-
2
-
-
84881296154
-
Trial watch: Phase II and Phase III attrition rates 2011-2012
-
Arrowsmith, J., &, Miller, P., Trial watch: Phase II and Phase III attrition rates 2011-2012. Nat. Rev. Drug Discov. 12, 569-569 (2013).
-
(2013)
Nat. Rev. Drug Discov
, vol.12
, pp. 569-569
-
-
Arrowsmith, J.1
Miller, P.2
-
3
-
-
84892153139
-
Clinical development success rates for investigational drugs
-
Hay, M., Thomas, D.W., Craighead, J.L., Economides, C., &, Rosenthal, J., Clinical development success rates for investigational drugs. Nat. Biotech. 32, 40-51 (2014).
-
(2014)
Nat. Biotech
, vol.32
, pp. 40-51
-
-
Hay, M.1
Thomas, D.W.2
Craighead, J.L.3
Economides, C.4
Rosenthal, J.5
-
4
-
-
67650445156
-
Toxicology for the twenty-first century
-
Hartung, T., Toxicology for the twenty-first century. Nature 460, 208-212 (2009).
-
(2009)
Nature
, vol.460
, pp. 208-212
-
-
Hartung, T.1
-
5
-
-
84874457770
-
Genomic responses in mouse models poorly mimic human inflammatory diseases
-
Seok, J., et al,. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc. Natl. Acad. Sci. U. S. A. 110, 3507-3512 (2013).
-
(2013)
Proc. Natl. Acad. Sci. U. S. A
, vol.110
, pp. 3507-3512
-
-
Seok, J.1
-
7
-
-
33644529130
-
Capturing complex 3D tissue physiology in vitro
-
Griffith, L.G., &, Swartz, M.A., Capturing complex 3D tissue physiology in vitro. Nat. Rev. Mol. Cell. Biol. 7, 211-224 (2006).
-
(2006)
Nat. Rev. Mol. Cell. Biol
, vol.7
, pp. 211-224
-
-
Griffith, L.G.1
Swartz, M.A.2
-
8
-
-
0028998479
-
A cell culture analogue of rodent physiology: Application to naphthalene toxicology
-
Sweeney, L.M., Shuler, M.L., Babish, J.G., &, Ghanem, A., A cell culture analogue of rodent physiology: Application to naphthalene toxicology. Toxicol. In Vitro 9, 307-316 (1995).
-
(1995)
Toxicol. in Vitro
, vol.9
, pp. 307-316
-
-
Sweeney, L.M.1
Shuler, M.L.2
Babish, J.G.3
Ghanem, A.4
-
9
-
-
0035768206
-
Animal on a chip: A microscale cell culture analog device for evaluating toxicological and pharmacological profiles
-
4560, Microfluidics and BioMEMS
-
Sin, A., Baxter, G.T., &, Shuler, M.L., Animal on a chip: A microscale cell culture analog device for evaluating toxicological and pharmacological profiles. Proc. SPIE 4560, Microfluidics and BioMEMS 98 (2001). doi: 10.1117/12.443045
-
(2001)
Proc. SPIE
, pp. 98
-
-
Sin, A.1
Baxter, G.T.2
Shuler, M.L.3
-
10
-
-
1142293800
-
The design and fabrication of three-chamber microscale cell culture analog devices with integrated dissolved oxygen sensors
-
Sin, A., Chin, K.C., Jamil, M.F., Kostov, Y., Rao, G., &, Shuler, M.L., The design and fabrication of three-chamber microscale cell culture analog devices with integrated dissolved oxygen sensors. Biotechnol. Prog. 20, 338-345 (2004).
-
(2004)
Biotechnol. Prog
, vol.20
, pp. 338-345
-
-
Sin, A.1
Chin, K.C.2
Jamil, M.F.3
Kostov, Y.4
Rao, G.5
Shuler, M.L.6
-
11
-
-
18244366662
-
Tissue engineering-current challenges and expanding opportunities
-
Griffith, L.G., &, Naughton, G., Tissue engineering-current challenges and expanding opportunities. Science 295, 1009-1014 (2002).
-
(2002)
Science
, vol.295
, pp. 1009-1014
-
-
Griffith, L.G.1
Naughton, G.2
-
12
-
-
77954038080
-
Reconstituting organ-level lung functions on a chip
-
Huh, D., Matthews, B.D., Mammoto, A., Montoya-Zavala, M., Hsin, H.Y., &, Ingber, D.E., Reconstituting organ-level lung functions on a chip. Science 328, 1662-1668 (2010).
