메뉴 건너뛰기




Volumn 10, Issue 10, 2015, Pages 2316-2324

Deciphering the Cellular Targets of Bioactive Compounds Using a Chloroalkane Capture Tag

Author keywords

[No Author keywords available]

Indexed keywords

ALKANE DERIVATIVE; CHLORINE DERIVATIVE; DASATINIB; DORAMAPIMOD; HISTONE DEACETYLASE; VORINOSTAT; ALKANE; CHLORINE; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID; PROTEIN BINDING;

EID: 84944790595     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/acschembio.5b00351     Document Type: Article
Times cited : (33)

References (40)
  • 2
    • 79959929769 scopus 로고    scopus 로고
    • How were new medicines discovered?
    • Swinney, D. C. and Anthony, J. (2011) How were new medicines discovered? Nat. Rev. Drug Discovery 10, 507-519 10.1038/nrd3480
    • (2011) Nat. Rev. Drug Discovery , vol.10 , pp. 507-519
    • Swinney, D.C.1    Anthony, J.2
  • 3
    • 84857911138 scopus 로고    scopus 로고
    • Chemoproteomic approaches to drug target identification and drug profiling
    • Bantscheff, M. and Drewes, G. (2012) Chemoproteomic approaches to drug target identification and drug profiling Bioorg. Med. Chem. 20, 1973-1978 10.1016/j.bmc.2011.11.003
    • (2012) Bioorg. Med. Chem. , vol.20 , pp. 1973-1978
    • Bantscheff, M.1    Drewes, G.2
  • 4
    • 84863500157 scopus 로고    scopus 로고
    • Fully functionalized small-molecule probes for integrated phenotypic screening and target identification
    • Cisar, J. S. and Cravatt, B. F. (2012) Fully functionalized small-molecule probes for integrated phenotypic screening and target identification J. Am. Chem. Soc. 134, 10385-10388 10.1021/ja304213w
    • (2012) J. Am. Chem. Soc. , vol.134 , pp. 10385-10388
    • Cisar, J.S.1    Cravatt, B.F.2
  • 5
    • 45749158648 scopus 로고    scopus 로고
    • Identification of the cellular targets of bioactive small organic molecules using affinity reagents
    • Leslie, B. J. and Hergenrother, P. J. (2008) Identification of the cellular targets of bioactive small organic molecules using affinity reagents Chem. Soc. Rev. 37, 1347-1360 10.1039/b702942j
    • (2008) Chem. Soc. Rev. , vol.37 , pp. 1347-1360
    • Leslie, B.J.1    Hergenrother, P.J.2
  • 6
    • 84873598090 scopus 로고    scopus 로고
    • Target Identification by Diazirine Photo-Cross-linking and Click Chemistry
    • Mackinnon, A. L. and Taunton, J. (2009) Target Identification by Diazirine Photo-Cross-linking and Click Chemistry Curr. Protoc. Chem. Biol. 1, 55-73 10.1002/9780470559277.ch090167
    • (2009) Curr. Protoc. Chem. Biol. , vol.1 , pp. 55-73
    • Mackinnon, A.L.1    Taunton, J.2
  • 7
    • 69249136243 scopus 로고    scopus 로고
    • Target profiling of small molecules by chemical proteomics
    • Rix, U. and Superti-Furga, G. (2009) Target profiling of small molecules by chemical proteomics Nat. Chem. Biol. 5, 616-624 10.1038/nchembio.216
    • (2009) Nat. Chem. Biol. , vol.5 , pp. 616-624
    • Rix, U.1    Superti-Furga, G.2
  • 8
    • 40849130043 scopus 로고    scopus 로고
    • Proteomic methods for drug target discovery
    • Sleno, L. and Emili, A. (2008) Proteomic methods for drug target discovery Curr. Opin. Chem. Biol. 12, 46-54 10.1016/j.cbpa.2008.01.022
    • (2008) Curr. Opin. Chem. Biol. , vol.12 , pp. 46-54
    • Sleno, L.1    Emili, A.2
  • 9
    • 77953708147 scopus 로고    scopus 로고
    • Biochemical target isolation for novices: Affinity-based strategies
    • Sato, S., Murata, A., Shirakawa, T., and Uesugi, M. (2010) Biochemical target isolation for novices: affinity-based strategies Chem. Biol. 17, 616-623 10.1016/j.chembiol.2010.05.015
    • (2010) Chem. Biol. , vol.17 , pp. 616-623
    • Sato, S.1    Murata, A.2    Shirakawa, T.3    Uesugi, M.4
  • 10
    • 84874630073 scopus 로고    scopus 로고
    • Target identification for small bioactive molecules: Finding the needle in the haystack
    • Ziegler, S., Pries, V., Hedberg, C., and Waldmann, H. (2013) Target identification for small bioactive molecules: finding the needle in the haystack Angew. Chem., Int. Ed. 52, 2744-2792 10.1002/anie.201208749
