Assessment of cation trapping by cellular acidic compartments

Methods in Enzymology

Volumn 534, Issue , 2014, Pages 119-131

  Marceau, François ^a   Roy, Caroline ^a   Bouthillier, Johanne ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

Autophagy; Cationic drugs; Ion trapping; Phospholipidosis; Quinacrine; Vacuolar ATPase

Indexed keywords

AMINE; BAFILOMYCIN A1; CATION; FLUORESCEIN; MEPACRINE; TERTIARY AMINE;

ARTICLE; AUTOPHAGY; CELL COMPARTMENTALIZATION; CYTOFLUOROMETRY; FLUOROMETRY; IMMUNOBLOTTING; LIPOPHILICITY; MICROSCOPY; PRIORITY JOURNAL;

ANIMALIA;

AUTOPHAGY; CATIONIC DRUGS; ION TRAPPING; PHOSPHOLIPIDOSIS; QUINACRINE; VACUOLAR ATPASE;

AUTOPHAGY; CATIONS; CELL ADHESION; CELLS, CULTURED; ENDOSOMES; ENZYME INHIBITORS; FLOW CYTOMETRY; GENE EXPRESSION; HUMANS; HYDROGEN-ION CONCENTRATION; ION TRANSPORT; KINETICS; LYSOSOMES; MACROLIDES; MICROTUBULE-ASSOCIATED PROTEINS; MYOCYTES, SMOOTH MUSCLE; QUINACRINE; VACUOLAR PROTON-TRANSLOCATING ATPASES; VACUOLES;

EID: 84890729234     PISSN: 00766879     EISSN: 15577988     Source Type: Book Series    
DOI: 10.1016/B978-0-12-397926-1.00007-X     Document Type: Chapter

References (18)

1. A. Ammoury, S. Michaud, C. Paul, C. Prost-Squarcioni, F. Alvarez, and L. Lamant Photodistribution of blue-gray hyperpigmentation after amiodarone treatment: Molecular characterization of amiodarone in the skin Archives of Dermatology 144 2008 92 96
2. M.T. Bawolak, G. Morissette, and F. Marceau Vacuolar ATPase-mediated sequestration of local anesthetics in swollen macroautophagosomes Canadian Journal of Anesthesia 57 2010 230 239
3. P.M. Chen, Z.J. Gombart, and J.W. Chen Chloroquine treatment of ARPE-19 cells leads to lysosome dilation and intracellular lipid accumulation: Possible implications of lysosomal dysfunction in macular degeneration Cell & Bioscience 1 2011 10
4. C. De Duve, T. de Barsy, B. Poole, A. Trouet, P. Tulkens, and F. Van Hoof Lysosomotropic agents Biochemical Pharmacology 23 1974 2495 2531
5. S.M. Doglia, B. Albinson, C. Hiort, B. Nordén, and A. Grässlund Quinacrine: Spectroscopic properties and interactions with polynucleotides Biopolymers 33 1993 1431 1442
6. S. Dohgu, A. Yamauchi, F. Takata, Y. Sawada, S. Higuchi, and M. Naito Uptake and efflux of quinacrine, a candidate for the treatment of prion diseases, at the blood-brain barrier Cellular and Molecular Neurobiology 24 2004 205 217
7. R. Ehsanian, C. Van Waes, and S.M. Feller Beyond DNA binding - A review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers Cell Communication and Signaling 9 2011 13
8. A.V. Gasparia, C.A. Burkart, A.A. Purmal, L. Brodsky, M. Pal, and M. Saranadasa Curaxins: Anti-cancer compounds that simultaneously suppress NK-κB and activate p53 by targeting FACT Science Translational Medicine 3 2011 95ra74
9. Y. Huang, H. Okochi, B.C. May, G. Legname, S.B. Prusiner, and L.Z. Benet Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein Drug Metabolism and Disposition 34 2006 1136 1144
10. A.M. Kaufmann, and J.P. Krise Lysosomal sequestration of amine-containing drugs: Analysis and therapeutic implications Journal of Pharmaceutical Sciences 96 2007 729 746
11. D.B. Kell, P.D. Dobson, E. Bilsland, and S.G. Oliver The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: What we (need to) know and how we can do so Drug Discovery Today 18 2013 218 239
12. F. Marceau, M.-T. Bawolak, J. Bouthillier, and G. Morissette Vacuolar ATPase-mediated cellular concentration and retention of quinacrine: A model for the distribution of lipophilic cationic drugs to autophagic vacuoles Drug Metabolism and Disposition 37 2009 2271 2274
13. F. Marceau, M.-T. Bawolak, R. Lodge, J. Bouthillier, A. Gagné-Henley, and R.C. Gaudreault Cation trapping by cellular acidic compartments: Beyond the concept of lysosomotropic drugs Toxicology and Applied Pharmacology 259 2012 1 12
14. J.O. Minta, and L. Pambrun In vitro induction of cytologic and functional differentiation of the immature human monocyte-like cell line U-937 with phorbol myristate acetate American Journal of Pathology 119 1985 111 126
15. G. Morissette, R. Lodge, and F. Marceau Intense pseudotransport of a cationic drug mediated by vacuolar ATPase: Procainamide-induced autophagic cell vacuolization Toxicology and Applied Pharmacology 228 2008 364 377
16. M.J. Reasor, K.L. Hastings, and R.G. Ulrich Drug-induced phospholipidosis: Issues and future directions Expert Opinion on Drug Safety 5 2006 567 583
17. C. Roy, V. Gagné, M.J.G. Fernandes, and F. Marceau High affinity capture and concentration of quinacrine in polymormonuclear neutrophil via vacuolar ATPase-mediated ion trapping: Comparison with other peripheral blood leukocytes and implications for the distribution of cationic drugs Toxicology and Applied Pharmacology 270 2013 77 86
18. H. Vallance, T. Chaba, L. Clarke, and G. Taylor Pseudo-lysosomal storage disease caused by EMLA cream Journal of Inherited Metabolic Disease 27 2004 507 511