-
(2010)
Science
, vol.328
, pp. 1662-1668
-
-
Huh, D.1
Matthews, B.D.2
Mammoto, A.3
Montoya-Zavala, M.4
Hsin, H.Y.5
Ingber, D.E.6
-
13
-
-
77951919817
-
Perfused multiwell plate for 3D liver tissue engineering
-
Domansky, K., Inman, W., Serdy, J., Dash, A., Lim, M.H.M., &, Griffith, L.G., Perfused multiwell plate for 3D liver tissue engineering. Lab Chip 10, 51-58 (2010).
-
(2010)
Lab Chip
, vol.10
, pp. 51-58
-
-
Domansky, K.1
Inman, W.2
Serdy, J.3
Dash, A.4
Lim, M.H.M.5
Griffith, L.G.6
-
14
-
-
84864295451
-
In vitro 3D human small intestinal villous model for drug permeability determination
-
Yu, J., Peng, S., Luo, D., &, March, J., In vitro 3D human small intestinal villous model for drug permeability determination. Biotechnol. Bioeng. 109, 2173-2178 (2012).
-
(2012)
Biotechnol. Bioeng
, vol.109
, pp. 2173-2178
-
-
Yu, J.1
Peng, S.2
Luo, D.3
March, J.4
-
15
-
-
84921672069
-
Pumpless microfluidic platform for drug testing on human skin equivalents
-
Abaci, H.E., Gledhill, K., Guo, Z., Christiano, A.M., &, Shuler, M.L., Pumpless microfluidic platform for drug testing on human skin equivalents. Lab Chip 15, 882-888 (2015).
-
(2015)
Lab Chip
, vol.15
, pp. 882-888
-
-
Abaci, H.E.1
Gledhill, K.2
Guo, Z.3
Christiano, A.M.4
Shuler, M.L.5
-
16
-
-
77956112678
-
A microfluidic platform for probing small artery structure and function
-
Gunther, A., et al,. A microfluidic platform for probing small artery structure and function. Lab Chip 10, 2341-2349 (2010).
-
(2010)
Lab Chip
, vol.10
, pp. 2341-2349
-
-
Gunther, A.1
-
17
-
-
84897510737
-
In vitro generation of colonic epithelium from primary cells guided by microstructures
-
Wang, Y., Ahmad, A.A., Sims, C.E., Magness, S.T., &, Allbritton, N.L., In vitro generation of colonic epithelium from primary cells guided by microstructures. Lab Chip 14, 1622-1631 (2014).
-
(2014)
Lab Chip
, vol.14
, pp. 1622-1631
-
-
Wang, Y.1
Ahmad, A.A.2
Sims, C.E.3
Magness, S.T.4
Allbritton, N.L.5
-
18
-
-
57749209963
-
Microfeature guided skeletal muscle tissue engineering for highly organized 3-dimensional free-standing constructs
-
Lam, M.T., Huang, Y.-C., Birla, R.K., &, Takayama, S., Microfeature guided skeletal muscle tissue engineering for highly organized 3-dimensional free-standing constructs. Biomaterials 30, 1150-1155 (2009).
-
(2009)
Biomaterials
, vol.30
, pp. 1150-1155
-
-
Lam, M.T.1
Huang, Y.-C.2
Birla, R.K.3
Takayama, S.4
-
19
-
-
84907009888
-
Organs-on-chips (microphysiological systems): Tools to expedite efficacy and toxicity testing in human tissue
-
Fabre, K.M., Livingston, C., &, Tagle, D.A., Organs-on-chips (microphysiological systems): tools to expedite efficacy and toxicity testing in human tissue. Exp. Biol. Med. 239, 1073-1077 (2014).
-
(2014)
Exp. Biol. Med.
, vol.239
, pp. 1073-1077
-
-
Fabre, K.M.1
Livingston, C.2
Tagle, D.A.3
-
20
-
-
0032974197
-
Modeling of pharmacokinetic/pharmacodynamic (PK/PD) relationships: Concepts and perspectives
-
Derendorf, H., &, Meibohm, B., Modeling of pharmacokinetic/pharmacodynamic (PK/PD) relationships: concepts and perspectives. Pharm. Res. 16, 176-185 (1999).