    • (2013) Angew. Chem., Int. Ed. , vol.52 , pp. 2744-2792
    • Ziegler, S.1    Pries, V.2    Hedberg, C.3    Waldmann, H.4
  • 11
    • 70350412263 scopus 로고    scopus 로고
    • Revealing promiscuous drug-target interactions by chemical proteomics
    • Bantscheff, M., Scholten, A., and Heck, A. J. (2009) Revealing promiscuous drug-target interactions by chemical proteomics Drug Discovery Today 14, 1021-1029 10.1016/j.drudis.2009.07.001
    • (2009) Drug Discovery Today , vol.14 , pp. 1021-1029
    • Bantscheff, M.1    Scholten, A.2    Heck, A.J.3
  • 12
    • 39549102872 scopus 로고    scopus 로고
    • Optimization of activity-based probes for proteomic profiling of histone deacetylase complexes
    • Salisbury, C. M. and Cravatt, B. F. (2008) Optimization of activity-based probes for proteomic profiling of histone deacetylase complexes J. Am. Chem. Soc. 130, 2184-2194 10.1021/ja074138u
    • (2008) J. Am. Chem. Soc. , vol.130 , pp. 2184-2194
    • Salisbury, C.M.1    Cravatt, B.F.2
  • 13
    • 84887186695 scopus 로고    scopus 로고
    • Target identification of biologically active small molecules via in situ methods
    • Su, Y., Ge, J., Zhu, B., Zheng, Y. G., Zhu, Q., and Yao, S. Q. (2013) Target identification of biologically active small molecules via in situ methods Curr. Opin. Chem. Biol. 17, 768-775 10.1016/j.cbpa.2013.06.005
    • (2013) Curr. Opin. Chem. Biol. , vol.17 , pp. 768-775
    • Su, Y.1    Ge, J.2    Zhu, B.3    Zheng, Y.G.4    Zhu, Q.5    Yao, S.Q.6
  • 14
    • 33846649707 scopus 로고    scopus 로고
    • Activity-based probes for proteomic profiling of histone deacetylase complexes
    • Salisbury, C. M. and Cravatt, B. F. (2007) Activity-based probes for proteomic profiling of histone deacetylase complexes Proc. Natl. Acad. Sci. U. S. A. 104, 1171-1176 10.1073/pnas.0608659104
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 1171-1176
    • Salisbury, C.M.1    Cravatt, B.F.2
  • 15
    • 52949094243 scopus 로고    scopus 로고
    • Binding is not enough: Flexibility is needed for photocrosslinking of Lck kinase by benzophenone photoligands
    • Kawamura, A., Hindi, S., Mihai, D. M., James, L., and Aminova, O. (2008) Binding is not enough: flexibility is needed for photocrosslinking of Lck kinase by benzophenone photoligands Bioorg. Med. Chem. 16, 8824-8829 10.1016/j.bmc.2008.08.077
    • (2008) Bioorg. Med. Chem. , vol.16 , pp. 8824-8829
    • Kawamura, A.1    Hindi, S.2    Mihai, D.M.3    James, L.4    Aminova, O.5
  • 16
    • 84903637862 scopus 로고    scopus 로고
    • Comparison of the reactivity of carbohydrate photoaffinity probes with different photoreactive groups
    • Sakurai, K., Ozawa, S., Yamada, R., Yasui, T., and Mizuno, S. (2014) Comparison of the reactivity of carbohydrate photoaffinity probes with different photoreactive groups ChemBioChem 15, 1399-1403 10.1002/cbic.201402051
    • (2014) ChemBioChem , vol.15 , pp. 1399-1403
    • Sakurai, K.1    Ozawa, S.2    Yamada, R.3    Yasui, T.4    Mizuno, S.5
  • 17
    • 33746760427 scopus 로고    scopus 로고
    • Site-specific, covalent attachment of proteins to a solid surface
    • Duckworth, B. P., Xu, J., Taton, T. A., Guo, A., and Distefano, M. D. (2006) Site-specific, covalent attachment of proteins to a solid surface Bioconjugate Chem. 17, 967-974 10.1021/bc060125e
    • (2006) Bioconjugate Chem. , vol.17 , pp. 967-974
    • Duckworth, B.P.1    Xu, J.2    Taton, T.A.3    Guo, A.4    Distefano, M.D.5
  • 18
    • 1942522084 scopus 로고    scopus 로고
    • Profiling enzyme activities in vivo using click chemistry methods
    • Speers, A. E. and Cravatt, B. F. (2004) Profiling enzyme activities in vivo using click chemistry methods Chem. Biol. 11, 535-546 10.1016/j.chembiol.2004.03.012
    • (2004) Chem. Biol. , vol.11 , pp. 535-546
    • Speers, A.E.1    Cravatt, B.F.2
  • 22
    • 0033524455 scopus 로고    scopus 로고
    • A bioluminescence resonance energy transfer (BRET) system: Application to interacting circadian clock proteins
