Autophagic flux inhibition and lysosomogenesis ensuing cellular capture and retention of the cationic drug quinacrine inmurine models

PeerJ

Volumn 2015, Issue 10, 2015, Pages

  Parks, Alexandre ^a   Charest Morin, Xavier ^a   Boivin Welch, Michael ^a   Bouthillier, Johanne ^a   Marceau, Francois ^a  

^a UNIVERSITÉ LAVAL   (Canada)

Author keywords

Drug reservoirs; Ion trapping; Lysosomogenesis; Macroautophagy; Quinacrine; TFEB; V ATPase

Indexed keywords

BAFILOMYCIN A1; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; MEPACRINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOLYSOSOME; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME INHIBITION; FIBROBLAST; FLUORESCENCE IMAGING; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; MACROAUTOPHAGY; MALE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; STEREOMICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION;

EID: 84945184185     PISSN: None     EISSN: 21678359     Source Type: Journal    
DOI: 10.7717/peerj.1314     Document Type: Article

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