The broad anti-viral agent glycyrrhizin directly modulates the fluidity of plasma membrane and HIV-1 envelope

Biochemical Journal

Volumn 392, Issue 1, 2005, Pages 191-199

  Harada, Shinji ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Enveloped virus; Fusion pore; Glycyrrhizin; HIV 1; Infectivity; Membrane fluidity

Indexed keywords

FLUIDIZATION; MEMBRANES; MOLECULES; PLASMAS; PROBABILITY; VIRUSES;

ENVELOPED VIRUS; FUSION PORE; GLYCYRRHIZIN; HIV-1; INFECTIVITY; MEMBRANE FLUIDITY;

CELLS;

ANTIVIRUS AGENT; GLYCYRRHIZIC ACID; HYBRID PROTEIN;

ADOPTIVE IMMUNOTHERAPY; ANTIVIRAL ACTIVITY; ARTICLE; CELL FUSION; CELL MEMBRANE; CONTROLLED STUDY; DRUG STRUCTURE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN T CELL LEUKEMIA VIRUS 1; INFECTION; INFECTION SENSITIVITY; INFLUENZA VIRUS A; MEMBRANE FLUIDITY; POLIOMYELITIS VIRUS; PRIORITY JOURNAL; PROBABILITY; TEMPERATURE; VESICULAR STOMATITIS VIRUS; VIRUS ENVELOPE;

ANTIVIRAL AGENTS; CELL LINE; CELL MEMBRANE; GLYCYRRHIZIC ACID; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; KINETICS; MEMBRANE FLUIDITY; MOLECULAR STRUCTURE; VIRAL ENVELOPE PROTEINS;

HTLV; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN T-LYMPHOTROPIC VIRUS 1; INFLUENZA A VIRUS; INFLUENZAVIRUS A; LEUKAEMIA VIRUS; POLIOVIRUS; VESICULAR STOMATITIS VIRUS;

EID: 28044459176     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20051069     Document Type: Article

References (49)

