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Volumn 57, Issue , 2012, Pages 211-216

Design, synthesis and structure-activity relationship of novel inhibitors against H5N1 hemagglutinin-mediated membrane fusion

(7) Zhu, Zhibo a Li, Runming a,b Xiao, Gaokeng c Chen, Zhipeng a Yang, Jie a Zhu, Qiuhua a Liu, Shuwen a

a SOUTHERN MEDICAL UNIVERSITY (China)

b Guangzhou Baidi Biotechnology Co Ltd (China)

c JINAN UNIVERSITY (China)

Author keywords

Fusion inhibitors; H5N1; Hemagglutinin; Influenza A virus; Membrane fusion; Structure activity relationship

Indexed keywords

3 FLUORO 5 (TRIFLUOROMETHYL) N [2 (THIOPHEN 2 YL)ETHYL]BENZAMIDE; AMIDE; ANTIVIRUS AGENT; BENZAMIDE DERIVATIVE; CL 385319; ENVELOPE PROTEIN; FUSION INHIBITOR; HYDROGEN; OXYGEN; UNCLASSIFIED DRUG; VIRUS HEMAGGLUTININ;

ARTICLE; CONFORMATIONAL TRANSITION; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ELECTROSPRAY MASS SPECTROMETRY; IC 50; INFLUENZA A (H5N1); INFLUENZA VIRUS A H5N1; MEMBRANE FUSION; MOLECULE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; VIRUS STRAIN;

ANIMALS; ANTIVIRAL AGENTS; BENZAMIDES; DOGS; GENES, REPORTER; HEK293 CELLS; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; HYDROGEN; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; INFLUENZA A VIRUS, H5N1 SUBTYPE; LUCIFERASES; MADIN DARBY CANINE KIDNEY CELLS; MEMBRANE FUSION; OXYGEN; PIPERIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION; VIRUS INTERNALIZATION;

EID: 84867037259 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2012.08.041 Document Type: Article

Times cited : (31)

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