-
1
-
-
27844445642
-
Perturbations of the AKT signaling pathway in human cancer
-
Altomare DA, Testa JR. (2005). Perturbations of the AKT signaling pathway in human cancer. Oncogene 24: 7455-64
-
(2005)
Oncogene
, vol.24
, pp. 7455-7464
-
-
Altomare, D.A.1
Testa, J.R.2
-
2
-
-
84901506759
-
Targeting apoptosis pathways for new cancer therapeutics
-
Bai L, Wang S. (2014). Targeting apoptosis pathways for new cancer therapeutics. Annu Rev Med 65: 139-55
-
(2014)
Annu Rev Med
, vol.65
, pp. 139-155
-
-
Bai, L.1
Wang, S.2
-
3
-
-
33746660331
-
P38 MAPK in development and cancer
-
Bradham C, McClay DR. (2006). p38 MAPK in development and cancer. Cell Cycle 5: 824-8
-
(2006)
Cell Cycle
, vol.5
, pp. 824-828
-
-
Bradham, C.1
McClay, D.R.2
-
4
-
-
84999986042
-
The MAPK pathway across different malignancies: A new perspective
-
Burotto M, Chiou VL, Lee JM, Kohn EC. (2014). The MAPK pathway across different malignancies: a new perspective. Cancer 120: 3446-56
-
(2014)
Cancer
, vol.120
, pp. 3446-3456
-
-
Burotto, M.1
Chiou, V.L.2
Lee, J.M.3
Kohn, E.C.4
-
5
-
-
0037352170
-
Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: A target for cancer chemotherapy
-
Chang F, Lee JT, Navolanic PM, et al. (2003). Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. Leukemia 17: 590-603
-
(2003)
Leukemia
, vol.17
, pp. 590-603
-
-
Chang, F.1
Lee, J.T.2
Navolanic, P.M.3
-
6
-
-
58149483488
-
Investigation of the genotoxicity of quinocetone, carbadox and olaquindox in vitro using Vero cells
-
Chen Q, Tang S, Jin X, et al. (2009). Investigation of the genotoxicity of quinocetone, carbadox and olaquindox in vitro using Vero cells. Food Chem Toxicol 47: 328-34
-
(2009)
Food Chem Toxicol
, vol.47
, pp. 328-334
-
-
Chen, Q.1
Tang, S.2
Jin, X.3
-
7
-
-
77953250415
-
Myosin light chain kinase is responsible for high proliferative ability of breast cancer cells via anti-apoptosis involving p38 pathway
-
Cui WJ, Liu Y, Zhou XL, et al. (2010). Myosin light chain kinase is responsible for high proliferative ability of breast cancer cells via anti-apoptosis involving p38 pathway. Acta Pharmacol Sin 31: 725-32
-
(2010)
Acta Pharmacol Sin
, vol.31
, pp. 725-732
-
-
Cui, W.J.1
Liu, Y.2
Zhou, X.L.3
-
8
-
-
0141757460
-
MAPK pathways in radiation responses
-
Dent P, Yacoub A, Fisher PB, et al. (2003). MAPK pathways in radiation responses. Oncogene 22: 5885-96
-
(2003)
Oncogene
, vol.22
, pp. 5885-5896
-
-
Dent, P.1
Yacoub, A.2
Fisher, P.B.3
-
9
-
-
0037462454
-
Liver tumor development. C-Jun antagonizes the proapoptotic activity of p53
-
Eferl R, Ricci R, Kenner L, et al. (2003). Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53. Cell 112: 181-92
-
(2003)
Cell
, vol.112
, pp. 181-192
-
-
Eferl, R.1
Ricci, R.2
Kenner, L.3
-
10
-
-
21744463058
-
Inhibiting myosin light chain kinase induces apoptosis in vitro and in vivo
-
Fazal F, Gu L, Ihnatovych I, et al. (2005). Inhibiting myosin light chain kinase induces apoptosis in vitro and in vivo. Mol Cell Biol 25: 6259-66
-
(2005)
Mol Cell Biol
, vol.25
, pp. 6259-6266
-
-
Fazal, F.1
Gu, L.2
Ihnatovych, I.3
-
11
-
-
0038348755
-
Small-molecule inhibitors of actin dynamics and cell motility