1. Jardetzky, T. S. and Lamb, R. A. (2004) A class act. Nature (London) 427, 307-308
2. Colman, P. M. and Lawrence, M. C. (2003) The structural biology of type I viral membrane fusion. Nat. Rev. Mol. Cell Biol. 4, 309-319
3. Gibbons, D. L., Vaney, M., Roussel, A, Vigouroux, A., Reilly, B., Lepault, J., Kielian, M. and Rey, F. A. (2004) Conformational change and protein-protein interactions of the fusion protein of Semliki Forest virus. Nature (London) 427, 320-325
4. Roche, S. and Gaudin, Y. (2002) Characterization of the equilibrium between the native and fusion-inactive conformation of rabies virus glycoprotein indicates that the fusion complex is made of several trimers. Virology 297, 128-135
5. Plonsky, I. and Zimmerberg, J. (1996) The initial fusion pore induced by baculovirus GP64 is large and forms quickly. J. Cell Biol. 135, 1831-1839
6. Markovic, I., Leikina, E., Zhukovsky, M., Zimmerberg, J. and Chernomordik, L. V. (2001) Synchronized activation and refolding of influenza haemagglutinin in multimeric fusion machines. J. Cell Biol. 155, 833-844
7. Gibbons, D. L., Erk, I., Reilly, B., Navaza, J., Kielian, M., Rey, F. A. and Lepault, J. (2003) Visualization of the target-membrane-inserted fusion protein of Semliki Forest virus by combined electron microscopy and crystallography. Cell (Cambridge, Mass.) 114, 573-583
8. Igakura, T., Stinchcombe, J. C., Goon, P. K., Taylor, G. P., Weber, J. N., Griffiths, G. M., Tanaka, Y., Osame, M. and Bangham, C. R. (2003) Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton. Science 299, 1713-1716
9. McDonald, D., Wu, L., Bonks, S. M., KewalRamani, V. N., Unutmaz, D. and Hope, T. J. (2003) Recruitment of HIV and its receptors to dendritic cell-T cell junctions. Science 300, 1295-1297
10. del Real, G., Jimenez-Baranda, S., Mira, E., Lacalle, R. A., Lucas, P., Gomez-Mouton, C., Alegret, M., Pena, J. M., Rodriguez-Zapata, M., Alvarez-Mon, M. et al. (2004) Stalins inhibit HIV-1 infection by down-regulating Rho activity. J. Exp. Med. 200, 541-547
11. Jolly, C., Kashefi, K., Hollinshead, M. and Sattentau, Q. J. (2004) HIV-1 cell to cell transfer across an env-induced, actin-dependent synapse. J. Exp. Med. 199, 283-293
12. Pontow, S. E., Vander Heyden, N., Wei, S. and Ratner, L. (2004) Actin cytoskeletal reorganizations and coreceptor-mediated activation of Rac during human immunodeficiency virus-induced cell fusion. J. Virol. 78, 7138-7174
13. Higgins, C. F. (1994) Flip-flop: the transmembrane translocation of lipids. Cell (Cambridge, Mass.) 79, 393-396
14. Sauerheber, R. D., Zimmermann, T. S., Esgate, J. A., VanderLaan, W. P. and Gordon, L. M. (1980) Effects of calcium, lanthanum, and temperature on the fluidity of spin-labelled human platelets. J. Membr. Biol. 52, 201-219
15. Harada, S., Yusa, K., Monde, K., Akaike, T. and Maeda, Y. (2005) Influence of membrane fluidity on human immunodeficiency virus type 1 entry. Biochem. Biophys. Res. Commun. 329, 480-486
16. Harada, S., Akaike, T., Yusa, K. and Maeda, Y. (2004) Adsorption and infectivity of human immunodeficiency virus type 1 are modified by the fluidity of the plasma membrane for multiple-site binding. Microbiol. Immunol. 48, 347-355
17. Aloia, R. C., Jensen, F. C., Curtain, C. C., Mobley, P. W. and Gordon, L. M. (1988) Lipid composition and fluidity of the human immunodeficiency virus. Proc. Natl. Acad. Sci. U.S.A. 85, 900-904
18. Aloia, R. C., Tian, H. and Jensen, F. C. (1993) Lipid composition and fluidity of the human immunodeficiency virus envelope and host plasma membranes. Proc. Natl. Acad. Sci. U.S.A. 90, 5181-5185
19. Bales, B. L. and Leon, V. (1978) Magnetic resonance studies of eukaryotic cells. III. Spin labelled fatty acids in the plasma membrane. Biochim. Biophys. Acta 509, 90-99
20. Kliewer, S. (2005) Cholesterol detoxification by the nuclear pregnane X receptor. Proc. Natl. Acad. Sci. U.S.A. 102, 2675-2676
21. Lange, Y., Ye, J. and Steck, T. L. (2004) How cholesterol homeostasis is regulated by plasma membrane cholesterol in excess of phospholipids. Proc. Natl. Acad. Sci. U.S.A. 101, 11664-11667
22. Pompei, R., Flore, O., Marccialis, M. A., Pani, A. and Loddo, B. (1979) Glycyrrhizic acid inhibits virus growth and inactivates virus particles. Nature (London) 281, 689-690
23. Baba, M. and Shigeta, S. (1987) Antiviral activity of glycyrrhizin against varicella-zoster virus in vitro. Antiviral Res. 7, 99-107
24. Hosoya, M., Shigeta, S., Nakamura, K. and De Clercq, E. (1989) Inhibitory effect of selected antiviral compounds on measles (SSPE) virus replication in vitro. Antiviral Res. 12, 87-98
25. Hattori, T., Ikematsu, S., Koito, A., Matsushita, S., Maeda, Y., Hada, M., Fujimaki, M. and Takatsuki, K. (1989) Preliminary evidence for inhibitory effect of glycyrrhizin on HIV replication in patients with AIDS. Antiviral Res. 11, 255-262
26. Ito, M., Sato, A., Hirabayashi, K., Tanabe, F., Shigeta, S., Baba, M., De Clercq, E., Nakashima, H. and Yamamoto, N. (1988) Mechanism of inhibitory effect of glycyrrhizin on replication of human immunodeficiency virus (HIV). Antiviral Res. 10, 289-298
