action in non-insulin-dependent diabetic patients
    • COI: 1:STN:280:DyaL2M%2FltVOjsQ%3D%3D, PID: 6389056
    • Trovati M, Carta Q, Cavalot F et al (1984) Influence of physical training on blood glucose control, glucose tolerance, insulin secretion, and insulin action in non-insulin-dependent diabetic patients. Diabetes Care 7:416–420
    • (1984) Diabetes Care , vol.7 , pp. 416-420
    • Trovati, M.1    Carta, Q.2    Cavalot, F.3
  • 51
    • 55549146772 scopus 로고    scopus 로고
    • Effects of low intensity exercise therapy on early phase insulin secretion in overweight subjects with impaired glucose tolerance and type 2 diabetes mellitus
    • COI: 1:CAS:528:DC%2BD1cXhtl2qt7bJ, PID: 18922594
    • Michishita R, Shono N, Kasahara T, Tsuruta T (2008) Effects of low intensity exercise therapy on early phase insulin secretion in overweight subjects with impaired glucose tolerance and type 2 diabetes mellitus. Diabetes Res Clin Pract 82:291–297
    • (2008) Diabetes Res Clin Pract , vol.82 , pp. 291-297
    • Michishita, R.1    Shono, N.2    Kasahara, T.3    Tsuruta, T.4
  • 52
    • 77955638311 scopus 로고    scopus 로고
    • Improved pancreatic beta-cell function in type 2 diabetic patients after lifestyle-induced weight loss is related to glucose-dependent insulinotropic polypeptide
    • COI: 1:CAS:528:DC%2BC3cXpslKgsr8%3D, PID: 20200305
    • Solomon TPJ, Haus JM, Kelly KR et al (2010) Improved pancreatic beta-cell function in type 2 diabetic patients after lifestyle-induced weight loss is related to glucose-dependent insulinotropic polypeptide. Diabetes Care 33:1561–1566
    • (2010) Diabetes Care , vol.33 , pp. 1561-1566
    • Solomon, T.P.J.1    Haus, J.M.2    Kelly, K.R.3
  • 53
    • 6044274618 scopus 로고    scopus 로고
    • Physical training may enhance beta-cell function in type 2 diabetes
    • COI: 1:CAS:528:DC%2BD2cXhtVaqs7nI, PID: 15251867
    • Dela F, von Linstow ME, Mikines KJ, Galbo H (2004) Physical training may enhance beta-cell function in type 2 diabetes. Am J Physiol Endocrinol Metab 287:E1024–E1031
    • (2004) Am J Physiol Endocrinol Metab , vol.287 , pp. E1024-E1031
    • Dela, F.1    von Linstow, M.E.2    Mikines, K.J.3    Galbo, H.4
  • 54
    • 84885235316 scopus 로고    scopus 로고
    • Pancreatic beta-cell function is a stronger predictor of changes in glycemic control after an aerobic exercise intervention than insulin sensitivity
    • COI: 1:CAS:528:DC%2BC3sXhs1elsLjI, PID: 23966244
    • Solomon TPJ, Malin SK, Karstoft K et al (2013) Pancreatic beta-cell function is a stronger predictor of changes in glycemic control after an aerobic exercise intervention than insulin sensitivity. J Clin Endocrinol Metab 98:4176–4186
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 4176-4186
    • Solomon, T.P.J.1    Malin, S.K.2    Karstoft, K.3
  • 55
    • 84865862726 scopus 로고    scopus 로고
    • Improvement in beta-cell function after diet-induced weight loss is associated with decrease in pancreatic polypeptide in subjects with type 2 diabetes
    • COI: 1:STN:280:DC%2BC38npsFCnug%3D%3D, PID: 22673566
