Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei

ACS Chemical Biology

Volumn 10, Issue 10, 2015, Pages 2373-2381

  Schulze, Christopher J ^a   Donia, Mohamed S ^b,f   Siqueira Neto, Jair L ^c   Ray, Debalina ^d   Raskatov, Jevgenij A ^a   Green, Richard E ^e   McKerrow, James H ^c   Fischbach, Michael A ^b   Linington, Roger G ^a,g  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e University of California Santa Cruz   (United States)

^f PRINCETON UNIVERSITY   (United States)

^g SIMON FRASER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITRYPANOSOMAL AGENT; LOBOSAMIDE A; LOBOSAMIDE B; LOBOSAMIDE C; LOBOSAMIDE C ACETONIDE; MACROCYCLIC LACTAM; MIRILACTAM A; MIRILACTAM B; POLYENE; UNCLASSIFIED DRUG; ANTIPROTOZOAL AGENT; LACTAM;

AFRICAN TRYPANOSOMIASIS; AMINO ACID SEQUENCE; ANTIPROTOZOAL ACTIVITY; ARTICLE; BACTERIAL GENOME; BIOINFORMATICS; BIOLOGICAL ACTIVITY; BIOSYNTHESIS; CONFORMATION; DERIVATIZATION; DIASTEREOISOMER; DNA BASE COMPOSITION; DRUG STRUCTURE; GENE CLUSTER; GENE SEQUENCE; HETERONUCLEAR MULTIPLE BOND CORRELATION; IC50; METABOLITE; MICROBIAL GENOME; MICROMONOSPORA; MOLECULAR BIOLOGY; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; OXIDATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STEROL ANALYSIS; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA BRUCEI; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; HUMAN; MULTIGENE FAMILY; PRECLINICAL STUDY; SYNTHESIS; TRYPANOSOMA BRUCEI BRUCEI;

ANIMALS; ANTIPROTOZOAL AGENTS; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; HUMANS; INHIBITORY CONCENTRATION 50; LACTAMS; MOLECULAR STRUCTURE; MULTIGENE FAMILY; POLYENES; TRYPANOSOMA BRUCEI BRUCEI;

EID: 84944727204     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/acschembio.5b00308     Document Type: Article

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