-
Fenteany G, Zhu ST. (2003). Small-molecule inhibitors of actin dynamics and cell motility. Curr Topics Med Chem 3: 593-616
-
(2003)
Curr Topics Med Chem
, vol.3
, pp. 593-616
-
-
Fenteany, G.1
Zhu, S.T.2
-
12
-
-
28544443984
-
Promoting apoptosis as a strategy for cancer drug discovery
-
Fesik SW. (2005). Promoting apoptosis as a strategy for cancer drug discovery. Nat Rev Cancer 5: 876-85
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 876-885
-
-
Fesik, S.W.1
-
13
-
-
1642471831
-
PI3K/Akt and apoptosis: Size matters
-
Franke TF, Hornik CP, Segev L, et al. (2003). PI3K/Akt and apoptosis: size matters. Oncogene 22: 8983-98
-
(2003)
Oncogene
, vol.22
, pp. 8983-8998
-
-
Franke, T.F.1
Hornik, C.P.2
Segev, L.3
-
14
-
-
33747792380
-
Actin-induced hyperactivation of the Ras signaling pathway leads to apoptosis in Saccharomyces cerevisiae
-
Gourlay CW, Ayscough KR. (2006). Actin-induced hyperactivation of the Ras signaling pathway leads to apoptosis in Saccharomyces cerevisiae. Mol Cell Biol 26: 6487-501
-
(2006)
Mol Cell Biol
, vol.26
, pp. 6487-6501
-
-
Gourlay, C.W.1
Ayscough, K.R.2
-
15
-
-
33646188288
-
Inhibiting myosin light chain kinase retards the growth of mammary and prostate cancer cells
-
Gu LZ, Hu WY, Antic N, et al. (2006). Inhibiting myosin light chain kinase retards the growth of mammary and prostate cancer cells. Eur J Cancer 42: 948-57
-
(2006)
Eur J Cancer
, vol.42
, pp. 948-957
-
-
Gu, L.Z.1
Hu, W.Y.2
Antic, N.3
-
16
-
-
24944480788
-
The Akt-mTOR tango and its relevance to cancer
-
Hay N. (2005). The Akt-mTOR tango and its relevance to cancer. Cancer Cell 8: 179-83
-
(2005)
Cancer Cell
, vol.8
, pp. 179-183
-
-
Hay, N.1
-
17
-
-
32044466838
-
Exploiting the PI3K/AKT pathway for cancer drug discovery
-
Hennessy BT, Smith DL, Ram PT, et al. (2005). Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov 4: 988-1004
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 988-1004
-
-
Hennessy, B.T.1
Smith, D.L.2
Ram, P.T.3
-
18
-
-
68949121798
-
Correlation of PI3K-Akt signal pathway to apoptosis of tumor cells
-
Huang XL, Cui GH, Zhou KY. (2008). Correlation of PI3K-Akt signal pathway to apoptosis of tumor cells. Chinese J Cancer 27: 331-6
-
(2008)
Chinese J Cancer
, vol.27
, pp. 331-336
-
-
Huang, X.L.1
Cui, G.H.2
Zhou, K.Y.3
-
19
-
-
84880096572
-
Genotoxicity of quinocetone, cyadox and olaquindox in vitro and in vivo
-
Ihsan A, Wang X, Zhang W, et al. (2013). Genotoxicity of quinocetone, cyadox and olaquindox in vitro and in vivo. Food Chem Toxicol 59: 207-14
-
(2013)
Food Chem Toxicol
, vol.59
, pp. 207-214
-
-
Ihsan, A.1
Wang, X.2
Zhang, W.3
-
20
-
-
33747642291
-
A specific isoform of nonmuscle myosin II-C is required for cytokinesis in a tumor cell line
-
Jana SS, Kawamoto S, Adelstein RS. (2006). A specific isoform of nonmuscle myosin II-C is required for cytokinesis in a tumor cell line. J Biol Chem 281: 24662-70
-
(2006)
J Biol Chem
, vol.281
, pp. 24662-24670
-
-
Jana, S.S.1
Kawamoto, S.2
Adelstein, R.S.3
-
21
-
-
70349388590
-
Investigation of quinocetone-induced genotoxicity in HepG2 cells using the comet assay, cytokinesis-block micronucleus test and RAPD analysis
