Organs-on-chips (microphysiological systems): tools to expedite efficacy and toxicity testing in human tissue

Experimental Biology and Medicine

Volumn 239, Issue 9, 2014, Pages 1073-1077

  Fabre, Kristin M ^a   Livingston, Christine ^b   Tagle, Danilo A ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DRUG EFFICACY; DRUG SCREENING; MEDICAL DEVICE; MICROPHYSIOLOGICAL SYSTEM; PLURIPOTENT STEM CELL; PUBLIC-PRIVATE PARTNERSHIP; TISSUE ENGINEERING; TOXICITY TESTING; ANIMAL; EQUIPMENT; HUMAN; LAB ON A CHIP; METHODOLOGY; REVIEW; TISSUE CULTURE TECHNIQUE;

ANIMALS; HUMANS; LAB-ON-A-CHIP DEVICES; TISSUE CULTURE TECHNIQUES;

EID: 84907009888     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1177/1535370214538916     Document Type: Article

References (8)

1. John Arrowsmith.Trial watch: phase III and submission failures: 2007–2010.Nature Reviews Drug Discovery. 2011;10:87-87
2. Pober JS,Neuhauser CS,Pober JM.Obstacles facing translational research in academic medical centers.FASEB J. 2001;15:2303-13
3. Collins FS. Reengineering translational science: the time is right. Sci Transl Med 2011;3(90). doi: 10.1126/scitranslmed.3002747.
4. FDA: Challenges and Opportunities Report – March 2004. http://www.fda.gov/ScienceResearch/SpecialTopics/CriticalPathInitiative/CriticalPathOpportunitiesReports/ucm077262.htm.
5. Pedro RL,Maria GC.Uncertainty in the translation of pre-clinical experiments to clinical trial. Why do most phase III clinical trials fail.Curr Gene Ther. 2009;9:368-74
6. Seok J,Warren HS,Cuenca AG,Mindrinos MN,Baker HV,Xu W,Richards DR,McDonald-Smith GP,Gao H,Hennessy L,Finnerty CC,López CM,Honari S,Moore EE,Minei JP,Cuschieri J,Bankey PE,Johnson JL,Sperry J,Nathens AB,Billiar TR,West MA,Jeschke MG,Klein MB,Gamelli RL,Gibran NS,Brownstein BH,Miller-Graziano C,Calvano SE,Mason PH,Cobb JP,Rahme LG,Lowry SF,Maier RV,Moldawer LL,Herndon DN,Davis RW,Xiao W,Tompkins RG.Inflammation and Host Response to Injury, Large Scale Collaborative Research Program. Genomic responses in mouse models poorly mimic human inflammatory diseases.Proc Natl Acad Sci USA. 2013;110:3507-12
7. Huh D,Leslie DC,Matthews BD,Fraser JP,Jurek S,Hamilton GA,Thorneloe KS,McAlexander MA,Ingber DE.A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice.Sci Transl Med. 2012;4:159ra147-159ra147
8. Huh D,Matthews BD,Mammoto A,Montoya-Zavala M,Hsin HY,Ingber DE.Reconstructing organ-level lung functions on a chip.Science. 2010;328:1662-8