-
(1999)
Pharm. Res
, vol.16
, pp. 176-185
-
-
Derendorf, H.1
Meibohm, B.2
-
21
-
-
33745792813
-
Pharmacokinetic-pharmacodynamic modelling: History and perspectives
-
Csajka, C., &, Verotta, D., Pharmacokinetic-pharmacodynamic modelling: history and perspectives. J. Pharmacokinet. Pharmacodyn. 33, 227-279 (2006).
-
(2006)
J. Pharmacokinet. Pharmacodyn
, vol.33
, pp. 227-279
-
-
Csajka, C.1
Verotta, D.2
-
22
-
-
84899986727
-
Bioreactor technologies to support liver function in vitro
-
Ebrahimkhani, M.R., Neiman, J.A.S., Raredon, M.S.B., Hughes, D.J., &, Griffith, L.G., Bioreactor technologies to support liver function in vitro. Adv. Drug Del. Rev. 69-70, 132-157 (2014).
-
(2014)
Adv. Drug Del. Rev.
, vol.6970
, pp. 132-157
-
-
Ebrahimkhani, M.R.1
Neiman, J.A.S.2
Raredon, M.S.B.3
Hughes, D.J.4
Griffith, L.G.5
-
23
-
-
84916918991
-
Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device
-
Vivares, A., et al,. Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device. Xenobiotica 45, 29-44 (2015).
-
(2015)
Xenobiotica
, vol.45
, pp. 29-44
-
-
Vivares, A.1
-
24
-
-
84907015391
-
A microphysiological system model of therapy for liver micrometastases
-
Clark, A.M., et al,. A microphysiological system model of therapy for liver micrometastases. Exp. Biol. Med. 239, 1170-1179 (2014).
-
(2014)
Exp. Biol. Med.
, vol.239
, pp. 1170-1179
-
-
Clark, A.M.1
-
25
-
-
0030806348
-
Physiological parameter values for physiologically based pharmacokinetic models
-
Brown, R.P., Delp, M.D., Lindstedt, S.L., Rhomberg, L.R., &, Beliles, R.P., Physiological parameter values for physiologically based pharmacokinetic models. Toxicol. Ind. Health 13, 407-484 (1997).
-
(1997)
Toxicol. Ind. Health
, vol.13
, pp. 407-484
-
-
Brown, R.P.1
Delp, M.D.2
Lindstedt, S.L.3
Rhomberg, L.R.4
Beliles, R.P.5
-
26
-
-
45449094504
-
A methodology for performing global uncertainty and sensitivity analysis in systems biology
-
Marino, S., Hogue, I.B., Ray, C.J., &, Kirschner, D.E., A methodology for performing global uncertainty and sensitivity analysis in systems biology. J Theor. Biol. 254, 178-196 (2008).
-
(2008)
J Theor. Biol
, vol.254
, pp. 178-196
-
-
Marino, S.1
Hogue, I.B.2
Ray, C.J.3
Kirschner, D.E.4
-
27
-
-
0030019028
-
Interspecies variations of corticosteroid-binding globulin parameters
-
Gayrard, V., Alvinerie, M., &, Toutain, P.L., Interspecies variations of corticosteroid-binding globulin parameters. Domest. Anim. Endocrinol. 13, 35-45 (1996).
-
(1996)
Domest. Anim. Endocrinol
, vol.13
, pp. 35-45
-
-
Gayrard, V.1
Alvinerie, M.2
Toutain, P.L.3
-
28
-
-
26844433194
-
Antiinflammatory action of glucocorticoids - New mechanisms for old drugs
-
Rhen, T., &, Cidlowski, J.A., Antiinflammatory action of glucocorticoids-new mechanisms for old drugs. N. Engl. J. Med. 353, 1711-1723 (2005).
-
(2005)
N. Engl. J. Med
, vol.353
, pp. 1711-1723
-
-
Rhen, T.1
Cidlowski, J.A.2
-
29
-
-
0001185391
-
Inactivity in vivo of transcortin-bound cortisol
-
Slaunwhite, W.R., Lockie, G.N., Back, N., &, Sandberg, A.A., Inactivity in vivo of transcortin-bound cortisol. Science 135, 1062-1063 (1962).
-
(1962)
Science
, vol.135
, pp. 1062-1063
-
-
Slaunwhite, W.R.1
Lockie, G.N.2
Back, N.3
Sandberg, A.A.4
-
30
-
-
0023105820
-
Clinical use of unbound plasma cortisol as calculated from total cortisol and corticosteroid-binding globulin
-
Coolens, J.-L., Van Baelen, H., &, Heyns, W., Clinical use of unbound plasma cortisol as calculated from total cortisol and corticosteroid-binding globulin. J. Steroid Biochem. 26, 197-202 (1987).
