Discovery of a new class of antiviral compounds: Camphor imine derivatives

European Journal of Medicinal Chemistry

Volumn 105, Issue , 2015, Pages 263-273

  Sokolova, Anastasiya S ^a,b   Yarovaya, Olga I ^a,b   Shernyukov, Andrey V ^a   Gatilov, Yuriy V ^a,b   Razumova, Yuliya V ^b   Zarubaev, Vladimir V ^c   Tretiak, Tatiana S ^c   Pokrovsky, Andrey G ^b   Kiselev, Oleg I ^c   Salakhutdinov, Nariman F ^a,b  

^a N N VOROZHTSOV NOVOSIBIRSK INSTITUTE OF ORGANIC CHEMISTRY   (Russian Federation)

^b NOVOSIBIRSK STATE UNIVERSITY   (Russian Federation)

^c Influenza Research Institute   (Russian Federation)

Author keywords

Antiviral; Cage compounds; Camphor derivatives; Influenza

Indexed keywords

1 (PYRIDIN 3 YL) N (1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YLIDENE)METHANAMINE; 1 PHENYL N (1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YLIDENE)METHANAMINE; 1 [(1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YLIDENE)AMINO] 3 [(1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YLIDENE)AMINO]PROPAN 2 OL; 1,1 DIPHENYL N (1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YLIDENE)METHANAMINE; 2 (1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YLAMINO)ETHANOL; 2 (1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YLIDENEAMINO)ETHANOL; 2 (1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YLIDENEAMINO)ETHYL ACETATE; 2 (1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YLIDENEAMINO)ETHYL CINNAMATE; 2 (1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YLIDENEAMINO)PHENOL; 2 (3,4 DIMETHOXYPHENYL) N (1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YLIDENE)ETHANAMINE; 2 METHOXY N (1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YLIDENE)ETHANAMINE; 2 PHENYL N (1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YLIDENE)ETHANAMINE; 3 (1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YLAMINO)PROPAN 1 OL; 3 (1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YLIDENEAMINO)PROPAN 1 OL; 3 METHOXY N (1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YLIDENE)PROPAN 1 AMINE; 3 MORPHOLINO N (1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YLIDENE)PROPAN 1 AMINE; 4 (1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YLIDENEAMINO)PHENOL; 5 (1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YLAMINO)PENTAN 1 OL; 5 (1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YLIDENEAMINO)PENTAN 1 OL; ANTIVIRUS AGENT; CAMPHOR DERIVATIVE; IMINE; N (1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YLIDENE)BENZO[C][1,2,5]THIADIAZOL 4 AMINE; N 1 (1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YLIDENE)HEXANE 1,6 DIAMINE; N 1, N 1 DIBUTYL N 3 (1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN-2 YLIDENE)PROPANE 1,3 DIAMINE; N 1,N 1 DIMETHYL N 3 (1,7,7 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YLIDENE)PROPANE 1,3 DIAMINE; UNCLASSIFIED DRUG; CAMPHOR;

ANTICONVULSANT ACTIVITY; ANTIGEN ANTIBODY REACTION; ANTIVIRAL ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DOSE; EC50; HEMAGGLUTINATION; HYDROGEN BOND; INFLUENZA A VIRUS (H1N1); INFLUENZA A VIRUS (H5N1); MEMBRANE FUSION; METHYLATION; NONHUMAN; OPTICAL DENSITY; REACTION TIME; SOLUBILITY; SPECTROSCOPY; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; X RAY DIFFRACTION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DOG; DOSE RESPONSE; DRUG DEVELOPMENT; DRUG EFFECTS; MDCK CELL LINE; MICROBIAL SENSITIVITY TEST; SYNTHESIS;

ANIMALS; ANTIVIRAL AGENTS; CAMPHOR; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; IMINES; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H5N1 SUBTYPE; MADIN DARBY CANINE KIDNEY CELLS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84944887540     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.10.010     Document Type: Article

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