    • Kahleova H, Mari A, Nofrate V et al (2012) Improvement in beta-cell function after diet-induced weight loss is associated with decrease in pancreatic polypeptide in subjects with type 2 diabetes. J Diabetes Complications 26:442–449
    • (2012) J Diabetes Complications , vol.26 , pp. 442-449
    • Kahleova, H.1    Mari, A.2    Nofrate, V.3
  • 56
    • 34249945638 scopus 로고    scopus 로고
    • Early-onset type 2 diabetes in obese white subjects is characterised by a marked defect in beta cell insulin secretion, severe insulin resistance and a lack of response to aerobic exercise training
    • COI: 1:CAS:528:DC%2BD2sXmtFekt7k%3D, PID: 17393133
    • Burns N, Finucane FM, Hatunic M et al (2007) Early-onset type 2 diabetes in obese white subjects is characterised by a marked defect in beta cell insulin secretion, severe insulin resistance and a lack of response to aerobic exercise training. Diabetologia 50:1500–1508
    • (2007) Diabetologia , vol.50 , pp. 1500-1508
    • Burns, N.1    Finucane, F.M.2    Hatunic, M.3
  • 57
    • 84868193197 scopus 로고    scopus 로고
    • Clinical evolution of beta cell function in youth with diabetes: the SEARCH for Diabetes in Youth study
    • COI: 1:STN:280:DC%2BC38bot1Wgtw%3D%3D, PID: 22990715
    • Dabelea D, Mayer-Davis EJ, Andrews JS et al (2012) Clinical evolution of beta cell function in youth with diabetes: the SEARCH for Diabetes in Youth study. Diabetologia 55:3359–3368
    • (2012) Diabetologia , vol.55 , pp. 3359-3368
    • Dabelea, D.1    Mayer-Davis, E.J.2    Andrews, J.S.3
  • 58
    • 0033020127 scopus 로고    scopus 로고
    • Only multiple autoantibodies to islet cells (ICA), insulin, GAD65, IA-2 and IA-2beta predict immune-mediated (type 1) diabetes in relatives
    • COI: 1:STN:280:DyaK1M3msValuw%3D%3D, PID: 10330299
    • Maclaren N, Lan M, Coutant R et al (1999) Only multiple autoantibodies to islet cells (ICA), insulin, GAD65, IA-2 and IA-2beta predict immune-mediated (type 1) diabetes in relatives. J Autoimmun 12:279–287
    • (1999) J Autoimmun , vol.12 , pp. 279-287
    • Maclaren, N.1    Lan, M.2    Coutant, R.3
  • 59
    • 84863938136 scopus 로고    scopus 로고
    • Structured exercise program improves functional capacity and delays relapse in euthyroid patients with Graves’ disease
    • PID: 22394073
    • Cutovic M, Konstantinovic L, Stankovic Z, Vesovic-Potic V (2012) Structured exercise program improves functional capacity and delays relapse in euthyroid patients with Graves’ disease. Disabil Rehabil 34:1511–1518
    • (2012) Disabil Rehabil , vol.34 , pp. 1511-1518
    • Cutovic, M.1    Konstantinovic, L.2    Stankovic, Z.3    Vesovic-Potic, V.4
  • 60
    • 84896085402 scopus 로고    scopus 로고
    • Diet and physical exercise in psoriasis: a randomized controlled trial
    • COI: 1:STN:280:DC%2BC2crkslOqtw%3D%3D, PID: 24641585
    • Naldi L, Conti A, Cazzaniga S et al (2014) Diet and physical exercise in psoriasis: a randomized controlled trial. Br J Dermatol 170:634–642
    • (2014) Br J Dermatol , vol.170 , pp. 634-642
    • Naldi, L.1    Conti, A.2    Cazzaniga, S.3
  • 61
    • 84858661723 scopus 로고    scopus 로고
    • Exercise and disease progression in multiple sclerosis: can exercise slow down the progression of multiple sclerosis?