-
(1987)
J. Steroid Biochem.
, vol.26
, pp. 197-202
-
-
Coolens, J.-L.1
Van Baelen, H.2
Heyns, W.3
-
31
-
-
57649109454
-
Validation of a simple method of estimating plasma free cortisol: Role of cortisol binding to albumin
-
Dorin, R.I., et al,. Validation of a simple method of estimating plasma free cortisol: role of cortisol binding to albumin. Clin. Biochem. 42, 64-71 (2009).
-
(2009)
Clin. Biochem
, vol.42
, pp. 64-71
-
-
Dorin, R.I.1
-
32
-
-
0025084239
-
Rates of dissociation of steroid and thyroid hormones from human serum albumin
-
Mendel, C.M., Miller, M.B., Siiteri, P.K., &, Murai, J.T., Rates of dissociation of steroid and thyroid hormones from human serum albumin. J. Steroid Biochem. Mol. Biol. 37, 245-250 (1990).
-
(1990)
J. Steroid Biochem. Mol. Biol
, vol.37
, pp. 245-250
-
-
Mendel, C.M.1
Miller, M.B.2
Siiteri, P.K.3
Murai, J.T.4
-
33
-
-
0034070414
-
Kupffer cell activation by lipopolysaccharide in rats: Role for lipopolysaccharide binding protein and toll-like receptor 4
-
Su, G.L., et al,. Kupffer cell activation by lipopolysaccharide in rats: role for lipopolysaccharide binding protein and toll-like receptor 4. Hepatology 31, 932-936 (2000).
-
(2000)
Hepatology
, vol.31
, pp. 932-936
-
-
Su, G.L.1
-
34
-
-
43049179999
-
LPS/TLR4 signal transduction pathway
-
Lu, Y.-C., Yeh, W.-C., &, Ohashi, P.S., LPS/TLR4 signal transduction pathway. Cytokine 42, 145-151 (2008).
-
(2008)
Cytokine
, vol.42
, pp. 145-151
-
-
Lu, Y.-C.1
Yeh, W.-C.2
Ohashi, P.S.3
-
35
-
-
0036074141
-
Lipopolysaccharides in liver injury: Molecular mechanisms of Kupffer cell activation
-
Su, G.L., Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation. Am. J. Physiol. Gastrointest. Liver Physiol. 283, G256-G265 (2002). doi: 10.1152/ajpgi.00550.2001
-
(2002)
Am. J. Physiol. Gastrointest. Liver Physiol
, vol.283
, pp. G256-G265
-
-
Su, G.L.1
-
36
-
-
34248141100
-
A cytokine-mediated link between innate immunity, inflammation, and cancer
-
Lin, W.-W., &, Karin, M., A cytokine-mediated link between innate immunity, inflammation, and cancer. J. Clin. Invest. 117, 1175-1183 (2007).
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1175-1183
-
-
Lin, W.-W.1
Karin, M.2
-
37
-
-
0036144815
-
Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distribution
-
Poulin, P., &, Theil, F.-P., Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distribution. J. Pharm. Sci. 91, 129-156 (2002).
-
(2002)
J. Pharm. Sci.
, vol.91
, pp. 129-156
-
-
Poulin, P.1
Theil, F.-P.2
-
38
-
-
75749153235
-
A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip
-
Sung, J.H., Kam, C., &, Shuler, M.L., A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip. Lab Chip 10, 446-455 (2010).
-
(2010)
Lab Chip
, vol.10
, pp. 446-455
-
-
Sung, J.H.1
Kam, C.2
Shuler, M.L.3
-
39
-
-
0034130030
-
Combining cell culture analogue reactor designs and PBPK models to probe mechanisms of naphthalene toxicity
-
Ghanem, A., &, Shuler, M.L., Combining cell culture analogue reactor designs and PBPK models to probe mechanisms of naphthalene toxicity. Biotechnol. Prog. 16, 334-345 (2000).
-
(2000)
Biotechnol. Prog
, vol.16
, pp. 334-345
-
-
Ghanem, A.1
Shuler, M.L.2
-
40
-
-
64749086511
-
A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers
-
Tatosian, D.A., &, Shuler, M.L., A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers. Biotechnol. Bioeng. 103, 187-198 (2009).
-
(2009)
Biotechnol. Bioeng
, vol.103
, pp. 187-198
-
-
Tatosian, D.A.1
Shuler, M.L.2
|