27. Ito, M., Nakashima, H., Baba, M., Pauwels, R., De Clercq, E., Shigeta, S. and Yamamoto, N. (1987) Inhibitory effect of glycyrrhizin on the in vitro infectivity and cytopathic activity of the human immunodeficiency virus [HIV (HTLV-III/LAV)]. Antiviral Res. 7, 127-137
28. Cinatl, J., Morgenstern, B., Bauer, G., Chandra, P., Rabenau, H. and Doerr, H. W. (2003) Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. Lancet 361, 2045-2046
29. Harada, S., Koyanagi, Y. and Yamamoto, N. (1985) Infection of HTLV-III/LAV in HTLV-l-carrying MT-2 and MT-4 and application in a plaque assay. Science 229, 563-566
30. Masuda, T., Matsushita, S., Kuroda, M. J., Kannagi, M., Takatsuki, K. and Harada, S. (1990) Generation of neutralization-resistant HIV-1 in vitro due to amino acid interchanges of third hypervariable env region. J. Immunol. 145, 3240-3246
31. Maeda, Y., Foda, M., Matsushita, S. and Harada, S. (2000) Involvement of both the V2 and V3 regions of the CCR5-tropic human immunodeficiency virus type 1 envelope in reduced sensitivity to macrophage inflammatory protein 1α. J. Virol. 74, 1787-1793
32. Foda, M., Harada, S. and Maeda, Y. (2001) Role of V3 independent domains on a dualtropic human immunodeficiency virus type 1 (HIV-1) envelope gp120 in CCR5 coreceptor utilization and viral infectivity. Microbiol. Immunol. 45, 521-530
33. Song, W., Yahara, S., Maeda, Y., Yusa, K., Tanaka, Y. and Harada, S. (2001) Enhanced infection of an X4 strain of HIV-1 due to capping and colocalization of CD4 and CXCR4 induced by capsianoside G, a diterpene glycoside. Biochem. Biophys. Res. Commun. 283, 423-429
34. Morizono, K. and Harada, S. (1998) Human immunodeficiency virus type 1 (HIV-1) infection and transcytosis activity of a HIV-1 susceptible clone from HeLa cell. Microbiol. Immunol. 42, 313-320
35. Yusa, K. and Tsuruo, T. (1989) Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells. Cancer Res. 49, 5002-5006
36. Miller, E. D., Duus, K. M., Townsend, M., Yi, Y., Collman, R., Reib, M. and Su, L. (2001) Human immunodeficiency virus type 11HB selected for replication in vivo exhibits increased envelope glycoproteins in virions without alteration in coreceptor usage: separation of in vivo replication from macrophage tropism. J. Virol. 75, 8498-8506
37. Bachrach, E., Dreja, H., Lin, Y., Mettling, C., Pinet, V., Corbeau, P. and Piechaczyk, M. (2005) Effects of virion surface gp120 density on infection by HIV-1 and viral production by infected cells. Virology 332, 418-429
38. Yuste, E., Reeves, J. D., Doms, R. W. and Desrosiers, R. C. (2004) Modulation of env content in virions of simian immunodeficiency virus: correlation with cell surface expression and virion infectivity. J. Virol. 78, 6775-6785
39. Harada, S., Yusa, K. and Maeda, Y. (2004) Heterogeneity of envelope molecules shown by different sensitivities to anti-V3 neutralizing antibody and CXCR4 antagonist regulates the formation of multiple-site binding of HIV-1. Microbiol. Immunol. 48, 357-365
40. Layne, S. P., Merges, M. J., Dembo, M., Spouge, J. L. and Nara, P. L. (1990) HIV requires multiple gp120 molecules for CD4-mediated infection. Nature (London) 346, 277-279
41. Picard, L., Simmons, G., Power, C. A., Meyer, A., Weiss, R. A. and Clapham, P. R. (1997) Multiple extracellular domains of CCR-5 contribute to human immunodeficiency virus type 1 entry and fusion. J. Virol. 71, 5003-5011
42. Platt, E. J., Wehrly, K., Kuhmann, S. E., Chesebro, B. and Kabat, D. (1998) Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolate of human immunodeficiency virus type 1. J. Virol. 72, 2855-2864
43. Steffens, C. M. and Hope, T. J. (2004) Mobility of the human immunodeficiency virus (HIV) receptor CD4 and coreceptor CCR5 in living cells: implications for HIV fusion and entry events. J. Virol. 78, 9573-9578
44. Ahn, K., Ou, W. and Silver, J. (2004) Inhibition of certain strains of HIV-1 by cell surface polyanions in the form of cholesterol-labelled oligonucleotides. Virology 330, 50-61
45. Ito, M., Baba, M., Sato, A., Pauwels, R., De Clercq, E. and Shigeta, S. (1987) Inhibitory effect of dextran sulfate and heparin on the replication of human immunodeficiency virus (HIV) in vitro. Antiviral Res. 7, 361-367
46. Abe, N., Ebina, T. and Ishida, N. (1982) Interferon induction by glycyrrhizin and glycyrrhetinic acid in mice. Microbiol. Immunol. 26, 535-539
47. Jeong, H. G. and Kim, J. Y. (2002) Induction of inducible nitric oxide synthase expression by 180-glycyrrhetinic acid in macrophages. FEBS Lett. 513, 208-212
48. Markowitz, M., Mohri, H., Mehandru, S., Shet, A., Berry, L., Kalyanaraman, R., Kim, A., Chung, C., Jean-Pierre, P., Horowitz, A. et al. (2005) Infection with multidrug resistant, dual-tropic HIV-1 and rapid progression to AIDS: a case report. Lancet 365, 1031-1038
49. Habib, E. E., Yokomizo, K., Nagao, K., Harada, S. and Uyeda, M. (2001) Antiviral activity of fattiviracin FV-8 against human immunodeficiency virus type 1 (HIV-1). Biosci., Biotechnol., Biochem. 65, 683-685