    • Xu, Y., Piston, D. W., and Johnson, C. H. (1999) A bioluminescence resonance energy transfer (BRET) system: application to interacting circadian clock proteins Proc. Natl. Acad. Sci. U. S. A. 96, 151-156 10.1073/pnas.96.1.151
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 151-156
    • Xu, Y.1    Piston, D.W.2    Johnson, C.H.3
  • 26
    • 36048958965 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Overview and perspectives
    • Dokmanovic, M., Clarke, C., and Marks, P. A. (2007) Histone deacetylase inhibitors: overview and perspectives Mol. Cancer Res. 5, 981-989 10.1158/1541-7786.MCR-07-0324
    • (2007) Mol. Cancer Res. , vol.5 , pp. 981-989
    • Dokmanovic, M.1    Clarke, C.2    Marks, P.A.3
  • 32
    • 70349423396 scopus 로고    scopus 로고
    • Cell cycle regulatory effects of retinoic Acid and forskolin are mediated by the cyclin C gene
    • Makkonen, K. M., Malinen, M., Ropponen, A., Vaisanen, S., and Carlberg, C. (2009) Cell cycle regulatory effects of retinoic Acid and forskolin are mediated by the cyclin C gene J. Mol. Biol. 393, 261-271 10.1016/j.jmb.2009.08.024
    • (2009) J. Mol. Biol. , vol.393 , pp. 261-271
    • Makkonen, K.M.1    Malinen, M.2    Ropponen, A.3    Vaisanen, S.4    Carlberg, C.5
  • 34
    • 0015861774 scopus 로고
    • Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50% inhibition (I50) of an enzymatic reaction
    • Cheng, Y. and Prusoff, W. H. (1973) Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50% inhibition (I50) of an enzymatic reaction Biochem. Pharmacol. 22, 3099-3108 10.1016/0006-2952(73)90196-2
    • (1973) Biochem. Pharmacol. , vol.22 , pp. 3099-3108
    • Cheng, Y.1    Prusoff, W.H.2
  • 35
    • 84879136169 scopus 로고    scopus 로고
    • CSTP1, a novel protein phosphatase, blocks cell cycle, promotes cell apoptosis, and suppresses tumor growth of bladder cancer by directly dephosphorylating Akt at Ser473 site
    • Zhuo, D. X., Zhang, X. W., Jin, B., Zhang, Z., Xie, B. S., Wu, C. L., Gong, K., and Mao, Z. B. (2013) CSTP1, a novel protein phosphatase, blocks cell cycle, promotes cell apoptosis, and suppresses tumor growth of bladder cancer by directly dephosphorylating Akt at Ser473 site PLoS One 8, e65679 10.1371/journal.pone.0065679
    • (2013) PLoS One , vol.8 , pp. e65679
    • Zhuo, D.X.1    Zhang, X.W.2    Jin, B.3    Zhang, Z.4    Xie, B.S.5    Wu, C.L.6    Gong, K.7    Mao, Z.B.8
  • 36
    • 34548477656 scopus 로고    scopus 로고
    • Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase
    • Dominy, J. E., Jr., Simmons, C. R., Hirschberger, L. L., Hwang, J., Coloso, R. M., and Stipanuk, M. H. (2007) Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase J. Biol. Chem. 282, 25189-25198 10.1074/jbc.M703089200
    • (2007) J. Biol. Chem. , vol.282 , pp. 25189-25198
    • Dominy, J.E.1    Simmons, C.R.2    Hirschberger, L.L.3    Hwang, J.4    Coloso, R.M.5    Stipanuk, M.H.6
  • 39
    • 0032948482 scopus 로고    scopus 로고
    • A study of the relative bioavailability of cysteamine hydrochloride, cysteamine bitartrate and phosphocysteamine in healthy adult male volunteers
    • Tenneze, L., Daurat, V., Tibi, A., Chaumet-Riffaud, P., and Funck-Brentano, C. (1999) A study of the relative bioavailability of cysteamine hydrochloride, cysteamine bitartrate and phosphocysteamine in healthy adult male volunteers Br. J. Clin. Pharmacol. 47, 49-52 10.1046/j.1365-2125.1999.00844.x
    • (1999) Br. J. Clin. Pharmacol. , vol.47 , pp. 49-52
    • Tenneze, L.1    Daurat, V.2    Tibi, A.3    Chaumet-Riffaud, P.4    Funck-Brentano, C.5
  • 40
    • 0036172346 scopus 로고    scopus 로고
    • Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine
    • Karpuj, M. V., Becher, M. W., Springer, J. E., Chabas, D., Youssef, S., Pedotti, R., Mitchell, D., and Steinman, L. (2002) Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine Nat. Med. 8, 143-149 10.1038/nm0202-143
    • (2002) Nat. Med. , vol.8 , pp. 143-149
    • Karpuj, M.V.1    Becher, M.W.2    Springer, J.E.3    Chabas, D.4    Youssef, S.5    Pedotti, R.6    Mitchell, D.7    Steinman, L.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.