-
Jin X, Chen Q, Tang SS, et al. (2009). Investigation of quinocetone-induced genotoxicity in HepG2 cells using the comet assay, cytokinesis-block micronucleus test and RAPD analysis. Toxicol In Vitro 23: 1209-14
-
(2009)
Toxicol in Vitro
, vol.23
, pp. 1209-1214
-
-
Jin, X.1
Chen, Q.2
Tang, S.S.3
-
22
-
-
0032006059
-
Microtubules and actin filaments: Dynamic targets for cancer chemotherapy
-
Jordan MA, Wilson L. (1998). Microtubules and actin filaments: dynamic targets for cancer chemotherapy. Curr Opin Cell Biol 10: 123-30
-
(1998)
Curr Opin Cell Biol
, vol.10
, pp. 123-130
-
-
Jordan, M.A.1
Wilson, L.2
-
23
-
-
1942438028
-
Microtubules as a target for anticancer drugs
-
Jordan MA, Wilson L. (2004). Microtubules as a target for anticancer drugs. Nat Rev Cancer 4: 253-65
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 253-265
-
-
Jordan, M.A.1
Wilson, L.2
-
24
-
-
84989899970
-
Macrophage-and RIP3-dependent inflammasome activation exacerbates retinal detachment-induced photoreceptor cell death
-
Kataoka K, Matsumoto H, Kaneko H, et al. (2015). Macrophage-and RIP3-dependent inflammasome activation exacerbates retinal detachment-induced photoreceptor cell death. Cell Death Dis 6: e1731
-
(2015)
Cell Death Dis
, vol.6
, pp. e1731
-
-
Kataoka, K.1
Matsumoto, H.2
Kaneko, H.3
-
25
-
-
2442593541
-
Use of human-derived liver cell lines for the detection of environmental and dietary genotoxicants; Current state of knowledge
-
Knasmuller S, Mersch-Sundermann V, Kevekordes S, et al. (2004). Use of human-derived liver cell lines for the detection of environmental and dietary genotoxicants; current state of knowledge. Toxicology 198: 315-28
-
(2004)
Toxicology
, vol.198
, pp. 315-328
-
-
Knasmuller, S.1
Mersch-Sundermann, V.2
Kevekordes, S.3
-
26
-
-
63749083112
-
Role of MAPK pathway oncoproteins in thyroid cancer pathogenesis and as drug targets
-
Knauf JA, Fagin JA. (2009). Role of MAPK pathway oncoproteins in thyroid cancer pathogenesis and as drug targets. Curr Opin Cell Biol 21: 296-303
-
(2009)
Curr Opin Cell Biol
, vol.21
, pp. 296-303
-
-
Knauf, J.A.1
Fagin, J.A.2
-
27
-
-
84901048224
-
Identification of ML-9 as a lysosomotropic agent targeting autophagy and cell death
-
Kondratskyi A, Yassine M, Slomianny C, et al. (2014). Identification of ML-9 as a lysosomotropic agent targeting autophagy and cell death. Cell Death Dis 5: e1193
-
(2014)
Cell Death Dis
, vol.5
, pp. e1193
-
-
Kondratskyi, A.1
Yassine, M.2
Slomianny, C.3
-
28
-
-
84962489209
-
Cytotoxic effects of myosin light chain kinase inhibitor Ml-7 alone and in combination with flavonoid against Hl-60
-
Lee JW, Ha TK, Woo HD, Chung HW. (2009). Cytotoxic effects of myosin light chain kinase inhibitor Ml-7 alone and in combination with flavonoid against Hl-60. Ann Oncol 20: 33
-
(2009)
Ann Oncol
, vol.20
, pp. 33
-
-
Lee, J.W.1
Ha, T.K.2
Woo, H.D.3
Chung, H.W.4
-
29
-
-
84904539767
-
The dual role of ERK signaling in the apoptosis of neurons
-
Li Q, Chen M, Liu HM, et al. (2014). The dual role of ERK signaling in the apoptosis of neurons. Front Biosci 19: 1411-17
