Vacuolar ATPase-mediated cellular concentration and retention of quinacrine: A model for the distribution of lipophilic cationic drugs to autophagic vacuoles

Drug Metabolism and Disposition

Volumn 37, Issue 12, 2009, Pages 2271-2274

  Marceau, François ^a   Bawolak, Marie Thérèse ^a   Bouthillier, Johanne ^a   Morissette, Guillaume ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; BAFILOMYCIN A1; CATION; MEPACRINE; MICROTUBULE ASSOCIATED PROTEIN; PROCAINAMIDE; RAB7 PROTEIN; TRIETHYLAMINE;

ARTICLE; AUTOPHAGY; BIOACCUMULATION; BIOLOGICAL MODEL; CELL LEVEL; CELL VACUOLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPATHOLOGY; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG RELEASE; DRUG RETENTION; DRUG SPECIFICITY; DRUG TRANSPORT; DRUG UPTAKE; ENZYME ACTIVITY; FLUORESCENCE; HUMAN; HUMAN CELL; LIGHT CHAIN; LIPOPHILICITY; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER;

ANTIPROTOZOAL AGENTS; AUTOPHAGY; BIOLOGICAL TRANSPORT; CATIONS; CELLS, CULTURED; CYTOPLASMIC VESICLES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; KINETICS; MACROLIDES; MYOCYTES, SMOOTH MUSCLE; ORGANELLE SIZE; PROCAINAMIDE; QUINACRINE; RAB GTP-BINDING PROTEINS; RAB5 GTP-BINDING PROTEINS; RECOMBINANT FUSION PROTEINS; TRANSFECTION; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 71049122853     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.028480     Document Type: Article

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