    • PID: 22435073
    • Dalgas U, Stenager E (2012) Exercise and disease progression in multiple sclerosis: can exercise slow down the progression of multiple sclerosis? Ther Adv Neurol Disord 5:81–95
    • (2012) Ther Adv Neurol Disord , vol.5 , pp. 81-95
    • Dalgas, U.1    Stenager, E.2
  • 62
    • 84856725150 scopus 로고    scopus 로고
    • What are the health benefits of physical activity in type 1 diabetes mellitus? A literature review
    • COI: 1:CAS:528:DC%2BC38Xhsl2gt7s%3D, PID: 22189486
    • Chimen M, Kennedy A, Nirantharakumar K et al (2012) What are the health benefits of physical activity in type 1 diabetes mellitus? A literature review. Diabetologia 55:542–551
    • (2012) Diabetologia , vol.55 , pp. 542-551
    • Chimen, M.1    Kennedy, A.2    Nirantharakumar, K.3
  • 63
    • 84889030853 scopus 로고    scopus 로고
    • Exercise and type 1 diabetes (T1DM)
    • PID: 23897688
    • Galassetti P, Riddell MC (2013) Exercise and type 1 diabetes (T1DM). Compr Physiol 3:1309–1336
    • (2013) Compr Physiol , vol.3 , pp. 1309-1336
    • Galassetti, P.1    Riddell, M.C.2
  • 64
    • 84871619180 scopus 로고    scopus 로고
    • Association of physical activity with all-cause mortality and incident and prevalent cardiovascular disease among patients with type 1 diabetes: the EURODIAB Prospective Complications Study
    • COI: 1:STN:280:DC%2BC3s%2FjvFWlsg%3D%3D, PID: 23052062
    • Tielemans SMAJ, Soedamah-Muthu SS, de Neve M et al (2013) Association of physical activity with all-cause mortality and incident and prevalent cardiovascular disease among patients with type 1 diabetes: the EURODIAB Prospective Complications Study. Diabetologia 56:82–91
    • (2013) Diabetologia , vol.56 , pp. 82-91
    • Tielemans, S.M.A.J.1    Soedamah-Muthu, S.S.2    de Neve, M.3
  • 65
    • 59249091586 scopus 로고    scopus 로고
    • Barriers to physical activity among patients with type 1 diabetes
    • PID: 18689694
    • Brazeau A-S, Rabasa-Lhoret R, Strychar I, Mircescu H (2008) Barriers to physical activity among patients with type 1 diabetes. Diabetes Care 31:2108–2109
    • (2008) Diabetes Care , vol.31 , pp. 2108-2109
    • Brazeau, A.-S.1    Rabasa-Lhoret, R.2    Strychar, I.3    Mircescu, H.4
  • 66
    • 0025297306 scopus 로고
    • Effect of exercise on insulin action, glucose tolerance, and insulin secretion in aging
    • COI: 1:CAS:528:DyaK3cXkslWls78%3D, PID: 2193534
    • Kahn SE, Larson VG, Beard JC et al (1990) Effect of exercise on insulin action, glucose tolerance, and insulin secretion in aging. Am J Physiol 258:E937–E943
    • (1990) Am J Physiol , vol.258 , pp. E937-E943
    • Kahn, S.E.1    Larson, V.G.2    Beard, J.C.3
  • 67
    • 0033864414 scopus 로고    scopus 로고
    • Aerobic exercise training-induced reductions in abdominal fat and glucose-stimulated insulin responses in middle-aged and older men
    • COI: 1:CAS:528:DC%2BD3cXntVCisLw%3D, PID: 10983904
    • Pratley RE, Hagberg JM, Dengel DR et al (2000) Aerobic exercise training-induced reductions in abdominal fat and glucose-stimulated insulin responses in middle-aged and older men. J Am Geriatr Soc 48:1055–1061
    • (2000) J Am Geriatr Soc , vol.48 , pp. 1055-1061
    • Pratley, R.E.1    Hagberg, J.M.2    Dengel, D.R.3
  • 68
    • 77953458815 scopus 로고    scopus 로고
    • Effect of physical training on insulin secretion and action in skeletal muscle and adipose tissue of first-degree relatives of type 2 diabetic patients
    • COI: 1:CAS:528:DC%2BC3cXpslSgtrw%3D, PID: 20407006
    • Dela F, Stallknecht B (2010) Effect of physical training on insulin secretion and action in skeletal muscle and adipose tissue of first-degree relatives of type 2 diabetic patients. Am J Physiol Endocrinol Metab 299:E80–E91
    • (2010) Am J Physiol Endocrinol Metab , vol.299 , pp. E80-E91
    • Dela, F.1    Stallknecht, B.2


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