-
(2014)
Front Biosci
, vol.19
, pp. 1411-1417
-
-
Li, Q.1
Chen, M.2
Liu, H.M.3
-
31
-
-
34250788809
-
AKT/PKB signaling: Navigating downstream
-
Manning BD, Cantley LC. (2007). AKT/PKB signaling: navigating downstream. Cell 129: 1261-74
-
(2007)
Cell
, vol.129
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
32
-
-
36248985545
-
G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis
-
New DC, Wu K, Kwok AWS, Wong YH. (2007). G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis. FEBS J 274: 6025-36
-
(2007)
FEBS J
, vol.274
, pp. 6025-6036
-
-
New, D.C.1
Wu, K.2
Kwok, A.W.S.3
Wong, Y.H.4
-
33
-
-
63849157597
-
Regulation of neutrophil apoptosis by modulation of PKB/Akt activation
-
Rane MJ, Klein JB. (2009). Regulation of neutrophil apoptosis by modulation of PKB/Akt activation. Front Biosci 14: 2400-12
-
(2009)
Front Biosci
, vol.14
, pp. 2400-2412
-
-
Rane, M.J.1
Klein, J.B.2
-
34
-
-
2942530310
-
ERK and p38 MAPK-activated protein kinases: A family of protein kinases with diverse biological functions
-
Roux PP, Blenis J. (2004). ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev 68: 320-44
-
(2004)
Microbiol Mol Biol Rev
, vol.68
, pp. 320-344
-
-
Roux, P.P.1
Blenis, J.2
-
37
-
-
84893692276
-
P38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents
-
Sui X, Kong N, Ye L, et al. (2014). p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents. Cancer Lett 344: 174-9
-
(2014)
Cancer Lett
, vol.344
, pp. 174-179
-
-
Sui, X.1
Kong, N.2
Ye, L.3
-
38
-
-
0036632368
-
The phosphatidylinositol 3-kinase AKT pathway in human cancer
-
Vivanco I, Sawyers CL. (2002). The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2: 489-501
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
39
-
-
2342562556
-
Mitogen-activated protein kinases in apoptosis regulation
-
Wada T, Penninger JM. (2004). Mitogen-activated protein kinases in apoptosis regulation. Oncogene 23: 2838-49
-
(2004)
Oncogene
, vol.23
, pp. 2838-2849
-
-
Wada, T.1
Penninger, J.M.2
-
40
-
-
67749117934
-
Signal integration by JNK and p38 MAPK pathways in cancer development
-
Wagner EF, Nebreda AR. (2009). Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer 9: 537-49
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 537-549
-
-
Wagner, E.F.1
Nebreda, A.R.2
-
41
-
-
78951491598
-
Pu-erh black tea supplementation decreases quinocetone-induced ROS generation and oxidative DNA damage in Balb/c mice
-
Wang D, Zhong Y, Luo XA, et al. (2011). Pu-erh black tea supplementation decreases quinocetone-induced ROS generation and oxidative DNA damage in Balb/c mice. Food Chem Toxicol 49: 477-84
-
(2011)
Food Chem Toxicol
, vol.49
, pp. 477-484
-
-
Wang, D.1
Zhong, Y.2
Luo, X.A.3
-
42
-
-
79952069722
-
Acute and sub-chronic oral toxicological evaluations of quinocetone in Wistar rats
-
Wang X, Zhang W, Wang YL, et al. (2010). Acute and sub-chronic oral toxicological evaluations of quinocetone in Wistar rats. Regul Toxicol Pharmacol 58: 421-7
-
(2010)
Regul Toxicol Pharmacol
, vol.58
, pp. 421-427
-
-
Wang, X.1
Zhang, W.2
Wang, Y.L.3
-
43
-
-
0036402460
-
SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kappaB-induced anti-apoptosis
-
Watanabe T, Nakagawa K, Ohata S, et al. (2002). SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kappaB-induced anti-apoptosis. Dev Biol 250: 332-47
-
(2002)
Dev Biol
, vol.250
, pp. 332-347
-
-
Watanabe, T.1
Nakagawa, K.2
Ohata, S.3
-
44
-
-
84875608037
-
Quinocetone triggers oxidative stress and induces cytotoxicity and genotoxicity in human peripheral lymphocytes of both genders
-
Yang W, Fu J, Xiao X, et al. (2013). Quinocetone triggers oxidative stress and induces cytotoxicity and genotoxicity in human peripheral lymphocytes of both genders. J Sci Food Agric 93: 1317-25
-
(2013)
J Sci Food Agric
, vol.93
, pp. 1317-1325
-
-
Yang, W.1
Fu, J.2
Xiao, X.3
-
45
-
-
84899922708
-
Quinocetone-induced Nrf2/HO-1 pathway suppression aggravates hepatocyte damage of Sprague-Dawley rats
-
Yu M, Wang D, Xu M, et al. (2014). Quinocetone-induced Nrf2/HO-1 pathway suppression aggravates hepatocyte damage of Sprague-Dawley rats. Food Chem Toxicol 69: 210-19
-
(2014)
Food Chem Toxicol
, vol.69
, pp. 210-219
-
-
Yu, M.1
Wang, D.2
Xu, M.3
-
46
-
-
84878903945
-
Nrf2/ARE is the potential pathway to protect Sprague-Dawley rats against oxidative stress induced by quinocetone
-
Yu M, Xu M, Liu Y, et al. (2013). Nrf2/ARE is the potential pathway to protect Sprague-Dawley rats against oxidative stress induced by quinocetone. Regul Toxicol Pharmacol 66: 279-85
-
(2013)
Regul Toxicol Pharmacol
, vol.66
, pp. 279-285
-
-
Yu, M.1
Xu, M.2
Liu, Y.3
-
47
-
-
84887330660
-
TNFR1/TNF-α and mitochondria interrelated signaling pathway mediates quinocetone-induced apoptosis in HepG2 cell
-
Zhang C, Wang C, Tang S, et al. (2013). TNFR1/TNF-α and mitochondria interrelated signaling pathway mediates quinocetone-induced apoptosis in HepG2 cell. Food Chem Toxicol 62: 825-38
-
(2013)
Food Chem Toxicol
, vol.62
, pp. 825-838
-
-
Zhang, C.1
Wang, C.2
Tang, S.3
-
48
-
-
0347997608
-
MAPK signal pathways in the regulation of cell proliferation in mammalian cells
-
Zhang W, Liu HT. (2002). MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res 12: 9-18
-
(2002)
Cell Res
, vol.12
, pp. 9-18
-
-
Zhang, W.1
Liu, H.T.2
-
49
-
-
80052962211
-
Akt, FoxO and regulation of apoptosis
-
Zhang XB, Tang NM, Hadden TJ, Rishi AK. (2011). Akt, FoxO and regulation of apoptosis. Biochim Biophys Acta 1813: 1978-86
-
(2011)
Biochim Biophys Acta
, vol.1813
, pp. 1978-1986
-
-
Zhang, X.B.1
Tang, N.M.2
Hadden, T.J.3
Rishi, A.K.4
-
50
-
-
80051729005
-
Pharmacokinetics of quinocetone and its major metabolites in swine after intravenous and oral administration
-
Zhong JL, Zhang GJ, Shen XG, et al. (2011). Pharmacokinetics of quinocetone and its major metabolites in swine after intravenous and oral administration. Agric Sci China 10: 1292-300
-
(2011)
Agric Sci China
, vol.10
, pp. 1292-1300
-
-
Zhong, J.L.1
Zhang, G.J.2
Shen, X.G.3
-
51
-
-
52149114882
-
Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2
-
Zhou XL, Liu Y, You JC, et al. (2008). Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2. Cancer Lett 270: 312-27
-
(2008)
Cancer Lett
, vol.270
, pp. 312-327
-
-
Zhou, X.L.1
Liu, Y.2
You, J.C.3
|